P09758 (TACD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor-associated calcium signal transducer 2

Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1

Gene names

Name:	TACSTD2
Synonyms:	GA733-1, M1S1, TROP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a growth factor receptor.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Placenta, pancreatic carcinoma cell lines.
Post-translational modification	The N-terminus is blocked.
Involvement in disease	Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Sequence similarities	Belongs to the EPCAM family. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Amyloid Membrane
Coding sequence diversity	Polymorphism
Disease	Amyloidosis Corneal dystrophy
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Tumor antigen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.3. Source: ProtInc cell surface receptor signaling pathway Traceable author statement Ref.3. Source: ProtInc negative regulation of branching involved in ureteric bud morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of epithelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of ruffle assembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of stress fiber assembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of substrate adhesion-dependent cell spreading Inferred from sequence or structural similarity. Source: UniProtKB regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara visual perception Traceable author statement Ref.8. Source: ProtInc
Cellular_component	basal plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB cytosol Traceable author statement Ref.8. Source: ProtInc integral to plasma membrane Traceable author statement Ref.3. Source: ProtInc lateral plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	receptor activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 323	297	Tumor-associated calcium signal transducer 2		PRO_0000022468
Regions
	Topological domain	27 – 274	248	Extracellular Potential
	Transmembrane	275 – 297	23	Helical; Potential
	Topological domain	298 – 323	26	Cytoplasmic Potential
	Domain	70 – 145	76	Thyroglobulin type-1
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Disulfide bond	73 ↔ 108		By similarity
	Disulfide bond	119 ↔ 125		By similarity
	Disulfide bond	127 ↔ 145		By similarity
Natural variations
	Natural variant	147	1	E → D. Ref.1 Corresponds to variant rs1062964 [ dbSNP | Ensembl ].		VAR_051407
	Natural variant	173	1	D → A. Ref.10 Corresponds to variant rs35075952 [ dbSNP | Ensembl ].		VAR_012451
	Natural variant	216	1	D → E. Ref.2 Ref.7 Corresponds to variant rs14008 [ dbSNP | Ensembl ].		VAR_016981
Experimental info
	Sequence conflict	220	1	G → D in CAG47056. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P09758 [UniParc]. Last modified November 13, 2007. Version 3. Checksum: C8081FBE1D0B9F73	FASTA	323	35,709
	10 20 30 40 50 60 MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG GRCQCRALGS 70 80 90 100 110 120 GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN DGLYDPDCDP EGRFKARQCN 130 140 150 160 170 180 QTSVCWCVNS VGVRRTDKGD LSLRCDELVR THHILIDLRH RPTAGAFNHS DLDAELRRLF 190 200 210 220 230 240 RERYRLHPKF VAAVHYEQPT IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG 250 260 270 280 290 300 GLDLRVRGEP LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR 310 320 RKSGKYKKVE IKELGELRKE PSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733." Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H. Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147. Tissue: Placenta.
[2]	"Retroposition in a family of carcinoma-associated antigen genes." Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K. Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216. Tissue: Placenta.
[3]	"Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas." Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S. Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216. Tissue: Pancreas.
[8]	"Identification of the gene responsible for gelatinous drop-like corneal dystrophy." Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y. Nat. Genet. 21:420-423(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN GDLD.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy." Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A. Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ALA-173.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13425 mRNA. Translation: CAA31781.1. J04152 Genomic DNA. Translation: AAA52505.1. X77753 mRNA. Translation: CAA54799.1. X77754 mRNA. Translation: CAA54801.1. BT007255 mRNA. Translation: AAP35919.1. CR542260 mRNA. Translation: CAG47056.1. AL035411 Genomic DNA. Translation: CAB72325.1. BC009409 mRNA. Translation: AAH09409.1.
IPI	IPI00297910.
PIR	A48149.
RefSeq	NP_002344.2. NM_002353.2.
UniGene	Hs.23582.
3D structure databases
ProteinModelPortal	P09758.
SMR	P09758. Positions 101-137.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09758. 2 interactions.
STRING	9606.ENSP00000360269.
PTM databases
PhosphoSite	P09758.
Polymorphism databases
DMDM	160113102.
Proteomic databases
PaxDb	P09758.
PRIDE	P09758.
Protocols and materials databases
DNASU	4070.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371225; ENSP00000360269; ENSG00000184292.
GeneID	4070.
KEGG	hsa:4070.
UCSC	uc001cyz.4. human.
Organism-specific databases
CTD	4070.
GeneCards	GC01M059041.
HGNC	HGNC:11530. TACSTD2.
HPA	HPA043104.
MIM	137290. gene. 204870. phenotype.
neXtProt	NX_P09758.
Orphanet	98957. Gelatinous drop-like corneal dystrophy. 98958. Honey-droplet corneal dystrophy.
PharmGKB	PA36305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46689.
HOGENOM	HOG000074086.
HOVERGEN	HBG053004.
InParanoid	P09758.
OMA	RQCNQTS.
OrthoDB	EOG4V6ZHK.
PhylomeDB	P09758.
Gene expression databases
Bgee	P09758.
CleanEx	HS_TACSTD2.
Genevestigator	P09758.
GermOnline	ENSG00000184292. Homo sapiens.
Family and domain databases
Gene3D	4.10.800.10. 1 hit.
InterPro	IPR000716. Thyroglobulin_1. [Graphical view]
Pfam	PF00086. Thyroglobulin_1. 1 hit. [Graphical view]
SMART	SM00211. TY. 1 hit. [Graphical view]
SUPFAM	SSF57610. Thyroglobulin_1. 1 hit.
PROSITE	PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TACSTD2. human.
GenomeRNAi	4070.
NextBio	15956.
SOURCE	Search...

Entry information

Entry name

TACD2_HUMAN

Accession

Primary (citable) accession number: P09758
Secondary accession number(s): Q15658 , Q6FG48, Q7Z7Q4, Q96QD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 146 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.