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P09613

- GP_UUKS

UniProt

P09613 - GP_UUKS

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Protein
Envelope glycoprotein
Gene
GP
Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei513 – 5142Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiUukuniemi virus (strain S23) (Uuk)
Taxonomic identifieri487099 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]
ProteomesiUP000008595: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 394377Lumenal Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Reviewed prediction
Add
BLAST
Topological domaini416 – 49681Cytoplasmic1 Publication
Add
BLAST
Topological domaini497 – 977481Lumenal Reviewed prediction
Add
BLAST
Transmembranei978 – 98811Helical; Reviewed prediction
Add
BLAST
Topological domaini989 – 100820Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 Publication
Add
BLAST
Chaini18 – 1008991Envelope glycoprotein
PRO_0000232521Add
BLAST
Chaini18 – 496479Glycoprotein G1 Reviewed prediction
PRO_0000036853Add
BLAST
Propeptidei497 – 51317
PRO_0000036854Add
BLAST
Chaini514 – 1008495Glycoprotein G2 Reviewed prediction
PRO_0000036855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi70 – 701N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi108 – 1081N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi208 – 2081N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi691 – 6911N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi696 – 6961N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi912 – 9121N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi949 – 9491N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Glycoprotein G1 and glycoprotein G2 are palmitoylated.1 Publication
Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09613-1 [UniParc]FASTAAdd to Basket

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MVRTYLLLLL LCGPATPFFN HLMDVTRRLL DSSNATWQRD QPDTHRLSRL     50
DAHVMSMLGV GSHIDEVSVN HSQHLHNFRS YNCEEGRRTL TMMDPKSGKF 100
KRLKCNENQT LSKDCASCIE KKSSIMKSEH LVYDDAICQS DYSSPEAMPD 150
HETHLCRIGP LHIQHCTHEA KRVQHVSWFW IDGKLRVYDD FSVSWTEGKF 200
LSLFDCLNET SKDHNCNKAV CLEGRCSGDL QFCTEFTCSY AKADCNCKRN 250
QVSGVAVVHT KHGSFMPECM GQSLWSVRKP LSKRSVTVQQ PCMDCESDCK 300
VDHILVIVRH FYPDHYQACL GSTCLTGRAK DKEFKIPFKM ADRLSDSHFE 350
IRIWDKERSN EYFLESRCES VDACAAITCW FCRANWANIH CFSKEQVLIL 400
VAVSSLCILL LASVLRALKV IATFTWKIIK PFWWILSLLC RTCSKRLNKR 450
AERLKESIHS LEEGLNNVDE GPREQNNPAR AVARPNVRQK MFNLTRLSPV 500
VVGMLCLACP VESCSDSISV TASSQRCSTS SDGVNSCFVS TSSLLQVSPK 550
GQESCLILKG PTGTAVDSIR IKTTDIKLEC VRRDLYWVPR VTHRCIGTRR 600
CHLMGACKGE ACSEFKINDY SPEWGHEEEL MAQLGWSYCV EQCGGALCQC 650
FNMRPSCFYL RKTFSHLSQD AFNIYECSEW SYRINVLVST NSTHSNLTLK 700
LGVPDSIPHG LISLSSVSQP PAIAYSECFG EDLHGTKFHT VCNRRTDYTL 750
GRIGEIQCPT KADALAVSKR CISSDSIIFS KVHKDSVDCQ SSIIDPMTIR 800
NRNKLPSTVG SVTFWPTETS VEAAIPDLAS ATMLIRLDGY TIQFRSDSNK 850
CSPRFLSLSG CYNCEAGAKL ELEHVTDFGT ALGILECPSL GYTTYYEVKN 900
TLEKSIRTMH LNGSHVEAKC YFRCPNSESQ LTIRGELIYL FNDDIRHHNQ 950
TLSPGLSPKS GSGWDPFGWF KASWLRAIWA ILGGTVSLII GVVIIYMVFT 1000
LCLKVKKS 1008
Length:1,008
Mass (Da):113,589
Last modified:November 1, 1995 - v2
Checksum:iF557C06D8DB77E32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1.
PIRiA28502. GNVUUK.
RefSeqiNP_941979.1. NC_005220.1.

Genome annotation databases

GeneIDi2943072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1 .
PIRi A28502. GNVUUK.
RefSeqi NP_941979.1. NC_005220.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943072.

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the M RNA segment of Uukuniemi virus encoding the membrane glycoproteins G1 and G2."
    Ronnholm R., Pettersson R.F.
    Virology 160:191-202(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 18-29 AND 514-525.
  2. "Processing and membrane topology of the spike proteins G1 and G2 of Uukuniemi virus."
    Andersson A.M., Melin L., Persson R., Raschperger E., Wikstrom L., Pettersson R.F.
    J. Virol. 71:218-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION, TOPOLOGY.

Entry informationi

Entry nameiGP_UUKS
AccessioniPrimary (citable) accession number: P09613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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