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Protein

Guanyl-specific ribonuclease Pc

Gene
N/A
Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38By similarity1
Active sitei56Proton acceptorBy similarity1
Active sitei90Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Guanyl-specific ribonuclease Pc (EC:3.1.27.3)
Short name:
RNase Pc
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum species complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373731 – 102Guanyl-specific ribonuclease PcAdd BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 10By similarity
Disulfide bondi6 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP09647.
SMRiP09647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonuclease N1/T1 family.Curated

Phylogenomic databases

eggNOGiENOG410J08G. Eukaryota.
ENOG411203S. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR000026. Gua-sp_ribonuclease_N1/T1/U2.
IPR016191. Ribonuclease/ribotoxin.
PfamiView protein in Pfam
PF00545. Ribonuclease. 1 hit.
SUPFAMiSSF53933. SSF53933. 1 hit.

Sequencei

Sequence statusi: Complete.

P09647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACAATCGSVC YTSSAISAAQ EAGYDLYSAN DDVSNYPHEY RNYEGFDFPV
60 70 80 90 100
SGTYYEFPIL RSGAVYSGNS PGADRVVFNG NDQLAGVITH TGASGNNFVA

CD
Length:102
Mass (Da):10,745
Last modified:July 1, 1989 - v1
Checksum:i49D8947B267D5506
GO

Sequence databases

PIRiA23620.

Cross-referencesi

Sequence databases

PIRiA23620.

3D structure databases

ProteinModelPortaliP09647.
SMRiP09647.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J08G. Eukaryota.
ENOG411203S. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR000026. Gua-sp_ribonuclease_N1/T1/U2.
IPR016191. Ribonuclease/ribotoxin.
PfamiView protein in Pfam
PF00545. Ribonuclease. 1 hit.
SUPFAMiSSF53933. SSF53933. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNPC_PENCH
AccessioniPrimary (citable) accession number: P09647
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.