P09758 (TACD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 133.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tumor-associated calcium signal transducer 2 Alternative name(s): Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May function as a growth factor receptor. |
| Subcellular location | |
| Tissue specificity | Placenta, pancreatic carcinoma cell lines. |
| Post-translational modification | The N-terminus is blocked. |
| Involvement in disease | Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Ref.9 |
| Sequence similarities | Belongs to the EPCAM family. Contains 1 thyroglobulin type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Vision |
| Cellular component | Amyloid Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal Transmembrane Transmembrane helix |
| Molecular function | Tumor antigen |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cell proliferation Traceable author statement. Source: ProtInc cell surface receptor linked signaling pathwayTraceable author statement. Source: ProtInc visual perceptionTraceable author statement. Source: ProtInc |
| Cellular component | cytosol Traceable author statement. Source: ProtInc integral to plasma membraneTraceable author statement. Source: ProtInc |
| Molecular function | receptor activity Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Potential | ||||||||
| Chain | 27 – 323 | 297 | Tumor-associated calcium signal transducer 2 | PRO_0000022468 | |||||||
Regions | |||||||||||
| Topological domain | 27 – 274 | 248 | Extracellular Potential | ||||||||
| Transmembrane | 275 – 297 | 23 | Helical; Potential | ||||||||
| Topological domain | 298 – 323 | 26 | Cytoplasmic Potential | ||||||||
| Domain | 70 – 145 | 76 | Thyroglobulin type-1 | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 322 | 1 | Phosphoserine Ref.8 | ||||||||
| Glycosylation | 33 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 120 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 168 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 208 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 73 ↔ 108 | By similarity | |||||||||
| Disulfide bond | 119 ↔ 125 | By similarity | |||||||||
| Disulfide bond | 127 ↔ 145 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 147 | 1 | E → D. Ref.1 Corresponds to variant rs1062964 [ dbSNP | Ensembl ]. | VAR_051407 | |||||||
| Natural variant | 173 | 1 | D → A. Ref.10 Corresponds to variant rs35075952 [ dbSNP | Ensembl ]. | VAR_012451 | |||||||
| Natural variant | 216 | 1 | D → E. Ref.2 Ref.7 Corresponds to variant rs14008 [ dbSNP | Ensembl ]. | VAR_016981 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 220 | 1 | G → D in CAG47056. Ref.5 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733." Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H. Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed: 2911574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147. Tissue: Placenta. |
| [2] | "Retroposition in a family of carcinoma-associated antigen genes." Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K. Mol. Cell. Biol. 13:1507-1515(1993) [PubMed: 8382772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216. Tissue: Placenta. |
| [3] | "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas." Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S. Int. J. Cancer 62:610-618(1995) [PubMed: 7665234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216. Tissue: Pancreas. |
| [8] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [9] | "Identification of the gene responsible for gelatinous drop-like corneal dystrophy." Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y. Nat. Genet. 21:420-423(1999) [PubMed: 10192395] [Abstract] Cited for: INVOLVEMENT IN GDLD. |
| [10] | "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy." Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A. Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed: 11687514] [Abstract] Cited for: VARIANT ALA-173. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X13425 mRNA. Translation: CAA31781.1. J04152 Genomic DNA. Translation: AAA52505.1. X77753 mRNA. Translation: CAA54799.1. X77754 mRNA. Translation: CAA54801.1. BT007255 mRNA. Translation: AAP35919.1. CR542260 mRNA. Translation: CAG47056.1. AL035411 Genomic DNA. Translation: CAB72325.1. BC009409 mRNA. Translation: AAH09409.1. |
| IPI | IPI00297910. |
| PIR | A48149. |
| RefSeq | NP_002344.2. NM_002353.2. |
| UniGene | Hs.23582. |
3D structure databases | |
| ProteinModelPortal | P09758. |
| SMR | P09758. Positions 101-137. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P09758. 1 interaction. |
| STRING | P09758. |
PTM databases | |
| PhosphoSite | P09758. |
Polymorphism databases | |
| DMDM | 160113102. |
Proteomic databases | |
| PRIDE | P09758. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000371225; ENSP00000360269; ENSG00000184292. |
| GeneID | 4070. |
| KEGG | hsa:4070. |
| UCSC | uc001cyz.2. human. |
Organism-specific databases | |
| CTD | 4070. |
| GeneCards | GC01M059041. |
| H-InvDB | HIX0199960. |
| HGNC | HGNC:11530. TACSTD2. |
| HPA | HPA043104. |
| MIM | 137290. gene. 204870. phenotype. |
| neXtProt | NX_P09758. |
| Orphanet | 98957. Gelatinous drop-like corneal dystrophy. |
| PharmGKB | PA36305. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG17387. |
| GeneTree | ENSGT00390000018245. |
| HOGENOM | HBG506459. |
| HOVERGEN | HBG053004. |
| InParanoid | P09758. |
| OMA | KARQCNQ. |
| OrthoDB | EOG4V6ZHK. |
| PhylomeDB | P09758. |
Gene expression databases | |
| ArrayExpress | P09758. |
| Bgee | P09758. |
| CleanEx | HS_TACSTD2. |
| Genevestigator | P09758. |
| GermOnline | ENSG00000184292. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000716. Thyroglobulin_1. [Graphical view] |
| Gene3D | G3DSA:4.10.800.10. Thyroglobulin_1. 1 hit. |
| Pfam | PF00086. Thyroglobulin_1. 1 hit. [Graphical view] |
| SMART | SM00211. TY. 1 hit. [Graphical view] |
| SUPFAM | SSF57610. Thyroglobulin_1. 1 hit. |
| PROSITE | PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 15956. |
| SOURCE | Search... |
Entry information
| Entry name | TACD2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P09758 Secondary accession number(s): Q15658 Q96QD2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with