P09669 (COX6C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 6C

Alternative name(s):
Cytochrome c oxidase polypeptide VIc

Gene names

Name:

COX6C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	75 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6c family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Traceable author statement. Source: Reactome
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 75	75	Cytochrome c oxidase subunit 6C		PRO_0000006131
Regions
	Topological domain	1 – 13	13	Mitochondrial matrix By similarity
	Transmembrane	14 – 54	41	Helical; By similarity
	Topological domain	55 – 75	21	Mitochondrial intermembrane By similarity
Amino acid modifications
	Modified residue	60	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09669 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: D09FEE0C0AA7A798	FASTA	75	8,781
	10 20 30 40 50 60 MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA DFYRNYDVMK 70 DFEEMRKAGI FQSVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc." Otsuka M., Mizuno Y., Yoshida M., Kagawa Y., Ohta S. Nucleic Acids Res. 16:10916-10916(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Ohta S. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 52.
[3]	"Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping." Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T. Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[8]	"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini." Xu G., Shin S.B., Jaffrey S.R. Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-11. Tissue: Leukemic T-cell.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13238 mRNA. Translation: CAA31624.1. AF067637, AF067636 Genomic DNA. Translation: AAC73061.1. BT007007 mRNA. Translation: AAP35653.1. AK311791 mRNA. Translation: BAG34734.1. CH471060 Genomic DNA. Translation: EAW91791.1. BC000187 mRNA. Translation: AAH00187.1.
IPI	IPI00015972.
PIR	OGHU6C. S01960.
RefSeq	NP_004365.1. NM_004374.3.
UniGene	Hs.351875.
3D structure databases
ProteinModelPortal	P09669.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09669. 6 interactions.
STRING	9606.ENSP00000297564.
PTM databases
PhosphoSite	P09669.
Polymorphism databases
DMDM	1352175.
Proteomic databases
PaxDb	P09669.
PeptideAtlas	P09669.
PRIDE	P09669.
Protocols and materials databases
DNASU	1345.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297564; ENSP00000297564; ENSG00000164919. ENST00000517682; ENSP00000429714; ENSG00000164919. ENST00000518171; ENSP00000429755; ENSG00000164919. ENST00000520271; ENSP00000428150; ENSG00000164919. ENST00000520468; ENSP00000428895; ENSG00000164919. ENST00000520517; ENSP00000429991; ENSG00000164919. ENST00000522934; ENSP00000428702; ENSG00000164919. ENST00000522940; ENSP00000428965; ENSG00000164919. ENST00000523016; ENSP00000429707; ENSG00000164919. ENST00000524245; ENSP00000429410; ENSG00000164919.
GeneID	1345.
KEGG	hsa:1345.
UCSC	uc003yiy.2. human.
Organism-specific databases
CTD	1345.
GeneCards	GC08M100885.
HGNC	HGNC:2285. COX6C.
HPA	CAB016244.
MIM	124090. gene.
neXtProt	NX_P09669.
PharmGKB	PA26802.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86594.
HOGENOM	HOG000039249.
HOVERGEN	HBG051091.
InParanoid	P09669.
KO	K02268.
OMA	VKEFNAM.
OrthoDB	EOG42JNT3.
PhylomeDB	P09669.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Bgee	P09669.
CleanEx	HS_COX6C.
Genevestigator	P09669.
GermOnline	ENSG00000164919. Homo sapiens.
Family and domain databases
Gene3D	4.10.93.10. 1 hit.
InterPro	IPR004204. Cyt_c_oxidase_su6c. [Graphical view]
PANTHER	PTHR12916. PTHR12916. 1 hit.
Pfam	PF02937. COX6C. 1 hit. [Graphical view]
ProDom	PD015032. Cyt_c_oxidase_su6c. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF81415. COX6C. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	1345.
NextBio	5453.
SOURCE	Search...

Entry information

Entry name

COX6C_HUMAN

Accession

Primary (citable) accession number: P09669
Secondary accession number(s): B2R4D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.