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Protein

Plasma membrane ATPase 1

Gene

pma1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3764-aspartylphosphate intermediateBy similarity1
Metal bindingi632MagnesiumBy similarity1
Metal bindingi636MagnesiumBy similarity1

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • hydrogen-exporting ATPase activity, phosphorylative mechanism Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • proton binding Source: PomBase

GO - Biological processi

  • ATP biosynthetic process Source: InterPro
  • proton transport Source: PomBase
  • regulation of intracellular pH Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPase 1 (EC:3.6.3.6)
Alternative name(s):
Proton pump 1
Gene namesi
Name:pma1
ORF Names:SPAC1071.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1071.10c.
PomBaseiSPAC1071.10c. pma1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113CytoplasmicSequence analysisAdd BLAST113
Transmembranei114 – 134Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini135 – 138ExtracellularSequence analysis4
Transmembranei139 – 158Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini159 – 289CytoplasmicSequence analysisAdd BLAST131
Transmembranei290 – 311Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini312 – 322ExtracellularSequence analysisAdd BLAST11
Transmembranei323 – 345Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini346 – 717CytoplasmicSequence analysisAdd BLAST372
Transmembranei718 – 736Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini737 – 752ExtracellularSequence analysisAdd BLAST16
Transmembranei753 – 772Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini773 – 824CytoplasmicSequence analysisAdd BLAST52
Transmembranei825 – 845Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini846 – 858ExtracellularSequence analysisAdd BLAST13
Transmembranei859 – 875Helical; Name=8Sequence analysisAdd BLAST17
Topological domaini876 – 919CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • Golgi apparatus Source: PomBase
  • integral component of membrane Source: PomBase
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
  • plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462691 – 919Plasma membrane ATPase 1Add BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89Phosphoserine1 Publication1
Modified residuei494Phosphoserine1 Publication1
Modified residuei899Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09627.
PRIDEiP09627.

PTM databases

iPTMnetiP09627.

Interactioni

Protein-protein interaction databases

BioGridi279117. 7 interactors.
DIPiDIP-59125N.
MINTiMINT-4687131.

Structurei

3D structure databases

ProteinModelPortaliP09627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000160005.
InParanoidiP09627.
KOiK01535.
OMAiIVFANIY.
OrthoDBiEOG092C0HLD.
PhylomeDBiP09627.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNAGEYHD AEKHAPEQQA PPPQQPAHAA APAQDDEPDD DIDALIEELF
60 70 80 90 100
SEDVQEEQED NDDAPAAGEA KAVPEELLQT DMNTGLTMSE VEERRKKYGL
110 120 130 140 150
NQMKEELENP FLKFIMFFVG PIQFVMEMAA ALAAGLRDWV DFGVICALLM
160 170 180 190 200
LNAVVGFVQE YQAGSIVDEL KKSLALKAVV IREGQVHELE ANEVVPGDIL
210 220 230 240 250
KLDEGTIICA DGRVVTPDVH LQVDQSAITG ESLAVDKHYG DPTFASSGVK
260 270 280 290 300
RGEGLMVVTA TGDSTFVGRA ASLVNAAAGG TGHFTEVLNG IGTILLVLVL
310 320 330 340 350
LTLFCIYTAA FYRSVRLARL LEYTLAITII GVPVGLPAVV TTTMAVGAAY
360 370 380 390 400
LAEKQAIVQK LSAIESLAGV EVLCSDKTGT LTKNKLSLGE PFTVSGVSGD
410 420 430 440 450
DLVLTACLAA SRKRKGLDAI DKAFLKALKN YPGPRSMLTK YKVIEFQPFD
460 470 480 490 500
PVSKKVTAYV QAPDGTRITC VKGAPLWVLK TVEEDHPIPE DVLSAYKDKV
510 520 530 540 550
GDLASRGYRS LGVARKIEGQ HWEIMGIMPC SDPPRHDTAR TISEAKRLGL
560 570 580 590 600
RVKMLTGDAV DIAKETARQL GMGTNIYNAE RLGLTGGGNM PGSEVYDFVE
610 620 630 640 650
AADGFGEVFP QHKYAVVDIL QQRGYLVAMT GDGVNDAPSL KKADTGIAVE
660 670 680 690 700
GATDAARSAA DIVFLAPGLS AIIDALKTSR QIFHRMYSYV VYRIALSLHL
710 720 730 740 750
EIFLGLWLII RNQLLNLELV VFIAIFADVA TLAIAYDNAP YSMKPVKWNL
760 770 780 790 800
PRLWGLSTVI GIVLAIGTWI TNTTMIAQGQ NRGIVQNFGV QDEVLFLEIS
810 820 830 840 850
LTENWLIFVT RCNGPFWSSI PSWQLSGAVL AVDILATMFC IFGWFKGGHQ
860 870 880 890 900
TSIVAVLRIW MYSFGIFCIM AGTYYILSES AGFDRMMNGK PKESRNQRSI
910
EDLVVALQRT STRHEKGDA
Length:919
Mass (Da):99,884
Last modified:July 1, 1989 - v1
Checksum:i0AE31B92ED607CC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03498 Genomic DNA. Translation: AAA35324.1.
CU329670 Genomic DNA. Translation: CAB59886.1.
PIRiA28454. PXZP1P.
RefSeqiNP_594360.1. NM_001019781.2.

Genome annotation databases

EnsemblFungiiSPAC1071.10c.1; SPAC1071.10c.1:pep; SPAC1071.10c.
GeneIDi2542664.
KEGGispo:SPAC1071.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03498 Genomic DNA. Translation: AAA35324.1.
CU329670 Genomic DNA. Translation: CAB59886.1.
PIRiA28454. PXZP1P.
RefSeqiNP_594360.1. NM_001019781.2.

3D structure databases

ProteinModelPortaliP09627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279117. 7 interactors.
DIPiDIP-59125N.
MINTiMINT-4687131.

PTM databases

iPTMnetiP09627.

Proteomic databases

MaxQBiP09627.
PRIDEiP09627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1071.10c.1; SPAC1071.10c.1:pep; SPAC1071.10c.
GeneIDi2542664.
KEGGispo:SPAC1071.10c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1071.10c.
PomBaseiSPAC1071.10c. pma1.

Phylogenomic databases

HOGENOMiHOG000160005.
InParanoidiP09627.
KOiK01535.
OMAiIVFANIY.
OrthoDBiEOG092C0HLD.
PhylomeDBiP09627.

Miscellaneous databases

PROiP09627.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMA1_SCHPO
AccessioniPrimary (citable) accession number: P09627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.