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P09795

- MTS1_SALIN

UniProt

P09795 - MTS1_SALIN

Protein

Modification methylase SinI

Gene

sinIM

Organism
Salmonella infantis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    • Comment

    Functioni

    This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the SinI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3504. M.SinI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase SinI (EC:2.1.1.37)
    Short name:
    M.SinI
    Alternative name(s):
    Cytosine-specific methyltransferase SinI
    Gene namesi
    Name:sinIM
    OrganismiSalmonella infantis
    Taxonomic identifieri595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Modification methylase SinIPRO_0000087905Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP09795.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini75 – 435361SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    IPR010093. Xis_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    TIGR01764. excise. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09795-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMNDIITVT EAAQLLELTP QRVRTMCKQG SIDAYQSGRT WLIKSSSVEK    50
    LMLVNSLSDA QNSYSMLASE PKNKPKALSF FSGAMGLDLG IEQAGFETLL 100
    ASEIDKAARD TILSNRPNMA LIGDIRDYTT EDILKLAGVS SGNEIDLIMG 150
    GPPCQAFSTA GKRLGLEDER GNVFIKYLDV ALDIRPKYIV IENVRGLLSA 200
    PMKHRPHNER GEGLPPLKSE EQPGGVLHYI IRIIKSAGYS VSFNLYNSAN 250
    FGVPQIRERV IIICSRDGSR VPFLQPTHSE KGEYGLPKWI TLRETITNLK 300
    NITHEHVLFP EKRLKYYRLL KEGQYWKHLP EDLQKEALGK SFFLGGGKTG 350
    FLRRVAWDRP SPTLVTHPAM PATDLAHPDE LRPLSVQEYK VIQQFPEEWV 400
    IKGKLLDKYR QLGNAVPIGL GLAVGKNILD HMNGRKIESF PNFRYSRYKN 450
    TSDLDIFGEL V 461
    Length:461
    Mass (Da):51,767
    Last modified:July 1, 1989 - v1
    Checksum:i5EA688C4F465BBC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03391 Genomic DNA. Translation: AAA27212.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03391 Genomic DNA. Translation: AAA27212.1 .

    3D structure databases

    ProteinModelPortali P09795.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3504. M.SinI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    IPR010093. Xis_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    TIGR01764. excise. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and complete nucleotide sequences of the type II restriction-modification genes of Salmonella infantis."
      Karreman C., de Waard A.
      J. Bacteriol. 170:2527-2532(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTS1_SALIN
    AccessioniPrimary (citable) accession number: P09795
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3