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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS09158-MONOMER.
ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Gene namesi
Name:COX6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2285. COX6C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13Mitochondrial matrixBy similarityAdd BLAST13
Transmembranei14 – 54HelicalBy similarityAdd BLAST41
Topological domaini55 – 75Mitochondrial intermembraneBy similarityAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1345.
OpenTargetsiENSG00000164919.
PharmGKBiPA26802.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX6C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000061311 – 75Cytochrome c oxidase subunit 6CAdd BLAST75

Proteomic databases

EPDiP09669.
MaxQBiP09669.
PaxDbiP09669.
PeptideAtlasiP09669.
PRIDEiP09669.
TopDownProteomicsiP09669.

PTM databases

iPTMnetiP09669.
PhosphoSitePlusiP09669.

Expressioni

Gene expression databases

BgeeiENSG00000164919.
CleanExiHS_COX6C.
ExpressionAtlasiP09669. baseline and differential.
GenevisibleiP09669. HS.

Organism-specific databases

HPAiCAB016244.
HPA014295.

Interactioni

Protein-protein interaction databases

BioGridi107738. 22 interactors.
IntActiP09669. 25 interactors.
STRINGi9606.ENSP00000297564.

Structurei

3D structure databases

ProteinModelPortaliP09669.
SMRiP09669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP09669.
KOiK02268.
OMAiKPVMRGL.
OrthoDBiEOG091G10KX.
PhylomeDBiP09669.
TreeFamiTF353619.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P09669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA
60 70
DFYRNYDVMK DFEEMRKAGI FQSVK
Length:75
Mass (Da):8,781
Last modified:February 1, 1996 - v2
Checksum:iD09FEE0C0AA7A798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
CCDSiCCDS6284.1.
PIRiS01960. OGHU6C.
RefSeqiNP_004365.1. NM_004374.3.
XP_016868509.1. XM_017013020.1.
UniGeneiHs.351875.

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneIDi1345.
KEGGihsa:1345.
UCSCiuc003yiy.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13238 mRNA. Translation: CAA31624.1.
AF067637, AF067636 Genomic DNA. Translation: AAC73061.1.
BT007007 mRNA. Translation: AAP35653.1.
AK311791 mRNA. Translation: BAG34734.1.
CH471060 Genomic DNA. Translation: EAW91791.1.
BC000187 mRNA. Translation: AAH00187.1.
CCDSiCCDS6284.1.
PIRiS01960. OGHU6C.
RefSeqiNP_004365.1. NM_004374.3.
XP_016868509.1. XM_017013020.1.
UniGeneiHs.351875.

3D structure databases

ProteinModelPortaliP09669.
SMRiP09669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107738. 22 interactors.
IntActiP09669. 25 interactors.
STRINGi9606.ENSP00000297564.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

PTM databases

iPTMnetiP09669.
PhosphoSitePlusiP09669.

Polymorphism and mutation databases

BioMutaiCOX6C.

Proteomic databases

EPDiP09669.
MaxQBiP09669.
PaxDbiP09669.
PeptideAtlasiP09669.
PRIDEiP09669.
TopDownProteomicsiP09669.

Protocols and materials databases

DNASUi1345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297564; ENSP00000297564; ENSG00000164919.
ENST00000517682; ENSP00000429714; ENSG00000164919.
ENST00000518171; ENSP00000429755; ENSG00000164919.
ENST00000520271; ENSP00000428150; ENSG00000164919.
ENST00000520468; ENSP00000428895; ENSG00000164919.
ENST00000520517; ENSP00000429991; ENSG00000164919.
ENST00000522934; ENSP00000428702; ENSG00000164919.
ENST00000522940; ENSP00000428965; ENSG00000164919.
ENST00000523016; ENSP00000429707; ENSG00000164919.
ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneIDi1345.
KEGGihsa:1345.
UCSCiuc003yiy.3. human.

Organism-specific databases

CTDi1345.
DisGeNETi1345.
GeneCardsiCOX6C.
HGNCiHGNC:2285. COX6C.
HPAiCAB016244.
HPA014295.
MIMi124090. gene.
neXtProtiNX_P09669.
OpenTargetsiENSG00000164919.
PharmGKBiPA26802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J83U. Eukaryota.
ENOG41124VH. LUCA.
GeneTreeiENSGT00390000004573.
HOGENOMiHOG000039249.
HOVERGENiHBG051091.
InParanoidiP09669.
KOiK02268.
OMAiKPVMRGL.
OrthoDBiEOG091G10KX.
PhylomeDBiP09669.
TreeFamiTF353619.

Enzyme and pathway databases

BioCyciZFISH:HS09158-MONOMER.
ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiCOX6C. human.
GeneWikiiCOX6C.
GenomeRNAii1345.
PROiP09669.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164919.
CleanExiHS_COX6C.
ExpressionAtlasiP09669. baseline and differential.
GenevisibleiP09669. HS.

Family and domain databases

CDDicd00927. Cyt_c_Oxidase_VIc. 1 hit.
Gene3Di4.10.93.10. 1 hit.
InterProiIPR004204. COX6C.
[Graphical view]
PANTHERiPTHR12916. PTHR12916. 1 hit.
ProDomiPD015032. Cyt_c_oxidase_su6c. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX6C_HUMAN
AccessioniPrimary (citable) accession number: P09669
Secondary accession number(s): B2R4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.