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P09632

- HXB8_MOUSE

UniProt

P09632 - HXB8_MOUSE

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Protein
Homeobox protein Hox-B8
Gene
Hoxb8, Hox-2.4, Hoxb-8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. dorsal spinal cord development Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. grooming behavior Source: MGI
  6. negative regulation of myeloid cell differentiation Source: UniProtKB
  7. sensory perception of pain Source: MGI
  8. skeletal system morphogenesis Source: MGI
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Gene namesi
Name:Hoxb8
Synonyms:Hox-2.4, Hoxb-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96189. Hoxb8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Homeobox protein Hox-B8
PRO_0000200149Add
BLAST

Proteomic databases

PRIDEiP09632.

PTM databases

PhosphoSiteiP09632.

Expressioni

Gene expression databases

ArrayExpressiP09632.
BgeeiP09632.
CleanExiMM_HOXB8.
GenevestigatoriP09632.

Interactioni

Protein-protein interaction databases

BioGridi200382. 14 interactions.
DIPiDIP-35618N.
IntActiP09632. 1 interaction.
STRINGi10090.ENSMUSP00000052496.

Structurei

3D structure databases

ProteinModelPortaliP09632.
SMRiP09632. Positions 150-205.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 1396Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00730000110212.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09632.
KOiK09308.
OMAiMERAQEV.
OrthoDBiEOG780RP4.
PhylomeDBiP09632.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09632-1 [UniParc]FASTAAdd to Basket

« Hide

MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH    50
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ 100
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR 150
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK 200
WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK 243
Length:243
Mass (Da):27,618
Last modified:January 1, 1990 - v2
Checksum:i368964C77884D21F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13961 Genomic DNA. Translation: CAA32141.1.
X13721 mRNA. Translation: CAA32000.1.
M18399 Genomic DNA. Translation: AAA88246.1. Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1.
CCDSiCCDS25293.1.
PIRiS03712. WJMS24.
RefSeqiNP_034591.1. NM_010461.2.
UniGeneiMm.4822.

Genome annotation databases

EnsembliENSMUST00000052650; ENSMUSP00000052496; ENSMUSG00000056648.
ENSMUST00000168043; ENSMUSP00000128136; ENSMUSG00000056648.
GeneIDi15416.
KEGGimmu:15416.
UCSCiuc007lbp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13961 Genomic DNA. Translation: CAA32141.1 .
X13721 mRNA. Translation: CAA32000.1 .
M18399 Genomic DNA. Translation: AAA88246.1 . Sequence problems.
X54077 Genomic DNA. Translation: CAA38014.1 .
CCDSi CCDS25293.1.
PIRi S03712. WJMS24.
RefSeqi NP_034591.1. NM_010461.2.
UniGenei Mm.4822.

3D structure databases

ProteinModelPortali P09632.
SMRi P09632. Positions 150-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200382. 14 interactions.
DIPi DIP-35618N.
IntActi P09632. 1 interaction.
STRINGi 10090.ENSMUSP00000052496.

PTM databases

PhosphoSitei P09632.

Proteomic databases

PRIDEi P09632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052650 ; ENSMUSP00000052496 ; ENSMUSG00000056648 .
ENSMUST00000168043 ; ENSMUSP00000128136 ; ENSMUSG00000056648 .
GeneIDi 15416.
KEGGi mmu:15416.
UCSCi uc007lbp.1. mouse.

Organism-specific databases

CTDi 3218.
MGIi MGI:96189. Hoxb8.

Phylogenomic databases

eggNOGi NOG314669.
GeneTreei ENSGT00730000110212.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P09632.
KOi K09308.
OMAi MERAQEV.
OrthoDBi EOG780RP4.
PhylomeDBi P09632.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288150.
PROi P09632.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09632.
Bgeei P09632.
CleanExi MM_HOXB8.
Genevestigatori P09632.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia."
    Kongsuan K., Allen J., Adams J.M.
    Nucleic Acids Res. 17:1881-1892(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "DNA rearrangement of a homeobox gene in myeloid leukaemic cells."
    Blatt C., Aberdam D., Schwartz R., Sachs L.
    EMBO J. 7:4283-4290(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  3. Blatt C.
    Submitted (JUL-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "A deletion and a rearrangement distinguish between the intracisternal A- particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells."
    Ben-David L., Aberdam D., Sachs L., Blatt C.
    Virology 182:382-387(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
    Hart C.P., Fainsod A., Ruddle F.H.
    Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 144-243.

Entry informationi

Entry nameiHXB8_MOUSE
AccessioniPrimary (citable) accession number: P09632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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