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Protein

Potassium-transporting ATPase alpha chain 1

Gene

Atp4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3854-aspartylphosphate intermediateBy similarity1
Metal bindingi726MagnesiumBy similarity1
Metal bindingi730MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi3.6.3.10. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:Atp4a
Synonyms:Hka
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2177. Atp4a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 96CytoplasmicSequence analysisAdd BLAST95
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 140LumenalSequence analysisAdd BLAST23
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 297CytoplasmicSequence analysisAdd BLAST136
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Topological domaini318 – 329LumenalSequence analysisAdd BLAST12
Transmembranei330 – 347HelicalSequence analysisAdd BLAST18
Topological domaini348 – 781CytoplasmicSequence analysisAdd BLAST434
Transmembranei782 – 801HelicalSequence analysisAdd BLAST20
Topological domaini802 – 811LumenalSequence analysis10
Transmembranei812 – 832HelicalSequence analysisAdd BLAST21
Topological domaini833 – 852CytoplasmicSequence analysisAdd BLAST20
Transmembranei853 – 875HelicalSequence analysisAdd BLAST23
Topological domaini876 – 927LumenalSequence analysisAdd BLAST52
Transmembranei928 – 947HelicalSequence analysisAdd BLAST20
Topological domaini948 – 961CytoplasmicSequence analysisAdd BLAST14
Transmembranei962 – 980HelicalSequence analysisAdd BLAST19
Topological domaini981 – 995LumenalSequence analysisAdd BLAST15
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1033CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2095199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000462572 – 1033Potassium-transporting ATPase alpha chain 1Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphotyrosineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei599PhosphoserineBy similarity1
Modified residuei838PhosphoserineCombined sources1
Modified residuei952Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09626.
PRIDEiP09626.

PTM databases

iPTMnetiP09626.
PhosphoSitePlusiP09626.
SwissPalmiP09626.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028508.

Chemistry databases

BindingDBiP09626.

Structurei

3D structure databases

ProteinModelPortaliP09626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP09626.
PhylomeDBiP09626.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKENYELYS VELGTGPGGD MAAKMSKKKA GGGGGKKKEK LENMKKEMEM
60 70 80 90 100
NDHQLSVSEL EQKYQTSATK GLKASLAAEL LLRDGPNALR PPRGTPEYVK
110 120 130 140 150
FARQLAGGLQ CLMWVAAAIC LIAFAIQASE GDLTTDDNLY LALALIAVVV
160 170 180 190 200
VTGCFGYYQE FKSTNIIASF KNLVPQQATV IRDGDKFQIN ADQLVVGDLV
210 220 230 240 250
EMKGGDRVPA DIRILSAQGC KVDNSSLTGE SEPQTRSPEC THESPLETRN
260 270 280 290 300
IAFFSTMCLE GTAQGLVVST GDRTIIGRIA SLASGVENEK TPIAIEIEHF
310 320 330 340 350
VDIIAGLAIL FGATFFVVAM CIGYTFLRAM VFFMAIVVAY VPEGLLATVT
360 370 380 390 400
VCLSLTAKRL ASKNCVVKNL EAVETLGSTS VICSDKTGTL TQNRMTVSHL
410 420 430 440 450
WFDNHIHTAD TTEDQSGQTF DQSSETWRAL CRVLTLCNRA AFKSGQDAVP
460 470 480 490 500
VPKRIVIGDA SETALLKFSE LTLGNAMGYR DRFPKVCEIP FNSTNKFQLS
510 520 530 540 550
IHTLEDPRDP RHLLVMKGAP ERVLERCSSI LIKGQELPLD EQWREAFQTA
560 570 580 590 600
YLSLGGLGER VLGFCQLYLN EKDYPPGYTF DVEAMNFPSS GLCFAGLVSM
610 620 630 640 650
IDPPRATVPD AVLKCRTAGI RVIMVTGDHP ITAKAIAASV GIISEGSETV
660 670 680 690 700
EDIAARLRMP VDQVNKKDAR ACVINGMQLK DMDPSELVEA LRTHPEMVFA
710 720 730 740 750
RTSPQQKLVI VESCQRLGAI VAVTGDGVND SPALKKADIG VAMGIAGSDA
760 770 780 790 800
AKNAADMILL DDNFASIVTG VEQGRLIFDN LKKSIAYTLT KNIPELTPYL
810 820 830 840 850
IYITVSVPLP LGCITILFIE LCTDIFPSVS LAYEKAESDI MHLRPRNPRR
860 870 880 890 900
DRLVNEPLAA YSYFQIGAIQ SFAGFADYFT AMAQEGWFPL LCVGLRPQWE
910 920 930 940 950
DHHLQDLQDS YGQEWTFGQR LYQQYTCYTV FFISIEMCQI ADVLIRKTRR
960 970 980 990 1000
LSAFQQGFFR NRILVIAIVF QVCIGCFLCY CPGMPNIFNF MPIRFQWWLV
1010 1020 1030
PMPFGLLIFV YDEIRKLGVR CCPGSWWDQE LYY
Length:1,033
Mass (Da):114,038
Last modified:January 23, 2007 - v3
Checksum:i5A8835BA0CAF987E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3K → KA in AAA72354 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02649 mRNA. Translation: AAA66036.1.
S74801 mRNA. Translation: AAP31528.1.
L11569 Genomic DNA. Translation: AAA72354.1.
X61934 Genomic DNA. Translation: CAA43938.1.
X61935 Genomic DNA. Translation: CAA43939.1.
PIRiA25344.
UniGeneiRn.214529.

Genome annotation databases

UCSCiRGD:2177. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02649 mRNA. Translation: AAA66036.1.
S74801 mRNA. Translation: AAP31528.1.
L11569 Genomic DNA. Translation: AAA72354.1.
X61934 Genomic DNA. Translation: CAA43938.1.
X61935 Genomic DNA. Translation: CAA43939.1.
PIRiA25344.
UniGeneiRn.214529.

3D structure databases

ProteinModelPortaliP09626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028508.

Chemistry databases

BindingDBiP09626.
ChEMBLiCHEMBL2095199.

PTM databases

iPTMnetiP09626.
PhosphoSitePlusiP09626.
SwissPalmiP09626.

Proteomic databases

PaxDbiP09626.
PRIDEiP09626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2177. rat.

Organism-specific databases

RGDi2177. Atp4a.

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP09626.
PhylomeDBiP09626.

Enzyme and pathway databases

BRENDAi3.6.3.10. 5301.

Miscellaneous databases

PROiP09626.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4A_RAT
AccessioniPrimary (citable) accession number: P09626
Secondary accession number(s): P70511
, P97892, Q63253, Q6LD86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.