Reviewed,
UniProtKB/Swiss-Prot P09669 (COX6C_HUMAN)
Last modified
June 16, 2009.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c oxidase subunit 6C Alternative name(s): Cytochrome c oxidase polypeptide VIc | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 75 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. |
| Subcellular location | |
| Sequence similarities | Belongs to the cytochrome c oxidase subunit 6c family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Domain | Transmembrane |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | generation of precursor metabolites and energy Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 75 | 74 | Cytochrome c oxidase subunit 6C | PRO_0000006131 | |||||
Regions | |||||||||
| Topological domain | 2 – 13 | 12 | Mitochondrial matrix By similarity | ||||||
| Transmembrane | 14 – 54 | 41 | By similarity | ||||||
| Topological domain | 55 – 75 | 21 | Mitochondrial intermembrane By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 60 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc." Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S. Nucleic Acids Res. 16:10916-10916(1988) [PubMed: 2849755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Ohta S. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 52. |
| [3] | "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping." Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T. Cytogenet. Cell Genet. 83:226-227(1998) [PubMed: 10072584] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| X13238 mRNA. Translation: CAA31624.1. AF067637, AF067636 Genomic DNA. Translation: AAC73061.1. BT007007 mRNA. Translation: AAP35653.1. BC000187 mRNA. Translation: AAH00187.1. | |
| IPI | IPI00015972. |
| PIR | OGHU6C. S01960. |
| RefSeq | NP_004365.1. |
| UniGene | Hs.191540 Hs.351875 |
3D structure databases | |
| SMR | P09669. Positions 6-75. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P09669. 2 interactions. |
PTM databases | |
| PhosphoSite | P09669. |
Proteomic databases | |
| PeptideAtlas | P09669. |
| PRIDE | P09669. |
Genome annotation databases | |
| Ensembl | ENSG00000164919. Homo sapiens. [Contig view] |
| GeneID | 1345. |
| KEGG | hsa:1345. |
Organism-specific databases | |
| GeneCards | GC08M100959. |
| H-InvDB | HIX0034326. |
| HGNC | HGNC:2285. COX6C. |
| HPA | CAB016244. |
| MIM | 124090. gene. |
| PharmGKB | PA26802. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P09669. |
| HOVERGEN | P09669. |
| OMA | P09669. LYKFGVA. |
Enzyme and pathway databases | |
| Reactome | REACT_6305. Electron Transport Chain. |
Gene expression databases | |
| ArrayExpress | P09669. |
| Bgee | P09669. |
| CleanEx | HS_COX6C. |
| GermOnline | ENSG00000164919. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004204. Cyt_c_oxidase_su6c. [Graphical view] |
| Gene3D | G3DSA:4.10.93.10. COX6C. 1 hit. |
| PANTHER | PTHR12916. COX6C. 1 hit. |
| Pfam | PF02937. COX6C. 1 hit. [Graphical view] |
| ProDom | PD015032. COX6C. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 5453. |
| SOURCE | Search... |
Entry information
| Entry name | COX6C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P09669 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


