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P09633

- HXC9_MOUSE

UniProt

P09633 - HXC9_MOUSE

Protein

Homeobox protein Hox-C9

Gene

Hoxc9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic skeletal system development Source: MGI
    3. embryonic skeletal system morphogenesis Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C9
    Alternative name(s):
    Homeobox protein Hox-3.2
    Gene namesi
    Name:Hoxc9
    Synonyms:Hox-3.2, Hoxc-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96199. Hoxc9.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Homeobox protein Hox-C9PRO_0000200185Add
    BLAST

    Proteomic databases

    PRIDEiP09633.

    Expressioni

    Gene expression databases

    BgeeiP09633.
    CleanExiMM_HOXC9.
    GenevestigatoriP09633.

    Interactioni

    Subunit structurei

    Interacts with Geminin/GMNN, which inhibits transcriptional activity.By similarity

    Protein-protein interaction databases

    BioGridi200390. 1 interaction.
    IntActiP09633. 1 interaction.
    MINTiMINT-1172589.
    STRINGi10090.ENSMUSP00000001706.

    Structurei

    3D structure databases

    ProteinModelPortaliP09633.
    SMRiP09633. Positions 192-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG288226.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiP09633.
    KOiK09294.
    OMAiSGPISNY.
    PhylomeDBiP09633.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09633-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF    50
    PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL 100
    SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGDGRSYPD YMYGSPGELR 150
    DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT 200
    KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM 250
    NKEKTDKEQS 260
    Length:260
    Mass (Da):29,234
    Last modified:July 1, 1993 - v2
    Checksum:i0A978FF948F5BCAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55318 mRNA. Translation: CAA39026.1.
    AK012173 mRNA. Translation: BAB28077.1.
    AK078758 mRNA. Translation: BAC37378.1.
    BC050838 mRNA. Translation: AAH50838.1.
    X07647 mRNA. Translation: CAA30487.1.
    M35603 Genomic DNA. Translation: AAA37856.1.
    CCDSiCCDS27893.1.
    PIRiA43821.
    RefSeqiNP_032298.1. NM_008272.3.
    UniGeneiMm.4765.

    Genome annotation databases

    EnsembliENSMUST00000001706; ENSMUSP00000001706; ENSMUSG00000036139.
    GeneIDi15427.
    KEGGimmu:15427.
    UCSCiuc007xxa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55318 mRNA. Translation: CAA39026.1 .
    AK012173 mRNA. Translation: BAB28077.1 .
    AK078758 mRNA. Translation: BAC37378.1 .
    BC050838 mRNA. Translation: AAH50838.1 .
    X07647 mRNA. Translation: CAA30487.1 .
    M35603 Genomic DNA. Translation: AAA37856.1 .
    CCDSi CCDS27893.1.
    PIRi A43821.
    RefSeqi NP_032298.1. NM_008272.3.
    UniGenei Mm.4765.

    3D structure databases

    ProteinModelPortali P09633.
    SMRi P09633. Positions 192-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200390. 1 interaction.
    IntActi P09633. 1 interaction.
    MINTi MINT-1172589.
    STRINGi 10090.ENSMUSP00000001706.

    Proteomic databases

    PRIDEi P09633.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001706 ; ENSMUSP00000001706 ; ENSMUSG00000036139 .
    GeneIDi 15427.
    KEGGi mmu:15427.
    UCSCi uc007xxa.1. mouse.

    Organism-specific databases

    CTDi 3225.
    MGIi MGI:96199. Hoxc9.

    Phylogenomic databases

    eggNOGi NOG288226.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi P09633.
    KOi K09294.
    OMAi SGPISNY.
    PhylomeDBi P09633.
    TreeFami TF317819.

    Miscellaneous databases

    NextBioi 288182.
    PROi P09633.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09633.
    CleanExi MM_HOXC9.
    Genevestigatori P09633.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression pattern of the murine Hox-3.2 gene."
      Erselius J.R., Goulding M.D., Gruss P.
      Development 110:629-642(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    4. "Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster."
      Breier G., Dressler G.R., Gruss P.
      EMBO J. 7:1329-1336(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 187-260.
    5. "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region."
      Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.
      Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-260.
      Strain: CD-1.

    Entry informationi

    Entry nameiHXC9_MOUSE
    AccessioniPrimary (citable) accession number: P09633
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3