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P09613 (GP_UUKS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein
Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismUukuniemi virus (strain S23) (Uuk) [Reference proteome]
Taxonomic identifier487099 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Bunyaviridae › Phlebovirus ›
Virus hostHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]

Protein attributes

Sequence length1008 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Glycoprotein G1 and glycoprotein G2 are palmitoylated. Ref.2

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the phlebovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.1
Chain18 – 1008991Envelope glycoprotein
PRO_0000232521
Chain18 – 496479Glycoprotein G1 Potential
PRO_0000036853
Propeptide497 – 51317
PRO_0000036854
Chain514 – 1008495Glycoprotein G2 Potential
PRO_0000036855

Regions

Topological domain18 – 394377Lumenal Potential
Transmembrane395 – 41521Helical; Potential
Topological domain416 – 49681Cytoplasmic Ref.2
Topological domain497 – 977481Lumenal Potential
Transmembrane978 – 98811Helical; Potential
Topological domain989 – 100820Cytoplasmic Potential

Sites

Site513 – 5142Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation341N-linked (GlcNAc...); by host Potential
Glycosylation701N-linked (GlcNAc...); by host Potential
Glycosylation1081N-linked (GlcNAc...); by host Potential
Glycosylation2081N-linked (GlcNAc...); by host Potential
Glycosylation6911N-linked (GlcNAc...); by host Potential
Glycosylation6961N-linked (GlcNAc...); by host Potential
Glycosylation9121N-linked (GlcNAc...); by host Potential
Glycosylation9491N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P09613 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: F557C06D8DB77E32

FASTA1,008113,589
        10         20         30         40         50         60 
MVRTYLLLLL LCGPATPFFN HLMDVTRRLL DSSNATWQRD QPDTHRLSRL DAHVMSMLGV 

        70         80         90        100        110        120 
GSHIDEVSVN HSQHLHNFRS YNCEEGRRTL TMMDPKSGKF KRLKCNENQT LSKDCASCIE 

       130        140        150        160        170        180 
KKSSIMKSEH LVYDDAICQS DYSSPEAMPD HETHLCRIGP LHIQHCTHEA KRVQHVSWFW 

       190        200        210        220        230        240 
IDGKLRVYDD FSVSWTEGKF LSLFDCLNET SKDHNCNKAV CLEGRCSGDL QFCTEFTCSY 

       250        260        270        280        290        300 
AKADCNCKRN QVSGVAVVHT KHGSFMPECM GQSLWSVRKP LSKRSVTVQQ PCMDCESDCK 

       310        320        330        340        350        360 
VDHILVIVRH FYPDHYQACL GSTCLTGRAK DKEFKIPFKM ADRLSDSHFE IRIWDKERSN 

       370        380        390        400        410        420 
EYFLESRCES VDACAAITCW FCRANWANIH CFSKEQVLIL VAVSSLCILL LASVLRALKV 

       430        440        450        460        470        480 
IATFTWKIIK PFWWILSLLC RTCSKRLNKR AERLKESIHS LEEGLNNVDE GPREQNNPAR 

       490        500        510        520        530        540 
AVARPNVRQK MFNLTRLSPV VVGMLCLACP VESCSDSISV TASSQRCSTS SDGVNSCFVS 

       550        560        570        580        590        600 
TSSLLQVSPK GQESCLILKG PTGTAVDSIR IKTTDIKLEC VRRDLYWVPR VTHRCIGTRR 

       610        620        630        640        650        660 
CHLMGACKGE ACSEFKINDY SPEWGHEEEL MAQLGWSYCV EQCGGALCQC FNMRPSCFYL 

       670        680        690        700        710        720 
RKTFSHLSQD AFNIYECSEW SYRINVLVST NSTHSNLTLK LGVPDSIPHG LISLSSVSQP 

       730        740        750        760        770        780 
PAIAYSECFG EDLHGTKFHT VCNRRTDYTL GRIGEIQCPT KADALAVSKR CISSDSIIFS 

       790        800        810        820        830        840 
KVHKDSVDCQ SSIIDPMTIR NRNKLPSTVG SVTFWPTETS VEAAIPDLAS ATMLIRLDGY 

       850        860        870        880        890        900 
TIQFRSDSNK CSPRFLSLSG CYNCEAGAKL ELEHVTDFGT ALGILECPSL GYTTYYEVKN 

       910        920        930        940        950        960 
TLEKSIRTMH LNGSHVEAKC YFRCPNSESQ LTIRGELIYL FNDDIRHHNQ TLSPGLSPKS 

       970        980        990       1000 
GSGWDPFGWF KASWLRAIWA ILGGTVSLII GVVIIYMVFT LCLKVKKS

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References

[1]"Complete nucleotide sequence of the M RNA segment of Uukuniemi virus encoding the membrane glycoproteins G1 and G2."
Ronnholm R., Pettersson R.F.
Virology 160:191-202(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 18-29 AND 514-525.
[2]"Processing and membrane topology of the spike proteins G1 and G2 of Uukuniemi virus."
Andersson A.M., Melin L., Persson R., Raschperger E., Wikstrom L., Pettersson R.F.
J. Virol. 71:218-225(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION, TOPOLOGY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M17417 Genomic RNA. Translation: AAA79512.1.
PIRGNVUUK. A28502.
RefSeqNP_941979.1. NC_005220.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943072.

Family and domain databases

InterProIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
[Graphical view]
PfamPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
[Graphical view]
PIRSFPIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_UUKS
AccessionPrimary (citable) accession number: P09613
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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