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P09683

- SECR_HUMAN

UniProt

P09683 - SECR_HUMAN

Protein

Secretin

Gene

SCT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB

    GO - Biological processi

    1. dentate gyrus development Source: Ensembl
    2. negative regulation of neuron apoptotic process Source: Ensembl
    3. neuronal stem cell maintenance Source: Ensembl
    4. pancreatic juice secretion Source: UniProtKB
    5. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretin
    Gene namesi
    Name:SCT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10607. SCT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35017.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 268PRO_0000011423
    Peptidei28 – 5427SecretinPRO_0000011424Add
    BLAST
    Propeptidei58 – 12164PRO_0000011425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541Valine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP09683.
    PRIDEiP09683.

    Miscellaneous databases

    PMAP-CutDBP09683.

    Expressioni

    Gene expression databases

    BgeeiP09683.
    CleanExiHS_SCT.
    GenevestigatoriP09683.

    Organism-specific databases

    HPAiHPA050961.

    Interactioni

    Protein-protein interaction databases

    BioGridi112247. 3 interactions.
    STRINGi9606.ENSP00000176195.

    Structurei

    3D structure databases

    ProteinModelPortaliP09683.
    SMRiP09683. Positions 28-55.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG329190.
    HOGENOMiHOG000133017.
    HOVERGENiHBG017786.
    InParanoidiP09683.
    KOiK05263.
    OMAiNIARIKP.
    OrthoDBiEOG77DJ88.
    PhylomeDBiP09683.
    TreeFamiTF338215.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view]
    PANTHERiPTHR17378. PTHR17378. 1 hit.
    PfamiPF00123. Hormone_2. 1 hit.
    [Graphical view]
    SMARTiSM00070. GLUCA. 1 hit.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09683-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL    50
    QGLVGKRSEQ DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL 100
    PPGPMVSEPA GAAAEGTLRP R 121
    Length:121
    Mass (Da):13,016
    Last modified:January 11, 2001 - v2
    Checksum:i44BDB4EFC0E161CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244355 Genomic DNA. Translation: AAG31443.1.
    CCDSiCCDS7709.1.
    RefSeqiNP_068739.1. NM_021920.2.
    UniGeneiHs.632324.

    Genome annotation databases

    EnsembliENST00000176195; ENSP00000176195; ENSG00000070031.
    GeneIDi6343.
    KEGGihsa:6343.
    UCSCiuc001lqo.1. human.

    Polymorphism databases

    DMDMi12231018.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Secretin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244355 Genomic DNA. Translation: AAG31443.1 .
    CCDSi CCDS7709.1.
    RefSeqi NP_068739.1. NM_021920.2.
    UniGenei Hs.632324.

    3D structure databases

    ProteinModelPortali P09683.
    SMRi P09683. Positions 28-55.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112247. 3 interactions.
    STRINGi 9606.ENSP00000176195.

    Polymorphism databases

    DMDMi 12231018.

    Proteomic databases

    PaxDbi P09683.
    PRIDEi P09683.

    Protocols and materials databases

    DNASUi 6343.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000176195 ; ENSP00000176195 ; ENSG00000070031 .
    GeneIDi 6343.
    KEGGi hsa:6343.
    UCSCi uc001lqo.1. human.

    Organism-specific databases

    CTDi 6343.
    GeneCardsi GC11M000626.
    HGNCi HGNC:10607. SCT.
    HPAi HPA050961.
    MIMi 182099. gene.
    neXtProti NX_P09683.
    PharmGKBi PA35017.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329190.
    HOGENOMi HOG000133017.
    HOVERGENi HBG017786.
    InParanoidi P09683.
    KOi K05263.
    OMAi NIARIKP.
    OrthoDBi EOG77DJ88.
    PhylomeDBi P09683.
    TreeFami TF338215.

    Enzyme and pathway databases

    Reactomei REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Secretin.
    GenomeRNAii 6343.
    NextBioi 24640.
    PMAP-CutDB P09683.
    PROi P09683.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09683.
    CleanExi HS_SCT.
    Genevestigatori P09683.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    IPR015675. Prosecretin.
    [Graphical view ]
    PANTHERi PTHR17378. PTHR17378. 1 hit.
    Pfami PF00123. Hormone_2. 1 hit.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 1 hit.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA."
      Whitmore T.E., Holloway J.L., Lofton-Day C.E., Maurer M.F., Chen L., Quinton T.J., Vincent J.B., Scherer S.W., Lok S.
      Cytogenet. Cell Genet. 90:47-52(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human secretin is not identical to the porcine/bovine hormone."
      Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C., Mutt V.
      IRCS Med. Sci. 13:217-218(1985)
      Cited for: PROTEIN SEQUENCE OF 28-54, AMIDATION AT VAL-54.

    Entry informationi

    Entry nameiSECR_HUMAN
    AccessioniPrimary (citable) accession number: P09683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3