Reviewed, UniProtKB/Swiss-Prot P09635 (HXA4_RAT)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A4
Alternative name(s):
    Homeobox protein R2

Gene names

Name:	Hoxa4
Synonyms:	Hox-a4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	67 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›67	›67	Homeobox protein Hox-A4		PRO_0000200050
Regions
	DNA binding	‹1 – 42	›42	Homeobox
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	67	1

Sequences

	Sequence		Length	Mass (Da)
	P09635-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 5BFDFEAE93193780	FASTA	67	8,346
	10 20 30 40 50 60 EFHFNRYLTR RRRIEIAHTL CLSERQVKIW FQNRRMKWKK DHKLPNTRCD LPTLPRPLPA RLGKHKL

References

[1]	"Cloning and expression of rat homeo-box-containing sequences." Falzon M., Sanderson N., Chung S.Y. Gene 54:23-32(1987) [PubMed: 2886401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
[2]	"Cloning of rat homeobox genes." Sakoyama Y., Mizuta I., Ogasawara N., Yoshikawa H. Biochem. Genet. 32:351-360(1994) [PubMed: 7702549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M16808 Genomic DNA. No translation available. S76296 Genomic DNA. No translation available.
IPI	IPI00188417.
PIR	B27471.
UniGene	Rn.8465
3D structure databases
ModBase	Search...
Organism-specific databases
RGD	2814. Hoxa4.
Phylogenomic databases
HOVERGEN	P09635.
Gene expression databases
Genevestigator	P09635.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. Partial match. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4_RAT

Accession

Primary (citable) accession number: P09635

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 24, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)