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Protein

Non-histone chromosomal protein HMG-17

Gene

Hmgn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:Hmgn2
Synonyms:Hmg-17, Hmg17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 4, Chromosome 8

Organism-specific databases

MGIiMGI:96136. Hmgn2.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Cytoplasmic enrichment upon phosphorylation.By similarity

GO - Cellular componenti

  1. chromatin Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei82 – 821N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP09602.
PaxDbiP09602.
PRIDEiP09602.

PTM databases

PhosphoSiteiP09602.

Expressioni

Gene expression databases

BgeeiP09602.
CleanExiMM_HMGN2.
ExpressionAtlasiP09602. baseline and differential.
GenevestigatoriP09602.

Interactioni

Protein-protein interaction databases

IntActiP09602. 1 interaction.
MINTiMINT-4097504.

Structurei

3D structure databases

ProteinModelPortaliP09602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiNOG44189.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP09602.
KOiK11300.
OMAiDVKASHE.
OrthoDBiEOG7FNCBN.
PhylomeDBiP09602.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAEGDA KGDKTKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKDANNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,423
Last modified:January 22, 2007 - v2
Checksum:iB614F853310532D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA. Translation: CAA31404.1.
AK002374 mRNA. Translation: BAB22051.1.
AK078413 mRNA. Translation: BAC37262.1.
BC084680 mRNA. Translation: AAH84680.1.
CCDSiCCDS18759.1.
PIRiS01946.
RefSeqiNP_058653.1. NM_016957.3.
UniGeneiMm.319660.

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713.
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038.
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038.
GeneIDi15331.
KEGGimmu:15331.
UCSCiuc008vdq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA. Translation: CAA31404.1.
AK002374 mRNA. Translation: BAB22051.1.
AK078413 mRNA. Translation: BAC37262.1.
BC084680 mRNA. Translation: AAH84680.1.
CCDSiCCDS18759.1.
PIRiS01946.
RefSeqiNP_058653.1. NM_016957.3.
UniGeneiMm.319660.

3D structure databases

ProteinModelPortaliP09602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09602. 1 interaction.
MINTiMINT-4097504.

PTM databases

PhosphoSiteiP09602.

Proteomic databases

MaxQBiP09602.
PaxDbiP09602.
PRIDEiP09602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713.
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038.
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038.
GeneIDi15331.
KEGGimmu:15331.
UCSCiuc008vdq.1. mouse.

Organism-specific databases

CTDi3151.
MGIiMGI:96136. Hmgn2.

Phylogenomic databases

eggNOGiNOG44189.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP09602.
KOiK11300.
OMAiDVKASHE.
OrthoDBiEOG7FNCBN.
PhylomeDBiP09602.

Miscellaneous databases

NextBioi287955.
PROiP09602.
SOURCEiSearch...

Gene expression databases

BgeeiP09602.
CleanExiMM_HMGN2.
ExpressionAtlasiP09602. baseline and differential.
GenevestigatoriP09602.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse non-histone chromosomal protein HMG-17 cDNA sequence."
    Landsman D., Zavou S., Soares N., Goodwin G.H., Bustin M.
    Nucleic Acids Res. 16:10386-10386(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells."
    Vartiainen E., Palvimo J., Mahonen A., Linnala-Kankkunen A., Maeenpaeae P.H.
    FEBS Lett. 228:45-48(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHMGN2_MOUSE
AccessioniPrimary (citable) accession number: P09602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1989
Last sequence update: January 22, 2007
Last modified: March 3, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.