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Protein

Homeobox protein Hox-B8

Gene

Hoxb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. dorsal spinal cord development Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. grooming behavior Source: MGI
  6. negative regulation of myeloid cell differentiation Source: UniProtKB
  7. sensory perception of pain Source: MGI
  8. skeletal system morphogenesis Source: MGI
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Gene namesi
Name:Hoxb8
Synonyms:Hox-2.4, Hoxb-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96189. Hoxb8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Homeobox protein Hox-B8PRO_0000200149Add
BLAST

Proteomic databases

MaxQBiP09632.
PRIDEiP09632.

PTM databases

PhosphoSiteiP09632.

Expressioni

Gene expression databases

BgeeiP09632.
CleanExiMM_HOXB8.
ExpressionAtlasiP09632. baseline and differential.
GenevestigatoriP09632.

Interactioni

Protein-protein interaction databases

BioGridi200382. 14 interactions.
DIPiDIP-35618N.
IntActiP09632. 1 interaction.
STRINGi10090.ENSMUSP00000052496.

Structurei

3D structure databases

ProteinModelPortaliP09632.
SMRiP09632. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 1396Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09632.
KOiK09308.
OMAiPQIQEFY.
OrthoDBiEOG780RP4.
PhylomeDBiP09632.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09632-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK
Length:243
Mass (Da):27,618
Last modified:January 1, 1990 - v2
Checksum:i368964C77884D21F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13961 Genomic DNA. Translation: CAA32141.1.
X13721 mRNA. Translation: CAA32000.1.
M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1.
CCDSiCCDS25293.1.
PIRiS03712. WJMS24.
RefSeqiNP_034591.1. NM_010461.2.
UniGeneiMm.4822.

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
GeneIDi15416.
KEGGimmu:15416.
UCSCiuc007lbp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13961 Genomic DNA. Translation: CAA32141.1.
X13721 mRNA. Translation: CAA32000.1.
M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1.
CCDSiCCDS25293.1.
PIRiS03712. WJMS24.
RefSeqiNP_034591.1. NM_010461.2.
UniGeneiMm.4822.

3D structure databases

ProteinModelPortaliP09632.
SMRiP09632. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200382. 14 interactions.
DIPiDIP-35618N.
IntActiP09632. 1 interaction.
STRINGi10090.ENSMUSP00000052496.

PTM databases

PhosphoSiteiP09632.

Proteomic databases

MaxQBiP09632.
PRIDEiP09632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
GeneIDi15416.
KEGGimmu:15416.
UCSCiuc007lbp.1. mouse.

Organism-specific databases

CTDi3218.
MGIiMGI:96189. Hoxb8.

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09632.
KOiK09308.
OMAiPQIQEFY.
OrthoDBiEOG780RP4.
PhylomeDBiP09632.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288150.
PROiP09632.
SOURCEiSearch...

Gene expression databases

BgeeiP09632.
CleanExiMM_HOXB8.
ExpressionAtlasiP09632. baseline and differential.
GenevestigatoriP09632.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia."
    Kongsuan K., Allen J., Adams J.M.
    Nucleic Acids Res. 17:1881-1892(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "DNA rearrangement of a homeobox gene in myeloid leukaemic cells."
    Blatt C., Aberdam D., Schwartz R., Sachs L.
    EMBO J. 7:4283-4290(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  3. Blatt C.
    Submitted (JUL-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "A deletion and a rearrangement distinguish between the intracisternal A- particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells."
    Ben-David L., Aberdam D., Sachs L., Blatt C.
    Virology 182:382-387(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
    Hart C.P., Fainsod A., Ruddle F.H.
    Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 144-243.

Entry informationi

Entry nameiHXB8_MOUSE
AccessioniPrimary (citable) accession number: P09632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: January 7, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.