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P09669

- COX6C_HUMAN

UniProt

P09669 - COX6C_HUMAN

Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. generation of precursor metabolites and energy Source: ProtInc
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6C
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIc
    Gene namesi
    Name:COX6C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:2285. COX6C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26802.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7575Cytochrome c oxidase subunit 6CPRO_0000006131Add
    BLAST

    Proteomic databases

    MaxQBiP09669.
    PaxDbiP09669.
    PeptideAtlasiP09669.
    PRIDEiP09669.

    PTM databases

    PhosphoSiteiP09669.

    Expressioni

    Gene expression databases

    BgeeiP09669.
    CleanExiHS_COX6C.
    GenevestigatoriP09669.

    Organism-specific databases

    HPAiCAB016244.
    HPA014295.

    Interactioni

    Protein-protein interaction databases

    BioGridi107738. 7 interactions.
    IntActiP09669. 17 interactions.
    STRINGi9606.ENSP00000297564.

    Structurei

    3D structure databases

    ProteinModelPortaliP09669.
    SMRiP09669. Positions 6-75.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini55 – 7521Mitochondrial intermembraneBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 5441HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86594.
    HOGENOMiHOG000039249.
    HOVERGENiHBG051091.
    InParanoidiP09669.
    KOiK02268.
    OMAiEYQKDGG.
    OrthoDBiEOG73807S.
    PhylomeDBiP09669.
    TreeFamiTF353619.

    Family and domain databases

    Gene3Di4.10.93.10. 1 hit.
    InterProiIPR004204. COX6C.
    [Graphical view]
    PANTHERiPTHR12916. PTHR12916. 1 hit.
    PfamiPF02937. COX6C. 1 hit.
    [Graphical view]
    ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P09669-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA   50
    DFYRNYDVMK DFEEMRKAGI FQSVK 75
    Length:75
    Mass (Da):8,781
    Last modified:February 1, 1996 - v2
    Checksum:iD09FEE0C0AA7A798
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13238 mRNA. Translation: CAA31624.1.
    AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
    BT007007 mRNA. Translation: AAP35653.1.
    AK311791 mRNA. Translation: BAG34734.1.
    CH471060 Genomic DNA. Translation: EAW91791.1.
    BC000187 mRNA. Translation: AAH00187.1.
    CCDSiCCDS6284.1.
    PIRiS01960. OGHU6C.
    RefSeqiNP_004365.1. NM_004374.3.
    UniGeneiHs.351875.

    Genome annotation databases

    EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
    ENST00000517682; ENSP00000429714; ENSG00000164919.
    ENST00000518171; ENSP00000429755; ENSG00000164919.
    ENST00000520271; ENSP00000428150; ENSG00000164919.
    ENST00000520468; ENSP00000428895; ENSG00000164919.
    ENST00000520517; ENSP00000429991; ENSG00000164919.
    ENST00000522934; ENSP00000428702; ENSG00000164919.
    ENST00000522940; ENSP00000428965; ENSG00000164919.
    ENST00000523016; ENSP00000429707; ENSG00000164919.
    ENST00000524245; ENSP00000429410; ENSG00000164919.
    GeneIDi1345.
    KEGGihsa:1345.
    UCSCiuc003yiy.2. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13238 mRNA. Translation: CAA31624.1 .
    AF067637 , AF067636 Genomic DNA. Translation: AAC73061.1 .
    BT007007 mRNA. Translation: AAP35653.1 .
    AK311791 mRNA. Translation: BAG34734.1 .
    CH471060 Genomic DNA. Translation: EAW91791.1 .
    BC000187 mRNA. Translation: AAH00187.1 .
    CCDSi CCDS6284.1.
    PIRi S01960. OGHU6C.
    RefSeqi NP_004365.1. NM_004374.3.
    UniGenei Hs.351875.

    3D structure databases

    ProteinModelPortali P09669.
    SMRi P09669. Positions 6-75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107738. 7 interactions.
    IntActi P09669. 17 interactions.
    STRINGi 9606.ENSP00000297564.

    PTM databases

    PhosphoSitei P09669.

    Proteomic databases

    MaxQBi P09669.
    PaxDbi P09669.
    PeptideAtlasi P09669.
    PRIDEi P09669.

    Protocols and materials databases

    DNASUi 1345.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297564 ; ENSP00000297564 ; ENSG00000164919 .
    ENST00000517682 ; ENSP00000429714 ; ENSG00000164919 .
    ENST00000518171 ; ENSP00000429755 ; ENSG00000164919 .
    ENST00000520271 ; ENSP00000428150 ; ENSG00000164919 .
    ENST00000520468 ; ENSP00000428895 ; ENSG00000164919 .
    ENST00000520517 ; ENSP00000429991 ; ENSG00000164919 .
    ENST00000522934 ; ENSP00000428702 ; ENSG00000164919 .
    ENST00000522940 ; ENSP00000428965 ; ENSG00000164919 .
    ENST00000523016 ; ENSP00000429707 ; ENSG00000164919 .
    ENST00000524245 ; ENSP00000429410 ; ENSG00000164919 .
    GeneIDi 1345.
    KEGGi hsa:1345.
    UCSCi uc003yiy.2. human.

    Organism-specific databases

    CTDi 1345.
    GeneCardsi GC08M100885.
    HGNCi HGNC:2285. COX6C.
    HPAi CAB016244.
    HPA014295.
    MIMi 124090. gene.
    neXtProti NX_P09669.
    PharmGKBi PA26802.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86594.
    HOGENOMi HOG000039249.
    HOVERGENi HBG051091.
    InParanoidi P09669.
    KOi K02268.
    OMAi EYQKDGG.
    OrthoDBi EOG73807S.
    PhylomeDBi P09669.
    TreeFami TF353619.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    GeneWikii COX6C.
    GenomeRNAii 1345.
    NextBioi 5453.
    PROi P09669.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09669.
    CleanExi HS_COX6C.
    Genevestigatori P09669.

    Family and domain databases

    Gene3Di 4.10.93.10. 1 hit.
    InterProi IPR004204. COX6C.
    [Graphical view ]
    PANTHERi PTHR12916. PTHR12916. 1 hit.
    Pfami PF02937. COX6C. 1 hit.
    [Graphical view ]
    ProDomi PD015032. Cyt_c_oxidase_su6c. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc."
      Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S.
      Nucleic Acids Res. 16:10916-10916(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Ohta S.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 52.
    3. "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping."
      Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T.
      Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    8. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-11.
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX6C_HUMAN
    AccessioniPrimary (citable) accession number: P09669
    Secondary accession number(s): B2R4D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3