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P09758 (TACD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 154. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1
Gene names
Name:TACSTD2
Synonyms:GA733-1, M1S1, TROP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a growth factor receptor.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Placenta, pancreatic carcinoma cell lines.

Post-translational modification

The N-terminus is blocked.

Involvement in disease

Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities

Belongs to the EPCAM family.

Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
   Biological processSensory transduction
Vision
   Cellular componentAmyloid
Membrane
   Coding sequence diversityPolymorphism
   DiseaseAmyloidosis
Corneal dystrophy
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionTumor antigen
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Traceable author statement Ref.3. Source: ProtInc

cell surface receptor signaling pathway

Traceable author statement Ref.3. Source: ProtInc

negative regulation of branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell motility

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of epithelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of ruffle assembly

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of stress fiber assembly

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of substrate adhesion-dependent cell spreading

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

visual perception

Traceable author statement Ref.8. Source: ProtInc

   Cellular_componentbasal plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Traceable author statement Ref.8. Source: ProtInc

extracellular space

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 19199708. Source: UniProt

integral component of plasma membrane

Traceable author statement Ref.3. Source: ProtInc

lateral plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

membrane

Traceable author statement Ref.2. Source: ProtInc

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionreceptor activity

Traceable author statement Ref.3. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 323297Tumor-associated calcium signal transducer 2
PRO_0000022468

Regions

Topological domain27 – 274248Extracellular Potential
Transmembrane275 – 29723Helical; Potential
Topological domain298 – 32326Cytoplasmic Potential
Domain70 – 14576Thyroglobulin type-1

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond73 ↔ 108 By similarity
Disulfide bond119 ↔ 125 By similarity
Disulfide bond127 ↔ 145 By similarity

Natural variations

Natural variant1471E → D. Ref.1
Corresponds to variant rs1062964 [ dbSNP | Ensembl ].
VAR_051407
Natural variant1731D → A. Ref.10
Corresponds to variant rs35075952 [ dbSNP | Ensembl ].
VAR_012451
Natural variant2161D → E. Ref.2 Ref.7
Corresponds to variant rs14008 [ dbSNP | Ensembl ].
VAR_016981

Experimental info

Sequence conflict2201G → D in CAG47056. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P09758 [UniParc].

Last modified November 13, 2007. Version 3.
Checksum: C8081FBE1D0B9F73

FASTA32335,709
        10         20         30         40         50         60 
MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG GRCQCRALGS 

        70         80         90        100        110        120 
GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN DGLYDPDCDP EGRFKARQCN 

       130        140        150        160        170        180 
QTSVCWCVNS VGVRRTDKGD LSLRCDELVR THHILIDLRH RPTAGAFNHS DLDAELRRLF 

       190        200        210        220        230        240 
RERYRLHPKF VAAVHYEQPT IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG 

       250        260        270        280        290        300 
GLDLRVRGEP LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR 

       310        320 
RKSGKYKKVE IKELGELRKE PSL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147.
Tissue: Placenta.
[2]"Retroposition in a family of carcinoma-associated antigen genes."
Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216.
Tissue: Placenta.
[3]"Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas."
Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.
Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216.
Tissue: Pancreas.
[8]"Identification of the gene responsible for gelatinous drop-like corneal dystrophy."
Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y.
Nat. Genet. 21:420-423(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN GDLD.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy."
Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A.
Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ALA-173.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13425 mRNA. Translation: CAA31781.1.
J04152 Genomic DNA. Translation: AAA52505.1.
X77753 mRNA. Translation: CAA54799.1.
X77754 mRNA. Translation: CAA54801.1.
BT007255 mRNA. Translation: AAP35919.1.
CR542260 mRNA. Translation: CAG47056.1.
AL035411 Genomic DNA. Translation: CAB72325.1.
BC009409 mRNA. Translation: AAH09409.1.
PIRA48149.
RefSeqNP_002344.2. NM_002353.2.
UniGeneHs.23582.

3D structure databases

ProteinModelPortalP09758.
SMRP09758. Positions 101-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110248. 3 interactions.
IntActP09758. 3 interactions.
STRING9606.ENSP00000360269.

PTM databases

PhosphoSiteP09758.

Polymorphism databases

DMDM160113102.

Proteomic databases

PaxDbP09758.
PRIDEP09758.

Protocols and materials databases

DNASU4070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371225; ENSP00000360269; ENSG00000184292.
GeneID4070.
KEGGhsa:4070.
UCSCuc001cyz.4. human.

Organism-specific databases

CTD4070.
GeneCardsGC01M059041.
HGNCHGNC:11530. TACSTD2.
HPAHPA043104.
HPA055067.
MIM137290. gene.
204870. phenotype.
neXtProtNX_P09758.
Orphanet98957. Gelatinous drop-like corneal dystrophy.
98958. Honey-droplet corneal dystrophy.
PharmGKBPA36305.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46689.
HOGENOMHOG000074086.
HOVERGENHBG053004.
InParanoidP09758.
KOK17288.
OMARQCNQTS.
OrthoDBEOG7HQN8S.
PhylomeDBP09758.
TreeFamTF332767.

Gene expression databases

BgeeP09758.
CleanExHS_TACSTD2.
GenevestigatorP09758.

Family and domain databases

Gene3D4.10.800.10. 1 hit.
InterProIPR000716. Thyroglobulin_1.
[Graphical view]
PfamPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTSM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57610. SSF57610. 1 hit.
PROSITEPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTACSTD2. human.
GeneWikiTACSTD2.
GenomeRNAi4070.
NextBio15956.
PROP09758.
SOURCESearch...

Entry information

Entry nameTACD2_HUMAN
AccessionPrimary (citable) accession number: P09758
Secondary accession number(s): Q15658 expand/collapse secondary AC list , Q6FG48, Q7Z7Q4, Q96QD2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM