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P09613

- GP_UUKS

UniProt

P09613 - GP_UUKS

Protein

Envelope glycoprotein

Gene

GP

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei513 – 5142Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiUukuniemi virus (strain S23) (Uuk)
    Taxonomic identifieri487099 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Ixodes ricinus (Common tick) [TaxID: 34613]
    ProteomesiUP000008595: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 1008991Envelope glycoproteinPRO_0000232521Add
    BLAST
    Chaini18 – 496479Glycoprotein G1Sequence AnalysisPRO_0000036853Add
    BLAST
    Propeptidei497 – 513171 PublicationPRO_0000036854Add
    BLAST
    Chaini514 – 1008495Glycoprotein G2Sequence AnalysisPRO_0000036855Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi70 – 701N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi691 – 6911N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi696 – 6961N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi912 – 9121N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi949 – 9491N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Glycoprotein G1 and glycoprotein G2 are palmitoylated.1 Publication
    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 394377LumenalSequence AnalysisAdd
    BLAST
    Topological domaini416 – 49681Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini497 – 977481LumenalSequence AnalysisAdd
    BLAST
    Topological domaini989 – 100820CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei978 – 98811HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    [Graphical view]
    PfamiPF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09613-1 [UniParc]FASTAAdd to Basket

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    MVRTYLLLLL LCGPATPFFN HLMDVTRRLL DSSNATWQRD QPDTHRLSRL     50
    DAHVMSMLGV GSHIDEVSVN HSQHLHNFRS YNCEEGRRTL TMMDPKSGKF 100
    KRLKCNENQT LSKDCASCIE KKSSIMKSEH LVYDDAICQS DYSSPEAMPD 150
    HETHLCRIGP LHIQHCTHEA KRVQHVSWFW IDGKLRVYDD FSVSWTEGKF 200
    LSLFDCLNET SKDHNCNKAV CLEGRCSGDL QFCTEFTCSY AKADCNCKRN 250
    QVSGVAVVHT KHGSFMPECM GQSLWSVRKP LSKRSVTVQQ PCMDCESDCK 300
    VDHILVIVRH FYPDHYQACL GSTCLTGRAK DKEFKIPFKM ADRLSDSHFE 350
    IRIWDKERSN EYFLESRCES VDACAAITCW FCRANWANIH CFSKEQVLIL 400
    VAVSSLCILL LASVLRALKV IATFTWKIIK PFWWILSLLC RTCSKRLNKR 450
    AERLKESIHS LEEGLNNVDE GPREQNNPAR AVARPNVRQK MFNLTRLSPV 500
    VVGMLCLACP VESCSDSISV TASSQRCSTS SDGVNSCFVS TSSLLQVSPK 550
    GQESCLILKG PTGTAVDSIR IKTTDIKLEC VRRDLYWVPR VTHRCIGTRR 600
    CHLMGACKGE ACSEFKINDY SPEWGHEEEL MAQLGWSYCV EQCGGALCQC 650
    FNMRPSCFYL RKTFSHLSQD AFNIYECSEW SYRINVLVST NSTHSNLTLK 700
    LGVPDSIPHG LISLSSVSQP PAIAYSECFG EDLHGTKFHT VCNRRTDYTL 750
    GRIGEIQCPT KADALAVSKR CISSDSIIFS KVHKDSVDCQ SSIIDPMTIR 800
    NRNKLPSTVG SVTFWPTETS VEAAIPDLAS ATMLIRLDGY TIQFRSDSNK 850
    CSPRFLSLSG CYNCEAGAKL ELEHVTDFGT ALGILECPSL GYTTYYEVKN 900
    TLEKSIRTMH LNGSHVEAKC YFRCPNSESQ LTIRGELIYL FNDDIRHHNQ 950
    TLSPGLSPKS GSGWDPFGWF KASWLRAIWA ILGGTVSLII GVVIIYMVFT 1000
    LCLKVKKS 1008
    Length:1,008
    Mass (Da):113,589
    Last modified:November 1, 1995 - v2
    Checksum:iF557C06D8DB77E32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17417 Genomic RNA. Translation: AAA79512.1.
    PIRiA28502. GNVUUK.
    RefSeqiNP_941979.1. NC_005220.1.

    Genome annotation databases

    GeneIDi2943072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17417 Genomic RNA. Translation: AAA79512.1 .
    PIRi A28502. GNVUUK.
    RefSeqi NP_941979.1. NC_005220.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943072.

    Family and domain databases

    InterProi IPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    [Graphical view ]
    Pfami PF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the M RNA segment of Uukuniemi virus encoding the membrane glycoproteins G1 and G2."
      Ronnholm R., Pettersson R.F.
      Virology 160:191-202(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 18-29 AND 514-525.
    2. "Processing and membrane topology of the spike proteins G1 and G2 of Uukuniemi virus."
      Andersson A.M., Melin L., Persson R., Raschperger E., Wikstrom L., Pettersson R.F.
      J. Virol. 71:218-225(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION, TOPOLOGY.

    Entry informationi

    Entry nameiGP_UUKS
    AccessioniPrimary (citable) accession number: P09613
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3