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P09631

- HXA9_MOUSE

UniProt

P09631 - HXA9_MOUSE

Protein

Homeobox protein Hox-A9

Gene

Hoxa9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi205 – 26460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. definitive hemopoiesis Source: MGI
    3. embryonic forelimb morphogenesis Source: MGI
    4. embryonic skeletal system development Source: MGI
    5. male gonad development Source: MGI
    6. mammary gland development Source: MGI
    7. negative regulation of myeloid cell differentiation Source: UniProtKB
    8. proximal/distal pattern formation Source: MGI
    9. regulation of gene expression Source: MGI
    10. single fertilization Source: MGI
    11. spermatogenesis Source: MGI
    12. transcription, DNA-templated Source: UniProtKB-KW
    13. uterus development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A9
    Alternative name(s):
    Homeobox protein Hox-1.7
    Gene namesi
    Name:Hoxa9
    Synonyms:Hox-1.7, Hoxa-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96180. Hoxa9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Homeobox protein Hox-A9PRO_0000200082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391Symmetric dimethylarginineBy similarity

    Post-translational modificationi

    Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiP09631.

    PTM databases

    PhosphoSiteiP09631.

    Expressioni

    Tissue specificityi

    Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.

    Gene expression databases

    BgeeiP09631.
    CleanExiMM_HOXA9.
    GenevestigatoriP09631.

    Interactioni

    Subunit structurei

    Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.By similarity

    Protein-protein interaction databases

    BioGridi200373. 13 interactions.
    DIPiDIP-35619N.
    IntActiP09631. 1 interaction.
    MINTiMINT-210007.

    Structurei

    Secondary structure

    1
    271
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni195 – 1984
    Helixi214 – 22613
    Helixi232 – 24211
    Helixi246 – 26722

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PUFX-ray1.90A193-269[»]
    ProteinModelPortaliP09631.
    SMRiP09631. Positions 193-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09631.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286554.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiP09631.
    KOiK09294.
    OMAiVPAVYHP.
    OrthoDBiEOG722J9F.
    PhylomeDBiP09631.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform HoxA-9 (identifier: P09631-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATTGALGNY YVDSFLLGAD AADELGAGRY APGTLGQPPR QAAALAEHPD    50
    FSPCSFQSKA AVFGASWNPV HAAGANAVPA AVYHHHHHPY VHPQAPVAAA 100
    APDGRYMRSW LEPTPGALSF AGLPSSRPYG IKPEPLSARR GDCPTLDTHT 150
    LSLTDYACGS PPVDREKQPS EGAFSENNAE NESGGDKPPI DPNNPAANWL 200
    HARSTRKKRC PYTKHQTLEL EKEFLFNMYL TRDRRYEVAR LLNLTERQVK 250
    IWFQNRRMKM KKINKDRAKD E 271
    Length:271
    Mass (Da):29,917
    Last modified:July 15, 1999 - v2
    Checksum:iC1E679D9CBF677B0
    GO
    Isoform HoxA-9T (identifier: P09631-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-105: R → S
         106-271: Missing.

    Show »
    Length:105
    Mass (Da):10,684
    Checksum:i923A157D0AA22579
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 1051R → S in isoform HoxA-9T. 1 PublicationVSP_002382
    Alternative sequencei106 – 271166Missing in isoform HoxA-9T. 1 PublicationVSP_002383Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005457 mRNA. Translation: BAA25800.1.
    AB005458 mRNA. Translation: BAA25801.1.
    AB008914 Genomic DNA. Translation: BAA25802.1.
    BC055059 mRNA. Translation: AAH55059.1.
    M28449 mRNA. Translation: AAA78790.1.
    CCDSiCCDS20146.1. [P09631-1]
    PIRiA31400.
    JC6553.
    RefSeqiNP_034586.1. NM_010456.3. [P09631-1]
    UniGeneiMm.4694.

    Genome annotation databases

    EnsembliENSMUST00000048680; ENSMUSP00000046939; ENSMUSG00000038227. [P09631-1]
    ENSMUST00000114425; ENSMUSP00000110068; ENSMUSG00000038227. [P09631-2]
    GeneIDi15405.
    KEGGimmu:15405.
    UCSCiuc009byl.1. mouse. [P09631-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005457 mRNA. Translation: BAA25800.1 .
    AB005458 mRNA. Translation: BAA25801.1 .
    AB008914 Genomic DNA. Translation: BAA25802.1 .
    BC055059 mRNA. Translation: AAH55059.1 .
    M28449 mRNA. Translation: AAA78790.1 .
    CCDSi CCDS20146.1. [P09631-1 ]
    PIRi A31400.
    JC6553.
    RefSeqi NP_034586.1. NM_010456.3. [P09631-1 ]
    UniGenei Mm.4694.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PUF X-ray 1.90 A 193-269 [» ]
    ProteinModelPortali P09631.
    SMRi P09631. Positions 193-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200373. 13 interactions.
    DIPi DIP-35619N.
    IntActi P09631. 1 interaction.
    MINTi MINT-210007.

    PTM databases

    PhosphoSitei P09631.

    Proteomic databases

    PRIDEi P09631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048680 ; ENSMUSP00000046939 ; ENSMUSG00000038227 . [P09631-1 ]
    ENSMUST00000114425 ; ENSMUSP00000110068 ; ENSMUSG00000038227 . [P09631-2 ]
    GeneIDi 15405.
    KEGGi mmu:15405.
    UCSCi uc009byl.1. mouse. [P09631-1 ]

    Organism-specific databases

    CTDi 3205.
    MGIi MGI:96180. Hoxa9.

    Phylogenomic databases

    eggNOGi NOG286554.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi P09631.
    KOi K09294.
    OMAi VPAVYHP.
    OrthoDBi EOG722J9F.
    PhylomeDBi P09631.
    TreeFami TF317819.

    Miscellaneous databases

    EvolutionaryTracei P09631.
    NextBioi 288114.
    PROi P09631.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09631.
    CleanExi MM_HOXA9.
    Genevestigatori P09631.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript encodes a truncated protein lacking the homeodomain."
      Fujimoto S., Araki K., Chisaka O., Araki M., Takagi K., Yamamura K.
      Gene 209:77-85(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HOXA-9 AND HOXA-9T).
      Strain: C57BL/6 and ICR.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HOXA-9).
      Strain: FVB/N.
      Tissue: Colon.
    3. "Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression."
      Rubin M.R., King W., Toth L.E., Sawczuk I.S., Levine M.S., D'Eustachio P., Nguyen-Huu M.C.
      Mol. Cell. Biol. 7:3836-3841(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 180-271 (HOXA-9).
    4. Erratum
      Rubin M.R., King W., Toth L.E., Sawczuk I.S., Levine M.S., D'Eustachio P., Nguyen-Huu M.C.
      Mol. Cell. Biol. 8:5593-5593(1988)
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiHXA9_MOUSE
    AccessioniPrimary (citable) accession number: P09631
    Secondary accession number(s): O70154, O70155
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3