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Protein

Envelopment polyprotein

Gene

GP

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

  • fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  • viral budding from Golgi membrane Source: UniProtKB
  • viral budding via host ESCRT complex Source: UniProtKB
  • virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G1
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G2
Gene namesi
Name:GP
OrganismiUukuniemi virus (strain S23) (Uuk)
Taxonomic identifieri487099 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]
Proteomesi
  • UP000008595 Componenti: Genome

Subcellular locationi

Glycoprotein N :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 394LumenalSequence analysisAdd BLAST377
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 496Cytoplasmic1 PublicationAdd BLAST81
Topological domaini497 – 977LumenalSequence analysisAdd BLAST481
Transmembranei978 – 988HelicalSequence analysisAdd BLAST11
Topological domaini989 – 1008CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000023252118 – 1008Envelopment polyproteinAdd BLAST991
ChainiPRO_000003685318 – 496Glycoprotein NSequence analysisAdd BLAST479
PropeptideiPRO_0000036854497 – 5131 PublicationAdd BLAST17
ChainiPRO_0000036855514 – 1008Glycoprotein CSequence analysisAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi70N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi108N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi208N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi691N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi696N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi912N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi949N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

Glycoprotein C and Glycoprotein N are palmitoylated.1 Publication
Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein Glycoprotein C and glycoprotein Glycoprotein N.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei513 – 514Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP09613.

Interactioni

Subunit structurei

Glycoprotein N and Glycoprotein C interact with each other.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRTYLLLLL LCGPATPFFN HLMDVTRRLL DSSNATWQRD QPDTHRLSRL
60 70 80 90 100
DAHVMSMLGV GSHIDEVSVN HSQHLHNFRS YNCEEGRRTL TMMDPKSGKF
110 120 130 140 150
KRLKCNENQT LSKDCASCIE KKSSIMKSEH LVYDDAICQS DYSSPEAMPD
160 170 180 190 200
HETHLCRIGP LHIQHCTHEA KRVQHVSWFW IDGKLRVYDD FSVSWTEGKF
210 220 230 240 250
LSLFDCLNET SKDHNCNKAV CLEGRCSGDL QFCTEFTCSY AKADCNCKRN
260 270 280 290 300
QVSGVAVVHT KHGSFMPECM GQSLWSVRKP LSKRSVTVQQ PCMDCESDCK
310 320 330 340 350
VDHILVIVRH FYPDHYQACL GSTCLTGRAK DKEFKIPFKM ADRLSDSHFE
360 370 380 390 400
IRIWDKERSN EYFLESRCES VDACAAITCW FCRANWANIH CFSKEQVLIL
410 420 430 440 450
VAVSSLCILL LASVLRALKV IATFTWKIIK PFWWILSLLC RTCSKRLNKR
460 470 480 490 500
AERLKESIHS LEEGLNNVDE GPREQNNPAR AVARPNVRQK MFNLTRLSPV
510 520 530 540 550
VVGMLCLACP VESCSDSISV TASSQRCSTS SDGVNSCFVS TSSLLQVSPK
560 570 580 590 600
GQESCLILKG PTGTAVDSIR IKTTDIKLEC VRRDLYWVPR VTHRCIGTRR
610 620 630 640 650
CHLMGACKGE ACSEFKINDY SPEWGHEEEL MAQLGWSYCV EQCGGALCQC
660 670 680 690 700
FNMRPSCFYL RKTFSHLSQD AFNIYECSEW SYRINVLVST NSTHSNLTLK
710 720 730 740 750
LGVPDSIPHG LISLSSVSQP PAIAYSECFG EDLHGTKFHT VCNRRTDYTL
760 770 780 790 800
GRIGEIQCPT KADALAVSKR CISSDSIIFS KVHKDSVDCQ SSIIDPMTIR
810 820 830 840 850
NRNKLPSTVG SVTFWPTETS VEAAIPDLAS ATMLIRLDGY TIQFRSDSNK
860 870 880 890 900
CSPRFLSLSG CYNCEAGAKL ELEHVTDFGT ALGILECPSL GYTTYYEVKN
910 920 930 940 950
TLEKSIRTMH LNGSHVEAKC YFRCPNSESQ LTIRGELIYL FNDDIRHHNQ
960 970 980 990 1000
TLSPGLSPKS GSGWDPFGWF KASWLRAIWA ILGGTVSLII GVVIIYMVFT

LCLKVKKS
Length:1,008
Mass (Da):113,589
Last modified:November 1, 1995 - v2
Checksum:iF557C06D8DB77E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1.
PIRiA28502. GNVUUK.
RefSeqiNP_941979.1. NC_005220.1.

Genome annotation databases

GeneIDi2943072.
KEGGivg:2943072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1.
PIRiA28502. GNVUUK.
RefSeqiNP_941979.1. NC_005220.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP09613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943072.
KEGGivg:2943072.

Family and domain databases

InterProiIPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP_UUKS
AccessioniPrimary (citable) accession number: P09613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.