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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_355377. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:COX6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2285. COX6C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei14 – 5441HelicalBy similarityAdd
BLAST
Topological domaini55 – 7521Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26802.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX6C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7575Cytochrome c oxidase subunit 6CPRO_0000006131Add
BLAST

Proteomic databases

MaxQBiP09669.
PaxDbiP09669.
PeptideAtlasiP09669.
PRIDEiP09669.

PTM databases

PhosphoSiteiP09669.

Expressioni

Gene expression databases

BgeeiP09669.
CleanExiHS_COX6C.
ExpressionAtlasiP09669. baseline and differential.
GenevisibleiP09669. HS.

Organism-specific databases

HPAiCAB016244.
HPA014295.

Interactioni

Protein-protein interaction databases

BioGridi107738. 5 interactions.
IntActiP09669. 18 interactions.
STRINGi9606.ENSP00000297564.

Structurei

3D structure databases

ProteinModelPortaliP09669.
SMRiP09669. Positions 6-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86594.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP09669.
KOiK02268.
OMAiKPVMRGL.
OrthoDBiEOG73807S.
PhylomeDBiP09669.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P09669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA
60 70
DFYRNYDVMK DFEEMRKAGI FQSVK
Length:75
Mass (Da):8,781
Last modified:February 1, 1996 - v2
Checksum:iD09FEE0C0AA7A798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
CCDSiCCDS6284.1.
PIRiS01960. OGHU6C.
RefSeqiNP_004365.1. NM_004374.3.
UniGeneiHs.351875.

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneIDi1345.
KEGGihsa:1345.
UCSCiuc003yiy.2. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
CCDSiCCDS6284.1.
PIRiS01960. OGHU6C.
RefSeqiNP_004365.1. NM_004374.3.
UniGeneiHs.351875.

3D structure databases

ProteinModelPortaliP09669.
SMRiP09669. Positions 6-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107738. 5 interactions.
IntActiP09669. 18 interactions.
STRINGi9606.ENSP00000297564.

Chemistry

DrugBankiDB02659. Cholic Acid.

PTM databases

PhosphoSiteiP09669.

Polymorphism and mutation databases

BioMutaiCOX6C.

Proteomic databases

MaxQBiP09669.
PaxDbiP09669.
PeptideAtlasiP09669.
PRIDEiP09669.

Protocols and materials databases

DNASUi1345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneIDi1345.
KEGGihsa:1345.
UCSCiuc003yiy.2. human.

Organism-specific databases

CTDi1345.
GeneCardsiGC08M100885.
HGNCiHGNC:2285. COX6C.
HPAiCAB016244.
HPA014295.
MIMi124090. gene.
neXtProtiNX_P09669.
PharmGKBiPA26802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86594.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP09669.
KOiK02268.
OMAiKPVMRGL.
OrthoDBiEOG73807S.
PhylomeDBiP09669.
TreeFamiTF353619.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_355377. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSiCOX6C. human.
GeneWikiiCOX6C.
GenomeRNAii1345.
NextBioi5453.
PROiP09669.
SOURCEiSearch...

Gene expression databases

BgeeiP09669.
CleanExiHS_COX6C.
ExpressionAtlasiP09669. baseline and differential.
GenevisibleiP09669. HS.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc."
    Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S.
    Nucleic Acids Res. 16:10916-10916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Ohta S.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 52.
  3. "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping."
    Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T.
    Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  8. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-11.
    Tissue: Leukemic T-cell.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX6C_HUMAN
AccessioniPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: July 22, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.