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Protein

Tumor-associated calcium signal transducer 2

Gene

TACSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a growth factor receptor.

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1
Gene namesi
Name:TACSTD2
Synonyms:GA733-1, M1S1, TROP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11530. TACSTD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 274248ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29723HelicalSequence AnalysisAdd
BLAST
Topological domaini298 – 32326CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basal plasma membrane Source: UniProtKB
  • cytosol Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • lateral plasma membrane Source: UniProtKB
  • membrane Source: ProtInc
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, gelatinous drop-like (GDLD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.

See also OMIM:204870

Keywords - Diseasei

Amyloidosis, Corneal dystrophy

Organism-specific databases

MIMi204870. phenotype.
Orphaneti98957. Gelatinous drop-like corneal dystrophy.
98958. Honey-droplet corneal dystrophy.
PharmGKBiPA36305.

Polymorphism and mutation databases

BioMutaiTACSTD2.
DMDMi160113102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 323297Tumor-associated calcium signal transducer 2PRO_0000022468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 108PROSITE-ProRule annotation
Disulfide bondi119 ↔ 125PROSITE-ProRule annotation
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 145PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP09758.
PaxDbiP09758.
PRIDEiP09758.

PTM databases

PhosphoSiteiP09758.

Expressioni

Tissue specificityi

Placenta, pancreatic carcinoma cell lines.

Gene expression databases

BgeeiP09758.
CleanExiHS_TACSTD2.
GenevisibleiP09758. HS.

Organism-specific databases

HPAiCAB072852.
HPA043104.
HPA055067.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLDN1O958322EBI-4324738,EBI-723889
CLDN7O954712EBI-4324738,EBI-740744

Protein-protein interaction databases

BioGridi110248. 3 interactions.
IntActiP09758. 7 interactions.
STRINGi9606.ENSP00000360269.

Structurei

Secondary structure

1
323
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi299 – 31719Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAENMR-A298-323[»]
2MVKNMR-A298-323[»]
2MVLNMR-A298-323[»]
ProteinModelPortaliP09758.
SMRiP09758. Positions 31-273, 298-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 14576Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EPCAM family.Curated
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46689.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
HOVERGENiHBG053004.
InParanoidiP09758.
KOiK17288.
OMAiRQCNQTS.
OrthoDBiEOG7HQN8S.
PhylomeDBiP09758.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG
60 70 80 90 100
GRCQCRALGS GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN
110 120 130 140 150
DGLYDPDCDP EGRFKARQCN QTSVCWCVNS VGVRRTDKGD LSLRCDELVR
160 170 180 190 200
THHILIDLRH RPTAGAFNHS DLDAELRRLF RERYRLHPKF VAAVHYEQPT
210 220 230 240 250
IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG GLDLRVRGEP
260 270 280 290 300
LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR
310 320
RKSGKYKKVE IKELGELRKE PSL
Length:323
Mass (Da):35,709
Last modified:November 13, 2007 - v3
Checksum:iC8081FBE1D0B9F73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201G → D in CAG47056 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471E → D.1 Publication
Corresponds to variant rs1062964 [ dbSNP | Ensembl ].
VAR_051407
Natural varianti173 – 1731D → A.1 Publication
Corresponds to variant rs35075952 [ dbSNP | Ensembl ].
VAR_012451
Natural varianti216 – 2161D → E.2 Publications
Corresponds to variant rs14008 [ dbSNP | Ensembl ].
VAR_016981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13425 mRNA. Translation: CAA31781.1.
J04152 Genomic DNA. Translation: AAA52505.1.
X77753 mRNA. Translation: CAA54799.1.
X77754 mRNA. Translation: CAA54801.1.
BT007255 mRNA. Translation: AAP35919.1.
CR542260 mRNA. Translation: CAG47056.1.
AL035411 Genomic DNA. Translation: CAB72325.1.
BC009409 mRNA. Translation: AAH09409.1.
CCDSiCCDS609.1.
PIRiA48149.
RefSeqiNP_002344.2. NM_002353.2.
UniGeneiHs.23582.

Genome annotation databases

EnsembliENST00000371225; ENSP00000360269; ENSG00000184292.
GeneIDi4070.
KEGGihsa:4070.
UCSCiuc001cyz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13425 mRNA. Translation: CAA31781.1.
J04152 Genomic DNA. Translation: AAA52505.1.
X77753 mRNA. Translation: CAA54799.1.
X77754 mRNA. Translation: CAA54801.1.
BT007255 mRNA. Translation: AAP35919.1.
CR542260 mRNA. Translation: CAG47056.1.
AL035411 Genomic DNA. Translation: CAB72325.1.
BC009409 mRNA. Translation: AAH09409.1.
CCDSiCCDS609.1.
PIRiA48149.
RefSeqiNP_002344.2. NM_002353.2.
UniGeneiHs.23582.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAENMR-A298-323[»]
2MVKNMR-A298-323[»]
2MVLNMR-A298-323[»]
ProteinModelPortaliP09758.
SMRiP09758. Positions 31-273, 298-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110248. 3 interactions.
IntActiP09758. 7 interactions.
STRINGi9606.ENSP00000360269.

Chemistry

GuidetoPHARMACOLOGYi2837.

PTM databases

PhosphoSiteiP09758.

Polymorphism and mutation databases

BioMutaiTACSTD2.
DMDMi160113102.

Proteomic databases

MaxQBiP09758.
PaxDbiP09758.
PRIDEiP09758.

Protocols and materials databases

DNASUi4070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371225; ENSP00000360269; ENSG00000184292.
GeneIDi4070.
KEGGihsa:4070.
UCSCiuc001cyz.4. human.

Organism-specific databases

CTDi4070.
GeneCardsiGC01M059041.
HGNCiHGNC:11530. TACSTD2.
HPAiCAB072852.
HPA043104.
HPA055067.
MIMi137290. gene.
204870. phenotype.
neXtProtiNX_P09758.
Orphaneti98957. Gelatinous drop-like corneal dystrophy.
98958. Honey-droplet corneal dystrophy.
PharmGKBiPA36305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46689.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
HOVERGENiHBG053004.
InParanoidiP09758.
KOiK17288.
OMAiRQCNQTS.
OrthoDBiEOG7HQN8S.
PhylomeDBiP09758.
TreeFamiTF332767.

Miscellaneous databases

ChiTaRSiTACSTD2. human.
GeneWikiiTACSTD2.
GenomeRNAii4070.
NextBioi15956.
PROiP09758.
SOURCEiSearch...

Gene expression databases

BgeeiP09758.
CleanExiHS_TACSTD2.
GenevisibleiP09758. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
    Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
    Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147.
    Tissue: Placenta.
  2. "Retroposition in a family of carcinoma-associated antigen genes."
    Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
    Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216.
    Tissue: Placenta.
  3. "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas."
    Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.
    Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216.
    Tissue: Pancreas.
  8. "Identification of the gene responsible for gelatinous drop-like corneal dystrophy."
    Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y.
    Nat. Genet. 21:420-423(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN GDLD.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy."
    Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A.
    Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-173.

Entry informationi

Entry nameiTACD2_HUMAN
AccessioniPrimary (citable) accession number: P09758
Secondary accession number(s): Q15658
, Q6FG48, Q7Z7Q4, Q96QD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: June 24, 2015
This is version 165 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.