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Protein

U2 small nuclear ribonucleoprotein A'

Gene

SNRPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • U2 snRNA binding Source: GO_Central

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131876-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein A'
Short name:
U2 snRNP A'
Gene namesi
Name:SNRPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11152. SNRPA1.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • nucleoplasm Source: HPA
  • small nuclear ribonucleoprotein complex Source: ProtInc
  • spliceosomal complex Source: HGNC
  • U2 snRNP Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131876.
PharmGKBiPA35994.

Polymorphism and mutation databases

BioMutaiSNRPA1.
DMDMi31077165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000741732 – 255U2 small nuclear ribonucleoprotein A'Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172N6-acetyllysineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09661.
MaxQBiP09661.
PaxDbiP09661.
PeptideAtlasiP09661.
PRIDEiP09661.

PTM databases

iPTMnetiP09661.
PhosphoSitePlusiP09661.

Expressioni

Gene expression databases

BgeeiENSG00000131876.
CleanExiHS_SNRPA1.
ExpressionAtlasiP09661. baseline and differential.
GenevisibleiP09661. HS.

Organism-specific databases

HPAiHPA045622.
HPA048499.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SNRPAP090126EBI-876439,EBI-607085
SNRPB2P085792EBI-876439,EBI-1053651

Protein-protein interaction databases

BioGridi112511. 143 interactors.
DIPiDIP-625N.
IntActiP09661. 21 interactors.
MINTiMINT-3007227.
STRINGi9606.ENSP00000254193.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 10Combined sources5
Beta strandi14 – 16Combined sources3
Beta strandi22 – 25Combined sources4
Helixi37 – 40Combined sources4
Beta strandi45 – 48Combined sources4
Beta strandi68 – 70Combined sources3
Helixi83 – 86Combined sources4
Beta strandi92 – 94Combined sources3
Helixi103 – 111Combined sources9
Beta strandi117 – 119Combined sources3
Helixi124 – 127Combined sources4
Helixi131 – 138Combined sources8
Beta strandi143 – 145Combined sources3
Helixi152 – 160Combined sources9
Helixi165 – 172Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38A/C1-176[»]
ProteinModelPortaliP09661.
SMRiP09661.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09661.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 41LRR 1Add BLAST22
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 86LRR 3Add BLAST22
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1644. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00510000047131.
HOGENOMiHOG000175472.
HOVERGENiHBG007330.
KOiK11092.
OMAiTKPNYRE.
OrthoDBiEOG091G0M17.
PhylomeDBiP09661.
TreeFamiTF313776.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS
60 70 80 90 100
DNEIRKLDGF PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL
110 120 130 140 150
VELGDLDPLA SLKSLTYLSI LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV
160 170 180 190 200
KLKERQEAEK MFKGKRGAQL AKDIARRSKT FNPGAGLPTD KKKGGPSPGD
210 220 230 240 250
VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD DGEEEMEEDT

VTNGS
Length:255
Mass (Da):28,416
Last modified:May 23, 2003 - v2
Checksum:i25902F07992B7209
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193K → R in CAA31838 (PubMed:2928112).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052030234R → H.Corresponds to variant rs1050843dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13482 mRNA. Translation: CAA31838.1.
AK312200 mRNA. Translation: BAG35133.1.
CH471101 Genomic DNA. Translation: EAX02300.1.
BC022816 mRNA. Translation: AAH22816.1.
BC071717 mRNA. Translation: AAH71717.1.
CCDSiCCDS10391.1.
PIRiS03616.
RefSeqiNP_003081.2. NM_003090.3.
UniGeneiHs.528763.

Genome annotation databases

EnsembliENST00000254193; ENSP00000254193; ENSG00000131876.
GeneIDi6627.
KEGGihsa:6627.
UCSCiuc002bww.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13482 mRNA. Translation: CAA31838.1.
AK312200 mRNA. Translation: BAG35133.1.
CH471101 Genomic DNA. Translation: EAX02300.1.
BC022816 mRNA. Translation: AAH22816.1.
BC071717 mRNA. Translation: AAH71717.1.
CCDSiCCDS10391.1.
PIRiS03616.
RefSeqiNP_003081.2. NM_003090.3.
UniGeneiHs.528763.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38A/C1-176[»]
ProteinModelPortaliP09661.
SMRiP09661.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112511. 143 interactors.
DIPiDIP-625N.
IntActiP09661. 21 interactors.
MINTiMINT-3007227.
STRINGi9606.ENSP00000254193.

PTM databases

iPTMnetiP09661.
PhosphoSitePlusiP09661.

Polymorphism and mutation databases

BioMutaiSNRPA1.
DMDMi31077165.

Proteomic databases

EPDiP09661.
MaxQBiP09661.
PaxDbiP09661.
PeptideAtlasiP09661.
PRIDEiP09661.

Protocols and materials databases

DNASUi6627.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254193; ENSP00000254193; ENSG00000131876.
GeneIDi6627.
KEGGihsa:6627.
UCSCiuc002bww.4. human.

Organism-specific databases

CTDi6627.
GeneCardsiSNRPA1.
H-InvDBHIX0203213.
HGNCiHGNC:11152. SNRPA1.
HPAiHPA045622.
HPA048499.
MIMi603521. gene.
neXtProtiNX_P09661.
OpenTargetsiENSG00000131876.
PharmGKBiPA35994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1644. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00510000047131.
HOGENOMiHOG000175472.
HOVERGENiHBG007330.
KOiK11092.
OMAiTKPNYRE.
OrthoDBiEOG091G0M17.
PhylomeDBiP09661.
TreeFamiTF313776.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131876-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

EvolutionaryTraceiP09661.
GeneWikiiSNRPA1.
GenomeRNAii6627.
PROiP09661.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131876.
CleanExiHS_SNRPA1.
ExpressionAtlasiP09661. baseline and differential.
GenevisibleiP09661. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRU2A_HUMAN
AccessioniPrimary (citable) accession number: P09661
Secondary accession number(s): B2R5I6, Q8TBD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 23, 2003
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.