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P09631 (HXA9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A9
Alternative name(s):
Homeobox protein Hox-1.7
Gene names
Name:Hoxa9
Synonyms:Hox-1.7, Hoxa-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation By similarity.

Subunit structure

Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.

Post-translational modification

Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction By similarity.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMMethylation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 8625797. Source: MGI

definitive hemopoiesis

Inferred from genetic interaction PubMed 17761289. Source: MGI

embryonic forelimb morphogenesis

Inferred from genetic interaction PubMed 8625797. Source: MGI

embryonic skeletal system development

Inferred from mutant phenotype PubMed 8625797. Source: MGI

male gonad development

Inferred from genetic interaction PubMed 23760953. Source: MGI

mammary gland development

Inferred from genetic interaction PubMed 9892669. Source: MGI

negative regulation of myeloid cell differentiation

Inferred from direct assay PubMed 11438208. Source: UniProtKB

proximal/distal pattern formation

Inferred from genetic interaction PubMed 8625797. Source: MGI

regulation of gene expression

Inferred from genetic interaction PubMed 23760953. Source: MGI

single fertilization

Inferred from genetic interaction PubMed 23760953. Source: MGI

spermatogenesis

Inferred from genetic interaction PubMed 23760953. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

uterus development

Inferred from genetic interaction PubMed 23760953. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15161102. Source: MGI

nucleus

Inferred from direct assay PubMed 15161102. Source: MGI

transcription factor complex

Inferred from direct assay PubMed 9343407. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15161102PubMed 9343407. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform HoxA-9 (identifier: P09631-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform HoxA-9T (identifier: P09631-2)

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: R → S
     106-271: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Homeobox protein Hox-A9
PRO_0000200082

Regions

DNA binding205 – 26460Homeobox

Amino acid modifications

Modified residue1391Symmetric dimethylarginine By similarity

Natural variations

Alternative sequence1051R → S in isoform HoxA-9T.
VSP_002382
Alternative sequence106 – 271166Missing in isoform HoxA-9T.
VSP_002383

Secondary structure

......... 271
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform HoxA-9 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: C1E679D9CBF677B0

FASTA27129,917
        10         20         30         40         50         60 
MATTGALGNY YVDSFLLGAD AADELGAGRY APGTLGQPPR QAAALAEHPD FSPCSFQSKA 

        70         80         90        100        110        120 
AVFGASWNPV HAAGANAVPA AVYHHHHHPY VHPQAPVAAA APDGRYMRSW LEPTPGALSF 

       130        140        150        160        170        180 
AGLPSSRPYG IKPEPLSARR GDCPTLDTHT LSLTDYACGS PPVDREKQPS EGAFSENNAE 

       190        200        210        220        230        240 
NESGGDKPPI DPNNPAANWL HARSTRKKRC PYTKHQTLEL EKEFLFNMYL TRDRRYEVAR 

       250        260        270 
LLNLTERQVK IWFQNRRMKM KKINKDRAKD E 

« Hide

Isoform HoxA-9T [UniParc].

Checksum: 923A157D0AA22579
Show »

FASTA10510,684

References

« Hide 'large scale' references
[1]"Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript encodes a truncated protein lacking the homeodomain."
Fujimoto S., Araki K., Chisaka O., Araki M., Takagi K., Yamamura K.
Gene 209:77-85(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HOXA-9 AND HOXA-9T).
Strain: C57BL/6 and ICR.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HOXA-9).
Strain: FVB/N.
Tissue: Colon.
[3]"Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression."
Rubin M.R., King W., Toth L.E., Sawczuk I.S., Levine M.S., D'Eustachio P., Nguyen-Huu M.C.
Mol. Cell. Biol. 7:3836-3841(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 180-271 (HOXA-9).
[4]Erratum
Rubin M.R., King W., Toth L.E., Sawczuk I.S., Levine M.S., D'Eustachio P., Nguyen-Huu M.C.
Mol. Cell. Biol. 8:5593-5593(1988)
Cited for: SEQUENCE REVISION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB005457 mRNA. Translation: BAA25800.1.
AB005458 mRNA. Translation: BAA25801.1.
AB008914 Genomic DNA. Translation: BAA25802.1.
BC055059 mRNA. Translation: AAH55059.1.
M28449 mRNA. Translation: AAA78790.1.
CCDSCCDS20146.1. [P09631-1]
PIRA31400.
JC6553.
RefSeqNP_034586.1. NM_010456.3. [P09631-1]
UniGeneMm.4694.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PUFX-ray1.90A193-269[»]
ProteinModelPortalP09631.
SMRP09631. Positions 193-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200373. 13 interactions.
DIPDIP-35619N.
IntActP09631. 1 interaction.
MINTMINT-210007.

PTM databases

PhosphoSiteP09631.

Proteomic databases

PRIDEP09631.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048680; ENSMUSP00000046939; ENSMUSG00000038227. [P09631-1]
ENSMUST00000114425; ENSMUSP00000110068; ENSMUSG00000038227. [P09631-2]
GeneID15405.
KEGGmmu:15405.
UCSCuc009byl.1. mouse. [P09631-1]

Organism-specific databases

CTD3205.
MGIMGI:96180. Hoxa9.

Phylogenomic databases

eggNOGNOG286554.
GeneTreeENSGT00750000117229.
HOGENOMHOG000231180.
HOVERGENHBG016849.
InParanoidP09631.
KOK09294.
OMAVPAVYHP.
OrthoDBEOG722J9F.
PhylomeDBP09631.
TreeFamTF317819.

Gene expression databases

BgeeP09631.
CleanExMM_HOXA9.
GenevestigatorP09631.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP09631.
NextBio288114.
PROP09631.
SOURCESearch...

Entry information

Entry nameHXA9_MOUSE
AccessionPrimary (citable) accession number: P09631
Secondary accession number(s): O70154, O70155
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1999
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries