Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B8

Gene

Hoxb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • dorsal spinal cord development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • grooming behavior Source: MGI
  • negative regulation of myeloid cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • sensory perception of pain Source: MGI
  • skeletal system morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Gene namesi
Name:Hoxb8
Synonyms:Hox-2.4, Hoxb-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96189. Hoxb8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001491 – 243Homeobox protein Hox-B8Add BLAST243

Proteomic databases

MaxQBiP09632.
PaxDbiP09632.
PRIDEiP09632.

PTM databases

iPTMnetiP09632.
PhosphoSitePlusiP09632.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056648.
CleanExiMM_HOXB8.
ExpressionAtlasiP09632. baseline and differential.
GenevisibleiP09632. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Pbx1P417783EBI-925374,EBI-6996259

Protein-protein interaction databases

BioGridi200382. 14 interactors.
DIPiDIP-35618N.
IntActiP09632. 2 interactors.
STRINGi10090.ENSMUSP00000052496.

Structurei

3D structure databases

ProteinModelPortaliP09632.
SMRiP09632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi134 – 139Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140792.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09632.
KOiK09308.
OMAiAGGTFQH.
OrthoDBiEOG091G09XD.
PhylomeDBiP09632.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK
Length:243
Mass (Da):27,618
Last modified:January 1, 1990 - v2
Checksum:i368964C77884D21F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13961 Genomic DNA. Translation: CAA32141.1.
X13721 mRNA. Translation: CAA32000.1.
M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1.
CCDSiCCDS25293.1.
PIRiS03712. WJMS24.
RefSeqiNP_034591.1. NM_010461.2.
XP_017169784.1. XM_017314295.1.
XP_017169785.1. XM_017314296.1.
XP_017169786.1. XM_017314297.1.
UniGeneiMm.4822.

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
GeneIDi15416.
KEGGimmu:15416.
UCSCiuc007lbp.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXB8_MOUSE
AccessioniPrimary (citable) accession number: P09632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: November 22, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families