P09758 (TACD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor-associated calcium signal transducer 2

Alternative name(s):
Cell surface glycoprotein Trop-2
Membrane component chromosome 1 surface marker 1
Pancreatic carcinoma marker protein GA733-1

Gene names

Name:	TACSTD2
Synonyms:	GA733-1, M1S1, TROP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a growth factor receptor.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Placenta, pancreatic carcinoma cell lines.
Post-translational modification	The N-terminus is blocked.
Involvement in disease	Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Ref.9
Sequence similarities	Belongs to the EPCAM family. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Amyloid Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Tumor antigen
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc cell surface receptor linked signaling pathway Traceable author statement. Source: ProtInc visual perception Traceable author statement. Source: ProtInc
Cellular component	cytosol Traceable author statement. Source: ProtInc integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 323	297	Tumor-associated calcium signal transducer 2		PRO_0000022468
Regions
	Topological domain	27 – 274	248	Extracellular Potential
	Transmembrane	275 – 297	23	Helical; Potential
	Topological domain	298 – 323	26	Cytoplasmic Potential
	Domain	70 – 145	76	Thyroglobulin type-1
Amino acid modifications
	Modified residue	322	1	Phosphoserine Ref.8
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Disulfide bond	73 ↔ 108		By similarity
	Disulfide bond	119 ↔ 125		By similarity
	Disulfide bond	127 ↔ 145		By similarity
Natural variations
	Natural variant	147	1	E → D. Ref.1 Corresponds to variant rs1062964 [ dbSNP | Ensembl ].		VAR_051407
	Natural variant	173	1	D → A. Ref.10 Corresponds to variant rs35075952 [ dbSNP | Ensembl ].		VAR_012451
	Natural variant	216	1	D → E. Ref.2 Ref.7 Corresponds to variant rs14008 [ dbSNP | Ensembl ].		VAR_016981
Experimental info
	Sequence conflict	220	1	G → D in CAG47056. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P09758 [UniParc]. Last modified November 13, 2007. Version 3. Checksum: C8081FBE1D0B9F73	FASTA	323	35,709
	10 20 30 40 50 60 MARGPGLAPP PLRLPLLLLV LAAVTGHTAA QDNCTCPTNK MTVCSPDGPG GRCQCRALGS 70 80 90 100 110 120 GMAVDCSTLT SKCLLLKARM SAPKNARTLV RPSEHALVDN DGLYDPDCDP EGRFKARQCN 130 140 150 160 170 180 QTSVCWCVNS VGVRRTDKGD LSLRCDELVR THHILIDLRH RPTAGAFNHS DLDAELRRLF 190 200 210 220 230 240 RERYRLHPKF VAAVHYEQPT IQIELRQNTS QKAAGDVDIG DAAYYFERDI KGESLFQGRG 250 260 270 280 290 300 GLDLRVRGEP LQVERTLIYY LDEIPPKFSM KRLTAGLIAV IVVVVVALVA GMAVLVITNR 310 320 RKSGKYKKVE IKELGELRKE PSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733." Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H. Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed: 2911574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-147. Tissue: Placenta.
[2]	"Retroposition in a family of carcinoma-associated antigen genes." Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K. Mol. Cell. Biol. 13:1507-1515(1993) [PubMed: 8382772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-216. Tissue: Placenta.
[3]	"Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas." Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S. Int. J. Cancer 62:610-618(1995) [PubMed: 7665234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-216. Tissue: Pancreas.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Identification of the gene responsible for gelatinous drop-like corneal dystrophy." Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y. Nat. Genet. 21:420-423(1999) [PubMed: 10192395] [Abstract] Cited for: INVOLVEMENT IN GDLD.
[10]	"A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy." Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A. Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001) [PubMed: 11687514] [Abstract] Cited for: VARIANT ALA-173.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13425 mRNA. Translation: CAA31781.1. J04152 Genomic DNA. Translation: AAA52505.1. X77753 mRNA. Translation: CAA54799.1. X77754 mRNA. Translation: CAA54801.1. BT007255 mRNA. Translation: AAP35919.1. CR542260 mRNA. Translation: CAG47056.1. AL035411 Genomic DNA. Translation: CAB72325.1. BC009409 mRNA. Translation: AAH09409.1.
IPI	IPI00297910.
PIR	A48149.
RefSeq	NP_002344.2. NM_002353.2.
UniGene	Hs.23582.
3D structure databases
ProteinModelPortal	P09758.
SMR	P09758. Positions 101-137.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09758. 1 interaction.
STRING	P09758.
PTM databases
PhosphoSite	P09758.
Polymorphism databases
DMDM	160113102.
Proteomic databases
PRIDE	P09758.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371225; ENSP00000360269; ENSG00000184292.
GeneID	4070.
KEGG	hsa:4070.
UCSC	uc001cyz.2. human.
Organism-specific databases
CTD	4070.
GeneCards	GC01M059041.
H-InvDB	HIX0199960.
HGNC	HGNC:11530. TACSTD2.
HPA	HPA043104.
MIM	137290. gene. 204870. phenotype.
neXtProt	NX_P09758.
Orphanet	98957. Gelatinous drop-like corneal dystrophy.
PharmGKB	PA36305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17387.
GeneTree	ENSGT00390000018245.
HOGENOM	HBG506459.
HOVERGEN	HBG053004.
InParanoid	P09758.
OMA	KARQCNQ.
OrthoDB	EOG4V6ZHK.
PhylomeDB	P09758.
Gene expression databases
ArrayExpress	P09758.
Bgee	P09758.
CleanEx	HS_TACSTD2.
Genevestigator	P09758.
GermOnline	ENSG00000184292. Homo sapiens.
Family and domain databases
InterPro	IPR000716. Thyroglobulin_1. [Graphical view]
Gene3D	G3DSA:4.10.800.10. Thyroglobulin_1. 1 hit.
Pfam	PF00086. Thyroglobulin_1. 1 hit. [Graphical view]
SMART	SM00211. TY. 1 hit. [Graphical view]
SUPFAM	SSF57610. Thyroglobulin_1. 1 hit.
PROSITE	PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	15956.
SOURCE	Search...

Entry information

Entry name

TACD2_HUMAN

Accession

Primary (citable) accession number: P09758
Secondary accession number(s): Q15658 , Q6FG48, Q7Z7Q4, Q96QD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 133 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.