Reviewed, UniProtKB/Swiss-Prot P09760 (FER_RAT)

Names and origin

Protein names

Recommended name:
    Proto-oncogene tyrosine-protein kinase Fer
    EC=2.7.10.2
Alternative name(s):
    Proto-oncogene c-Fer
    p94-Fer
    Tyrosine-protein kinase FLK

Gene names

Name:	Fer
Synonyms:	Fert2, Flk

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	323 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Rab GTPase binding Inferred from physical interaction. Source: RGD actin binding Inferred from physical interaction. Source: RGD cadherin binding Inferred from physical interaction. Source: RGD gamma-catenin binding Inferred from physical interaction. Source: RGD non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC protein kinase binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 323	›323	Proto-oncogene tyrosine-protein kinase Fer		PRO_0000088093
Regions
	Domain	‹1 – 51	›51	SH2
	Domain	64 – 317	254	Protein kinase
	Nucleotide binding	70 – 78	9	ATP By similarity
Sites
	Active site	185	1	Proton acceptor By similarity
	Binding site	92	1	ATP By similarity
Amino acid modifications
	Modified residue	215	1	Phosphotyrosine; by autocatalysis By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P09760-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: D7BA8BDE50C3EAC1	FASTA	323	37,104
	10 20 30 40 50 60 RQRRHFIIQF VDNLYRFEGT GFSNIPQLID HHFNTKQVIT KKSGVVLLNP IPKDKKWVLN 70 80 90 100 110 120 HEDVSLGELL GKGNFGEVYK GTLKDKTPVA VKTCKEDLPQ ELKIKFLQEA KILKQYDHPN 130 140 150 160 170 180 IVKLIGVCTQ RQPVYIIMEL VPGGDFLSFL RKRKDELKLK QLVRFSLDVA AGMLYLEGKN 190 200 210 220 230 240 CIHRDLAARN CLVGENNTLK ISDFGMSRQE DGGVYSSSGL KQIPIKWTAP EALNYGRYSS 250 260 270 280 290 300 ESDVWSFGIL LWETFSLGVC PYPGMTNQQA REQVERGYRM SAPQNCPEEI FTIMMKCWDY 310 320 KPENRPKFSD LHKELTAIKK KIT

References

[1]	"Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody." Letwin K., Yee S.P., Pawson T. Oncogene 3:621-627(1988) [PubMed: 2485255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13412 mRNA. Translation: CAA31778.1.
IPI	IPI00768068.
PIR	S04328.
UniGene	Rn.102629
3D structure databases
SMR	P09760. Positions 4-321.
ModBase	Search...
Protein-protein interaction databases
STRING	P09760.
PTM databases
PhosphoSite	P09760.
Genome annotation databases
Ensembl	ENSRNOT00000021758; ENSRNOP00000021758; ENSRNOG00000015898; Rattus norvegicus. [Genome view] ENSRNOT00000049486; ENSRNOP00000040705; ENSRNOG00000015898; Rattus norvegicus. [Genome view] ENSRNOT00000056430; ENSRNOP00000053268; ENSRNOG00000015898; Rattus norvegicus. [Genome view]
Organism-specific databases
RGD	1306273. Fert2.
Phylogenomic databases
eggNOG	roNOG11172.
HOVERGEN	P09760.
InParanoid	P09760.
Enzyme and pathway databases
BRENDA	2.7.10.2. 248.
Gene expression databases
ArrayExpress	P09760.
Genevestigator	P09760.
GermOnline	ENSRNOG00000015898. Rattus norvegicus.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR23256. Tyr_prot_kinase. 1 hit.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FER_RAT

Accession

Primary (citable) accession number: P09760

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	February 9, 2010
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)