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P09630

- HXC6_HUMAN

UniProt

P09630 - HXC6_HUMAN

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Protein
Homeobox protein Hox-C6
Gene
HOXC6, HOX3C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 20060Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription corepressor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system development Source: Ensembl
  3. multicellular organismal development Source: ProtInc
  4. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein CP25
Homeobox protein HHO.C8
Homeobox protein Hox-3C
Gene namesi
Name:HOXC6
Synonyms:HOX3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5128. HOXC6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Homeobox protein Hox-C6
PRO_0000200174Add
BLAST

Proteomic databases

PaxDbiP09630.
PRIDEiP09630.

PTM databases

PhosphoSiteiP09630.

Expressioni

Gene expression databases

ArrayExpressiP09630.
BgeeiP09630.
CleanExiHS_HOXC6.
GenevestigatoriP09630.

Organism-specific databases

HPAiHPA054981.

Interactioni

Protein-protein interaction databases

BioGridi109463. 4 interactions.
STRINGi9606.ENSP00000243108.

Structurei

3D structure databases

ProteinModelPortaliP09630.
SMRiP09630. Positions 148-200.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi122 – 1276Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 1714Poly-Arg
Compositional biasi208 – 2125Poly-Gly
Compositional biasi221 – 23515Glu/Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG266030.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09630.
KOiK09306.
OMAiMNSYFAN.
PhylomeDBiP09630.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P09630-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY    50
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI 100
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR 150
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES 200
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE 235
Length:235
Mass (Da):26,915
Last modified:October 3, 2006 - v3
Checksum:iBD695C7347CB71C0
GO
Isoform 2 (identifier: P09630-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,834
Checksum:i291E2439914263AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 2.
VSP_002392Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181L → M1 Publication
Sequence conflicti218 – 2181L → M1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82986 mRNA. Translation: AAB46892.1.
M16938 mRNA. Translation: AAA36007.1.
AK314829 mRNA. Translation: BAG37349.1.
CH471054 Genomic DNA. Translation: EAW96746.1.
BC074844 mRNA. Translation: AAH74844.1.
BC074845 mRNA. Translation: AAH74845.1.
CCDSiCCDS41792.1. [P09630-2]
CCDS8871.1. [P09630-1]
PIRiB28030. WJHU3C.
RefSeqiNP_004494.1. NM_004503.3. [P09630-1]
NP_710160.1. NM_153693.4. [P09630-2]
UniGeneiHs.549040.

Genome annotation databases

EnsembliENST00000243108; ENSP00000243108; ENSG00000197757. [P09630-1]
ENST00000394331; ENSP00000377864; ENSG00000197757. [P09630-2]
GeneIDi3223.
KEGGihsa:3223.
UCSCiuc001ses.3. human. [P09630-1]

Polymorphism databases

DMDMi115502398.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82986 mRNA. Translation: AAB46892.1 .
M16938 mRNA. Translation: AAA36007.1 .
AK314829 mRNA. Translation: BAG37349.1 .
CH471054 Genomic DNA. Translation: EAW96746.1 .
BC074844 mRNA. Translation: AAH74844.1 .
BC074845 mRNA. Translation: AAH74845.1 .
CCDSi CCDS41792.1. [P09630-2 ]
CCDS8871.1. [P09630-1 ]
PIRi B28030. WJHU3C.
RefSeqi NP_004494.1. NM_004503.3. [P09630-1 ]
NP_710160.1. NM_153693.4. [P09630-2 ]
UniGenei Hs.549040.

3D structure databases

ProteinModelPortali P09630.
SMRi P09630. Positions 148-200.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109463. 4 interactions.
STRINGi 9606.ENSP00000243108.

PTM databases

PhosphoSitei P09630.

Polymorphism databases

DMDMi 115502398.

Proteomic databases

PaxDbi P09630.
PRIDEi P09630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243108 ; ENSP00000243108 ; ENSG00000197757 . [P09630-1 ]
ENST00000394331 ; ENSP00000377864 ; ENSG00000197757 . [P09630-2 ]
GeneIDi 3223.
KEGGi hsa:3223.
UCSCi uc001ses.3. human. [P09630-1 ]

Organism-specific databases

CTDi 3223.
GeneCardsi GC12P054384.
HGNCi HGNC:5128. HOXC6.
HPAi HPA054981.
MIMi 142972. gene.
neXtProti NX_P09630.
PharmGKBi PA29403.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266030.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P09630.
KOi K09306.
OMAi MNSYFAN.
PhylomeDBi P09630.
TreeFami TF316310.

Miscellaneous databases

GeneWikii HOXC6.
GenomeRNAii 3223.
NextBioi 12825.
PROi P09630.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09630.
Bgeei P09630.
CleanExi HS_HOXC6.
Genevestigatori P09630.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "At least three human homeoboxes on chromosome 12 belong to the same transcription unit."
    Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.
    Nucleic Acids Res. 16:5379-5390(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning and expression of a new HOXC6 transcript encoding a repressing protein."
    Chariot A., Castronovo V., Le P., Gillet C., Sobel M.E., Gielen J.
    Biochem. J. 319:91-97(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Synovium.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-206.

Entry informationi

Entry nameiHXC6_HUMAN
AccessioniPrimary (citable) accession number: P09630
Secondary accession number(s): B2RBV2, Q6DK09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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