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P09758

- TACD2_HUMAN

UniProt

P09758 - TACD2_HUMAN

Protein

Tumor-associated calcium signal transducer 2

Gene

TACSTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 3 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May function as a growth factor receptor.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    4. negative regulation of cell motility Source: UniProtKB
    5. negative regulation of epithelial cell migration Source: UniProtKB
    6. negative regulation of ruffle assembly Source: UniProtKB
    7. negative regulation of stress fiber assembly Source: UniProtKB
    8. negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
    9. positive regulation of stem cell differentiation Source: Ensembl
    10. regulation of epithelial cell proliferation Source: Ensembl
    11. ureteric bud morphogenesis Source: Ensembl
    12. visual perception Source: ProtInc

    Keywords - Molecular functioni

    Tumor antigen

    Keywords - Biological processi

    Sensory transduction, Vision

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor-associated calcium signal transducer 2
    Alternative name(s):
    Cell surface glycoprotein Trop-2
    Membrane component chromosome 1 surface marker 1
    Pancreatic carcinoma marker protein GA733-1
    Gene namesi
    Name:TACSTD2
    Synonyms:GA733-1, M1S1, TROP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11530. TACSTD2.

    Subcellular locationi

    GO - Cellular componenti

    1. basal plasma membrane Source: UniProtKB
    2. cytosol Source: ProtInc
    3. extracellular space Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of plasma membrane Source: ProtInc
    6. lateral plasma membrane Source: UniProtKB
    7. membrane Source: ProtInc
    8. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Amyloid, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Amyloidosis, Corneal dystrophy

    Organism-specific databases

    MIMi204870. phenotype.
    Orphaneti98957. Gelatinous drop-like corneal dystrophy.
    98958. Honey-droplet corneal dystrophy.
    PharmGKBiPA36305.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 323297Tumor-associated calcium signal transducer 2PRO_0000022468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 108PROSITE-ProRule annotation
    Disulfide bondi119 ↔ 125PROSITE-ProRule annotation
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 145PROSITE-ProRule annotation
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP09758.
    PaxDbiP09758.
    PRIDEiP09758.

    PTM databases

    PhosphoSiteiP09758.

    Expressioni

    Tissue specificityi

    Placenta, pancreatic carcinoma cell lines.

    Gene expression databases

    BgeeiP09758.
    CleanExiHS_TACSTD2.
    GenevestigatoriP09758.

    Organism-specific databases

    HPAiHPA043104.
    HPA055067.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLDN1O958322EBI-4324738,EBI-723889
    CLDN7O954712EBI-4324738,EBI-740744

    Protein-protein interaction databases

    BioGridi110248. 3 interactions.
    IntActiP09758. 7 interactions.
    STRINGi9606.ENSP00000360269.

    Structurei

    3D structure databases

    ProteinModelPortaliP09758.
    SMRiP09758. Positions 101-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 274248ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32326CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei275 – 29723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 14576Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPCAM family.Curated
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46689.
    HOGENOMiHOG000074086.
    HOVERGENiHBG053004.
    InParanoidiP09758.
    KOiK17288.
    OMAiRQCNQTS.
    OrthoDBiEOG7HQN8S.
    PhylomeDBiP09758.
    TreeFamiTF332767.

    Family and domain databases

    Gene3Di4.10.800.10. 1 hit.
    InterProiIPR000716. Thyroglobulin_1.
    [Graphical view]
    PfamiPF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09758-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG    50
    GRCQCRALGS GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN 100
    DGLYDPDCDP EGRFKARQCN QTSVCWCVNS VGVRRTDKGD LSLRCDELVR 150
    THHILIDLRH RPTAGAFNHS DLDAELRRLF RERYRLHPKF VAAVHYEQPT 200
    IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG GLDLRVRGEP 250
    LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR 300
    RKSGKYKKVE IKELGELRKE PSL 323
    Length:323
    Mass (Da):35,709
    Last modified:November 13, 2007 - v3
    Checksum:iC8081FBE1D0B9F73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201G → D in CAG47056. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471E → D.1 Publication
    Corresponds to variant rs1062964 [ dbSNP | Ensembl ].
    VAR_051407
    Natural varianti173 – 1731D → A.1 Publication
    Corresponds to variant rs35075952 [ dbSNP | Ensembl ].
    VAR_012451
    Natural varianti216 – 2161D → E.2 Publications
    Corresponds to variant rs14008 [ dbSNP | Ensembl ].
    VAR_016981

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13425 mRNA. Translation: CAA31781.1.
    J04152 Genomic DNA. Translation: AAA52505.1.
    X77753 mRNA. Translation: CAA54799.1.
    X77754 mRNA. Translation: CAA54801.1.
    BT007255 mRNA. Translation: AAP35919.1.
    CR542260 mRNA. Translation: CAG47056.1.
    AL035411 Genomic DNA. Translation: CAB72325.1.
    BC009409 mRNA. Translation: AAH09409.1.
    CCDSiCCDS609.1.
    PIRiA48149.
    RefSeqiNP_002344.2. NM_002353.2.
    UniGeneiHs.23582.

    Genome annotation databases

    EnsembliENST00000371225; ENSP00000360269; ENSG00000184292.
    GeneIDi4070.
    KEGGihsa:4070.
    UCSCiuc001cyz.4. human.

    Polymorphism databases

    DMDMi160113102.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13425 mRNA. Translation: CAA31781.1 .
    J04152 Genomic DNA. Translation: AAA52505.1 .
    X77753 mRNA. Translation: CAA54799.1 .
    X77754 mRNA. Translation: CAA54801.1 .
    BT007255 mRNA. Translation: AAP35919.1 .
    CR542260 mRNA. Translation: CAG47056.1 .
    AL035411 Genomic DNA. Translation: CAB72325.1 .
    BC009409 mRNA. Translation: AAH09409.1 .
    CCDSi CCDS609.1.
    PIRi A48149.
    RefSeqi NP_002344.2. NM_002353.2.
    UniGenei Hs.23582.

    3D structure databases

    ProteinModelPortali P09758.
    SMRi P09758. Positions 101-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110248. 3 interactions.
    IntActi P09758. 7 interactions.
    STRINGi 9606.ENSP00000360269.

    PTM databases

    PhosphoSitei P09758.

    Polymorphism databases

    DMDMi 160113102.

    Proteomic databases

    MaxQBi P09758.
    PaxDbi P09758.
    PRIDEi P09758.

    Protocols and materials databases

    DNASUi 4070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371225 ; ENSP00000360269 ; ENSG00000184292 .
    GeneIDi 4070.
    KEGGi hsa:4070.
    UCSCi uc001cyz.4. human.

    Organism-specific databases

    CTDi 4070.
    GeneCardsi GC01M059041.
    HGNCi HGNC:11530. TACSTD2.
    HPAi HPA043104.
    HPA055067.
    MIMi 137290. gene.
    204870. phenotype.
    neXtProti NX_P09758.
    Orphaneti 98957. Gelatinous drop-like corneal dystrophy.
    98958. Honey-droplet corneal dystrophy.
    PharmGKBi PA36305.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46689.
    HOGENOMi HOG000074086.
    HOVERGENi HBG053004.
    InParanoidi P09758.
    KOi K17288.
    OMAi RQCNQTS.
    OrthoDBi EOG7HQN8S.
    PhylomeDBi P09758.
    TreeFami TF332767.

    Miscellaneous databases

    ChiTaRSi TACSTD2. human.
    GeneWikii TACSTD2.
    GenomeRNAii 4070.
    NextBioi 15956.
    PROi P09758.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09758.
    CleanExi HS_TACSTD2.
    Genevestigatori P09758.

    Family and domain databases

    Gene3Di 4.10.800.10. 1 hit.
    InterProi IPR000716. Thyroglobulin_1.
    [Graphical view ]
    Pfami PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
      Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
      Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147.
      Tissue: Placenta.
    2. "Retroposition in a family of carcinoma-associated antigen genes."
      Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
      Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216.
      Tissue: Placenta.
    3. "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas."
      Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.
      Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216.
      Tissue: Pancreas.
    8. "Identification of the gene responsible for gelatinous drop-like corneal dystrophy."
      Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y.
      Nat. Genet. 21:420-423(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN GDLD.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy."
      Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A.
      Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ALA-173.

    Entry informationi

    Entry nameiTACD2_HUMAN
    AccessioniPrimary (citable) accession number: P09758
    Secondary accession number(s): Q15658
    , Q6FG48, Q7Z7Q4, Q96QD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 158 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3