P09717 (US16_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein HVLF2

Gene names

Name:

US16

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Human cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytomegalovirus US12 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Uncharacterized protein HVLF2		PRO_0000115275
Regions
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential
Amino acid modifications
	Glycosylation	178	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P09717 [UniParc]. Last modified August 1, 1990. Version 2. Checksum: 6E1FE3B1B1CEF9DE	FASTA	309	34,717
	10 20 30 40 50 60 MGLRFPTATQ RQIVFRRLFD SGNNDDYDEA AVVAVLGWVH RFEVVVRIAG LLLFQISAAV 70 80 90 100 110 120 AVLGSFSLVF PTATLKSRPG FPCHVVWAPE VLLLVPVASA LFVYFRYERP VLAQRNRHPR 130 140 150 160 170 180 CRRPFRQLVL LLAGLLAHIP ALGVTCACQE PREVLTSFVL TLVITLLCAE VVFICRDNCT 190 200 210 220 230 240 LSDQFTLING VWVVVFLVNV LIVFTRPWTW PLRLLLGFYS TVGLIFAGHF SQQVLFVRHV 250 260 270 280 290 300 LMPRDVAHTS LQLFITFISL FFLILRIRNC QDLLSDLRLL ELPSSDAMTL TPNDLSHASS STPLSTLSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirus." Weston K.M., Barrell B.G. J. Mol. Biol. 192:177-208(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[4]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35283.1. X04650 Genomic DNA. Translation: CAB37108.1. BK000394 Genomic DNA. Translation: DAA00204.1.
PIR	QQBEF8. H27230.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006214. Bax_inhibitor_1-related. [Graphical view]
Pfam	PF01027. Bax1-I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

US16_HCMVA

Accession

Primary (citable) accession number: P09717
Secondary accession number(s): Q7M6I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	August 1, 1990
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program