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P09683 (SECR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretin
Gene names
Name:SCT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length121 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glucagon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 268
PRO_0000011423
Peptide28 – 5427Secretin Ref.2
PRO_0000011424
Propeptide58 – 12164
PRO_0000011425

Amino acid modifications

Modified residue541Valine amide

Sequences

Sequence LengthMass (Da)Tools
P09683 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: 44BDB4EFC0E161CF

FASTA12113,016
        10         20         30         40         50         60 
MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ 

        70         80         90        100        110        120 
DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL PPGPMVSEPA GAAAEGTLRP 


R 

« Hide

References

[1]"Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA."
Whitmore T.E., Holloway J.L., Lofton-Day C.E., Maurer M.F., Chen L., Quinton T.J., Vincent J.B., Scherer S.W., Lok S.
Cytogenet. Cell Genet. 90:47-52(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human secretin is not identical to the porcine/bovine hormone."
Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C., Mutt V.
IRCS Med. Sci. 13:217-218(1985)
Cited for: PROTEIN SEQUENCE OF 28-54.
+Additional computationally mapped references.

Web resources

Wikipedia

Secretin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF244355 Genomic DNA. Translation: AAG31443.1.
RefSeqNP_068739.1. NM_021920.2.
UniGeneHs.632324.

3D structure databases

ProteinModelPortalP09683.
SMRP09683. Positions 28-65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112247. 3 interactions.
STRING9606.ENSP00000176195.

Polymorphism databases

DMDM12231018.

Proteomic databases

PaxDbP09683.
PRIDEP09683.

Protocols and materials databases

DNASU6343.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000176195; ENSP00000176195; ENSG00000070031.
GeneID6343.
KEGGhsa:6343.
UCSCuc001lqo.1. human.

Organism-specific databases

CTD6343.
GeneCardsGC11M000626.
HGNCHGNC:10607. SCT.
HPAHPA050961.
MIM182099. gene.
neXtProtNX_P09683.
PharmGKBPA35017.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329190.
HOGENOMHOG000133017.
HOVERGENHBG017786.
InParanoidP09683.
KOK05263.
OMAMPILQAW.
OrthoDBEOG77DJ88.
PhylomeDBP09683.
TreeFamTF338215.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP09683.
CleanExHS_SCT.
GenevestigatorP09683.

Family and domain databases

InterProIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Secretin.
[Graphical view]
PANTHERPTHR17378. PTHR17378. 1 hit.
PfamPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSecretin.
GenomeRNAi6343.
NextBio24640.
PMAP-CutDBP09683.
PROP09683.
SOURCESearch...

Entry information

Entry nameSECR_HUMAN
AccessionPrimary (citable) accession number: P09683
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2001
Last modified: March 19, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM