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Protein

Unique short US2 glycoprotein

Gene

US2

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Unique short US2 glycoprotein
Alternative name(s):
Protein HQLF2
gpUS2
Gene namesi
Name:US2
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 161LumenalSequence analysisAdd BLAST161
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 199CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232751 – 199Unique short US2 glycoproteinAdd BLAST199
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 1331 Publication
Glycosylationi68N-linked (GlcNAc...); by host1 Publication1

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at early period of virus infection.

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Monomer (Probable). Interacts with host TRAM1; this interaction promotes efficient US2-dependent dislocation of major histocompatibility complex class I heavy chains.Curated1 Publication

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 54Combined sources10
Beta strandi56 – 67Combined sources12
Beta strandi72 – 82Combined sources11
Beta strandi84 – 86Combined sources3
Helixi91 – 93Combined sources3
Beta strandi94 – 97Combined sources4
Turni98 – 100Combined sources3
Beta strandi101 – 110Combined sources10
Beta strandi117 – 124Combined sources8
Beta strandi127 – 133Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM3X-ray2.20D/H/L/P43-137[»]
ProteinModelPortaliP09713.
SMRiP09713.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 137Ig-like H-typeAdd BLAST95

Domaini

The lumenal domain allows tight interaction with class I molecules encoded by the HLA-A locus.

Sequence similaritiesi

Belongs to the cytomegalovirus US2 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.1200. 1 hit.
InterProiIPR009237. Herpes_US2/US3.
IPR014749. Herpes_US2_cytomegalovirus.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF05963. Cytomega_US3. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P09713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLWKAWVG LWTSMGPLIR LPDGITKAGE DALRPWKSTA KHPWFQIEDN
60 70 80 90 100
RCYIDNGKLF ARGSIVGNMS RFVFDPKADY GGVGENLYVH ADDVEFVPGE
110 120 130 140 150
SLKWNVRNLD VMPIFETLAL RLVLQGDVIW LRCVPELRVD YTSSAYMWNM
160 170 180 190
QYGMVRKSYT HVAWTIVFYS INITLLVLFI VYVTVDCNLS MMWMRFFVC
Length:199
Mass (Da):23,111
Last modified:July 1, 1989 - v1
Checksum:i4DD2DF3D692393F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35313.1.
X04650 Genomic DNA. Translation: CAB37096.1.
BK000394 Genomic DNA. Translation: DAA00208.1.
PIRiE26078. QQBEC5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35313.1.
X04650 Genomic DNA. Translation: CAB37096.1.
BK000394 Genomic DNA. Translation: DAA00208.1.
PIRiE26078. QQBEC5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM3X-ray2.20D/H/L/P43-137[»]
ProteinModelPortaliP09713.
SMRiP09713.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP09713.

Family and domain databases

Gene3Di2.60.40.1200. 1 hit.
InterProiIPR009237. Herpes_US2/US3.
IPR014749. Herpes_US2_cytomegalovirus.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF05963. Cytomega_US3. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUS02_HCMVA
AccessioniPrimary (citable) accession number: P09713
Secondary accession number(s): Q7M6I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.