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P09630 (HXC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein CP25
Homeobox protein HHO.C8
Homeobox protein Hox-3C
Gene names
Name:HOXC6
Synonyms:HOX3C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P09630-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P09630-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Homeobox protein Hox-C6
PRO_0000200174

Regions

DNA binding141 – 20060Homeobox
Motif122 – 1276Antp-type hexapeptide
Compositional bias168 – 1714Poly-Arg
Compositional bias208 – 2125Poly-Gly
Compositional bias221 – 23515Glu/Lys-rich

Natural variations

Alternative sequence1 – 8282Missing in isoform 2.
VSP_002392

Experimental info

Sequence conflict2181L → M Ref.1
Sequence conflict2181L → M Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 3, 2006. Version 3.
Checksum: BD695C7347CB71C0

FASTA23526,915
        10         20         30         40         50         60 
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN 

        70         80         90        100        110        120 
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI 

       130        140        150        160        170        180 
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL 

       190        200        210        220        230 
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE 

« Hide

Isoform 2 [UniParc].

Checksum: 291E2439914263AE
Show »

FASTA15317,834

References

« Hide 'large scale' references
[1]"Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development."
Simeone A., Mavilio F., Acampora D., Giampaolo A., Faiella A., Zappavigna V., D'Esposito M., Pannese M., Russo G., Boncinelli E., Peschle C.
Proc. Natl. Acad. Sci. U.S.A. 84:4914-4918(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"At least three human homeoboxes on chromosome 12 belong to the same transcription unit."
Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.
Nucleic Acids Res. 16:5379-5390(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Cloning and expression of a new HOXC6 transcript encoding a repressing protein."
Chariot A., Castronovo V., Le P., Gillet C., Sobel M.E., Gielen J.
Biochem. J. 319:91-97(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Synovium.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[7]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-206.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82986 mRNA. Translation: AAB46892.1.
M16938 mRNA. Translation: AAA36007.1.
AK314829 mRNA. Translation: BAG37349.1.
CH471054 Genomic DNA. Translation: EAW96746.1.
BC074844 mRNA. Translation: AAH74844.1.
BC074845 mRNA. Translation: AAH74845.1.
CCDSCCDS41792.1. [P09630-2]
CCDS8871.1. [P09630-1]
PIRWJHU3C. B28030.
RefSeqNP_004494.1. NM_004503.3. [P09630-1]
NP_710160.1. NM_153693.4. [P09630-2]
UniGeneHs.549040.

3D structure databases

ProteinModelPortalP09630.
SMRP09630. Positions 148-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109463. 4 interactions.
STRING9606.ENSP00000243108.

PTM databases

PhosphoSiteP09630.

Polymorphism databases

DMDM115502398.

Proteomic databases

PaxDbP09630.
PRIDEP09630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243108; ENSP00000243108; ENSG00000197757. [P09630-1]
ENST00000394331; ENSP00000377864; ENSG00000197757. [P09630-2]
GeneID3223.
KEGGhsa:3223.
UCSCuc001ses.3. human. [P09630-1]

Organism-specific databases

CTD3223.
GeneCardsGC12P054384.
HGNCHGNC:5128. HOXC6.
HPAHPA054981.
MIM142972. gene.
neXtProtNX_P09630.
PharmGKBPA29403.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG266030.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP09630.
KOK09306.
OMAMNSYFAN.
PhylomeDBP09630.
TreeFamTF316310.

Gene expression databases

ArrayExpressP09630.
BgeeP09630.
CleanExHS_HOXC6.
GenevestigatorP09630.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXC6.
GenomeRNAi3223.
NextBio12825.
PROP09630.
SOURCESearch...

Entry information

Entry nameHXC6_HUMAN
AccessionPrimary (citable) accession number: P09630
Secondary accession number(s): B2RBV2, Q6DK09
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries