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P09671

- SODM_MOUSE

UniProt

P09671 - SODM_MOUSE

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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501ManganeseBy similarity
Metal bindingi98 – 981ManganeseBy similarity
Metal bindingi183 – 1831ManganeseBy similarity
Metal bindingi187 – 1871ManganeseBy similarity

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. manganese ion binding Source: UniProtKB
  3. oxygen binding Source: Ensembl
  4. superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  1. age-dependent response to oxidative stress Source: MGI
  2. age-dependent response to reactive oxygen species Source: UniProtKB
  3. apoptotic mitochondrial changes Source: MGI
  4. cellular response to ethanol Source: Ensembl
  5. detection of oxygen Source: MGI
  6. erythrophore differentiation Source: MGI
  7. glutathione metabolic process Source: MGI
  8. heart development Source: MGI
  9. hemopoiesis Source: MGI
  10. hydrogen peroxide biosynthetic process Source: Ensembl
  11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
  13. iron ion homeostasis Source: MGI
  14. liver development Source: MGI
  15. locomotory behavior Source: MGI
  16. mitochondrion organization Source: MGI
  17. negative regulation of fat cell differentiation Source: MGI
  18. negative regulation of fibroblast proliferation Source: MGI
  19. negative regulation of neuron apoptotic process Source: Ensembl
  20. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
  21. neuron development Source: MGI
  22. oxygen homeostasis Source: Ensembl
  23. positive regulation of nitric oxide biosynthetic process Source: MGI
  24. post-embryonic development Source: MGI
  25. protein homotetramerization Source: Ensembl
  26. regulation of blood pressure Source: MGI
  27. regulation of catalytic activity Source: MGI
  28. regulation of mitochondrial membrane potential Source: MGI
  29. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  30. release of cytochrome c from mitochondria Source: MGI
  31. removal of superoxide radicals Source: MGI
  32. respiratory electron transport chain Source: MGI
  33. response to activity Source: MGI
  34. response to axon injury Source: MGI
  35. response to cadmium ion Source: Ensembl
  36. response to drug Source: Ensembl
  37. response to electrical stimulus Source: Ensembl
  38. response to gamma radiation Source: MGI
  39. response to hydrogen peroxide Source: MGI
  40. response to hyperoxia Source: MGI
  41. response to hypoxia Source: Ensembl
  42. response to L-ascorbic acid Source: Ensembl
  43. response to lipopolysaccharide Source: Ensembl
  44. response to manganese ion Source: Ensembl
  45. response to oxidative stress Source: MGI
  46. response to reactive oxygen species Source: MGI
  47. response to selenium ion Source: Ensembl
  48. response to silicon dioxide Source: Ensembl
  49. response to superoxide Source: MGI
  50. response to zinc ion Source: Ensembl
  51. superoxide anion generation Source: MGI
  52. superoxide metabolic process Source: UniProtKB
  53. vasodilation Source: MGI
  54. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:Sod2
Synonyms:Sod-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:98352. Sod2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial nucleoid Source: Ensembl
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221K → R: Reverses IR-Induced increases in superoxide and genomic Instability in SIRT3-deficient mice. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionAdd
BLAST
Chaini25 – 222198Superoxide dismutase [Mn], mitochondrialPRO_0000032871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Nitrated tyrosineBy similarity
Modified residuei68 – 681N6-acetyllysine; alternate1 Publication
Modified residuei68 – 681N6-succinyllysine; alternate1 Publication
Modified residuei75 – 751N6-acetyllysine; alternate1 Publication
Modified residuei75 – 751N6-succinyllysine; alternate1 Publication
Modified residuei114 – 1141N6-acetyllysine1 Publication
Modified residuei122 – 1221N6-acetyllysine; alternate2 Publications
Modified residuei122 – 1221N6-succinyllysine; alternate1 Publication
Modified residuei130 – 1301N6-acetyllysine; alternate2 Publications
Modified residuei130 – 1301N6-succinyllysine; alternate1 Publication
Modified residuei202 – 2021N6-acetyllysine1 Publication

Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity (By similarity).By similarity
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.3 Publications

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

MaxQBiP09671.
PaxDbiP09671.
PRIDEiP09671.

2D gel databases

REPRODUCTION-2DPAGEIPI00109109.
P09671.
SWISS-2DPAGEP09671.

PTM databases

PhosphoSiteiP09671.

Expressioni

Inductioni

Expression is regulated by KRIT1.1 Publication

Gene expression databases

BgeeiP09671.
CleanExiMM_SOD2.
ExpressionAtlasiP09671. baseline and differential.
GenevestigatoriP09671.

Interactioni

Subunit structurei

Homotetramer.

Binary interactionsi

WithEntry#Exp.IntActNotes
PolgP540992EBI-1635071,EBI-863636
Tp53P023402EBI-1635071,EBI-474016

Protein-protein interaction databases

BioGridi203388. 1 interaction.
IntActiP09671. 5 interactions.
MINTiMINT-1861884.

