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Reviewed, UniProtKB/Swiss-Prot P09793 (CTLA4_MOUSE)

Last modified January 19, 2010. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytotoxic T-lymphocyte protein 4
Alternative name(s):
    Cytotoxic T-lymphocyte-associated antigen 4
      Short name=CTLA-4
    CD_antigen=CD152
Gene names
Name: Ctla4
Synonyms: Cd152
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Possibly involved in T-cell activation. Binds to B7-1 (CD80) and B7-2 (CD86).

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Widely expressed with highest levels in lymphoid tissues. Ref.2

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Signal
Transmembrane
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processimmune response

Inferred from electronic annotation. Source: InterPro

   Cellular componentexternal side of plasma membrane

Inferred from direct assay. Source: MGI

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 223188Cytotoxic T-lymphocyte protein 4
PRO_0000014735

Regions

Topological domain36 – 161126Extracellular Potential
Transmembrane162 – 18221 Potential
Topological domain183 – 22341Cytoplasmic Potential
Domain36 – 145110Ig-like V-type

Amino acid modifications

Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 129
Disulfide bond85 ↔ 103

Experimental info

Sequence conflict1821S → T in AAF01489. Ref.2

Secondary structure

1 ......................... 223
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P09793-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 5318FAAF416F4685

FASTA22324,993
        10         20         30         40         50         60 
MACLGLRRYK AQLQLPSRTW PFVALLTLLF IPVFSEAIQV TQPSVVLASS HGVASFPCEY 

        70         80         90        100        110        120 
SPSHNTDEVR VTVLRQTNDQ MTEVCATTFT EKNTVGFLDY PFCSGTFNES RVNLTIQGLR 

       130        140        150        160        170        180 
AVDTGLYLCK VELMYPPPYF VGMGNGTQIY VIDPEPCPDS DFLLWILVAV SLGLFFYSFL 

       190        200        210        220 
VSAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN

« Hide

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References

[1]"A new member of the immunoglobulin superfamily -- CTLA-4."
Brunet J.-F., Denizot F., Luciani M.-F., Roux-Dosseto M., Suzan M., Mattei M.-G., Golstein P.
Nature 328:267-270(1987) [PubMed: 3496540] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders."
Ling V., Wu P.W., Finnerty H.F., Sharpe A.H., Gray G.S., Collins M.
Genomics 60:341-355(1999) [PubMed: 10493833] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/SvJ.
[3]"CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."
Harper K., Balzano C., Rouvier E., Mattei M.-G., Luciani M.-F., Golstein P.
J. Immunol. 147:1037-1044(1991) [PubMed: 1713603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-36.
[4]"Structure of murine CTLA-4 and its role in modulating T cell responsiveness."
Ostrov D.A., Shi W., Schwartz J.-C., Almo S.C., Nathenson S.G.
Science 290:816-819(2000) [PubMed: 11052947] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 38-154.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X05719 mRNA. Translation: CAA29191.1.
AF142145 Genomic DNA. Translation: AAF01489.1.
M74362 Genomic DNA. Translation: AAA37489.1.
IPIIPI00110378.
PIRA29063.
RefSeqNP_033973.2.
UniGeneMm.390

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DQTX-ray2.00A/B/C/D38-154[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP09793.

PTM databases

PhosphoSiteP09793.

Proteomic databases

PRIDEP09793.

Genome annotation databases

EnsemblENSMUST00000027164; ENSMUSP00000027164; ENSMUSG00000026011; Mus musculus. [Genome view]
GeneID12477.
KEGGmmu:12477.

Organism-specific databases

CTD12477.
MGIMGI:88556. Ctla4.

Phylogenomic databases

eggNOGmaNOG13609.
HOGENOMHBG280302.
HOVERGENP09793.
InParanoidP09793.

Gene expression databases

ArrayExpressP09793.
BgeeP09793.
CleanExMM_CTLA4.
GenevestigatorP09793.
GermOnlineENSMUSG00000026011. Mus musculus.

Family and domain databases

InterProIPR008096. CTLA4.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01720. CTLANTIGEN4.
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameCTLA4_MOUSE
AccessionPrimary (citable) accession number: P09793
Secondary accession number(s): Q9QZZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 19, 2010
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents