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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi98ManganeseBy similarity1
Metal bindingi183ManganeseBy similarity1
Metal bindingi187ManganeseBy similarity1

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • enzyme binding Source: Ensembl
  • identical protein binding Source: MGI
  • manganese ion binding Source: UniProtKB
  • oxidoreductase activity Source: CACAO
  • oxygen binding Source: Ensembl
  • superoxide dismutase activity Source: MGI

GO - Biological processi

  • acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGI
  • age-dependent response to oxidative stress Source: MGI
  • age-dependent response to reactive oxygen species Source: UniProtKB
  • apoptotic mitochondrial changes Source: MGI
  • cellular response to ethanol Source: Ensembl
  • detection of oxygen Source: MGI
  • erythrophore differentiation Source: MGI
  • glutathione metabolic process Source: MGI
  • heart development Source: MGI
  • hemopoiesis Source: MGI
  • hydrogen peroxide biosynthetic process Source: Ensembl
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
  • iron ion homeostasis Source: MGI
  • liver development Source: MGI
  • locomotory behavior Source: MGI
  • mitochondrion organization Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: MGI
  • neuron development Source: MGI
  • oxygen homeostasis Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of nitric oxide biosynthetic process Source: MGI
  • post-embryonic development Source: MGI
  • protein homotetramerization Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of catalytic activity Source: MGI
  • regulation of mitochondrial membrane potential Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • release of cytochrome c from mitochondria Source: MGI
  • removal of superoxide radicals Source: MGI
  • respiratory electron transport chain Source: MGI
  • response to activity Source: MGI
  • response to axon injury Source: MGI
  • response to cadmium ion Source: Ensembl
  • response to cold Source: Ensembl
  • response to electrical stimulus Source: Ensembl
  • response to gamma radiation Source: MGI
  • response to hydrogen peroxide Source: MGI
  • response to hyperoxia Source: MGI
  • response to hypoxia Source: Ensembl
  • response to immobilization stress Source: Ensembl
  • response to isolation stress Source: Ensembl
  • response to L-ascorbic acid Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to magnetism Source: Ensembl
  • response to manganese ion Source: Ensembl
  • response to oxidative stress Source: MGI
  • response to reactive oxygen species Source: MGI
  • response to selenium ion Source: Ensembl
  • response to silicon dioxide Source: Ensembl
  • response to superoxide Source: MGI
  • response to zinc ion Source: Ensembl
  • superoxide anion generation Source: MGI
  • superoxide metabolic process Source: MGI
  • vasodilation Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2151201 Transcriptional activation of mitochondrial biogenesis
R-MMU-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:Sod2
Synonyms:Sod-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98352 Sod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi122K → R: Reverses IR-Induced increases in superoxide and genomic Instability in SIRT3-deficient mice. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionAdd BLAST24
ChainiPRO_000003287125 – 222Superoxide dismutase [Mn], mitochondrialAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Nitrated tyrosineBy similarity1
Modified residuei68N6-acetyllysine; alternateCombined sources1
Modified residuei68N6-succinyllysine; alternateCombined sources1
Modified residuei75N6-acetyllysine; alternateCombined sources1
Modified residuei75N6-succinyllysine; alternateCombined sources1
Modified residuei114N6-acetyllysineCombined sources1
Modified residuei122N6-acetyllysine; alternateCombined sources1 Publication1
Modified residuei122N6-succinyllysine; alternateCombined sources1
Modified residuei130N6-acetyllysine; alternateCombined sources1
Modified residuei130N6-succinyllysine; alternateCombined sources1
Modified residuei202N6-acetyllysineCombined sources1

Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity (By similarity).By similarity
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.1 Publication
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.By similarity

Keywords - PTMi

Acetylation, Nitration, Ubl conjugation

Proteomic databases

EPDiP09671
PaxDbiP09671
PeptideAtlasiP09671
PRIDEiP09671
TopDownProteomicsiP09671

2D gel databases

REPRODUCTION-2DPAGEiIPI00109109
P09671
SWISS-2DPAGEiP09671

PTM databases

iPTMnetiP09671
PhosphoSitePlusiP09671
SwissPalmiP09671

Expressioni

Inductioni

Expression is regulated by KRIT1.1 Publication

Gene expression databases

BgeeiENSMUSG00000006818
CleanExiMM_SOD2
ExpressionAtlasiP09671 baseline and differential
GenevisibleiP09671 MM

Interactioni

Subunit structurei

Homotetramer.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203388, 2 interactors
IntActiP09671, 5 interactors
MINTiP09671
STRINGi10090.ENSMUSP00000007012

Structurei

3D structure databases

ProteinModelPortaliP09671
SMRiP09671
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
HOVERGENiHBG004451
InParanoidiP09671
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG091G0MVL
PhylomeDBiP09671
TreeFamiTF105132

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYTAC KK
Length:222
Mass (Da):24,603
Last modified:July 15, 1998 - v3
Checksum:i9AE804C55A8357D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → G in AAH18173 (PubMed:16141072).Curated1
Sequence conflicti18G → V in CAA28645 (PubMed:3797253).Curated1
Sequence conflicti138V → M (PubMed:3797253).Curated1
Sequence conflicti138V → M (PubMed:7875582).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04972 mRNA Translation: CAA28645.1
Z18857 mRNA Translation: CAA79308.1
L35528
, L35525, L35526, L35527 Genomic DNA Translation: AAB60902.1
S78846
, S78832, S78842, S78844 Genomic DNA Translation: AAB34899.1
AK002428 mRNA Translation: BAB22095.1
AK002534 mRNA Translation: BAB22170.1
AK012354 mRNA Translation: BAB28183.1
BC010548 mRNA Translation: AAH10548.1
BC018173 mRNA Translation: AAH18173.1
CCDSiCCDS28399.1
PIRiI57023
RefSeqiNP_038699.2, NM_013671.3
UniGeneiMm.290876

Genome annotation databases

EnsembliENSMUST00000007012; ENSMUSP00000007012; ENSMUSG00000006818
GeneIDi20656
KEGGimmu:20656
UCSCiuc008alv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSODM_MOUSE
AccessioniPrimary (citable) accession number: P09671
Secondary accession number(s): Q64670, Q8VEM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1998
Last modified: April 25, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health