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Protein

Homeobox protein Hox-B7

Gene

HOXB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP09629.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein HHO.C1
Homeobox protein Hox-2C
Gene namesi
Name:HOXB7
Synonyms:HOX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5118. HOXB7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • nuclear body Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3217.
OpenTargetsiENSG00000260027.

Polymorphism and mutation databases

BioMutaiHOXB7.
DMDMi311033482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001421 – 217Homeobox protein Hox-B7Add BLAST217

Proteomic databases

MaxQBiP09629.
PaxDbiP09629.
PeptideAtlasiP09629.
PRIDEiP09629.

PTM databases

iPTMnetiP09629.
PhosphoSitePlusiP09629.

Expressioni

Gene expression databases

BgeeiENSG00000260027.
CleanExiHS_HOXB7.
GenevisibleiP09629. HS.

Organism-specific databases

HPAiHPA049940.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109457. 12 interactors.
IntActiP09629. 5 interactors.
STRINGi9606.ENSP00000239165.

Structurei

3D structure databases

ProteinModelPortaliP09629.
SMRiP09629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 131Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi212 – 217Glu-rich (acidic)6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09629.
KOiK09307.
OMAiNLSGVCP.
OrthoDBiEOG091G09XD.
PhylomeDBiP09629.
TreeFamiTF316310.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS
60 70 80 90 100
FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG
210
PGTTGQDRAE AEEEEEE
Length:217
Mass (Da):24,015
Last modified:November 2, 2010 - v4
Checksum:iE92D63F437D34628
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → V in BAF83342 (PubMed:14702039).Curated1
Sequence conflicti49A → V in BAD96969 (Ref. 3) Curated1
Sequence conflicti53A → G in AAA36003 (PubMed:2885844).Curated1
Sequence conflicti94Q → L in BAD96969 (Ref. 3) Curated1
Sequence conflicti108A → G in AAB19469 (PubMed:1678287).Curated1
Sequence conflicti118L → F in AAB19469 (PubMed:1678287).Curated1
Sequence conflicti129W → S in AAA36003 (PubMed:2885844).Curated1
Sequence conflicti153E → G in BAD96969 (Ref. 3) Curated1
Sequence conflicti154K → N in AAB19469 (PubMed:1678287).Curated1
Sequence conflicti173T → A in AAA36003 (PubMed:2885844).Curated1
Sequence conflicti173T → A in AAB19469 (PubMed:1678287).Curated1
Sequence conflicti194K → N in AAB19469 (PubMed:1678287).Curated1
Sequence conflicti200 – 202GPG → APA in AAB19469 (PubMed:1678287).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0582049T → A5 PublicationsCorresponds to variant dbSNP:rs7406910Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16937 mRNA. Translation: AAA36003.1.
AK290653 mRNA. Translation: BAF83342.1.
AK223249 mRNA. Translation: BAD96969.1.
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1.
BC015345 mRNA. Translation: AAH15345.1.
S49765 mRNA. Translation: AAB19469.2.
M30598 mRNA. Translation: AAA36005.1.
CCDSiCCDS11532.1.
PIRiA28030. WJHU2C.
RefSeqiNP_004493.3. NM_004502.3.
UniGeneiHs.436181.

Genome annotation databases

EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
GeneIDi3217.
KEGGihsa:3217.
UCSCiuc002inv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16937 mRNA. Translation: AAA36003.1.
AK290653 mRNA. Translation: BAF83342.1.
AK223249 mRNA. Translation: BAD96969.1.
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1.
BC015345 mRNA. Translation: AAH15345.1.
S49765 mRNA. Translation: AAB19469.2.
M30598 mRNA. Translation: AAA36005.1.
CCDSiCCDS11532.1.
PIRiA28030. WJHU2C.
RefSeqiNP_004493.3. NM_004502.3.
UniGeneiHs.436181.

3D structure databases

ProteinModelPortaliP09629.
SMRiP09629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109457. 12 interactors.
IntActiP09629. 5 interactors.
STRINGi9606.ENSP00000239165.

PTM databases

iPTMnetiP09629.
PhosphoSitePlusiP09629.

Polymorphism and mutation databases

BioMutaiHOXB7.
DMDMi311033482.

Proteomic databases

MaxQBiP09629.
PaxDbiP09629.
PeptideAtlasiP09629.
PRIDEiP09629.

Protocols and materials databases

DNASUi3217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
GeneIDi3217.
KEGGihsa:3217.
UCSCiuc002inv.4. human.

Organism-specific databases

CTDi3217.
DisGeNETi3217.
GeneCardsiHOXB7.
HGNCiHGNC:5118. HOXB7.
HPAiHPA049940.
MIMi142962. gene.
neXtProtiNX_P09629.
OpenTargetsiENSG00000260027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09629.
KOiK09307.
OMAiNLSGVCP.
OrthoDBiEOG091G09XD.
PhylomeDBiP09629.
TreeFamiTF316310.

Enzyme and pathway databases

SIGNORiP09629.

Miscellaneous databases

GeneWikiiHOXB7.
GenomeRNAii3217.
PROiPR:P09629.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000260027.
CleanExiHS_HOXB7.
GenevisibleiP09629. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXB7_HUMAN
AccessioniPrimary (citable) accession number: P09629
Secondary accession number(s): A8K3N8
, Q15957, Q53FN3, Q96BQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 2, 2010
Last modified: May 10, 2017
This is version 164 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.