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P09630

- HXC6_HUMAN

UniProt

P09630 - HXC6_HUMAN

Protein

Homeobox protein Hox-C6

Gene

HOXC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 3 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system development Source: Ensembl
    3. multicellular organismal development Source: ProtInc
    4. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C6
    Alternative name(s):
    Homeobox protein CP25
    Homeobox protein HHO.C8
    Homeobox protein Hox-3C
    Gene namesi
    Name:HOXC6
    Synonyms:HOX3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5128. HOXC6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29403.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Homeobox protein Hox-C6PRO_0000200174Add
    BLAST

    Proteomic databases

    PaxDbiP09630.
    PRIDEiP09630.

    PTM databases

    PhosphoSiteiP09630.

    Expressioni

    Gene expression databases

    ArrayExpressiP09630.
    BgeeiP09630.
    CleanExiHS_HOXC6.
    GenevestigatoriP09630.

    Organism-specific databases

    HPAiHPA054981.

    Interactioni

    Protein-protein interaction databases

    BioGridi109463. 4 interactions.
    STRINGi9606.ENSP00000243108.

    Structurei

    3D structure databases

    ProteinModelPortaliP09630.
    SMRiP09630. Positions 148-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi122 – 1276Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi168 – 1714Poly-Arg
    Compositional biasi208 – 2125Poly-Gly
    Compositional biasi221 – 23515Glu/Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG266030.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP09630.
    KOiK09306.
    OMAiMNSYFAN.
    PhylomeDBiP09630.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P09630-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY    50
    STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI 100
    AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR 150
    YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES 200
    NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE 235
    Length:235
    Mass (Da):26,915
    Last modified:October 3, 2006 - v3
    Checksum:iBD695C7347CB71C0
    GO
    Isoform 2 (identifier: P09630-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Show »
    Length:153
    Mass (Da):17,834
    Checksum:i291E2439914263AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti218 – 2181L → M(PubMed:2885844)Curated
    Sequence conflicti218 – 2181L → M(PubMed:2898768)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 2. 2 PublicationsVSP_002392Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82986 mRNA. Translation: AAB46892.1.
    M16938 mRNA. Translation: AAA36007.1.
    AK314829 mRNA. Translation: BAG37349.1.
    CH471054 Genomic DNA. Translation: EAW96746.1.
    BC074844 mRNA. Translation: AAH74844.1.
    BC074845 mRNA. Translation: AAH74845.1.
    CCDSiCCDS41792.1. [P09630-2]
    CCDS8871.1. [P09630-1]
    PIRiB28030. WJHU3C.
    RefSeqiNP_004494.1. NM_004503.3. [P09630-1]
    NP_710160.1. NM_153693.4. [P09630-2]
    UniGeneiHs.549040.

    Genome annotation databases

    EnsembliENST00000243108; ENSP00000243108; ENSG00000197757. [P09630-1]
    ENST00000394331; ENSP00000377864; ENSG00000197757. [P09630-2]
    GeneIDi3223.
    KEGGihsa:3223.
    UCSCiuc001ses.3. human. [P09630-1]

    Polymorphism databases

    DMDMi115502398.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82986 mRNA. Translation: AAB46892.1 .
    M16938 mRNA. Translation: AAA36007.1 .
    AK314829 mRNA. Translation: BAG37349.1 .
    CH471054 Genomic DNA. Translation: EAW96746.1 .
    BC074844 mRNA. Translation: AAH74844.1 .
    BC074845 mRNA. Translation: AAH74845.1 .
    CCDSi CCDS41792.1. [P09630-2 ]
    CCDS8871.1. [P09630-1 ]
    PIRi B28030. WJHU3C.
    RefSeqi NP_004494.1. NM_004503.3. [P09630-1 ]
    NP_710160.1. NM_153693.4. [P09630-2 ]
    UniGenei Hs.549040.

    3D structure databases

    ProteinModelPortali P09630.
    SMRi P09630. Positions 148-200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109463. 4 interactions.
    STRINGi 9606.ENSP00000243108.

    PTM databases

    PhosphoSitei P09630.

    Polymorphism databases

    DMDMi 115502398.

    Proteomic databases

    PaxDbi P09630.
    PRIDEi P09630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243108 ; ENSP00000243108 ; ENSG00000197757 . [P09630-1 ]
    ENST00000394331 ; ENSP00000377864 ; ENSG00000197757 . [P09630-2 ]
    GeneIDi 3223.
    KEGGi hsa:3223.
    UCSCi uc001ses.3. human. [P09630-1 ]

    Organism-specific databases

    CTDi 3223.
    GeneCardsi GC12P054384.
    HGNCi HGNC:5128. HOXC6.
    HPAi HPA054981.
    MIMi 142972. gene.
    neXtProti NX_P09630.
    PharmGKBi PA29403.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG266030.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P09630.
    KOi K09306.
    OMAi MNSYFAN.
    PhylomeDBi P09630.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXC6.
    GenomeRNAii 3223.
    NextBioi 12825.
    PROi P09630.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09630.
    Bgeei P09630.
    CleanExi HS_HOXC6.
    Genevestigatori P09630.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "At least three human homeoboxes on chromosome 12 belong to the same transcription unit."
      Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.
      Nucleic Acids Res. 16:5379-5390(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning and expression of a new HOXC6 transcript encoding a repressing protein."
      Chariot A., Castronovo V., Le P., Gillet C., Sobel M.E., Gielen J.
      Biochem. J. 319:91-97(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Synovium.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    7. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-206.

    Entry informationi

    Entry nameiHXC6_HUMAN
    AccessioniPrimary (citable) accession number: P09630
    Secondary accession number(s): B2RBV2, Q6DK09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 152 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3