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Reviewed, UniProtKB/Swiss-Prot P09790 (IGA_NEIGO)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    IgA-specific serine endopeptidase
    EC=3.4.21.72
Alternative name(s):
    IgA protease
Gene names
Name: iga
OrganismNeisseria gonorrhoeae
Taxonomic identifier485 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

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Protein attributes

Sequence length1532 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This protease is specific for immunoglobulin A.

Catalytic activity

Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.

Subcellular location

Secreted.

Domain

The signal peptide guides the precursor to the periplasmic space, and the C-terminal helper domain associates with the outer membrane to form a pore for excretion of the protease domain. The helper domain is then released by autoproteolysis.

Sequence similarities

Contains 1 autotransporter (TC 1.B.12) domain. [View classification]

Contains 1 peptidase S6 domain.

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Ontologies

Keywords
   Cellular componentMembrane
Secreted
   DomainSignal
Transmembrane
   Molecular functionHydrolase
Protease
Serine protease
   PTMAutocatalytic cleavage
Zymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

outer membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727
Chain28 – 986959IgA-specific serine endopeptidase
PRO_0000026968
Propeptide987 – 1532546Helper peptide
PRO_0000026969

Regions

Domain1280 – 1532253Autotransporter

Sites

Active site2781 Potential
Site986 – 9872Cleavage; by autolysis
Site1018 – 10192Cleavage; by autolysis
Site1121 – 11222Cleavage; by autolysis

Experimental info

Sequence conflict3261H → N Ref.2
Sequence conflict3381H → N Ref.2
Sequence conflict4281N → M Ref.2
Sequence conflict5321H → N Ref.2
Sequence conflict6161I → V Ref.2
Sequence conflict6321H → N Ref.2
Sequence conflict6681K → N Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P09790-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 68FF4112BD22F40D

FASTA1,532168,976
        10         20         30         40         50         60 
MKAKRFKINA ISLSIFLAYA LTPYSEAALV RDDVDYQIFR DFAENKGKFF VGATDLSVKN 

        70         80         90        100        110        120 
KRGQNIGNAL SNVPMIDFSV ADVNKRIATV VDPQYAVSVK HAKAEVHTFY YGQYNGHNDV 

       130        140        150        160        170        180 
ADKENEYRVV EQNNYEPHKA WGASNLGRLE DYNMARFNKF VTEVAPIAPT DAGGGLDTYK 

       190        200        210        220        230        240 
DKNRFSSFVR IGAGRQLVYE KGVYHQEGNE KGYDLRDLSQ AYRYAIAGTP YKDINIDQTM 

       250        260        270        280        290        300 
NTEGLIGFGN HNKQYSAEEL KQALSQDALT NYGVLGDSGS PLFAFDKQKN QWVFLGTYDY 

       310        320        330        340        350        360 
WAGYGKKSWQ EWNIYKKEFA DKIKQHDNAG TVKGNGEHHW KTTGTNSHIG STAVRLANNE 

       370        380        390        400        410        420 
GDANNGQNVT FEDNGTLVLN QNINQGAGGL FFKGDYTVKG ANNDITWLGA GIDVADGKKV 

       430        440        450        460        470        480 
VWQVKNPNGD RLAKIGKGTL EINGTGVNQG QLKVGDGTVI LNQKADADKK VQAFSQVGIV 

       490        500        510        520        530        540 
SGRGTLVLNS SNQINPDNLY FGFRGGRLDA NGNDLTFEHI RNVDEGARIV NHNTDHASTI 

       550        560        570        580        590        600 
TLTGKSLITN PNSLSVHSIQ NDYDEDDYSY YYRPRRPIPQ GKDLYYKNYR YYALKSGGRL 

       610        620        630        640        650        660 
NAPMPENGVA ENNDWIFMGY TQEEARKNAM NHKNNRRIGD FGGFFDEENG KGHNGALNLN 

       670        680        690        700        710        720 
FNGKSAQKRF LLTGGANLNG KISVTQGNVL LSGRPTPHAR DFVNKSSARK DAHFSKNNEV 

       730        740        750        760        770        780 
VFEDDWINRT FKAAEIAVNQ SASFSSGRNV SDITANITAT DNAKVNLGYK NGDEVCVRSD 

