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P09632

- HXB8_MOUSE

UniProt

P09632 - HXB8_MOUSE

Protein

Homeobox protein Hox-B8

Gene

Hoxb8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. dorsal spinal cord development Source: MGI
    4. embryonic skeletal system morphogenesis Source: MGI
    5. grooming behavior Source: MGI
    6. negative regulation of myeloid cell differentiation Source: UniProtKB
    7. sensory perception of pain Source: MGI
    8. skeletal system morphogenesis Source: MGI
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B8
    Alternative name(s):
    Homeobox protein Hox-2.4
    Gene namesi
    Name:Hoxb8
    Synonyms:Hox-2.4, Hoxb-8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96189. Hoxb8.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Homeobox protein Hox-B8PRO_0000200149Add
    BLAST

    Proteomic databases

    PRIDEiP09632.

    PTM databases

    PhosphoSiteiP09632.

    Expressioni

    Gene expression databases

    ArrayExpressiP09632.
    BgeeiP09632.
    CleanExiMM_HOXB8.
    GenevestigatoriP09632.

    Interactioni

    Protein-protein interaction databases

    BioGridi200382. 14 interactions.
    DIPiDIP-35618N.
    IntActiP09632. 1 interaction.
    STRINGi10090.ENSMUSP00000052496.

    Structurei

    3D structure databases

    ProteinModelPortaliP09632.
    SMRiP09632. Positions 150-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi134 – 1396Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP09632.
    KOiK09308.
    OMAiMERAQEV.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09632.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09632-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH    50
    PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ 100
    DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR 150
    QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK 200
    WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK 243
    Length:243
    Mass (Da):27,618
    Last modified:January 1, 1990 - v2
    Checksum:i368964C77884D21F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13961 Genomic DNA. Translation: CAA32141.1.
    X13721 mRNA. Translation: CAA32000.1.
    M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
    X54077 Genomic DNA. Translation: CAA38014.1.
    CCDSiCCDS25293.1.
    PIRiS03712. WJMS24.
    RefSeqiNP_034591.1. NM_010461.2.
    UniGeneiMm.4822.

    Genome annotation databases

    EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
    ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
    GeneIDi15416.
    KEGGimmu:15416.
    UCSCiuc007lbp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13961 Genomic DNA. Translation: CAA32141.1 .
    X13721 mRNA. Translation: CAA32000.1 .
    M18399 Genomic DNA. Translation: AAA88246.1 . Sequence problems.
    X54077 Genomic DNA. Translation: CAA38014.1 .
    CCDSi CCDS25293.1.
    PIRi S03712. WJMS24.
    RefSeqi NP_034591.1. NM_010461.2.
    UniGenei Mm.4822.

    3D structure databases

    ProteinModelPortali P09632.
    SMRi P09632. Positions 150-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200382. 14 interactions.
    DIPi DIP-35618N.
    IntActi P09632. 1 interaction.
    STRINGi 10090.ENSMUSP00000052496.

    PTM databases

    PhosphoSitei P09632.

    Proteomic databases

    PRIDEi P09632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052650 ; ENSMUSP00000052496 ; ENSMUSG00000056648 .
    ENSMUST00000168043 ; ENSMUSP00000128136 ; ENSMUSG00000056648 .
    GeneIDi 15416.
    KEGGi mmu:15416.
    UCSCi uc007lbp.1. mouse.

    Organism-specific databases

    CTDi 3218.
    MGIi MGI:96189. Hoxb8.

    Phylogenomic databases

    eggNOGi NOG314669.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P09632.
    KOi K09308.
    OMAi MERAQEV.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09632.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288150.
    PROi P09632.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09632.
    Bgeei P09632.
    CleanExi MM_HOXB8.
    Genevestigatori P09632.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia."
      Kongsuan K., Allen J., Adams J.M.
      Nucleic Acids Res. 17:1881-1892(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "DNA rearrangement of a homeobox gene in myeloid leukaemic cells."
      Blatt C., Aberdam D., Schwartz R., Sachs L.
      EMBO J. 7:4283-4290(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
    3. Blatt C.
      Submitted (JUL-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "A deletion and a rearrangement distinguish between the intracisternal A- particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells."
      Ben-David L., Aberdam D., Sachs L., Blatt C.
      Virology 182:382-387(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
      Hart C.P., Fainsod A., Ruddle F.H.
      Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 144-243.

    Entry informationi

    Entry nameiHXB8_MOUSE
    AccessioniPrimary (citable) accession number: P09632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3