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P09690

- ACHB_MOUSE

UniProt

P09690 - ACHB_MOUSE

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Protein

Acetylcholine receptor subunit beta

Gene
Chrnb1, Acrb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: MGI
  2. acetylcholine binding Source: UniProtKB
  3. acetylcholine receptor activity Source: Ensembl
  4. protein binding Source: MGI

GO - Biological processi

  1. behavioral response to nicotine Source: Ensembl
  2. muscle contraction Source: Ensembl
  3. muscle fiber development Source: Ensembl
  4. neurological system process Source: Ensembl
  5. neuromuscular synaptic transmission Source: Ensembl
  6. postsynaptic membrane organization Source: Ensembl
  7. regulation of membrane potential Source: MGI
  8. synaptic transmission, cholinergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit beta
Gene namesi
Name:Chrnb1
Synonyms:Acrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:87890. Chrnb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 244221Extracellular Reviewed predictionAdd
BLAST
Transmembranei245 – 26925Helical; Reviewed predictionAdd
BLAST
Transmembranei277 – 29519Helical; Reviewed predictionAdd
BLAST
Transmembranei311 – 33222Helical; Reviewed predictionAdd
BLAST
Topological domaini333 – 469137Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei470 – 48819Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: MGI
  2. cell junction Source: UniProtKB-KW
  3. plasma membrane Source: MGI
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 501478Acetylcholine receptor subunit betaPRO_0000000316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi151 ↔ 165 By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Modified residuei390 – 3901Phosphotyrosine; by Tyr-kinases By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP09690.

PTM databases

PhosphoSiteiP09690.

Expressioni

Gene expression databases

BgeeiP09690.
GenevestigatoriP09690.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

BioGridi197935. 1 interaction.
IntActiP09690. 4 interactions.
MINTiMINT-2983098.

Structurei

3D structure databases

ProteinModelPortaliP09690.
SMRiP09690. Positions 24-341, 435-500.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG243276.
GeneTreeiENSGT00750000117375.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiQ5F292.
KOiK04812.
OMAiFIDGPNR.
OrthoDBiEOG70ZZN7.
PhylomeDBiP09690.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09690-1 [UniParc]FASTAAdd to Basket

« Hide

MALGALLLLL GVLGTPLAPG ARGSEAEGQL IKKLFSNYDS SVRPAREVGD    50
RVGVSIGLTL AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIDS 100
LRITAESVWL PDVVLLNNND GNFDVALDIN VVVSFEGSVR WQPPGLYRSS 150
CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS LKTGLDPEGE ERQEVYIHEG 200
TFIENGQWEI IHKPSRLIQL PGDQRGGKEG HHEEVIFYLI IRRKPLFYLV 250
NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE 300
TSLAVPIIIK YLMFTMVLVT FSVILSVVVL NLHHRSPHTH QMPFWVRQIF 350
IHKLPPYLGL KRPKPERDQL PEPHHSLSPR SGWGRGTDEY FIRKPPSDFL 400
FPKLNRFQPE SSAPDLRRFI DGPTRAVGLP QELREVISSI SYMARQLQEQ 450
EDHDALKEDW QFVAMVVDRL FLWTFIVFTS VGTLVIFLDA TYHLPPPEPF 500
P 501
Length:501
Mass (Da):56,931
Last modified:July 1, 1989 - v1
Checksum:i787BDDA90EBB0EF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14537 mRNA. Translation: AAA37154.1.
J04699 Genomic DNA. Translation: AAA37156.1.
AK087554 mRNA. Translation: BAC39924.1.
AL603707 Genomic DNA. Translation: CAI51959.1.
CCDSiCCDS24910.1.
PIRiA33358. A25338.
RefSeqiNP_033731.3. NM_009601.4.
UniGeneiMm.86425.

Genome annotation databases

EnsembliENSMUST00000045971; ENSMUSP00000047270; ENSMUSG00000041189.
GeneIDi11443.
KEGGimmu:11443.
UCSCiuc007jrq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14537 mRNA. Translation: AAA37154.1 .
J04699 Genomic DNA. Translation: AAA37156.1 .
AK087554 mRNA. Translation: BAC39924.1 .
AL603707 Genomic DNA. Translation: CAI51959.1 .
CCDSi CCDS24910.1.
PIRi A33358. A25338.
RefSeqi NP_033731.3. NM_009601.4.
UniGenei Mm.86425.

3D structure databases

ProteinModelPortali P09690.
SMRi P09690. Positions 24-341, 435-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197935. 1 interaction.
IntActi P09690. 4 interactions.
MINTi MINT-2983098.

Chemistry

BindingDBi P09690.
ChEMBLi CHEMBL3038460.
GuidetoPHARMACOLOGYi 471.

PTM databases

PhosphoSitei P09690.

Proteomic databases

PRIDEi P09690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045971 ; ENSMUSP00000047270 ; ENSMUSG00000041189 .
GeneIDi 11443.
KEGGi mmu:11443.
UCSCi uc007jrq.2. mouse.

Organism-specific databases

CTDi 1140.
MGIi MGI:87890. Chrnb1.

Phylogenomic databases

eggNOGi NOG243276.
GeneTreei ENSGT00750000117375.
HOGENOMi HOG000006757.
HOVERGENi HBG003756.
InParanoidi Q5F292.
KOi K04812.
OMAi FIDGPNR.
OrthoDBi EOG70ZZN7.
PhylomeDBi P09690.
TreeFami TF315605.

Miscellaneous databases

NextBioi 278748.
PROi P09690.
SOURCEi Search...

Gene expression databases

Bgeei P09690.
Genevestigatori P09690.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A universal oligonucleotide probe for acetylcholine receptor genes. Selection and sequencing of cDNA clones for the mouse muscle beta subunit."
    Buonanno A., Mudd J., Shah V., Merlie J.P.
    J. Biol. Chem. 261:16451-16458(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the beta and epsilon subunit genes of mouse muscle acetylcholine receptor."
    Buonanno A., Mudd J., Merlie J.P.
    J. Biol. Chem. 264:7611-7616(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiACHB_MOUSE
AccessioniPrimary (citable) accession number: P09690
Secondary accession number(s): Q5F292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi