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P09681

- GIP_HUMAN

UniProt

P09681 - GIP_HUMAN

Protein

Gastric inhibitory polypeptide

Gene

GIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. cellular protein metabolic process Source: Reactome
    3. digestive system development Source: Ensembl
    4. endocrine pancreas development Source: Ensembl
    5. exploration behavior Source: Ensembl
    6. female pregnancy Source: Ensembl
    7. long-term synaptic potentiation Source: Ensembl
    8. memory Source: Ensembl
    9. positive regulation of cAMP-mediated signaling Source: Ensembl
    10. positive regulation of glucagon secretion Source: Ensembl
    11. positive regulation of glucose transport Source: Ensembl
    12. positive regulation of insulin secretion Source: Ensembl
    13. regulation of insulin secretion Source: Reactome
    14. response to amino acid Source: Ensembl
    15. response to axon injury Source: Ensembl
    16. response to drug Source: Ensembl
    17. response to glucose Source: Ensembl
    18. response to lipid Source: Ensembl
    19. response to organic cyclic compound Source: Ensembl
    20. response to peptide hormone Source: Ensembl
    21. response to selenium ion Source: Ensembl
    22. response to starvation Source: Ensembl
    23. sensory perception of pain Source: Ensembl
    24. signal transduction Source: ProtInc
    25. triglyceride homeostasis Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastric inhibitory polypeptide
    Short name:
    GIP
    Alternative name(s):
    Glucose-dependent insulinotropic polypeptide
    Incretin hormone
    Gene namesi
    Name:GIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4270. GIP.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular region Source: Reactome
    3. extracellular space Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. secretory granule lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28681.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 5029PRO_0000011214Add
    BLAST
    Peptidei52 – 9342Gastric inhibitory polypeptidePRO_0000011215Add
    BLAST
    Propeptidei95 – 15359PRO_0000011216Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP09681.
    PeptideAtlasiP09681.
    PRIDEiP09681.

    PTM databases

    PhosphoSiteiP09681.

    Expressioni

    Gene expression databases

    BgeeiP09681.
    CleanExiHS_GIP.
    GenevestigatoriP09681.

    Organism-specific databases

    HPAiCAB016729.
    HPA021612.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-46469N.
    IntActiP09681. 2 interactions.
    MINTiMINT-8090589.
    STRINGi9606.ENSP00000350005.

    Structurei

    Secondary structure

    1
    153
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi57 – 7923
    Turni80 – 823
    Beta strandi86 – 883

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1T5QNMR-A52-81[»]
    2B4NNMR-A52-93[»]
    2L70NMR-A52-93[»]
    2L71NMR-A52-93[»]
    2OBUNMR-A52-93[»]
    2QKHX-ray1.90B52-93[»]
    ProteinModelPortaliP09681.
    SMRiP09681. Positions 52-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09681.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44984.
    HOGENOMiHOG000112725.
    HOVERGENiHBG005839.
    InParanoidiP09681.
    KOiK05258.
    OMAiLAWMVDQ.
    OrthoDBiEOG7C8GKZ.
    PhylomeDBiP09681.
    TreeFamiTF332333.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    [Graphical view]
    PfamiPF00123. Hormone_2. 1 hit.
    [Graphical view]
    SMARTiSM00070. GLUCA. 1 hit.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09681-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVATKTFALL LLSLFLAVGL GEKKEGHFSA LPSLPVGSHA KVSSPQPRGP    50
    RYAEGTFISD YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALE 100
    LASQANRKEE EAVEPQSSPA KNPSDEDLLR DLLIQELLAC LLDQTNLCRL 150
    RSR 153
    Length:153
    Mass (Da):17,108
    Last modified:July 1, 1989 - v1
    Checksum:i51F5FC388A8897EC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031S → G.1 Publication
    Corresponds to variant rs2291725 [ dbSNP | Ensembl ].
    VAR_021897
    Natural varianti146 – 1461N → S.
    Corresponds to variant rs35703924 [ dbSNP | Ensembl ].
    VAR_033973

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18185 mRNA. Translation: AAA88043.1.
    M31679
    , M31675, M31676, M31677, M31678 Genomic DNA. Translation: AAA53192.1.
    BC069100 mRNA. Translation: AAH69100.1.
    BC069663 mRNA. Translation: AAH69663.1.
    BC069686 mRNA. Translation: AAH69686.1.
    BC069746 mRNA. Translation: AAH69746.1.
    BC096146 mRNA. Translation: AAH96146.1.
    BC096147 mRNA. Translation: AAH96147.1.
    BC096148 mRNA. Translation: AAH96148.1.
    BC096149 mRNA. Translation: AAH96149.1.
    CCDSiCCDS11542.1.
    PIRiA28406.
    RefSeqiNP_004114.1. NM_004123.2.
    UniGeneiHs.1454.

