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Protein

Troponin T, cardiac muscle

Gene

TNNT2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
Gene namesi
Name:TNNT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001861752 – 301Troponin T, cardiac muscleAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine; by CK21 Publication1
Modified residuei207Phosphothreonine; by PKC/PRKCABy similarity1
Modified residuei211Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei216Phosphothreonine; by PKC/PRKCA and RAF1By similarity1
Modified residuei297Phosphothreonine; by PKC/PRKCABy similarity1

Post-translational modificationi

Phosphorylation at Thr-216 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP09741

Expressioni

Tissue specificityi

The major isoform in adult heart is CTNT4.

Interactioni

Subunit structurei

Binds with troponins I and C to make the thin-filament regulatory complex, troponin.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP09741
SMRiP09741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP09741

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CTNT1 (identifier: P09741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDLEEVVEE YEEEQEAEEA AAEEEDWRED EDEQEAGEEE EAGGGREAEA
60 70 80 90 100
ETEETQAEED GQEEEDKEDE DGPVEESKPK PRPFMPNLVP PKIPDGERVD
110 120 130 140 150
FDDIHRKRME KDLNELQTLI EAHFENRKKE EEELVSLKDR IEKRRADAEQ
160 170 180 190 200
LRIRAEREKE RQNRLAEERA RREEEESRRK AEDEARKKKA LSNMMHFGGY
210 220 230 240 250
IQKQAQTERK SGKRQTEREK KKKILAERRK VLAIDHLNED QLREKAKELW
260 270 280 290 300
QSIYNLEAEK FDLQEKFKQQ KYEINVLRNR INDNQKVSKT RGKAKVTGRW

K
Length:301
Mass (Da):35,876
Last modified:January 23, 2007 - v3
Checksum:i88777671C9F35541
GO
Isoform CTNT2 (identifier: P09741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-22: Missing.

Show »
Length:295
Mass (Da):35,334
Checksum:i33597E5DE2A56617
GO
Isoform CTNT3 (identifier: P09741-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-33: Missing.

Show »
Length:291
Mass (Da):34,543
Checksum:i2EC20F7836F3A4AA
GO
Isoform CTNT4 (identifier: P09741-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-22: Missing.
     24-33: Missing.

Show »
Length:285
Mass (Da):34,001
Checksum:i6F34E0EECB2CC50B
GO

Sequence cautioni

The sequence AAB51160 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 33EQEAE…EDEDE → QQAG AA sequence (PubMed:3782144).CuratedAdd BLAST20
Sequence conflicti17 – 32Missing AA sequence (PubMed:3782144).CuratedAdd BLAST16
Sequence conflicti38 – 41EEEE → AGGG AA sequence (PubMed:3782144).Curated4
Sequence conflicti46R → A AA sequence (PubMed:3782144).Curated1
Sequence conflicti139D → E AA sequence (PubMed:3782144).Curated1
Sequence conflicti147D → ER AA sequence (PubMed:3782144).Curated1
Sequence conflicti184E → D AA sequence (PubMed:3782144).Curated1
Sequence conflicti206 – 214Missing AA sequence (PubMed:3782144).Curated9

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00665117 – 22Missing in isoform CTNT2 and isoform CTNT4. Curated6
Alternative sequenceiVSP_00665224 – 33Missing in isoform CTNT3 and isoform CTNT4. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40178 mRNA Translation: AAB51160.1 Different initiation.
PIRiA25345
A61032
B25345
I46903
UniGeneiOcu.2129

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT2_RABIT
AccessioniPrimary (citable) accession number: P09741
Secondary accession number(s): P09742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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