P09635 (HXA4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A4

Alternative name(s):
Homeobox protein R2

Gene names

Name:	Hoxa4
Synonyms:	Hox-a4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	67 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›67	›67	Homeobox protein Hox-A4		PRO_0000200050
Regions
	DNA binding	‹1 – 42	›42	Homeobox
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	67	1

Sequences

	Sequence		Length	Mass (Da)
	P09635 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 5BFDFEAE93193780	FASTA	67	8,346
	10 20 30 40 50 60 EFHFNRYLTR RRRIEIAHTL CLSERQVKIW FQNRRMKWKK DHKLPNTRCD LPTLPRPLPA RLGKHKL

References

[1]	"Cloning and expression of rat homeo-box-containing sequences." Falzon M., Sanderson N., Chung S.Y. Gene 54:23-32(1987) [PubMed: 2886401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
[2]	"Cloning of rat homeobox genes." Sakoyama Y., Mizuta I., Ogasawara N., Yoshikawa H. Biochem. Genet. 32:351-360(1994) [PubMed: 7702549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M16808 Genomic DNA. No translation available. S76296 Genomic DNA. No translation available.
IPI	IPI00188417.
PIR	B27471.
UniGene	Rn.224463.
3D structure databases
ProteinModelPortal	P09635.
SMR	P09635. Positions 1-43.
ModBase	Search...
Protein-protein interaction databases
STRING	P09635.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	2814. Hoxa4.
Phylogenomic databases
eggNOG	maNOG14020.
Gene expression databases
Genevestigator	P09635.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. Partial match. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4_RAT

Accession

Primary (citable) accession number: P09635

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	December 14, 2011
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program