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Protein

Gastric inhibitory polypeptide

Gene

GIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Incretin hormone
Gene namesi
Name:GIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4270. GIP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28681.

Polymorphism and mutation databases

BioMutaiGIP.
DMDMi121194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 5029PRO_0000011214Add
BLAST
Peptidei52 – 9342Gastric inhibitory polypeptidePRO_0000011215Add
BLAST
Propeptidei95 – 15359PRO_0000011216Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09681.
PeptideAtlasiP09681.
PRIDEiP09681.

PTM databases

PhosphoSiteiP09681.

Expressioni

Gene expression databases

BgeeiP09681.
CleanExiHS_GIP.
GenevisibleiP09681. HS.

Organism-specific databases

HPAiCAB016729.
HPA021612.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8588553,EBI-10173507
NOTCH2NLQ7Z3S93EBI-8588553,EBI-945833
SGTAO437653EBI-8588553,EBI-347996

Protein-protein interaction databases

BioGridi108962. 4 interactions.
DIPiDIP-46469N.
IntActiP09681. 5 interactions.
MINTiMINT-8090589.
STRINGi9606.ENSP00000350005.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi57 – 7923Combined sources
Turni80 – 823Combined sources
Beta strandi86 – 883Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5QNMR-A52-81[»]
2B4NNMR-A52-93[»]
2L70NMR-A52-93[»]
2L71NMR-A52-93[»]
2OBUNMR-A52-93[»]
2QKHX-ray1.90B52-93[»]
ProteinModelPortaliP09681.
SMRiP09681. Positions 52-93.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09681.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44984.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP09681.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
PhylomeDBiP09681.
TreeFamiTF332333.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATKTFALL LLSLFLAVGL GEKKEGHFSA LPSLPVGSHA KVSSPQPRGP
60 70 80 90 100
RYAEGTFISD YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALE
110 120 130 140 150
LASQANRKEE EAVEPQSSPA KNPSDEDLLR DLLIQELLAC LLDQTNLCRL

RSR
Length:153
Mass (Da):17,108
Last modified:July 1, 1989 - v1
Checksum:i51F5FC388A8897EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031S → G.1 Publication
Corresponds to variant rs2291725 [ dbSNP | Ensembl ].
VAR_021897
Natural varianti146 – 1461N → S.
Corresponds to variant rs35703924 [ dbSNP | Ensembl ].
VAR_033973

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18185 mRNA. Translation: AAA88043.1.
M31679
, M31675, M31676, M31677, M31678 Genomic DNA. Translation: AAA53192.1.
BC069100 mRNA. Translation: AAH69100.1.
BC069663 mRNA. Translation: AAH69663.1.
BC069686 mRNA. Translation: AAH69686.1.
BC069746 mRNA. Translation: AAH69746.1.
BC096146 mRNA. Translation: AAH96146.1.
BC096147 mRNA. Translation: AAH96147.1.
BC096148 mRNA. Translation: AAH96148.1.
BC096149 mRNA. Translation: AAH96149.1.
CCDSiCCDS11542.1.
PIRiA28406.
RefSeqiNP_004114.1. NM_004123.2.
UniGeneiHs.1454.

Genome annotation databases

EnsembliENST00000357424; ENSP00000350005; ENSG00000159224.
GeneIDi2695.
KEGGihsa:2695.
UCSCiuc002iol.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18185 mRNA. Translation: AAA88043.1.
M31679
, M31675, M31676, M31677, M31678 Genomic DNA. Translation: AAA53192.1.
BC069100 mRNA. Translation: AAH69100.1.
BC069663 mRNA. Translation: AAH69663.1.
BC069686 mRNA. Translation: AAH69686.1.
BC069746 mRNA. Translation: AAH69746.1.
BC096146 mRNA. Translation: AAH96146.1.
BC096147 mRNA. Translation: AAH96147.1.
BC096148 mRNA. Translation: AAH96148.1.
BC096149 mRNA. Translation: AAH96149.1.
CCDSiCCDS11542.1.
PIRiA28406.
RefSeqiNP_004114.1. NM_004123.2.
UniGeneiHs.1454.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5QNMR-A52-81[»]
2B4NNMR-A52-93[»]
2L70NMR-A52-93[»]
2L71NMR-A52-93[»]
2OBUNMR-A52-93[»]
2QKHX-ray1.90B52-93[»]
ProteinModelPortaliP09681.
SMRiP09681. Positions 52-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108962. 4 interactions.
DIPiDIP-46469N.
IntActiP09681. 5 interactions.
MINTiMINT-8090589.
STRINGi9606.ENSP00000350005.

Chemistry

BindingDBiP09681.
ChEMBLiCHEMBL5571.

PTM databases

PhosphoSiteiP09681.

Polymorphism and mutation databases

BioMutaiGIP.
DMDMi121194.

Proteomic databases

PaxDbiP09681.
PeptideAtlasiP09681.
PRIDEiP09681.

Protocols and materials databases

DNASUi2695.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357424; ENSP00000350005; ENSG00000159224.
GeneIDi2695.
KEGGihsa:2695.
UCSCiuc002iol.1. human.

Organism-specific databases

CTDi2695.
GeneCardsiGC17M047037.
HGNCiHGNC:4270. GIP.
HPAiCAB016729.
HPA021612.
MIMi137240. gene.
neXtProtiNX_P09681.
PharmGKBiPA28681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44984.
GeneTreeiENSGT00390000005121.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP09681.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
PhylomeDBiP09681.
TreeFamiTF332333.

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Miscellaneous databases

EvolutionaryTraceiP09681.
GenomeRNAii2695.
NextBioi10660.
PROiP09681.
SOURCEiSearch...

Gene expression databases

BgeeiP09681.
CleanExiHS_GIP.
GenevisibleiP09681. HS.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor."
    Takeda J., Seino Y., Tanaka K., Fukumoto H., Kayano T., Takahashi H., Mitani T., Kurono M., Suzuki T., Tobe T., Imura H.
    Proc. Natl. Acad. Sci. U.S.A. 84:7005-7008(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene."
    Inagaki N., Seino Y., Takeda J., Yano H., Yamada Y., Bell G.I., Eddy R.L. Jr., Fukushima Y., Byers M.G., Shows T.B., Imura H.
    Mol. Endocrinol. 3:1014-1021(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-103.
  4. "The isolation and sequencing of human gastric inhibitory peptide (GIP)."
    Moody A.J., Thim L., Valverde I.
    FEBS Lett. 172:142-148(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-93.
  5. "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide."
    Alana I., Hewage C.M., Malthouse J.P., Parker J.C., Gault V.A., O'Harte F.P.
    Biochem. Biophys. Res. Commun. 325:281-286(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 52-81.

Entry informationi

Entry nameiGIP_HUMAN
AccessioniPrimary (citable) accession number: P09681
Secondary accession number(s): Q4VB42, Q6NTD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.