Structurei

3D structure databases

ProteinModelPortaliP09671.
SMRiP09671. Positions 25-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
HOVERGENiHBG004451.
InParanoidiP09671.
KOiK04564.
OMAiTERYTAC.
OrthoDBiEOG7FV3R5.
PhylomeDBiP09671.
TreeFamiTF105132.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09671-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYTAC KK
Length:222
Mass (Da):24,603
Last modified:July 15, 1998 - v3
Checksum:i9AE804C55A8357D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → G in AAH18173. (PubMed:16141072)Curated
Sequence conflicti18 – 181G → V in CAA28645. (PubMed:3797253)Curated
Sequence conflicti138 – 1381V → M(PubMed:3797253)Curated
Sequence conflicti138 – 1381V → M(PubMed:7875582)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04972 mRNA. Translation: CAA28645.1.
Z18857 mRNA. Translation: CAA79308.1.
L35528
, L35525, L35526, L35527 Genomic DNA. Translation: AAB60902.1.
S78846
, S78832, S78842, S78844 Genomic DNA. Translation: AAB34899.1.
AK002428 mRNA. Translation: BAB22095.1.
AK002534 mRNA. Translation: BAB22170.1.
AK012354 mRNA. Translation: BAB28183.1.
BC010548 mRNA. Translation: AAH10548.1.
BC018173 mRNA. Translation: AAH18173.1.
CCDSiCCDS28399.1.
PIRiI57023.
RefSeqiNP_038699.2. NM_013671.3.
UniGeneiMm.290876.

Genome annotation databases

EnsembliENSMUST00000007012; ENSMUSP00000007012; ENSMUSG00000006818.
GeneIDi20656.
KEGGimmu:20656.
UCSCiuc008alv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04972 mRNA. Translation: CAA28645.1 .
Z18857 mRNA. Translation: CAA79308.1 .
L35528
, L35525 , L35526 , L35527 Genomic DNA. Translation: AAB60902.1 .
S78846
, S78832 , S78842 , S78844 Genomic DNA. Translation: AAB34899.1 .
AK002428 mRNA. Translation: BAB22095.1 .
AK002534 mRNA. Translation: BAB22170.1 .
AK012354 mRNA. Translation: BAB28183.1 .
BC010548 mRNA. Translation: AAH10548.1 .
BC018173 mRNA. Translation: AAH18173.1 .
CCDSi CCDS28399.1.
PIRi I57023.
RefSeqi NP_038699.2. NM_013671.3.
UniGenei Mm.290876.

3D structure databases

ProteinModelPortali P09671.
SMRi P09671. Positions 25-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203388. 1 interaction.
IntActi P09671. 5 interactions.
MINTi MINT-1861884.

PTM databases

PhosphoSitei P09671.

2D gel databases

REPRODUCTION-2DPAGE IPI00109109.
P09671.
SWISS-2DPAGE P09671.

Proteomic databases

MaxQBi P09671.
PaxDbi P09671.
PRIDEi P09671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007012 ; ENSMUSP00000007012 ; ENSMUSG00000006818 .
GeneIDi 20656.
KEGGi mmu:20656.
UCSCi uc008alv.1. mouse.

Organism-specific databases

CTDi 6648.
MGIi MGI:98352. Sod2.

Phylogenomic databases

eggNOGi COG0605.
HOGENOMi HOG000013583.
HOVERGENi HBG004451.
InParanoidi P09671.
KOi K04564.
OMAi TERYTAC.
OrthoDBi EOG7FV3R5.
PhylomeDBi P09671.
TreeFami TF105132.

Enzyme and pathway databases

Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

ChiTaRSi Sod2. mouse.
NextBioi 299085.
PROi P09671.
SOURCEi Search...

Gene expression databases

Bgeei P09671.
CleanExi MM_SOD2.
ExpressionAtlasi P09671. baseline and differential.
Genevestigatori P09671.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cDNA coding for mouse manganese superoxide dismutase."
    Hallewell R.A., Mullenbach G.T., Stempien M.M., Bell G.I.
    Nucleic Acids Res. 14:9539-9539(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Sequence of manganese superoxide dismutase-encoding cDNAs from multiple mouse organs."
    Sun Y., Hegamyer G., Colburn N.M.
    Gene 131:301-302(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c and C3H.
  3. "Cloning and characterization of the murine manganous superoxide dismutase-encoding gene."
    Jones P.L., Kucera G., Gordon H.M., Boss J.M.
    Gene 153:155-161(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Structure and DNA sequence of the mouse MnSOD gene."
    Disilvestre D., Kleeberger S.R., Johns J., Levitt R.C.
    Mamm. Genome 6:281-284(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  7. Lubec G., Kang S.U., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 54-68; 76-108; 115-130 AND 203-216, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  8. "Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress."
    Tao R., Coleman M.C., Pennington J.D., Ozden O., Park S.H., Jiang H., Kim H.S., Flynn C.R., Hill S., Hayes McDonald W., Olivier A.K., Spitz D.R., Gius D.
    Mol. Cell 40:893-904(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT LYS-122, DEACETYLATION BY SIRT3, MUTAGENESIS OF LYS-122.
  9. "KRIT1 regulates the homeostasis of intracellular reactive oxygen species."
    Goitre L., Balzac F., Degani S., Degan P., Marchi S., Pinton P., Retta S.F.
    PLoS ONE 5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-68; LYS-75; LYS-122 AND LYS-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast and Liver.
  11. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68; LYS-75; LYS-114; LYS-122; LYS-130 AND LYS-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSODM_MOUSE
AccessioniPrimary (citable) accession number: P09671
Secondary accession number(s): Q64670, Q8VEM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1998
Last modified: November 26, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3