UniProtKB - P09734 (TBA3_YEAST)
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Protein
Tubulin alpha-3 chain
Gene
TUB3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Miscellaneous
Present with 12300 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 143 – 149 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: InterPro
GO - Biological processi
- homologous chromosome segregation Source: SGD
- mitotic sister chromatid segregation Source: SGD
- nuclear migration along microtubule Source: SGD
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32703-MONOMER. |
Reactomei | R-SCE-5610787. Hedgehog 'off' state. R-SCE-5617833. Cilium Assembly. R-SCE-5626467. RHO GTPases activate IQGAPs. R-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic. R-SCE-983189. Kinesins. |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin alpha-3 chain |
Gene namesi | Name:TUB3 Ordered Locus Names:YML124C ORF Names:YM7056.02C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML124C. |
SGDi | S000004593. TUB3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048240 | 1 – 445 | Tubulin alpha-3 chainAdd BLAST | 445 |
Proteomic databases
MaxQBi | P09734. |
PaxDbi | P09734. |
PRIDEi | P09734. |
Interactioni
Subunit structurei
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with NUM1.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 35081. 217 interactors. |
DIPi | DIP-2206N. |
IntActi | P09734. 106 interactors. |
MINTi | P09734. |
STRINGi | 4932.YML124C. |
Structurei
3D structure databases
ProteinModelPortali | P09734. |
SMRi | P09734. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the tubulin family.Curated
Phylogenomic databases
GeneTreei | ENSGT00910000144648. |
HOGENOMi | HOG000165711. |
InParanoidi | P09734. |
OMAi | ICNEPSA. |
OrthoDBi | EOG092C2JRV. |
Family and domain databases
Gene3Di | 1.10.287.600. 1 hit. 3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit. |
InterProi | View protein in InterPro IPR002452. Alpha_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. |
PANTHERi | PTHR11588. PTHR11588. 1 hit. |
Pfami | View protein in Pfam PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. |
PRINTSi | PR01162. ALPHATUBULIN. PR01161. TUBULIN. |
SMARTi | View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. |
SUPFAMi | SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit. |
PROSITEi | View protein in PROSITE PS00227. TUBULIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
P09734-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREVISINVG QAGCQIGNAC WELYSLEHGI KEDGHLEDGL SKPKGGEEGF
60 70 80 90 100
STFFHETGYG KFVPRAIYVD LEPNVIDEVR TGRFKELFHP EQLINGKEDA
110 120 130 140 150
ANNYARGHYT VGREIVDEVE ERIRKMADQC DGLQGFLFTH SLGGGTGSGL
160 170 180 190 200
GSLLLENLSY EYGKKSKLEF AVYPAPQLST SVVEPYNTVL TTHTTLEHAD
210 220 230 240 250
CTFMVDNEAI YDICKRNLGI SRPSFSNLNG LIAQVISSVT ASLRFDGSLN
260 270 280 290 300
VDLNEFQTNL VPYPRIHFPL VSYAPILSKK RATHESNSVS EITNACFEPG
310 320 330 340 350
NQMVKCDPTK GKYMANCLLY RGDVVTRDVQ RAVEQVKNKK TVQMVDWCPT
360 370 380 390 400
GFKIGICYEP PSVIPSSELA NVDRAVCMLS NTTAIADAWK RIDQKFDLMY
410 420 430 440
AKRAFVHWYV GEGMEEGEFT EAREDLAALE RDYIEVGADS YAEEF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28428 mRNA. Translation: AAA35181.1. Z49218 Genomic DNA. Translation: CAA89156.1. D90346 Genomic DNA. No translation available. BK006946 Genomic DNA. Translation: DAA09775.1. |
PIRi | B25076. |
RefSeqi | NP_013582.1. NM_001182487.1. |
Genome annotation databases
EnsemblFungii | YML124C; YML124C; YML124C. |
GeneIDi | 854915. |
KEGGi | sce:YML124C. |
Similar proteinsi
Entry informationi
Entry namei | TBA3_YEAST | |
Accessioni | P09734Primary (citable) accession number: P09734 Secondary accession number(s): D6W0G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | March 28, 2018 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |