Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09612

- GP_BUNL7

UniProt

P09612 - GP_BUNL7

Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei473 – 4742Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. modulation by virus of host morphology or physiology Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiBunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
    Taxonomic identifieri11578 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCervidae (deer) [TaxID: 9850]
    Homo sapiens (Human) [TaxID: 9606]
    Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
    Tamias [TaxID: 13712]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.By similarity
    Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
    Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1313Sequence AnalysisAdd
    BLAST
    Chaini14 – 14411428Envelope glycoproteinPRO_0000036790Add
    BLAST
    Chaini22 – 299278Glycoprotein G2By similarityPRO_0000036791Add
    BLAST
    Chaini300 – 473174Non-structural protein NSmBy similarityPRO_0000036792Add
    BLAST
    Chaini474 – 1441968Glycoprotein G1By similarityPRO_0000036793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1177 – 11771N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini14 – 200187LumenalSequence AnalysisAdd
    BLAST
    Topological domaini222 – 30584CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 36539LumenalSequence AnalysisAdd
    BLAST
    Topological domaini387 – 45266CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini474 – 1395922LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1417 – 144125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1396 – 141621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view]
    PfamiPF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09612-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRMLVLIVV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT     50
    EARYVKNATG VFSNNVAIRK WLVSDWHDCR PKKIVGGHIN VIEVGDDLSL 100
    HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTTVK SGWFKSTTYI 150
    TLDQTCEHLK VSCAPKSVQF HACFNQHMSC VRFLHRTILP GSIANSICQN 200
    IEIIILVTLT LLIFILLSIL SKTYICYLLM PIFIPIAYMY GVIYNKSCKK 250
    CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 300
    MCKSKGPASI LSIITAVLVL TFVTPINSMV LGESKETFEL EELPDDMLEM 350
    ALRINSYYFT CILNYAVSWG LIIAGLLVGL IFKKYQHRFL NIYAMYCEEC 400
    NMYHDKSGLK RHGDFTNKCR QCTCGQYEDA TGLITHRKTY NCLVQYKAKW 450
    MMNFLIIYIF LILIKDSAIV GQATGTDFTT CLETESINWN CTGPFLNLGN 500
    CQKQQKKEPY TNIATQLKGL KAISVLDIPI ITSIPDDIAG ALRYIEEKED 550
    FHVQLTTEYA MLSKYCDYYT QFSDNSGYSQ TTWRVYLRSH DFEACILYPN 600
    QHFCKCVKNG EKCSSSNWDF ANGMKNYYSG KQAKFDKDLN LALTALHHAF 650
    RGTSSAYIAA MLSKKSNDDL IAYTNKIKAK FPGNALLKAI IDYIAYMKGL 700
    PEMANFKYDE FWDELLYKPN PAKASNLARG KESSYNFKLA ISSKSIKTCK 750
    NVKDVACLSP RSGAIYSSII ACGEPNGPSV YRKPSGGVFQ SSTDRSIYCL 800
    LDSHCLEEFE AISQEELDAV KKSKCWEIEY PDVRPLQESD GAKSCRMKDS 850
    GNCNVATNRW PVMQCENDKF YYSELQKDYD KTQDIGHYCL SPGCTTIRYP 900
    INPKHISNCN WQVSRSSIAK IDVHNVEDIE QYKKAITQKL QTSLSLFKYA 950
    KTKNLPHIRP IYKYITMKET ETAEGIESAY IESEVPALAG TSVGFKINSK 1000
    EGKHLLDVIA YVKSASYSSV YAKLYSTGPT SGINTKHDEL CTGPCPANIN 1050
    HQVGWLTFAR ERTSSWGCEE FGCLAVSDGC VFGSCQDIIK EELSVYRKET 1100
    EEVTNVELCL TFSDKTYCTN LNPVTPIITD LFEVQFKTVE TYSLPRIVAV 1150
    QNHEIKIGQI NDLGVYSKGC GNVQKVNGTV YGNGVPRFDY LCHLASRKEV 1200
    IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTIIDYKKIL GTIKMKAILG 1250
    DVKYKTFADS VDITAEGSCA GCINCFQNIH CELTLHTTIE ASCPIKSSCT 1300
    VFHDRILVTP NEHKYALKIV CTEKPGNTLT IKVCNTRIEA SMALVDAKPI 1350
    IELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY 1400
    TFIISIIALL VIIYVLLPIC FKLRDTLRKH DDAYKREMKI R 1441
    Length:1,441
    Mass (Da):162,541
    Last modified:February 1, 1996 - v3
    Checksum:i50973CE30973C55B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401C → S(PubMed:7086954)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10370 Genomic RNA. Translation: BAA01201.1.
    J02231 Genomic RNA. No translation available.
    PIRiA29377. GNVULC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10370 Genomic RNA. Translation: BAA01201.1 .
    J02231 Genomic RNA. No translation available.
    PIRi A29377. GNVULC.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view ]
    Pfami PF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the M RNA of an isolate of La Crosse virus."
      Grady L.J., Sanders M.L., Campbell W.P.
      J. Gen. Virol. 68:3057-3071(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
      Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
      J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.

    Entry informationi

    Entry nameiGP_BUNL7
    AccessioniPrimary (citable) accession number: P09612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3