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Protein

Gastric inhibitory polypeptide

Gene

GIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Incretin hormone
Gene namesi
Name:GIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159224.4
HGNCiHGNC:4270 GIP
MIMi137240 gene
neXtProtiNX_P09681

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2695
OpenTargetsiENSG00000159224
PharmGKBiPA28681

Chemistry databases

ChEMBLiCHEMBL5571

Polymorphism and mutation databases

BioMutaiGIP
DMDMi121194

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001121422 – 50Add BLAST29
PeptideiPRO_000001121552 – 93Gastric inhibitory polypeptideAdd BLAST42
PropeptideiPRO_000001121695 – 153Add BLAST59

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP09681
PeptideAtlasiP09681
PRIDEiP09681
ProteomicsDBi52264

PTM databases

iPTMnetiP09681
PhosphoSitePlusiP09681

Expressioni

Gene expression databases

BgeeiENSG00000159224
CleanExiHS_GIP
GenevisibleiP09681 HS

Organism-specific databases

HPAiCAB016729
HPA021612

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • hormone activity Source: ProtInc

Protein-protein interaction databases

BioGridi108962, 12 interactors
DIPiDIP-46469N
IntActiP09681, 7 interactors
MINTiP09681
STRINGi9606.ENSP00000350005

Chemistry databases

BindingDBiP09681

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 79Combined sources23
Turni80 – 82Combined sources3
Beta strandi86 – 88Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5QNMR-A52-81[»]
2B4NNMR-A52-93[»]
2L70NMR-A52-93[»]
2L71NMR-A52-93[»]
2OBUNMR-A52-93[»]
2QKHX-ray1.90B52-93[»]
ProteinModelPortaliP09681
SMRiP09681
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09681

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A Eukaryota
ENOG4111BXQ LUCA
GeneTreeiENSGT00390000005121
HOGENOMiHOG000112725
HOVERGENiHBG005839
InParanoidiP09681
KOiK05258
OMAiLAWMVDQ
OrthoDBiEOG091G153X
PhylomeDBiP09681
TreeFamiTF332333

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATKTFALL LLSLFLAVGL GEKKEGHFSA LPSLPVGSHA KVSSPQPRGP
60 70 80 90 100
RYAEGTFISD YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALE
110 120 130 140 150
LASQANRKEE EAVEPQSSPA KNPSDEDLLR DLLIQELLAC LLDQTNLCRL

RSR
Length:153
Mass (Da):17,108
Last modified:July 1, 1989 - v1
Checksum:i51F5FC388A8897EC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021897103S → G1 PublicationCorresponds to variant dbSNP:rs2291725Ensembl.1
Natural variantiVAR_033973146N → S. Corresponds to variant dbSNP:rs35703924Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18185 mRNA Translation: AAA88043.1
M31679
, M31675, M31676, M31677, M31678 Genomic DNA Translation: AAA53192.1
BC069100 mRNA Translation: AAH69100.1
BC069663 mRNA Translation: AAH69663.1
BC069686 mRNA Translation: AAH69686.1
BC069746 mRNA Translation: AAH69746.1
BC096146 mRNA Translation: AAH96146.1
BC096147 mRNA Translation: AAH96147.1
BC096148 mRNA Translation: AAH96148.1
BC096149 mRNA Translation: AAH96149.1
CCDSiCCDS11542.1
PIRiA28406
RefSeqiNP_004114.1, NM_004123.2
UniGeneiHs.1454

Genome annotation databases

EnsembliENST00000357424; ENSP00000350005; ENSG00000159224
GeneIDi2695
KEGGihsa:2695
UCSCiuc002iol.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGIP_HUMAN
AccessioniPrimary (citable) accession number: P09681
Secondary accession number(s): Q4VB42, Q6NTD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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