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P09738

- SODM_STRMU

UniProt

P09738 - SODM_STRMU

Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese or iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Manganese or ironBy similarity
    Metal bindingi81 – 811Manganese or ironBy similarity
    Metal bindingi163 – 1631Manganese or ironBy similarity
    Metal bindingi167 – 1671Manganese or ironBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-613-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
    Gene namesi
    Name:sodA
    Synonyms:sod
    Ordered Locus Names:SMU_629
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 203202Superoxide dismutase [Mn/Fe]PRO_0000160094Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.629.

    Structurei

    3D structure databases

    ProteinModelPortaliP09738.
    SMRiP09738. Positions 5-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    KOiK04564.
    OMAiTIFWQIM.
    OrthoDBiEOG63NMNT.
    PhylomeDBiP09738.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09738-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAILLPDLPY AYDALEPYID AETMTLHHDK HHATYVANAN AALEKHPEIG    50
    ENLEVLLADV EQIPADIRQS LINNGGGHLN HALFWELLSP EKTKVTAEVA 100
    AAINEAFGSF DDFKAAFTAA ATTRFGSGWA WLVVDKEGKL EVTSTANQDT 150
    PISQGLKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEVINW NTVARLYAEA 200
    LTK 203
    Length:203
    Mass (Da):22,626
    Last modified:January 23, 2007 - v3
    Checksum:iCC86C35928C415A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41L → T AA sequence (PubMed:3722201)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01037 Genomic DNA. Translation: BAB86870.1.
    AE014133 Genomic DNA. Translation: AAN58363.1.
    PIRiA42710.
    RefSeqiNP_721057.1. NC_004350.2.
    YP_006489870.1. NC_018089.1.

    Genome annotation databases

    EnsemblBacteriaiAAN58363; AAN58363; SMU_629.
    GeneIDi1029605.
    13299631.
    KEGGismu:SMU_629.
    smut:SMUGS5_02755.
    PATRICi19663445. VBIStrMut61772_0555.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01037 Genomic DNA. Translation: BAB86870.1 .
    AE014133 Genomic DNA. Translation: AAN58363.1 .
    PIRi A42710.
    RefSeqi NP_721057.1. NC_004350.2.
    YP_006489870.1. NC_018089.1.

    3D structure databases

    ProteinModelPortali P09738.
    SMRi P09738. Positions 5-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN58363 ; AAN58363 ; SMU_629 .
    GeneIDi 1029605.
    13299631.
    KEGGi smu:SMU_629.
    smut:SMUGS5_02755.
    PATRICi 19663445. VBIStrMut61772_0555.

    Phylogenomic databases

    eggNOGi COG0605.
    KOi K04564.
    OMAi TIFWQIM.
    OrthoDBi EOG63NMNT.
    PhylomeDBi P09738.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-613-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of Streptococcus mutans superoxide dismutase gene and isolation of insertion mutants."
      Nakayama K.
      J. Bacteriol. 174:4928-4934(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GS-5.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.
    3. "A Streptococcus mutans superoxide dismutase that is active with either manganese or iron as a cofactor."
      Martin M.E., Byers B.R., Olson M.O.J., Salin M.L., Arceneaux J.E.L., Tolbert C.
      J. Biol. Chem. 261:9361-9367(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-23.

    Entry informationi

    Entry nameiSODM_STRMU
    AccessioniPrimary (citable) accession number: P09738
    Secondary accession number(s): Q59791
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3