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P09681

- GIP_HUMAN

UniProt

P09681 - GIP_HUMAN

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Protein

Gastric inhibitory polypeptide

Gene
GIP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

  1. hormone activity Source: ProtInc

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular protein metabolic process Source: Reactome
  3. digestive system development Source: Ensembl
  4. endocrine pancreas development Source: Ensembl
  5. exploration behavior Source: Ensembl
  6. female pregnancy Source: Ensembl
  7. long-term synaptic potentiation Source: Ensembl
  8. memory Source: Ensembl
  9. positive regulation of cAMP-mediated signaling Source: Ensembl
  10. positive regulation of glucagon secretion Source: Ensembl
  11. positive regulation of glucose transport Source: Ensembl
  12. positive regulation of insulin secretion Source: Ensembl
  13. regulation of insulin secretion Source: Reactome
  14. response to amino acid Source: Ensembl
  15. response to axon injury Source: Ensembl
  16. response to drug Source: Ensembl
  17. response to glucose Source: Ensembl
  18. response to lipid Source: Ensembl
  19. response to organic cyclic compound Source: Ensembl
  20. response to peptide hormone Source: Ensembl
  21. response to selenium ion Source: Ensembl
  22. response to starvation Source: Ensembl
  23. sensory perception of pain Source: Ensembl
  24. signal transduction Source: ProtInc
  25. triglyceride homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Incretin hormone
Gene namesi
Name:GIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4270. GIP.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular region Source: Reactome
  3. extracellular space Source: Ensembl
  4. neuronal cell body Source: Ensembl
  5. secretory granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 5029PRO_0000011214Add
BLAST
Peptidei52 – 9342Gastric inhibitory polypeptide1 PublicationPRO_0000011215Add
BLAST
Propeptidei95 – 15359PRO_0000011216Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09681.
PeptideAtlasiP09681.
PRIDEiP09681.

PTM databases

PhosphoSiteiP09681.

Expressioni

Gene expression databases

BgeeiP09681.
CleanExiHS_GIP.
GenevestigatoriP09681.

Organism-specific databases

HPAiCAB016729.
HPA021612.

Interactioni

Protein-protein interaction databases

DIPiDIP-46469N.
IntActiP09681. 2 interactions.
MINTiMINT-8090589.
STRINGi9606.ENSP00000350005.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi57 – 7923
Turni80 – 823
Beta strandi86 – 883

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5QNMR-A52-81[»]
2B4NNMR-A52-93[»]
2L70NMR-A52-93[»]
2L71NMR-A52-93[»]
2OBUNMR-A52-93[»]
2QKHX-ray1.90B52-93[»]
ProteinModelPortaliP09681.
SMRiP09681. Positions 52-93.

Miscellaneous databases

EvolutionaryTraceiP09681.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44984.
HOGENOMiHOG000112725.
HOVERGENiHBG005839.
InParanoidiP09681.
KOiK05258.
OMAiLAWMVDQ.
OrthoDBiEOG7C8GKZ.
PhylomeDBiP09681.
TreeFamiTF332333.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09681-1 [UniParc]FASTAAdd to Basket

« Hide

MVATKTFALL LLSLFLAVGL GEKKEGHFSA LPSLPVGSHA KVSSPQPRGP    50
RYAEGTFISD YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALE 100
LASQANRKEE EAVEPQSSPA KNPSDEDLLR DLLIQELLAC LLDQTNLCRL 150
RSR 153
Length:153
Mass (Da):17,108
Last modified:July 1, 1989 - v1
Checksum:i51F5FC388A8897EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031S → G.1 Publication
Corresponds to variant rs2291725 [ dbSNP | Ensembl ].
VAR_021897
Natural varianti146 – 1461N → S.
Corresponds to variant rs35703924 [ dbSNP | Ensembl ].
VAR_033973

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18185 mRNA. Translation: AAA88043.1.
M31679
, M31675, M31676, M31677, M31678 Genomic DNA. Translation: AAA53192.1.
BC069100 mRNA. Translation: AAH69100.1.
BC069663 mRNA. Translation: AAH69663.1.
BC069686 mRNA. Translation: AAH69686.1.
BC069746 mRNA. Translation: AAH69746.1.
BC096146 mRNA. Translation: AAH96146.1.
BC096147 mRNA. Translation: AAH96147.1.
BC096148 mRNA. Translation: AAH96148.1.
BC096149 mRNA. Translation: AAH96149.1.
CCDSiCCDS11542.1.
PIRiA28406.
RefSeqiNP_004114.1. NM_004123.2.
UniGeneiHs.1454.

