P09737 (SODM1_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn] 1
EC=1.15.1.1

Gene names

Name:	sod1
Synonyms:	sod
Ordered Locus Names:	VNG_1190G

Organism

Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › Halobacterium salinarum

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Ref.5 Ref.6
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2. Ref.5 Ref.6
Cofactor	Binds 1 manganese ion per subunit. Ref.5 Ref.6
Enzyme regulation	Inhibited by hydrogen peroxide. Is resistant to cyanide and azide inhibition. Ref.5
Subunit structure	Homodimer or homotetramer. Ref.5 Ref.6
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 200	199	Superoxide dismutase [Mn] 1		PRO_0000160114
Sites
	Metal binding	29	1	Manganese By similarity
	Metal binding	76	1	Manganese By similarity
	Metal binding	158	1	Manganese By similarity
	Metal binding	162	1	Manganese By similarity
Experimental info
	Sequence conflict	2	1	S → T AA sequence Ref.5
	Sequence conflict	52	1	E → N AA sequence Ref.5
	Sequence conflict	100	1	A → V in AAA73373. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P09737 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: CA1433C6A8884819	FASTA	200	22,385
	10 20 30 40 50 60 MSEYELPPLP YDYDALEPHI SEQVLTWHHD THHQGYVNGW NDAEETLAEN RETGDHASTA 70 80 90 100 110 120 GALGDVTHNG SGHILHTLFW QSMSPAGGDE PSGALADRIA ADFGSYENWR AEFEAAASAA 130 140 150 160 170 180 SGWALLVYDS HSNTLRNVAV DNHDEGALWG SHPILALDVW EHSYYYDYGP DRGSFVDAFF 190 200 EVVDWDEPTE RFEQAAERFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The expression of the superoxide dismutase gene in Halobacterium cutirubrum and Halobacterium volcanii." May B.P., Tam P., Dennis P.P. Can. J. Microbiol. 35:171-175(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution and regulation of the gene encoding superoxide dismutase from the archaebacterium Halobacterium cutirubrum." May B.P., Dennis P.P. J. Biol. Chem. 264:12253-12258(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Characterization of paralogous and orthologous members of the superoxide dismutase gene family from genera of the halophilic archaebacteria." Joshi P.B., Dennis P.P. J. Bacteriol. 175:1561-1571(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GRB.
[4]	"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.
[5]	"Superoxide dismutase from the extremely halophilic archaebacterium Halobacterium cutirubrum." May B.P., Dennis P.P. J. Bacteriol. 169:1417-1422(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-57, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ENZYME REGULATION, SUBUNIT.
[6]	"Purification of a manganese-containing superoxide dismutase from Halobacterium halobium." Salin M.L., Oesterhelt D. Arch. Biochem. Biophys. 260:806-810(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT. Strain: NRL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04956 Genomic DNA. Translation: AAA72217.1. M97484 Genomic DNA. Translation: AAA73373.1. AE004437 Genomic DNA. Translation: AAG19564.1.
PIR	A34319. H84274. T50043.
RefSeq	NP_280084.1. NC_002607.1.
3D structure databases
ProteinModelPortal	P09737.
ModBase	Search...
Protein-protein interaction databases
STRING	64091.VNG1190G.
Proteomic databases
PaxDb	P09737.
PRIDE	P09737.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG19564; AAG19564; VNG_1190G.
GeneID	1447864.
KEGG	hal:VNG1190G.
Phylogenomic databases
eggNOG	COG0605.
KO	K04564.
OMA	MAPPGKG.
ProtClustDB	CLSK511336.
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM1_HALSA

Accession

Primary (citable) accession number: P09737
Secondary accession number(s): Q03303, Q9HQF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program