SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P09669

- COX6C_HUMAN

UniProt

P09669 - COX6C_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 6C

Gene
COX6C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. generation of precursor metabolites and energy Source: ProtInc
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:COX6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:2285. COX6C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Mitochondrial matrix By similarityAdd
BLAST
Transmembranei14 – 5441Helical; By similarityAdd
BLAST
Topological domaini55 – 7521Mitochondrial intermembrane By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7575Cytochrome c oxidase subunit 6CPRO_0000006131Add
BLAST

Proteomic databases

MaxQBiP09669.
PaxDbiP09669.
PeptideAtlasiP09669.
PRIDEiP09669.

PTM databases

PhosphoSiteiP09669.

Expressioni

Gene expression databases

BgeeiP09669.
CleanExiHS_COX6C.
GenevestigatoriP09669.

Organism-specific databases

HPAiCAB016244.
HPA014295.

Interactioni

Protein-protein interaction databases

BioGridi107738. 7 interactions.
IntActiP09669. 17 interactions.
STRINGi9606.ENSP00000297564.

Structurei

3D structure databases

ProteinModelPortaliP09669.
SMRiP09669. Positions 6-75.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86594.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP09669.
KOiK02268.
OMAiEYQKDGG.
OrthoDBiEOG73807S.
PhylomeDBiP09669.
TreeFamiTF353619.

Family and domain databases

Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
PfamiPF02937. COX6C. 1 hit.
[Graphical view]
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P09669-1 [UniParc]FASTAAdd to Basket

« Hide

MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA   50
DFYRNYDVMK DFEEMRKAGI FQSVK 75
Length:75
Mass (Da):8,781
Last modified:February 1, 1996 - v2
Checksum:iD09FEE0C0AA7A798
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
CCDSiCCDS6284.1.
PIRiS01960. OGHU6C.
RefSeqiNP_004365.1. NM_004374.3.
UniGeneiHs.351875.

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneIDi1345.
KEGGihsa:1345.
UCSCiuc003yiy.2. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13238 mRNA. Translation: CAA31624.1 .
AF067637 , AF067636 Genomic DNA. Translation: AAC73061.1 .
BT007007 mRNA. Translation: AAP35653.1 .
AK311791 mRNA. Translation: BAG34734.1 .
CH471060 Genomic DNA. Translation: EAW91791.1 .
BC000187 mRNA. Translation: AAH00187.1 .
CCDSi CCDS6284.1.
PIRi S01960. OGHU6C.
RefSeqi NP_004365.1. NM_004374.3.
UniGenei Hs.351875.

3D structure databases

ProteinModelPortali P09669.
SMRi P09669. Positions 6-75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107738. 7 interactions.
IntActi P09669. 17 interactions.
STRINGi 9606.ENSP00000297564.

PTM databases

PhosphoSitei P09669.

Proteomic databases

MaxQBi P09669.
PaxDbi P09669.
PeptideAtlasi P09669.
PRIDEi P09669.

Protocols and materials databases

DNASUi 1345.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297564 ; ENSP00000297564 ; ENSG00000164919 .
ENST00000517682 ; ENSP00000429714 ; ENSG00000164919 .
ENST00000518171 ; ENSP00000429755 ; ENSG00000164919 .
ENST00000520271 ; ENSP00000428150 ; ENSG00000164919 .
ENST00000520468 ; ENSP00000428895 ; ENSG00000164919 .
ENST00000520517 ; ENSP00000429991 ; ENSG00000164919 .
ENST00000522934 ; ENSP00000428702 ; ENSG00000164919 .
ENST00000522940 ; ENSP00000428965 ; ENSG00000164919 .
ENST00000523016 ; ENSP00000429707 ; ENSG00000164919 .
ENST00000524245 ; ENSP00000429410 ; ENSG00000164919 .
GeneIDi 1345.
KEGGi hsa:1345.
UCSCi uc003yiy.2. human.

Organism-specific databases

CTDi 1345.
GeneCardsi GC08M100885.
HGNCi HGNC:2285. COX6C.
HPAi CAB016244.
HPA014295.
MIMi 124090. gene.
neXtProti NX_P09669.
PharmGKBi PA26802.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86594.
HOGENOMi HOG000039249.
HOVERGENi HBG051091.
InParanoidi P09669.
KOi K02268.
OMAi EYQKDGG.
OrthoDBi EOG73807S.
PhylomeDBi P09669.
TreeFami TF353619.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GeneWikii COX6C.
GenomeRNAii 1345.
NextBioi 5453.
PROi P09669.
SOURCEi Search...

Gene expression databases

Bgeei P09669.
CleanExi HS_COX6C.
Genevestigatori P09669.

Family and domain databases

Gene3Di 4.10.93.10. 1 hit.
InterProi IPR004204. COX6C.
[Graphical view ]
PANTHERi PTHR12916. PTHR12916. 1 hit.
Pfami PF02937. COX6C. 1 hit.
[Graphical view ]
ProDomi PD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc."
    Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S.
    Nucleic Acids Res. 16:10916-10916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Ohta S.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 52.
  3. "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping."
    Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T.
    Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  8. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-11.
    Tissue: Leukemic T-cell.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX6C_HUMAN
AccessioniPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi