P09722 (US22_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Early nuclear protein HWLF1

Alternative name(s):
Tegument protein US22

Gene names

Name:

US22

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Virion tegument Ref.3.
Sequence similarities	Belongs to the herpesviridae US22 family.
Sequence caution	The sequence CAA35289.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB37114.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Virion Virion tegument
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Early nuclear protein HWLF1		PRO_0000115284

Sequences

	Sequence		Length	Mass (Da)
	P09722 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: B33EA9A510DE2494	FASTA	576	65,031
	10 20 30 40 50 60 MSLLTKAAAE AWGTYLRQRD ERCEDAIRCD YGVFQFRNTV FQKTLSMLQG LYLRQYDPPA 70 80 90 100 110 120 LRTYVQRHQG TTVALRNPAN WFLVMREQAA IPQIYARSLA ADYLCCDDTL EAVGVLAVRP 130 140 150 160 170 180 PDSDLTRNTK QAQELPCVLM LSHYGTVYVY DWETDGLYEV ASDIKAFSKN GLLWCEYVYR 190 200 210 220 230 240 HPQTPFATTE PRYHVQKFLC TDPTDAAAVA KTAREMSGLN LVIRTPGRTE VEPLLMLGSI 250 260 270 280 290 300 EGLRACRPFD HMPAADFRDL LNFIRQRLCC EWYVVGLVGY YLAYGPFVPS GLVLLDKFGV 310 320 330 340 350 360 VYLHKIEDSD LYRIADNFHM FLKCGLLKLR GLCRFDRGLR GECRLEELPV CHHTLKRDVL 370 380 390 400 410 420 RWHGALGTIT RSQLESALDW FLRPTRGTDK VPNNSSAWGR TDLLPTGALQ DNQNWAFPSH 430 440 450 460 470 480 SVETLPALQG GLWEDNDETT QTVDGQRCFR MPKFFPPPMC RVPYNECGVE LPGGDSSDED 490 500 510 520 530 540 ESGRPRRIAN RIGDTPETPC NSENEDDTTV EGTSGGPEAM DSQAPYPSED SPTTEKEAWL 550 560 570 QRGRRAKAMH ARGHTLKQVP IPEPDQMGDD GPDPGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirus." Weston K.M., Barrell B.G. J. Mol. Biol. 192:177-208(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are tegument components." Adair R., Douglas E.R., Maclean J.B., Graham S.Y., Aitken J.D., Jamieson F.E., Dargan D.J. J. Gen. Virol. 83:1315-1324(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[4]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO N-TERMINUS.
[5]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[6]	"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome." Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:10960-10966(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	Erratum Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:13395-13395(2004)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35289.1. Different initiation. X04650 Genomic DNA. Translation: CAB37114.1. Different initiation. BK000394 Genomic DNA. Translation: DAA00238.1.
PIR	QQBEG6. F27231.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003360. Herpes_US22-like. [Graphical view]
Pfam	PF02393. US22. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

US22_HCMVA

Accession

Primary (citable) accession number: P09722
Secondary accession number(s): Q7M6F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	February 15, 2005
Last modified:	April 3, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program