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Protein

Secretin

Gene

SCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  1. hormone activity Source: UniProtKB

GO - Biological processi

  1. dentate gyrus development Source: Ensembl
  2. negative regulation of neuron apoptotic process Source: Ensembl
  3. neuronal stem cell maintenance Source: Ensembl
  4. pancreatic juice secretion Source: UniProtKB
  5. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:SCT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:10607. SCT.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 268PRO_0000011423
Peptidei28 – 5427SecretinPRO_0000011424Add
BLAST
Propeptidei58 – 12164PRO_0000011425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541Valine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09683.
PRIDEiP09683.

Miscellaneous databases

PMAP-CutDBP09683.

Expressioni

Gene expression databases

BgeeiP09683.
CleanExiHS_SCT.
GenevestigatoriP09683.

Organism-specific databases

HPAiHPA050961.

Interactioni

Protein-protein interaction databases

BioGridi112247. 3 interactions.
STRINGi9606.ENSP00000176195.

Structurei

3D structure databases

ProteinModelPortaliP09683.
SMRiP09683. Positions 28-55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG329190.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP09683.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG77DJ88.
PhylomeDBiP09683.
TreeFamiTF338215.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL
60 70 80 90 100
QGLVGKRSEQ DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL
110 120
PPGPMVSEPA GAAAEGTLRP R
Length:121
Mass (Da):13,016
Last modified:January 11, 2001 - v2
Checksum:i44BDB4EFC0E161CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244355 Genomic DNA. Translation: AAG31443.1.
CCDSiCCDS7709.1.
RefSeqiNP_068739.1. NM_021920.2.
UniGeneiHs.632324.

Genome annotation databases

EnsembliENST00000176195; ENSP00000176195; ENSG00000070031.
ENST00000622382; ENSP00000483559; ENSG00000274473.
GeneIDi6343.
KEGGihsa:6343.
UCSCiuc001lqo.1. human.

Polymorphism databases

DMDMi12231018.

Cross-referencesi

Web resourcesi

Wikipedia

Secretin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244355 Genomic DNA. Translation: AAG31443.1.
CCDSiCCDS7709.1.
RefSeqiNP_068739.1. NM_021920.2.
UniGeneiHs.632324.

3D structure databases

ProteinModelPortaliP09683.
SMRiP09683. Positions 28-55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112247. 3 interactions.
STRINGi9606.ENSP00000176195.

Polymorphism databases

DMDMi12231018.

Proteomic databases

PaxDbiP09683.
PRIDEiP09683.

Protocols and materials databases

DNASUi6343.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000176195; ENSP00000176195; ENSG00000070031.
ENST00000622382; ENSP00000483559; ENSG00000274473.
GeneIDi6343.
KEGGihsa:6343.
UCSCiuc001lqo.1. human.

Organism-specific databases

CTDi6343.
GeneCardsiGC11M000626.
HGNCiHGNC:10607. SCT.
HPAiHPA050961.
MIMi182099. gene.
neXtProtiNX_P09683.
PharmGKBiPA35017.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329190.
GeneTreeiENSGT00390000002624.
HOGENOMiHOG000133017.
HOVERGENiHBG017786.
InParanoidiP09683.
KOiK05263.
OMAiMPILQAW.
OrthoDBiEOG77DJ88.
PhylomeDBiP09683.
TreeFamiTF338215.

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiSecretin.
GenomeRNAii6343.
NextBioi24640.
PMAP-CutDBP09683.
PROiP09683.
SOURCEiSearch...

Gene expression databases

BgeeiP09683.
CleanExiHS_SCT.
GenevestigatoriP09683.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015675. Prosecretin.
[Graphical view]
PANTHERiPTHR17378. PTHR17378. 1 hit.
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA."
    Whitmore T.E., Holloway J.L., Lofton-Day C.E., Maurer M.F., Chen L., Quinton T.J., Vincent J.B., Scherer S.W., Lok S.
    Cytogenet. Cell Genet. 90:47-52(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human secretin is not identical to the porcine/bovine hormone."
    Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C., Mutt V.
    IRCS Med. Sci. 13:217-218(1985)
    Cited for: PROTEIN SEQUENCE OF 28-54, AMIDATION AT VAL-54.

Entry informationi

Entry nameiSECR_HUMAN
AccessioniPrimary (citable) accession number: P09683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2001
Last modified: January 7, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.