Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn2+ or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or ironBy similarity1
Metal bindingi81Manganese or ironBy similarity1
Metal bindingi163Manganese or ironBy similarity1
Metal bindingi167Manganese or ironBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
Ordered Locus Names:SMU_629
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001600942 – 203Superoxide dismutase [Mn/Fe]Add BLAST202

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_629.

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 18Combined sources7
Helixi21 – 29Combined sources9
Helixi31 – 45Combined sources15
Helixi47 – 49Combined sources3
Helixi53 – 58Combined sources6
Helixi59 – 62Combined sources4
Helixi65 – 87Combined sources23
Helixi97 – 107Combined sources11
Helixi110 – 123Combined sources14
Beta strandi126 – 134Combined sources9
Beta strandi140 – 146Combined sources7
Helixi151 – 154Combined sources4
Beta strandi157 – 163Combined sources7
Helixi166 – 168Combined sources3
Helixi170 – 173Combined sources4
Helixi177 – 184Combined sources8
Helixi185 – 187Combined sources3
Helixi190 – 202Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YIPX-ray2.15A/B/C/D1-202[»]
ProteinModelPortaliP09738.
SMRiP09738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.
OMAiMASISKY.
PhylomeDBiP09738.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILLPDLPY AYDALEPYID AETMTLHHDK HHATYVANAN AALEKHPEIG
60 70 80 90 100
ENLEVLLADV EQIPADIRQS LINNGGGHLN HALFWELLSP EKTKVTAEVA
110 120 130 140 150
AAINEAFGSF DDFKAAFTAA ATTRFGSGWA WLVVDKEGKL EVTSTANQDT
160 170 180 190 200
PISQGLKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEVINW NTVARLYAEA

LTK
Length:203
Mass (Da):22,626
Last modified:January 23, 2007 - v3
Checksum:iCC86C35928C415A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → T AA sequence (PubMed:3722201).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01037 Genomic DNA. Translation: BAB86870.1.
AE014133 Genomic DNA. Translation: AAN58363.1.
PIRiA42710.
RefSeqiNP_721057.1. NC_004350.2.
WP_002261912.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58363; AAN58363; SMU_629.
GeneIDi1029605.
KEGGismu:SMU_629.
PATRICi19663445. VBIStrMut61772_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01037 Genomic DNA. Translation: BAB86870.1.
AE014133 Genomic DNA. Translation: AAN58363.1.
PIRiA42710.
RefSeqiNP_721057.1. NC_004350.2.
WP_002261912.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YIPX-ray2.15A/B/C/D1-202[»]
ProteinModelPortaliP09738.
SMRiP09738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58363; AAN58363; SMU_629.
GeneIDi1029605.
KEGGismu:SMU_629.
PATRICi19663445. VBIStrMut61772_0555.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.
OMAiMASISKY.
PhylomeDBiP09738.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_STRMU
AccessioniPrimary (citable) accession number: P09738
Secondary accession number(s): Q59791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.