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Protein

Homeobox protein Hox-B7

Gene

HOXB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein HHO.C1
Homeobox protein Hox-2C
Gene namesi
Name:HOXB7
Synonyms:HOX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5118. HOXB7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiHOXB7.
DMDMi311033482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Homeobox protein Hox-B7PRO_0000200142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP09629.
PaxDbiP09629.
PRIDEiP09629.

PTM databases

PhosphoSiteiP09629.

Expressioni

Gene expression databases

BgeeiP09629.
CleanExiHS_HOXB7.
GenevisibleiP09629. HS.

Organism-specific databases

HPAiHPA049940.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLK3P497613EBI-1248457,EBI-745579
PRKDCP785272EBI-1248457,EBI-352053
XRCC5P130109EBI-1248457,EBI-357997

Protein-protein interaction databases

BioGridi109457. 11 interactions.
IntActiP09629. 5 interactions.
STRINGi9606.ENSP00000239165.

Structurei

3D structure databases

ProteinModelPortaliP09629.
SMRiP09629. Positions 141-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1316Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 2176Glu-rich (acidic)

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09629.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP09629.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS
60 70 80 90 100
FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG
210
PGTTGQDRAE AEEEEEE
Length:217
Mass (Da):24,015
Last modified:November 2, 2010 - v4
Checksum:iE92D63F437D34628
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → V in BAF83342 (PubMed:14702039).Curated
Sequence conflicti49 – 491A → V in BAD96969 (Ref. 3) Curated
Sequence conflicti53 – 531A → G in AAA36003 (PubMed:2885844).Curated
Sequence conflicti94 – 941Q → L in BAD96969 (Ref. 3) Curated
Sequence conflicti108 – 1081A → G in AAB19469 (PubMed:1678287).Curated
Sequence conflicti118 – 1181L → F in AAB19469 (PubMed:1678287).Curated
Sequence conflicti129 – 1291W → S in AAA36003 (PubMed:2885844).Curated
Sequence conflicti153 – 1531E → G in BAD96969 (Ref. 3) Curated
Sequence conflicti154 – 1541K → N in AAB19469 (PubMed:1678287).Curated
Sequence conflicti173 – 1731T → A in AAA36003 (PubMed:2885844).Curated
Sequence conflicti173 – 1731T → A in AAB19469 (PubMed:1678287).Curated
Sequence conflicti194 – 1941K → N in AAB19469 (PubMed:1678287).Curated
Sequence conflicti200 – 2023GPG → APA in AAB19469 (PubMed:1678287).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91T → A.5 Publications
Corresponds to variant rs7406910 [ dbSNP | Ensembl ].
VAR_058204

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16937 mRNA. Translation: AAA36003.1.
AK290653 mRNA. Translation: BAF83342.1.
AK223249 mRNA. Translation: BAD96969.1.
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1.
BC015345 mRNA. Translation: AAH15345.1.
S49765 mRNA. Translation: AAB19469.2.
M30598 mRNA. Translation: AAA36005.1.
CCDSiCCDS11532.1.
PIRiA28030. WJHU2C.
RefSeqiNP_004493.3. NM_004502.3.
UniGeneiHs.436181.

Genome annotation databases

EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
GeneIDi3217.
KEGGihsa:3217.
UCSCiuc002inv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16937 mRNA. Translation: AAA36003.1.
AK290653 mRNA. Translation: BAF83342.1.
AK223249 mRNA. Translation: BAD96969.1.
AC103702 mRNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94725.1.
BC015345 mRNA. Translation: AAH15345.1.
S49765 mRNA. Translation: AAB19469.2.
M30598 mRNA. Translation: AAA36005.1.
CCDSiCCDS11532.1.
PIRiA28030. WJHU2C.
RefSeqiNP_004493.3. NM_004502.3.
UniGeneiHs.436181.

3D structure databases

ProteinModelPortaliP09629.
SMRiP09629. Positions 141-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109457. 11 interactions.
IntActiP09629. 5 interactions.
STRINGi9606.ENSP00000239165.

PTM databases

PhosphoSiteiP09629.

Polymorphism and mutation databases

BioMutaiHOXB7.
DMDMi311033482.

Proteomic databases

MaxQBiP09629.
PaxDbiP09629.
PRIDEiP09629.

Protocols and materials databases

DNASUi3217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239165; ENSP00000239165; ENSG00000260027.
GeneIDi3217.
KEGGihsa:3217.
UCSCiuc002inv.3. human.

Organism-specific databases

CTDi3217.
GeneCardsiGC17M046684.
HGNCiHGNC:5118. HOXB7.
HPAiHPA049940.
MIMi142962. gene.
neXtProtiNX_P09629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09629.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP09629.
TreeFamiTF316310.

Miscellaneous databases

GeneWikiiHOXB7.
GenomeRNAii3217.
NextBioi12800.
PROiP09629.
SOURCEiSearch...

Gene expression databases

BgeeiP09629.
CleanExiHS_HOXB7.
GenevisibleiP09629. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-9.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Embryo.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Gastric mucosa.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-9.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-9.
    Tissue: Liver.
  7. "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain."
    Baier L.J., Hannibal M.C., Hanley E.W., Nabel G.J.
    Blood 78:1047-1055(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-217.
  8. "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
    Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-217.
  9. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-202.
  10. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-191 AND LYS-193.
    Tissue: Lung adenocarcinoma.

Entry informationi

Entry nameiHXB7_HUMAN
AccessioniPrimary (citable) accession number: P09629
Secondary accession number(s): A8K3N8
, Q15957, Q53FN3, Q96BQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 2, 2010
Last modified: June 24, 2015
This is version 148 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.