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P09613

- GP_UUKS

UniProt

P09613 - GP_UUKS

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Protein

Envelope glycoprotein

Gene

GP

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei513 – 5142Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiUukuniemi virus (strain S23) (Uuk)
Taxonomic identifieri487099 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]
ProteomesiUP000008595: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 1008991Envelope glycoproteinPRO_0000232521Add
BLAST
Chaini18 – 496479Glycoprotein G1Sequence AnalysisPRO_0000036853Add
BLAST
Propeptidei497 – 513171 PublicationPRO_0000036854Add
BLAST
Chaini514 – 1008495Glycoprotein G2Sequence AnalysisPRO_0000036855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi70 – 701N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi691 – 6911N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi696 – 6961N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi912 – 9121N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi949 – 9491N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Glycoprotein G1 and glycoprotein G2 are palmitoylated.1 Publication
Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 394377LumenalSequence AnalysisAdd
BLAST
Topological domaini416 – 49681Cytoplasmic1 PublicationAdd
BLAST
Topological domaini497 – 977481LumenalSequence AnalysisAdd
BLAST
Topological domaini989 – 100820CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei978 – 98811HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09613-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRTYLLLLL LCGPATPFFN HLMDVTRRLL DSSNATWQRD QPDTHRLSRL
60 70 80 90 100
DAHVMSMLGV GSHIDEVSVN HSQHLHNFRS YNCEEGRRTL TMMDPKSGKF
110 120 130 140 150
KRLKCNENQT LSKDCASCIE KKSSIMKSEH LVYDDAICQS DYSSPEAMPD
160 170 180 190 200
HETHLCRIGP LHIQHCTHEA KRVQHVSWFW IDGKLRVYDD FSVSWTEGKF
210 220 230 240 250
LSLFDCLNET SKDHNCNKAV CLEGRCSGDL QFCTEFTCSY AKADCNCKRN
260 270 280 290 300
QVSGVAVVHT KHGSFMPECM GQSLWSVRKP LSKRSVTVQQ PCMDCESDCK
310 320 330 340 350
VDHILVIVRH FYPDHYQACL GSTCLTGRAK DKEFKIPFKM ADRLSDSHFE
360 370 380 390 400
IRIWDKERSN EYFLESRCES VDACAAITCW FCRANWANIH CFSKEQVLIL
410 420 430 440 450
VAVSSLCILL LASVLRALKV IATFTWKIIK PFWWILSLLC RTCSKRLNKR
460 470 480 490 500
AERLKESIHS LEEGLNNVDE GPREQNNPAR AVARPNVRQK MFNLTRLSPV
510 520 530 540 550
VVGMLCLACP VESCSDSISV TASSQRCSTS SDGVNSCFVS TSSLLQVSPK
560 570 580 590 600
GQESCLILKG PTGTAVDSIR IKTTDIKLEC VRRDLYWVPR VTHRCIGTRR
610 620 630 640 650
CHLMGACKGE ACSEFKINDY SPEWGHEEEL MAQLGWSYCV EQCGGALCQC
660 670 680 690 700
FNMRPSCFYL RKTFSHLSQD AFNIYECSEW SYRINVLVST NSTHSNLTLK
710 720 730 740 750
LGVPDSIPHG LISLSSVSQP PAIAYSECFG EDLHGTKFHT VCNRRTDYTL
760 770 780 790 800
GRIGEIQCPT KADALAVSKR CISSDSIIFS KVHKDSVDCQ SSIIDPMTIR
810 820 830 840 850
NRNKLPSTVG SVTFWPTETS VEAAIPDLAS ATMLIRLDGY TIQFRSDSNK
860 870 880 890 900
CSPRFLSLSG CYNCEAGAKL ELEHVTDFGT ALGILECPSL GYTTYYEVKN
910 920 930 940 950
TLEKSIRTMH LNGSHVEAKC YFRCPNSESQ LTIRGELIYL FNDDIRHHNQ
960 970 980 990 1000
TLSPGLSPKS GSGWDPFGWF KASWLRAIWA ILGGTVSLII GVVIIYMVFT

LCLKVKKS
Length:1,008
Mass (Da):113,589
Last modified:November 1, 1995 - v2
Checksum:iF557C06D8DB77E32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1.
PIRiA28502. GNVUUK.
RefSeqiNP_941979.1. NC_005220.1.

Genome annotation databases

GeneIDi2943072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17417 Genomic RNA. Translation: AAA79512.1 .
PIRi A28502. GNVUUK.
RefSeqi NP_941979.1. NC_005220.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943072.

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the M RNA segment of Uukuniemi virus encoding the membrane glycoproteins G1 and G2."
    Ronnholm R., Pettersson R.F.
    Virology 160:191-202(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 18-29 AND 514-525.
  2. "Processing and membrane topology of the spike proteins G1 and G2 of Uukuniemi virus."
    Andersson A.M., Melin L., Persson R., Raschperger E., Wikstrom L., Pettersson R.F.
    J. Virol. 71:218-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION, TOPOLOGY.

Entry informationi

Entry nameiGP_UUKS
AccessioniPrimary (citable) accession number: P09613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3