ID   HXC6_HUMAN              Reviewed;         235 AA.
AC   P09630; B2RBV2; Q6DK09;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 3.
DT   27-MAR-2024, entry version 214.
DE   RecName: Full=Homeobox protein Hox-C6;
DE   AltName: Full=Homeobox protein CP25;
DE   AltName: Full=Homeobox protein HHO.C8;
DE   AltName: Full=Homeobox protein Hox-3C;
GN   Name=HOXC6; Synonyms=HOX3C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2885844; DOI=10.1073/pnas.84.14.4914;
RA   Simeone A., Mavilio F., Acampora D., Giampaolo A., Faiella A.,
RA   Zappavigna V., D'Esposito M., Pannese M., Russo G., Boncinelli E.,
RA   Peschle C.;
RT   "Two human homeobox genes, c1 and c8: structure analysis and expression in
RT   embryonic development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:4914-4918(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2898768; DOI=10.1093/nar/16.12.5379;
RA   Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.;
RT   "At least three human homeoboxes on chromosome 12 belong to the same
RT   transcription unit.";
RL   Nucleic Acids Res. 16:5379-5390(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=8870653; DOI=10.1042/bj3190091;
RA   Chariot A., Castronovo V., Le P., Gillet C., Sobel M.E., Gielen J.;
RT   "Cloning and expression of a new HOXC6 transcript encoding a repressing
RT   protein.";
RL   Biochem. J. 319:91-97(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Synovium;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-206.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P09630-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P09630-2; Sequence=VSP_002392;
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; S82986; AAB46892.1; -; mRNA.
DR   EMBL; M16938; AAA36007.1; -; mRNA.
DR   EMBL; AK314829; BAG37349.1; -; mRNA.
DR   EMBL; CH471054; EAW96746.1; -; Genomic_DNA.
DR   EMBL; BC074844; AAH74844.1; -; mRNA.
DR   EMBL; BC074845; AAH74845.1; -; mRNA.
DR   CCDS; CCDS41792.1; -. [P09630-2]
DR   CCDS; CCDS8871.1; -. [P09630-1]
DR   PIR; B28030; WJHU3C.
DR   RefSeq; NP_004494.1; NM_004503.3. [P09630-1]
DR   RefSeq; NP_710160.1; NM_153693.4. [P09630-2]
DR   AlphaFoldDB; P09630; -.
DR   SMR; P09630; -.
DR   BioGRID; 109463; 16.
DR   IntAct; P09630; 8.
DR   MINT; P09630; -.
DR   STRING; 9606.ENSP00000243108; -.
DR   GlyGen; P09630; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P09630; -.
DR   PhosphoSitePlus; P09630; -.
DR   BioMuta; HOXC6; -.
DR   DMDM; 115502398; -.
DR   jPOST; P09630; -.
DR   MassIVE; P09630; -.
DR   PaxDb; 9606-ENSP00000243108; -.
DR   PeptideAtlas; P09630; -.
DR   ProteomicsDB; 52256; -. [P09630-1]
DR   ProteomicsDB; 52257; -. [P09630-2]
DR   Pumba; P09630; -.
DR   Antibodypedia; 15318; 276 antibodies from 31 providers.
DR   DNASU; 3223; -.
DR   Ensembl; ENST00000243108.5; ENSP00000243108.4; ENSG00000197757.8. [P09630-1]
DR   Ensembl; ENST00000394331.3; ENSP00000377864.3; ENSG00000197757.8. [P09630-2]
DR   GeneID; 3223; -.
DR   KEGG; hsa:3223; -.
DR   MANE-Select; ENST00000243108.5; ENSP00000243108.4; NM_004503.4; NP_004494.1.
DR   UCSC; uc001ses.5; human. [P09630-1]
DR   AGR; HGNC:5128; -.
DR   CTD; 3223; -.
DR   DisGeNET; 3223; -.
DR   GeneCards; HOXC6; -.
DR   HGNC; HGNC:5128; HOXC6.
DR   HPA; ENSG00000197757; Tissue enhanced (fallopian tube, ovary).
DR   MIM; 142972; gene.
DR   neXtProt; NX_P09630; -.
DR   OpenTargets; ENSG00000197757; -.
DR   PharmGKB; PA29403; -.
DR   VEuPathDB; HostDB:ENSG00000197757; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159254; -.
DR   HOGENOM; CLU_061398_4_0_1; -.
DR   InParanoid; P09630; -.
DR   OMA; CHLTGGQ; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09630; -.
DR   TreeFam; TF316310; -.
DR   PathwayCommons; P09630; -.
DR   SignaLink; P09630; -.
DR   SIGNOR; P09630; -.
DR   BioGRID-ORCS; 3223; 18 hits in 1163 CRISPR screens.
DR   GeneWiki; HOXC6; -.
DR   GenomeRNAi; 3223; -.
DR   Pharos; P09630; Tbio.
DR   PRO; PR:P09630; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P09630; Protein.
DR   Bgee; ENSG00000197757; Expressed in renal medulla and 151 other cell types or tissues.
DR   ExpressionAtlas; P09630; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF1; HOMEOBOX PROTEIN HOX-C6; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P09630; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..235
FT                   /note="Homeobox protein Hox-C6"
FT                   /id="PRO_0000200174"
FT   DNA_BIND        141..200
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          200..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           122..127
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        218..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..82
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:8870653"
FT                   /id="VSP_002392"
FT   CONFLICT        218
FT                   /note="L -> M (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   235 AA;  26915 MW;  BD695C7347CB71C0 CRC64;
     MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN
     VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI
     QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
     TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
//