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P09632 (HXB8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Gene names
Name:Hoxb8
Synonyms:Hox-2.4, Hoxb-8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult locomotory behavior

Inferred from mutant phenotype PubMed 10559485. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 10559485PubMed 11311170PubMed 14623233. Source: MGI

dorsal spinal cord development

Inferred from mutant phenotype PubMed 10559485PubMed 18430798. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 10559485. Source: MGI

grooming behavior

Inferred from mutant phenotype PubMed 11779477PubMed 18430798. Source: MGI

negative regulation of myeloid cell differentiation

Inferred from direct assay PubMed 11438208. Source: UniProtKB

sensory perception of pain

Inferred from mutant phenotype PubMed 18430798. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 11311170. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Homeobox protein Hox-B8
PRO_0000200149

Regions

DNA binding146 – 20560Homeobox
Motif134 – 1396Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P09632 [UniParc].

Last modified January 1, 1990. Version 2.
Checksum: 368964C77884D21F

FASTA24327,618
        10         20         30         40         50         60 
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 

        70         80         90        100        110        120 
PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 

       130        140        150        160        170        180 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 

       190        200        210        220        230        240 
HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG 


DKK 

« Hide

References

[1]"Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia."
Kongsuan K., Allen J., Adams J.M.
Nucleic Acids Res. 17:1881-1892(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"DNA rearrangement of a homeobox gene in myeloid leukaemic cells."
Blatt C., Aberdam D., Schwartz R., Sachs L.
EMBO J. 7:4283-4290(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
[3]Blatt C.
Submitted (JUL-1989) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"A deletion and a rearrangement distinguish between the intracisternal A- particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells."
Ben-David L., Aberdam D., Sachs L., Blatt C.
Virology 182:382-387(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
Hart C.P., Fainsod A., Ruddle F.H.
Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 144-243.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13961 Genomic DNA. Translation: CAA32141.1.
X13721 mRNA. Translation: CAA32000.1.
M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1.
CCDSCCDS25293.1.
PIRWJMS24. S03712.
RefSeqNP_034591.1. NM_010461.2.
UniGeneMm.4822.

3D structure databases

ProteinModelPortalP09632.
SMRP09632. Positions 150-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200382. 14 interactions.
DIPDIP-35618N.
IntActP09632. 1 interaction.
STRING10090.ENSMUSP00000052496.

PTM databases

PhosphoSiteP09632.

Proteomic databases

PRIDEP09632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
GeneID15416.
KEGGmmu:15416.
UCSCuc007lbp.1. mouse.

Organism-specific databases

CTD3218.
MGIMGI:96189. Hoxb8.

Phylogenomic databases

eggNOGNOG314669.
GeneTreeENSGT00730000110212.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP09632.
KOK09308.
OMAMERAQEV.
OrthoDBEOG780RP4.
PhylomeDBP09632.
TreeFamTF316310.

Gene expression databases

ArrayExpressP09632.
BgeeP09632.
CleanExMM_HOXB8.
GenevestigatorP09632.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288150.
PROP09632.
SOURCESearch...

Entry information

Entry nameHXB8_MOUSE
AccessionPrimary (citable) accession number: P09632
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries