P09683 (SECR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretin

Gene names

Name:

SCT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glucagon family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	pancreatic juice secretion Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Molecular_function	hormone activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 26	8			PRO_0000011423
	Peptide	28 – 54	27	Secretin Ref.2		PRO_0000011424
	Propeptide	58 – 121	64			PRO_0000011425
Amino acid modifications
	Modified residue	54	1	Valine amide

Sequences

	Sequence		Length	Mass (Da)
	P09683 [UniParc]. Last modified January 11, 2001. Version 2. Checksum: 44BDB4EFC0E161CF	FASTA	121	13,016
	10 20 30 40 50 60 MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ 70 80 90 100 110 120 DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL PPGPMVSEPA GAAAEGTLRP R

References

[1]	"Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA." Whitmore T.E., Holloway J.L., Lofton-Day C.E., Maurer M.F., Chen L., Quinton T.J., Vincent J.B., Scherer S.W., Lok S. Cytogenet. Cell Genet. 90:47-52(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human secretin is not identical to the porcine/bovine hormone." Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C., Mutt V. IRCS Med. Sci. 13:217-218(1985) Cited for: PROTEIN SEQUENCE OF 28-54.
+	Additional computationally mapped references.

Web resources

Wikipedia

Secretin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF244355 Genomic DNA. Translation: AAG31443.1.
IPI	IPI00016001.
RefSeq	NP_068739.1. NM_021920.2.
UniGene	Hs.632324.
3D structure databases
ProteinModelPortal	P09683.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000176195.
Polymorphism databases
DMDM	12231018.
Proteomic databases
PaxDb	P09683.
PRIDE	P09683.
Protocols and materials databases
DNASU	6343.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000176195; ENSP00000176195; ENSG00000070031.
GeneID	6343.
KEGG	hsa:6343.
UCSC	uc001lqo.1. human.
Organism-specific databases
CTD	6343.
GeneCards	GC11M000626.
HGNC	HGNC:10607. SCT.
HPA	HPA050961.
MIM	182099. gene.
neXtProt	NX_P09683.
PharmGKB	PA35017.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329190.
HOGENOM	HOG000133017.
HOVERGEN	HBG017786.
InParanoid	P09683.
KO	K05263.
OMA	MPILQAW.
OrthoDB	EOG454916.
PhylomeDB	P09683.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P09683.
CleanEx	HS_SCT.
Genevestigator	P09683.
GermOnline	ENSG00000070031. Homo sapiens.
Family and domain databases
InterPro	IPR000532. Glucagon_GIP_secretin_VIP. IPR015675. Secretin. [Graphical view]
PANTHER	PTHR17378. PTHR17378. 1 hit.
Pfam	PF00123. Hormone_2. 1 hit. [Graphical view]
SMART	SM00070. GLUCA. 1 hit. [Graphical view]
PROSITE	PS00260. GLUCAGON. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6343.
NextBio	24640.
PMAP-CutDB	P09683.
SOURCE	Search...

Entry information

Entry name

SECR_HUMAN

Accession

Primary (citable) accession number: P09683

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 11, 2001
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.