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P09629

- HXB7_HUMAN

UniProt

P09629 - HXB7_HUMAN

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Protein

Homeobox protein Hox-B7

Gene
HOXB7, HOX2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi137 – 19660HomeoboxAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. multicellular organismal development Source: UniProtKB
  4. myeloid cell differentiation Source: Ensembl
  5. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  6. regulation of transcription, DNA-templated Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein HHO.C1
Homeobox protein Hox-2C
Gene namesi
Name:HOXB7
Synonyms:HOX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5118. HOXB7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Homeobox protein Hox-B7PRO_0000200142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP09629.
PaxDbiP09629.
PRIDEiP09629.

PTM databases

PhosphoSiteiP09629.

Expressioni

Gene expression databases

ArrayExpressiP09629.
BgeeiP09629.
CleanExiHS_HOXB7.
GenevestigatoriP09629.

Organism-specific databases

HPAiHPA049940.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKDCP785272EBI-1248457,EBI-352053
XRCC5P130109EBI-1248457,EBI-357997

Protein-protein interaction databases

BioGridi109457. 9 interactions.
IntActiP09629. 4 interactions.
STRINGi9606.ENSP00000239165.

Structurei

3D structure databases

ProteinModelPortaliP09629.
SMRiP09629. Positions 141-196.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1316Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 2176Glu-rich (acidic)

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09629.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP09629.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09629-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS    50
FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC 100
PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL 150
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG 200
PGTTGQDRAE AEEEEEE 217
Length:217
Mass (Da):24,015
Last modified:November 2, 2010 - v4
Checksum:iE92D63F437D34628
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91T → A.5 Publications
Corresponds to variant rs7406910 [ dbSNP | Ensembl ].
VAR_058204

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → V in BAF83342. 1 Publication
Sequence conflicti49 – 491A → V in BAD96969. 1 Publication
Sequence conflicti53 – 531A → G in AAA36003. 1 Publication
Sequence conflicti94 – 941Q → L in BAD96969. 1 Publication
Sequence conflicti108 – 1081A → G in AAB19469. 1 Publication
Sequence conflicti118 – 1181L → F in AAB19469. 1 Publication
Sequence conflicti129 – 1291W → S in AAA36003. 1 Publication
Sequence conflicti153 – 1531E → G in BAD96969. 1 Publication
Sequence conflicti154 – 1541K → N in AAB19469. 1 Publication
Sequence conflicti173 – 1731T → A in AAA36003. 1 Publication
Sequence conflicti173 – 1731T → A in AAB19469. 1 Publication
Sequence conflicti194 – 1941K → N in AAB19469. 1 Publication
Sequence conflicti200 – 2023GPG → APA in AAB19469. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16937 mRNA. Translation: AAA36003.1.
AK290653 mRNA. Translation: BAF83342.1.
AK223249 mRNA. Translation: BAD96969.1.
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1.
BC015345 mRNA. Translation: AAH15345.1.
S49765 mRNA. Translation: AAB19469.2.
M30598 mRNA. Translation: AAA36005.1.
CCDSiCCDS11532.1.
PIRiA28030. WJHU2C.
RefSeqiNP_004493.3. NM_004502.3.
UniGeneiHs.436181.

Genome annotation databases

EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
GeneIDi3217.
KEGGihsa:3217.
UCSCiuc002inv.3. human.

Polymorphism databases

DMDMi311033482.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16937 mRNA. Translation: AAA36003.1 .
AK290653 mRNA. Translation: BAF83342.1 .
AK223249 mRNA. Translation: BAD96969.1 .
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1 .
BC015345 mRNA. Translation: AAH15345.1 .
S49765 mRNA. Translation: AAB19469.2 .
M30598 mRNA. Translation: AAA36005.1 .
CCDSi CCDS11532.1.
PIRi A28030. WJHU2C.
RefSeqi NP_004493.3. NM_004502.3.
UniGenei Hs.436181.

3D structure databases

ProteinModelPortali P09629.
SMRi P09629. Positions 141-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109457. 9 interactions.
IntActi P09629. 4 interactions.
STRINGi 9606.ENSP00000239165.

PTM databases

PhosphoSitei P09629.

Polymorphism databases

DMDMi 311033482.

Proteomic databases

MaxQBi P09629.
PaxDbi P09629.
PRIDEi P09629.

Protocols and materials databases

DNASUi 3217.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239165 ; ENSP00000239165 ; ENSG00000260027 .
GeneIDi 3217.
KEGGi hsa:3217.
UCSCi uc002inv.3. human.

Organism-specific databases

CTDi 3217.
GeneCardsi GC17M046684.
HGNCi HGNC:5118. HOXB7.
HPAi HPA049940.
MIMi 142962. gene.
neXtProti NX_P09629.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238660.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P09629.
KOi K09307.
OMAi SMQGLYP.
OrthoDBi EOG780RP4.
PhylomeDBi P09629.
TreeFami TF316310.

Miscellaneous databases

GeneWikii HOXB7.
GenomeRNAii 3217.
NextBioi 12800.
PROi P09629.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09629.
Bgeei P09629.
CleanExi HS_HOXB7.
Genevestigatori P09629.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-9.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Embryo.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Gastric mucosa.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-9.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Liver.
  7. "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain."
    Baier L.J., Hannibal M.C., Hanley E.W., Nabel G.J.
    Blood 78:1047-1055(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-217.
  8. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
    Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-217.
  9. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-202.
  10. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-191 AND LYS-193.
    Tissue: Lung adenocarcinoma.

Entry informationi

Entry nameiHXB7_HUMAN
AccessioniPrimary (citable) accession number: P09629
Secondary accession number(s): A8K3N8
, Q15957, Q53FN3, Q96BQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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