##gff-version 3 P09651 UniProtKB Chain 1 372 . . . ID=PRO_0000424509;Note=Heterogeneous nuclear ribonucleoprotein A1 P09651 UniProtKB Initiator methionine 1 1 . . . Note=Removed%3B alternate;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:22814378;Dbxref=PMID:20068231,PMID:22814378 P09651 UniProtKB Chain 2 372 . . . ID=PRO_0000081828;Note=Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed P09651 UniProtKB Domain 14 97 . . . Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 P09651 UniProtKB Domain 105 184 . . . Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 P09651 UniProtKB Region 4 94 . . . Note=Globular A domain P09651 UniProtKB Region 95 185 . . . Note=Globular B domain P09651 UniProtKB Region 182 216 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P09651 UniProtKB Region 218 240 . . . Note=RNA-binding RGG-box P09651 UniProtKB Region 317 372 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P09651 UniProtKB Region 320 357 . . . Note=Nuclear targeting sequence (M9) P09651 UniProtKB Compositional bias 184 199 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P09651 UniProtKB Compositional bias 355 372 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P09651 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 P09651 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine%3B in Heterogeneous nuclear ribonucleoprotein A1%2C N-terminally processed;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:22814378;Dbxref=PMID:20068231,PMID:22814378 P09651 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P09651 UniProtKB Modified residue 3 3 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P09651 UniProtKB Modified residue 4 4 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 P09651 UniProtKB Modified residue 6 6 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 P09651 UniProtKB Modified residue 22 22 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49312 P09651 UniProtKB Modified residue 192 192 . . . Note=Phosphoserine%3B by MKNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16111636;Dbxref=PMID:16111636 P09651 UniProtKB Modified residue 194 194 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09867 P09651 UniProtKB Modified residue 194 194 . . . Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:15782174;Dbxref=PMID:15782174 P09651 UniProtKB Modified residue 194 194 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49312 P09651 UniProtKB Modified residue 199 199 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 P09651 UniProtKB Modified residue 206 206 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 206 206 . . . Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:15782174;Dbxref=PMID:15782174 P09651 UniProtKB Modified residue 206 206 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 218 218 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 218 218 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 225 225 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 225 225 . . . Note=Dimethylated arginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:15782174;Dbxref=PMID:15782174 P09651 UniProtKB Modified residue 225 225 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.9,ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 232 232 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04256 P09651 UniProtKB Modified residue 232 232 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 336 336 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 337 337 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P09651 UniProtKB Modified residue 350 350 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P09651 UniProtKB Modified residue 352 352 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Modified residue 361 361 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P09651 UniProtKB Modified residue 362 362 . . . Note=Phosphoserine%3B by MKNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16111636;Dbxref=PMID:16111636 P09651 UniProtKB Modified residue 363 363 . . . Note=Phosphoserine%3B by MKNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16111636;Dbxref=PMID:16111636 P09651 UniProtKB Modified residue 364 364 . . . Note=Phosphoserine%3B by MKNK2;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:16111636,ECO:0007744|PubMed:23186163;Dbxref=PMID:16111636,PMID:23186163 P09651 UniProtKB Modified residue 365 365 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 P09651 UniProtKB Modified residue 368 368 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:21406692,PMID:23186163 P09651 UniProtKB Modified residue 370 370 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P09651 UniProtKB Cross-link 3 3 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P09651 UniProtKB Cross-link 8 8 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25755297,PMID:28112733 P09651 UniProtKB Cross-link 78 78 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P09651 UniProtKB Cross-link 113 113 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15161980;Dbxref=PMID:15161980 P09651 UniProtKB Cross-link 179 179 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P09651 UniProtKB Cross-link 183 183 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P09651 UniProtKB Cross-link 350 350 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P09651 UniProtKB Alternative sequence 203 307 . . . ID=VSP_034076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P09651 UniProtKB Alternative sequence 252 303 . . . ID=VSP_005824;Note=In isoform A1-A. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2836799,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334,PMID:2836799 P09651 UniProtKB Natural variant 277 277 . . . ID=VAR_077531;Note=In ALS20%3B uncertain significance. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27694260;Dbxref=PMID:27694260 P09651 UniProtKB Natural variant 283 283 . . . ID=VAR_077532;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27694260;Dbxref=dbSNP:rs375259222,PMID:27694260 P09651 UniProtKB Natural variant 314 314 . . . ID=VAR_070588;Note=In ALS20. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23455423;Dbxref=dbSNP:rs397518453,PMID:23455423 P09651 UniProtKB Natural variant 314 314 . . . ID=VAR_070589;Note=In IBMPFD3%3B reduces binding to UBQLN2. D->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23455423,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs397518452,PMID:23455423,PMID:25616961 P09651 UniProtKB Natural variant 319 319 . . . ID=VAR_070590;Note=In ALS20. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23455423;Dbxref=dbSNP:rs397518454,PMID:23455423 P09651 UniProtKB Natural variant 340 340 . . . ID=VAR_077533;Note=In ALS20%3B increases subcellular localization of HNRNPA1 in cytoplasmic inclusions with stress granules. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27694260;Dbxref=PMID:27694260 P09651 UniProtKB Mutagenesis 218 218 . . . Note=Abolishes interaction with HOXB-AS3 peptide%3B when associated with A-225 and A-232. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985503;Dbxref=PMID:28985503 P09651 UniProtKB Mutagenesis 225 225 . . . Note=Abolishes interaction with HOXB-AS3 peptide%3B when associated with A-218 and A-232. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985503;Dbxref=PMID:28985503 P09651 UniProtKB Mutagenesis 232 232 . . . Note=Abolishes interaction with HOXB-AS3 peptide%3B when associated with A-218 and A-225. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28985503;Dbxref=PMID:28985503 P09651 UniProtKB Mutagenesis 326 326 . . . Note=No nuclear import nor export. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7730395;Dbxref=PMID:7730395 P09651 UniProtKB Mutagenesis 327 327 . . . Note=No nuclear import nor export. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7730395;Dbxref=PMID:7730395 P09651 UniProtKB Mutagenesis 334 335 . . . Note=Normal nuclear import and export. GG->LL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7730395;Dbxref=PMID:7730395 P09651 UniProtKB Sequence conflict 128 128 . . . Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09651 UniProtKB Sequence conflict 140 140 . . . Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09651 UniProtKB Sequence conflict 146 146 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P09651 UniProtKB Helix 11 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 15 20 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 27 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 35 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 40 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Turn 49 51 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 54 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 65 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 76 79 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1U1R P09651 UniProtKB Beta strand 85 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 94 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1U1Q P09651 UniProtKB Turn 98 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1U1Q P09651 UniProtKB Beta strand 105 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Turn 113 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 118 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Turn 126 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 131 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Turn 140 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 145 155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 156 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Beta strand 168 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1U1Q P09651 UniProtKB Beta strand 176 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L3K P09651 UniProtKB Helix 183 188 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1U1Q P09651 UniProtKB Beta strand 305 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BX7 P09651 UniProtKB Beta strand 312 314 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BX7 P09651 UniProtKB Beta strand 317 326 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BX7 P09651 UniProtKB Beta strand 330 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BX7