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P09795

- MTS1_SALIN

UniProt

P09795 - MTS1_SALIN

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Protein

Modification methylase SinI

Gene
sinIM
Organism
Salmonella infantis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the SinI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3504. M.SinI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase SinI (EC:2.1.1.37)
Short name:
M.SinI
Alternative name(s):
Cytosine-specific methyltransferase SinI
Gene namesi
Name:sinIM
OrganismiSalmonella infantis
Taxonomic identifieri595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Modification methylase SinIPRO_0000087905Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 435361SAM-dependent MTase C5-typeAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
IPR010093. Xis_DNA-bd.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
TIGR01764. excise. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09795-1 [UniParc]FASTAAdd to Basket

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MIMNDIITVT EAAQLLELTP QRVRTMCKQG SIDAYQSGRT WLIKSSSVEK    50
LMLVNSLSDA QNSYSMLASE PKNKPKALSF FSGAMGLDLG IEQAGFETLL 100
ASEIDKAARD TILSNRPNMA LIGDIRDYTT EDILKLAGVS SGNEIDLIMG 150
GPPCQAFSTA GKRLGLEDER GNVFIKYLDV ALDIRPKYIV IENVRGLLSA 200
PMKHRPHNER GEGLPPLKSE EQPGGVLHYI IRIIKSAGYS VSFNLYNSAN 250
FGVPQIRERV IIICSRDGSR VPFLQPTHSE KGEYGLPKWI TLRETITNLK 300
NITHEHVLFP EKRLKYYRLL KEGQYWKHLP EDLQKEALGK SFFLGGGKTG 350
FLRRVAWDRP SPTLVTHPAM PATDLAHPDE LRPLSVQEYK VIQQFPEEWV 400
IKGKLLDKYR QLGNAVPIGL GLAVGKNILD HMNGRKIESF PNFRYSRYKN 450
TSDLDIFGEL V 461
Length:461
Mass (Da):51,767
Last modified:July 1, 1989 - v1
Checksum:i5EA688C4F465BBC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03391 Genomic DNA. Translation: AAA27212.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03391 Genomic DNA. Translation: AAA27212.1 .

3D structure databases

ProteinModelPortali P09795.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3504. M.SinI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
IPR010093. Xis_DNA-bd.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
TIGR01764. excise. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and complete nucleotide sequences of the type II restriction-modification genes of Salmonella infantis."
    Karreman C., de Waard A.
    J. Bacteriol. 170:2527-2532(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTS1_SALIN
AccessioniPrimary (citable) accession number: P09795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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