Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vimentin

Gene

VIM

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei345StutterBy similarity1

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vimentin
Gene namesi
Name:VIM
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cell Source: AgBase
  • cell projection Source: AgBase
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000637612 – 460VimentinAdd BLAST459

Post-translational modificationi

One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09654.
PRIDEiP09654.

Interactioni

Subunit structurei

Homopolymer assembled from elementary dimers. Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM (By similarity).By similarity

Protein-protein interaction databases

BioGridi681466. 1 interactor.
IntActiP09654. 1 interactor.
STRINGi9031.ENSGALP00000014107.

Structurei

3D structure databases

ProteinModelPortaliP09654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 89HeadAdd BLAST88
Regioni90 – 401RodAdd BLAST312
Regioni90 – 125Coil 1AAdd BLAST36
Regioni126 – 147Linker 1Add BLAST22
Regioni148 – 239Coil 1BAdd BLAST92
Regioni240 – 262Linker 12Add BLAST23
Regioni263 – 401Coil 2Add BLAST139
Regioni402 – 460TailAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 125Add BLAST36
Coiled coili148 – 239Add BLAST92
Coiled coili297 – 401Add BLAST105

Domaini

The central alpha-helical coiled-coil rod region mediates elementary homodimerization.By similarity

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZ1. Eukaryota.
ENOG410XRBS. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP09654.
PhylomeDBiP09654.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR027699. Vimentin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF27. PTHR23239:SF27. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTSSKNSS YRRMFGGGSR PSSGTRYITS STRYSLGSAL RPSSARYVSA
60 70 80 90 100
SPGGVYRTKA TSVRLRSSMP PMRMHDAVDF TLADAINTEF KANRTNEKVE
110 120 130 140 150
LQELNDRFAN YIDKVRFLEQ QNKILLAELE QLKGKGTSRL GDLYEEEMRD
160 170 180 190 200
VRRQVDQLTN DKARVEVERD NLADDIMRLR EKLQEEMLQR EEAESTLQSF
210 220 230 240 250
RQDVDNASLA GLDLERPVES LQEEIVFLKK LHDEEIRELQ AQLQEQHIQI
260 270 280 290 300
DMDVSKPDLT AALRDVRQQY ESVAAKNLQE AEEWYKSKFA DLSEAANRNN
310 320 330 340 350
DALRQAKQEA NEYRRQIQSL TCEVDALKGS NESLERQMRE MEENFAVEAA
360 370 380 390 400
NYQDTIGRLQ DEIQNMKEEM ARHLREYQDL LNVKMALDIE IATYRKLLEG
410 420 430 440 450
EESRINMPIP TFASLNLRET NIESQPIVDT HSKRTLLIKT VETRDGQVIN
460
ETSQHHDDLE
Length:460
Mass (Da):53,142
Last modified:January 23, 2007 - v2
Checksum:iC3B509E21ABA6DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15852, M15850, M15851 Genomic DNA. Translation: AAA49134.1.
V00447 Genomic DNA. Translation: CAA23726.2.
PIRiA29329.
UniGeneiGga.9346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15852, M15850, M15851 Genomic DNA. Translation: AAA49134.1.
V00447 Genomic DNA. Translation: CAA23726.2.
PIRiA29329.
UniGeneiGga.9346.

3D structure databases

ProteinModelPortaliP09654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi681466. 1 interactor.
IntActiP09654. 1 interactor.
STRINGi9031.ENSGALP00000014107.

Proteomic databases

PaxDbiP09654.
PRIDEiP09654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IFZ1. Eukaryota.
ENOG410XRBS. LUCA.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP09654.
PhylomeDBiP09654.

Family and domain databases

InterProiIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR027699. Vimentin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF27. PTHR23239:SF27. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIME_CHICK
AccessioniPrimary (citable) accession number: P09654
Secondary accession number(s): Q91023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.