    Genome annotation databases

    EnsembliENST00000357424; ENSP00000350005; ENSG00000159224.
    GeneIDi2695.
    KEGGihsa:2695.
    UCSCiuc002iol.1. human.

    Polymorphism databases

    DMDMi121194.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18185 mRNA. Translation: AAA88043.1 .
    M31679
    , M31675 , M31676 , M31677 , M31678 Genomic DNA. Translation: AAA53192.1 .
    BC069100 mRNA. Translation: AAH69100.1 .
    BC069663 mRNA. Translation: AAH69663.1 .
    BC069686 mRNA. Translation: AAH69686.1 .
    BC069746 mRNA. Translation: AAH69746.1 .
    BC096146 mRNA. Translation: AAH96146.1 .
    BC096147 mRNA. Translation: AAH96147.1 .
    BC096148 mRNA. Translation: AAH96148.1 .
    BC096149 mRNA. Translation: AAH96149.1 .
    CCDSi CCDS11542.1.
    PIRi A28406.
    RefSeqi NP_004114.1. NM_004123.2.
    UniGenei Hs.1454.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1T5Q NMR - A 52-81 [» ]
    2B4N NMR - A 52-93 [» ]
    2L70 NMR - A 52-93 [» ]
    2L71 NMR - A 52-93 [» ]
    2OBU NMR - A 52-93 [» ]
    2QKH X-ray 1.90 B 52-93 [» ]
    ProteinModelPortali P09681.
    SMRi P09681. Positions 52-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46469N.
    IntActi P09681. 2 interactions.
    MINTi MINT-8090589.
    STRINGi 9606.ENSP00000350005.

    Chemistry

    BindingDBi P09681.
    ChEMBLi CHEMBL5571.

    PTM databases

    PhosphoSitei P09681.

    Polymorphism databases

    DMDMi 121194.

    Proteomic databases

    PaxDbi P09681.
    PeptideAtlasi P09681.
    PRIDEi P09681.

    Protocols and materials databases

    DNASUi 2695.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357424 ; ENSP00000350005 ; ENSG00000159224 .
    GeneIDi 2695.
    KEGGi hsa:2695.
    UCSCi uc002iol.1. human.

    Organism-specific databases

    CTDi 2695.
    GeneCardsi GC17M047037.
    HGNCi HGNC:4270. GIP.
    HPAi CAB016729.
    HPA021612.
    MIMi 137240. gene.
    neXtProti NX_P09681.
    PharmGKBi PA28681.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44984.
    HOGENOMi HOG000112725.
    HOVERGENi HBG005839.
    InParanoidi P09681.
    KOi K05258.
    OMAi LAWMVDQ.
    OrthoDBi EOG7C8GKZ.
    PhylomeDBi P09681.
    TreeFami TF332333.

    Enzyme and pathway databases

    Reactomei REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

    Miscellaneous databases

    EvolutionaryTracei P09681.
    GenomeRNAii 2695.
    NextBioi 10660.
    PROi P09681.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09681.
    CleanExi HS_GIP.
    Genevestigatori P09681.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    [Graphical view ]
    Pfami PF00123. Hormone_2. 1 hit.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 1 hit.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor."
      Takeda J., Seino Y., Tanaka K., Fukumoto H., Kayano T., Takahashi H., Mitani T., Kurono M., Suzuki T., Tobe T., Imura H.
      Proc. Natl. Acad. Sci. U.S.A. 84:7005-7008(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene."
      Inagaki N., Seino Y., Takeda J., Yano H., Yamada Y., Bell G.I., Eddy R.L. Jr., Fukushima Y., Byers M.G., Shows T.B., Imura H.
      Mol. Endocrinol. 3:1014-1021(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-103.
    4. "The isolation and sequencing of human gastric inhibitory peptide (GIP)."
      Moody A.J., Thim L., Valverde I.
      FEBS Lett. 172:142-148(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 52-93.
    5. "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide."
      Alana I., Hewage C.M., Malthouse J.P., Parker J.C., Gault V.A., O'Harte F.P.
      Biochem. Biophys. Res. Commun. 325:281-286(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 52-81.

    Entry informationi

    Entry nameiGIP_HUMAN
    AccessioniPrimary (citable) accession number: P09681
    Secondary accession number(s): Q4VB42, Q6NTD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3