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Protein

Homeobox protein Hox-C9

Gene

Hoxc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 251HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3.2
Gene namesi
Name:Hoxc9
Synonyms:Hox-3.2, Hoxc-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96199. Hoxc9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001851 – 260Homeobox protein Hox-C9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09633.
PaxDbiP09633.
PRIDEiP09633.

PTM databases

PhosphoSitePlusiP09633.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036139.
CleanExiMM_HOXC9.
GenevisibleiP09633. MM.

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.By similarity

Protein-protein interaction databases

BioGridi200390. 1 interactor.
IntActiP09633. 1 interactor.
MINTiMINT-1172589.
STRINGi10090.ENSMUSP00000001706.

Structurei

3D structure databases

ProteinModelPortaliP09633.
SMRiP09633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP09633.
KOiK09294.
OMAiSGPISNY.
OrthoDBiEOG091G0ECO.
PhylomeDBiP09633.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGDGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,234
Last modified:July 1, 1993 - v2
Checksum:i0A978FF948F5BCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55318 mRNA. Translation: CAA39026.1.
AK012173 mRNA. Translation: BAB28077.1.
AK078758 mRNA. Translation: BAC37378.1.
BC050838 mRNA. Translation: AAH50838.1.
X07647 mRNA. Translation: CAA30487.1.
M35603 Genomic DNA. Translation: AAA37856.1.
CCDSiCCDS27893.1.
PIRiA43821.
RefSeqiNP_032298.1. NM_008272.3.
UniGeneiMm.4765.

Genome annotation databases

EnsembliENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139.
GeneIDi15427.
KEGGimmu:15427.
UCSCiuc007xxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55318 mRNA. Translation: CAA39026.1.
AK012173 mRNA. Translation: BAB28077.1.
AK078758 mRNA. Translation: BAC37378.1.
BC050838 mRNA. Translation: AAH50838.1.
X07647 mRNA. Translation: CAA30487.1.
M35603 Genomic DNA. Translation: AAA37856.1.
CCDSiCCDS27893.1.
PIRiA43821.
RefSeqiNP_032298.1. NM_008272.3.
UniGeneiMm.4765.

3D structure databases

ProteinModelPortaliP09633.
SMRiP09633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200390. 1 interactor.
IntActiP09633. 1 interactor.
MINTiMINT-1172589.
STRINGi10090.ENSMUSP00000001706.

PTM databases

PhosphoSitePlusiP09633.

Proteomic databases

MaxQBiP09633.
PaxDbiP09633.
PRIDEiP09633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139.
GeneIDi15427.
KEGGimmu:15427.
UCSCiuc007xxa.1. mouse.

Organism-specific databases

CTDi3225.
MGIiMGI:96199. Hoxc9.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP09633.
KOiK09294.
OMAiSGPISNY.
OrthoDBiEOG091G0ECO.
PhylomeDBiP09633.
TreeFamiTF317819.

Miscellaneous databases

PROiP09633.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036139.
CleanExiMM_HOXC9.
GenevisibleiP09633. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXC9_MOUSE
AccessioniPrimary (citable) accession number: P09633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.