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P09612

- GP_BUNL7

UniProt

P09612 - GP_BUNL7

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Protein
Envelope glycoprotein
Gene
GP
Organism
Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei473 – 4742Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
Taxonomic identifieri11578 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 200187Lumenal Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 30584Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Topological domaini327 – 36539Lumenal Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Topological domaini387 – 45266Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST
Topological domaini474 – 1395922Lumenal Reviewed prediction
Add
BLAST
Transmembranei1396 – 141621Helical; Reviewed prediction
Add
BLAST
Topological domaini1417 – 144125Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313 Reviewed prediction
Add
BLAST
Chaini14 – 14411428Envelope glycoprotein
PRO_0000036790Add
BLAST
Chaini22 – 299278Glycoprotein G2 By similarity
PRO_0000036791Add
BLAST
Chaini300 – 473174Non-structural protein NSm By similarity
PRO_0000036792Add
BLAST
Chaini474 – 1441968Glycoprotein G1 By similarity
PRO_0000036793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1177 – 11771N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09612-1 [UniParc]FASTAAdd to Basket

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MIRMLVLIVV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT     50
EARYVKNATG VFSNNVAIRK WLVSDWHDCR PKKIVGGHIN VIEVGDDLSL 100
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTTVK SGWFKSTTYI 150
TLDQTCEHLK VSCAPKSVQF HACFNQHMSC VRFLHRTILP GSIANSICQN 200
IEIIILVTLT LLIFILLSIL SKTYICYLLM PIFIPIAYMY GVIYNKSCKK 250
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 300
MCKSKGPASI LSIITAVLVL TFVTPINSMV LGESKETFEL EELPDDMLEM 350
ALRINSYYFT CILNYAVSWG LIIAGLLVGL IFKKYQHRFL NIYAMYCEEC 400
NMYHDKSGLK RHGDFTNKCR QCTCGQYEDA TGLITHRKTY NCLVQYKAKW 450
MMNFLIIYIF LILIKDSAIV GQATGTDFTT CLETESINWN CTGPFLNLGN 500
CQKQQKKEPY TNIATQLKGL KAISVLDIPI ITSIPDDIAG ALRYIEEKED 550
FHVQLTTEYA MLSKYCDYYT QFSDNSGYSQ TTWRVYLRSH DFEACILYPN 600
QHFCKCVKNG EKCSSSNWDF ANGMKNYYSG KQAKFDKDLN LALTALHHAF 650
RGTSSAYIAA MLSKKSNDDL IAYTNKIKAK FPGNALLKAI IDYIAYMKGL 700
PEMANFKYDE FWDELLYKPN PAKASNLARG KESSYNFKLA ISSKSIKTCK 750
NVKDVACLSP RSGAIYSSII ACGEPNGPSV YRKPSGGVFQ SSTDRSIYCL 800
LDSHCLEEFE AISQEELDAV KKSKCWEIEY PDVRPLQESD GAKSCRMKDS 850
GNCNVATNRW PVMQCENDKF YYSELQKDYD KTQDIGHYCL SPGCTTIRYP 900
INPKHISNCN WQVSRSSIAK IDVHNVEDIE QYKKAITQKL QTSLSLFKYA 950
KTKNLPHIRP IYKYITMKET ETAEGIESAY IESEVPALAG TSVGFKINSK 1000
EGKHLLDVIA YVKSASYSSV YAKLYSTGPT SGINTKHDEL CTGPCPANIN 1050
HQVGWLTFAR ERTSSWGCEE FGCLAVSDGC VFGSCQDIIK EELSVYRKET 1100
EEVTNVELCL TFSDKTYCTN LNPVTPIITD LFEVQFKTVE TYSLPRIVAV 1150
QNHEIKIGQI NDLGVYSKGC GNVQKVNGTV YGNGVPRFDY LCHLASRKEV 1200
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTIIDYKKIL GTIKMKAILG 1250
DVKYKTFADS VDITAEGSCA GCINCFQNIH CELTLHTTIE ASCPIKSSCT 1300
VFHDRILVTP NEHKYALKIV CTEKPGNTLT IKVCNTRIEA SMALVDAKPI 1350
IELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY 1400
TFIISIIALL VIIYVLLPIC FKLRDTLRKH DDAYKREMKI R 1441
Length:1,441
Mass (Da):162,541
Last modified:February 1, 1996 - v3
Checksum:i50973CE30973C55B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401C → S1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10370 Genomic RNA. Translation: BAA01201.1.
J02231 Genomic RNA. No translation available.
PIRiA29377. GNVULC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10370 Genomic RNA. Translation: BAA01201.1 .
J02231 Genomic RNA. No translation available.
PIRi A29377. GNVULC.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The sequence of the M RNA of an isolate of La Crosse virus."
    Grady L.J., Sanders M.L., Campbell W.P.
    J. Gen. Virol. 68:3057-3071(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
    Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
    J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.

Entry informationi

Entry nameiGP_BUNL7
AccessioniPrimary (citable) accession number: P09612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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