Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn(2+) or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese or ironBy similarity
Metal bindingi81 – 811Manganese or ironBy similarity
Metal bindingi163 – 1631Manganese or ironBy similarity
Metal bindingi167 – 1671Manganese or ironBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
Ordered Locus Names:SMU_629
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 203202Superoxide dismutase [Mn/Fe]PRO_0000160094Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.629.

Structurei

3D structure databases

ProteinModelPortaliP09738.
SMRiP09738. Positions 5-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiGTEWAEW.
OrthoDBiEOG63NMNT.
PhylomeDBiP09738.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAILLPDLPY AYDALEPYID AETMTLHHDK HHATYVANAN AALEKHPEIG
60 70 80 90 100
ENLEVLLADV EQIPADIRQS LINNGGGHLN HALFWELLSP EKTKVTAEVA
110 120 130 140 150
AAINEAFGSF DDFKAAFTAA ATTRFGSGWA WLVVDKEGKL EVTSTANQDT
160 170 180 190 200
PISQGLKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEVINW NTVARLYAEA

LTK
Length:203
Mass (Da):22,626
Last modified:January 23, 2007 - v3
Checksum:iCC86C35928C415A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → T AA sequence (PubMed:3722201)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01037 Genomic DNA. Translation: BAB86870.1.
AE014133 Genomic DNA. Translation: AAN58363.1.
PIRiA42710.
RefSeqiNP_721057.1. NC_004350.2.
YP_006489870.1. NC_018089.1.

Genome annotation databases

EnsemblBacteriaiAAN58363; AAN58363; SMU_629.
GeneIDi1029605.
13299631.
KEGGismu:SMU_629.
smut:SMUGS5_02755.
PATRICi19663445. VBIStrMut61772_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01037 Genomic DNA. Translation: BAB86870.1.
AE014133 Genomic DNA. Translation: AAN58363.1.
PIRiA42710.
RefSeqiNP_721057.1. NC_004350.2.
YP_006489870.1. NC_018089.1.

3D structure databases

ProteinModelPortaliP09738.
SMRiP09738. Positions 5-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU.629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58363; AAN58363; SMU_629.
GeneIDi1029605.
13299631.
KEGGismu:SMU_629.
smut:SMUGS5_02755.
PATRICi19663445. VBIStrMut61772_0555.

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiGTEWAEW.
OrthoDBiEOG63NMNT.
PhylomeDBiP09738.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-613-MONOMER.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of Streptococcus mutans superoxide dismutase gene and isolation of insertion mutants."
    Nakayama K.
    J. Bacteriol. 174:4928-4934(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GS-5.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  3. "A Streptococcus mutans superoxide dismutase that is active with either manganese or iron as a cofactor."
    Martin M.E., Byers B.R., Olson M.O.J., Salin M.L., Arceneaux J.E.L., Tolbert C.
    J. Biol. Chem. 261:9361-9367(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-23.

Entry informationi

Entry nameiSODM_STRMU
AccessioniPrimary (citable) accession number: P09738
Secondary accession number(s): Q59791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.