Genome annotation databases

EnsembliENST00000357424; ENSP00000350005; ENSG00000159224.
GeneIDi2695.
KEGGihsa:2695.
UCSCiuc002iol.1. human.

Polymorphism databases

DMDMi121194.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18185 mRNA. Translation: AAA88043.1 .
M31679
, M31675 , M31676 , M31677 , M31678 Genomic DNA. Translation: AAA53192.1 .
BC069100 mRNA. Translation: AAH69100.1 .
BC069663 mRNA. Translation: AAH69663.1 .
BC069686 mRNA. Translation: AAH69686.1 .
BC069746 mRNA. Translation: AAH69746.1 .
BC096146 mRNA. Translation: AAH96146.1 .
BC096147 mRNA. Translation: AAH96147.1 .
BC096148 mRNA. Translation: AAH96148.1 .
BC096149 mRNA. Translation: AAH96149.1 .
CCDSi CCDS11542.1.
PIRi A28406.
RefSeqi NP_004114.1. NM_004123.2.
UniGenei Hs.1454.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1T5Q NMR - A 52-81 [» ]
2B4N NMR - A 52-93 [» ]
2L70 NMR - A 52-93 [» ]
2L71 NMR - A 52-93 [» ]
2OBU NMR - A 52-93 [» ]
2QKH X-ray 1.90 B 52-93 [» ]
ProteinModelPortali P09681.
SMRi P09681. Positions 52-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46469N.
IntActi P09681. 2 interactions.
MINTi MINT-8090589.
STRINGi 9606.ENSP00000350005.

Chemistry

BindingDBi P09681.
ChEMBLi CHEMBL5571.

PTM databases

PhosphoSitei P09681.

Polymorphism databases

DMDMi 121194.

Proteomic databases

PaxDbi P09681.
PeptideAtlasi P09681.
PRIDEi P09681.

Protocols and materials databases

DNASUi 2695.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357424 ; ENSP00000350005 ; ENSG00000159224 .
GeneIDi 2695.
KEGGi hsa:2695.
UCSCi uc002iol.1. human.

Organism-specific databases

CTDi 2695.
GeneCardsi GC17M047037.
HGNCi HGNC:4270. GIP.
HPAi CAB016729.
HPA021612.
MIMi 137240. gene.
neXtProti NX_P09681.
PharmGKBi PA28681.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44984.
HOGENOMi HOG000112725.
HOVERGENi HBG005839.
InParanoidi P09681.
KOi K05258.
OMAi LAWMVDQ.
OrthoDBi EOG7C8GKZ.
PhylomeDBi P09681.
TreeFami TF332333.

Enzyme and pathway databases

Reactomei REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Miscellaneous databases

EvolutionaryTracei P09681.
GenomeRNAii 2695.
NextBioi 10660.
PROi P09681.
SOURCEi Search...

Gene expression databases

Bgeei P09681.
CleanExi HS_GIP.
Genevestigatori P09681.

Family and domain databases

InterProi IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view ]
Pfami PF00123. Hormone_2. 1 hit.
[Graphical view ]
SMARTi SM00070. GLUCA. 1 hit.
[Graphical view ]
PROSITEi PS00260. GLUCAGON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor."
    Takeda J., Seino Y., Tanaka K., Fukumoto H., Kayano T., Takahashi H., Mitani T., Kurono M., Suzuki T., Tobe T., Imura H.
    Proc. Natl. Acad. Sci. U.S.A. 84:7005-7008(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene."
    Inagaki N., Seino Y., Takeda J., Yano H., Yamada Y., Bell G.I., Eddy R.L. Jr., Fukushima Y., Byers M.G., Shows T.B., Imura H.
    Mol. Endocrinol. 3:1014-1021(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-103.
  4. "The isolation and sequencing of human gastric inhibitory peptide (GIP)."
    Moody A.J., Thim L., Valverde I.
    FEBS Lett. 172:142-148(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-93.
  5. "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide."
    Alana I., Hewage C.M., Malthouse J.P., Parker J.C., Gault V.A., O'Harte F.P.
    Biochem. Biophys. Res. Commun. 325:281-286(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 52-81.

Entry informationi

Entry nameiGIP_HUMAN
AccessioniPrimary (citable) accession number: P09681
Secondary accession number(s): Q4VB42, Q6NTD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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