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P09629

- HXB7_HUMAN

UniProt

P09629 - HXB7_HUMAN

Protein

Homeobox protein Hox-B7

Gene

HOXB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system morphogenesis Source: Ensembl
    3. multicellular organismal development Source: UniProtKB
    4. myeloid cell differentiation Source: Ensembl
    5. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    6. regulation of transcription, DNA-templated Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B7
    Alternative name(s):
    Homeobox protein HHO.C1
    Homeobox protein Hox-2C
    Gene namesi
    Name:HOXB7
    Synonyms:HOX2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5118. HOXB7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Homeobox protein Hox-B7PRO_0000200142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP09629.
    PaxDbiP09629.
    PRIDEiP09629.

    PTM databases

    PhosphoSiteiP09629.

    Expressioni

    Gene expression databases

    ArrayExpressiP09629.
    BgeeiP09629.
    CleanExiHS_HOXB7.
    GenevestigatoriP09629.

    Organism-specific databases

    HPAiHPA049940.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKDCP785272EBI-1248457,EBI-352053
    XRCC5P130109EBI-1248457,EBI-357997

    Protein-protein interaction databases

    BioGridi109457. 9 interactions.
    IntActiP09629. 4 interactions.
    STRINGi9606.ENSP00000239165.

    Structurei

    3D structure databases

    ProteinModelPortaliP09629.
    SMRiP09629. Positions 141-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi126 – 1316Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi212 – 2176Glu-rich (acidic)

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238660.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP09629.
    KOiK09307.
    OMAiSMQGLYP.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09629.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS    50
    FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC 100
    PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL 150
    ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG 200
    PGTTGQDRAE AEEEEEE 217
    Length:217
    Mass (Da):24,015
    Last modified:November 2, 2010 - v4
    Checksum:iE92D63F437D34628
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491A → V in BAF83342. (PubMed:14702039)Curated
    Sequence conflicti49 – 491A → V in BAD96969. 1 PublicationCurated
    Sequence conflicti53 – 531A → G in AAA36003. (PubMed:2885844)Curated
    Sequence conflicti94 – 941Q → L in BAD96969. 1 PublicationCurated
    Sequence conflicti108 – 1081A → G in AAB19469. (PubMed:1678287)Curated
    Sequence conflicti118 – 1181L → F in AAB19469. (PubMed:1678287)Curated
    Sequence conflicti129 – 1291W → S in AAA36003. (PubMed:2885844)Curated
    Sequence conflicti153 – 1531E → G in BAD96969. 1 PublicationCurated
    Sequence conflicti154 – 1541K → N in AAB19469. (PubMed:1678287)Curated
    Sequence conflicti173 – 1731T → A in AAA36003. (PubMed:2885844)Curated
    Sequence conflicti173 – 1731T → A in AAB19469. (PubMed:1678287)Curated
    Sequence conflicti194 – 1941K → N in AAB19469. (PubMed:1678287)Curated
    Sequence conflicti200 – 2023GPG → APA in AAB19469. (PubMed:1678287)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91T → A.5 Publications
    Corresponds to variant rs7406910 [ dbSNP | Ensembl ].
    VAR_058204

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16937 mRNA. Translation: AAA36003.1.
    AK290653 mRNA. Translation: BAF83342.1.
    AK223249 mRNA. Translation: BAD96969.1.
    AC103702 mRNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94725.1.
    BC015345 mRNA. Translation: AAH15345.1.
    S49765 mRNA. Translation: AAB19469.2.
    M30598 mRNA. Translation: AAA36005.1.
    CCDSiCCDS11532.1.
    PIRiA28030. WJHU2C.
    RefSeqiNP_004493.3. NM_004502.3.
    UniGeneiHs.436181.

    Genome annotation databases

    EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
    GeneIDi3217.
    KEGGihsa:3217.
    UCSCiuc002inv.3. human.

    Polymorphism databases

    DMDMi311033482.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16937 mRNA. Translation: AAA36003.1 .
    AK290653 mRNA. Translation: BAF83342.1 .
    AK223249 mRNA. Translation: BAD96969.1 .
    AC103702 mRNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94725.1 .
    BC015345 mRNA. Translation: AAH15345.1 .
    S49765 mRNA. Translation: AAB19469.2 .
    M30598 mRNA. Translation: AAA36005.1 .
    CCDSi CCDS11532.1.
    PIRi A28030. WJHU2C.
    RefSeqi NP_004493.3. NM_004502.3.
    UniGenei Hs.436181.

    3D structure databases

    ProteinModelPortali P09629.
    SMRi P09629. Positions 141-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109457. 9 interactions.
    IntActi P09629. 4 interactions.
    STRINGi 9606.ENSP00000239165.

    PTM databases

    PhosphoSitei P09629.

    Polymorphism databases

    DMDMi 311033482.

    Proteomic databases

    MaxQBi P09629.
    PaxDbi P09629.
    PRIDEi P09629.

    Protocols and materials databases

    DNASUi 3217.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239165 ; ENSP00000239165 ; ENSG00000260027 .
    GeneIDi 3217.
    KEGGi hsa:3217.
    UCSCi uc002inv.3. human.

    Organism-specific databases

    CTDi 3217.
    GeneCardsi GC17M046684.
    HGNCi HGNC:5118. HOXB7.
    HPAi HPA049940.
    MIMi 142962. gene.
    neXtProti NX_P09629.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238660.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P09629.
    KOi K09307.
    OMAi SMQGLYP.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09629.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXB7.
    GenomeRNAii 3217.
    NextBioi 12800.
    PROi P09629.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09629.
    Bgeei P09629.
    CleanExi HS_HOXB7.
    Genevestigatori P09629.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-9.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
      Tissue: Embryo.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
      Tissue: Gastric mucosa.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-9.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
      Tissue: Liver.
    7. "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain."
      Baier L.J., Hannibal M.C., Hanley E.W., Nabel G.J.
      Blood 78:1047-1055(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-217.
    8. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
      Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
      Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-217.
    9. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-202.
    10. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-191 AND LYS-193.
      Tissue: Lung adenocarcinoma.

    Entry informationi

    Entry nameiHXB7_HUMAN
    AccessioniPrimary (citable) accession number: P09629
    Secondary accession number(s): A8K3N8
    , Q15957, Q53FN3, Q96BQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 142 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3