       790        800        810        820        830        840 
YTGYVTCNTG NLSDKALNSF DATRINGNVN LNQNAALVLG KAALWGKIQG QGNSRVSLNQ 

       850        860        870        880        890        900 
HSKWHLTGDS QVHNLSLADS HIHLNNASDA QSANKYHTIK INHLSGNGHF HYLTDLAKNL 

       910        920        930        940        950        960 
GDKVLVKESA SGHYQLHVQN KTGEPNQEGL DLFDASSVQD RSRLFVSLAN HYVDLGALRY 

       970        980        990       1000       1010       1020 
TIKTENGITR LYNPYAGNGR PVKPAPSPAA NTASQAQKAT QTDGAQIAKP QNIVVAPPSP 

      1030       1040       1050       1060       1070       1080 
QANQAEEALR QQAKAEQVKR QQAAEAEKVA RQKDEEAKRK AAEIARQQEE ARKAAELAAK 

      1090       1100       1110       1120       1130       1140 
QKAEAERKAR ELARQKAEEA SHQANAKPKR RRRRAILPRP PAPVFSLDDY DAKDNSESSI 

      1150       1160       1170       1180       1190       1200 
GNLARVIPRM GRELINDYEE IPLEELEDEA EEERRQATQF HSKSRNRRAI SSEPSSDEDA 

      1210       1220       1230       1240       1250       1260 
SESVSTSDKH PQDNTELHEK VETAGLQPRA AQPRTQAAAQ ADAVSTNTNS ALSDAMASTQ 

      1270       1280       1290       1300       1310       1320 
SILLDTGAYL TRHIAQKSRA DAEKNSVWMS NTGYGRDYAS AQYRRFSSKR TQTQIGIDRS 

      1330       1340       1350       1360       1370       1380 
LSENMQIGGV LTYSDSQHTF DQAGGKNTFV QANLYGKYYL NDAWYVAGDI GAGSLRSRLQ 

      1390       1400       1410       1420       1430       1440 
TQQKANFNRT SIQTGLTLGN TLKINQFEIV PSAGIRYSRL SSADYKLGDD SVKVSSMAVK 

      1450       1460       1470       1480       1490       1500 
TLTAGLDFAY RFKVGNLTVK PLLSAAYFAN YGKGGVNVGG KSFAYKADNQ QQYSAGVALL 

      1510       1520       1530 
YRNVTLNVNG SITKGKQLEK QKSGQIKIQI RF

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References

[1]"Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease."
Pohlner J., Halter R., Beyreuther K., Meyer T.F.
Nature 325:458-462(1987) [PubMed: 3027577] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: MS11.
[2]"Mosaic-like organization of IgA protease genes in Neisseria gonorrhoeae generated by horizontal genetic exchange in vivo."
Halter R., Pohlner J., Meyer T.F.
EMBO J. 8:2737-2744(1989) [PubMed: 2511009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-680 AND 957-1256.
Strain: MS11.
[3]"Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids."
Bachovchin W.W., Plaut A.G., Flentke G.R., Lynch M., Kettner C.A.
J. Biol. Chem. 265:3738-3743(1990) [PubMed: 2105953] [Abstract]
Cited for: ACTIVE SITE.

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Cross-references

Sequence databases

X04835 Genomic DNA. Translation: CAA28538.1.
PIRA26039.

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB1.B.12.3.1. autotransporter-1 (AT-1) family.

Enzyme and pathway databases

BRENDA3.4.21.72. 588.

Family and domain databases

InterProIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR012332. P22_tailspike.
IPR000710. Peptidase_S6.
IPR004899. Pertactin.
[Graphical view]
Gene3DG3DSA:2.160.20.20. P22_tailspike. 1 hit.
PfamPF03797. Autotransporter. 1 hit.
PF02395. Peptidase_S6. 1 hit.
PF03212. Pertactin. 1 hit.
[Graphical view]
PRINTSPR00921. IGASERPTASE.
TIGRFAMsTIGR01414. autotrans_barl. 1 hit.
PROSITEPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

PMAP-CutDBP09790.

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Entry information

Entry nameIGA_NEIGO
AccessionPrimary (citable) accession number: P09790
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents