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P09669 (COX6C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene names
Name:COX6C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 6c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7575Cytochrome c oxidase subunit 6C
PRO_0000006131

Regions

Topological domain1 – 1313Mitochondrial matrix By similarity
Transmembrane14 – 5441Helical; By similarity
Topological domain55 – 7521Mitochondrial intermembrane By similarity

Sequences

Sequence LengthMass (Da)Tools
P09669 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D09FEE0C0AA7A798

FASTA758,781
        10         20         30         40         50         60 
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA DFYRNYDVMK 

        70 
DFEEMRKAGI FQSVK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc."
Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S.
Nucleic Acids Res. 16:10916-10916(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Ohta S.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 52.
[3]"Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping."
Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T.
Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[8]"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
Xu G., Shin S.B., Jaffrey S.R.
Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-11.
Tissue: Leukemic T-cell.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
PIROGHU6C. S01960.
RefSeqNP_004365.1. NM_004374.3.
UniGeneHs.351875.

3D structure databases

ProteinModelPortalP09669.
SMRP09669. Positions 6-75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107738. 7 interactions.
IntActP09669. 16 interactions.
STRING9606.ENSP00000297564.

PTM databases

PhosphoSiteP09669.

Proteomic databases

PaxDbP09669.
PeptideAtlasP09669.
PRIDEP09669.

Protocols and materials databases

DNASU1345.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneID1345.
KEGGhsa:1345.
UCSCuc003yiy.2. human.

Organism-specific databases

CTD1345.
GeneCardsGC08M100885.
HGNCHGNC:2285. COX6C.
HPACAB016244.
HPA014295.
MIM124090. gene.
neXtProtNX_P09669.
PharmGKBPA26802.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86594.
HOGENOMHOG000039249.
HOVERGENHBG051091.
InParanoidP09669.
KOK02268.
OMAVKEFNAM.
OrthoDBEOG73807S.
PhylomeDBP09669.
TreeFamTF353619.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeP09669.
CleanExHS_COX6C.
GenevestigatorP09669.

Family and domain databases

Gene3D4.10.93.10. 1 hit.
InterProIPR004204. COX6C.
[Graphical view]
PANTHERPTHR12916. PTHR12916. 1 hit.
PfamPF02937. COX6C. 1 hit.
[Graphical view]
ProDomPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GeneWikiCOX6C.
GenomeRNAi1345.
NextBio5453.
PROP09669.
SOURCESearch...

Entry information

Entry nameCOX6C_HUMAN
AccessionPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM