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Protein

Non-histone chromosomal protein HMG-17

Gene

Hmgn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of development, heterochronic Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:Hmgn2
Synonyms:Hmg-17, Hmg17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 4, Chromosome 8

Organism-specific databases

MGIiMGI:96136. Hmgn2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Cytoplasmic enrichment upon phosphorylation.By similarity

GO - Cellular componenti

  • chromatin Source: InterPro
  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: MGI

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066982 – 90Non-histone chromosomal protein HMG-17Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Modified residuei29ADP-ribosylserine; alternateBy similarity1
Modified residuei29Phosphoserine; alternateBy similarity1
Modified residuei82N6-acetyllysine; alternateCombined sources1
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09602.
PaxDbiP09602.
PRIDEiP09602.

PTM databases

iPTMnetiP09602.
PhosphoSitePlusiP09602.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003038.
CleanExiMM_HMGN2.
ExpressionAtlasiP09602. baseline and differential.
GenevisibleiP09602. MM.

Interactioni

Protein-protein interaction databases

IntActiP09602. 1 interactor.
MINTiMINT-4097504.
STRINGi10090.ENSMUSP00000099612.

Structurei

3D structure databases

ProteinModelPortaliP09602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP09602.
KOiK11300.
OMAiSARLSAX.
PhylomeDBiP09602.

Family and domain databases

InterProiView protein in InterPro
IPR000079. HMGN_fam.
PfamiView protein in Pfam
PF01101. HMG14_17. 1 hit.
PRINTSiPR00925. NONHISHMG17.
SMARTiView protein in SMART
SM00527. HMG17. 1 hit.
PROSITEiView protein in PROSITE
PS00355. HMG14_17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAEGDA KGDKTKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKDANNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,423
Last modified:January 23, 2007 - v2
Checksum:iB614F853310532D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA. Translation: CAA31404.1.
AK002374 mRNA. Translation: BAB22051.1.
AK078413 mRNA. Translation: BAC37262.1.
BC084680 mRNA. Translation: AAH84680.1.
CCDSiCCDS18759.1.
PIRiS01946.
RefSeqiNP_058653.1. NM_016957.3.
UniGeneiMm.319660.

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713.
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038.
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038.
GeneIDi15331.
KEGGimmu:15331.
UCSCiuc008vdq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12944 mRNA. Translation: CAA31404.1.
AK002374 mRNA. Translation: BAB22051.1.
AK078413 mRNA. Translation: BAC37262.1.
BC084680 mRNA. Translation: AAH84680.1.
CCDSiCCDS18759.1.
PIRiS01946.
RefSeqiNP_058653.1. NM_016957.3.
UniGeneiMm.319660.

3D structure databases

ProteinModelPortaliP09602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09602. 1 interactor.
MINTiMINT-4097504.
STRINGi10090.ENSMUSP00000099612.

PTM databases

iPTMnetiP09602.
PhosphoSitePlusiP09602.

Proteomic databases

EPDiP09602.
PaxDbiP09602.
PRIDEiP09602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713.
ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038.
ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038.
GeneIDi15331.
KEGGimmu:15331.
UCSCiuc008vdq.1. mouse.

Organism-specific databases

CTDi3151.
MGIiMGI:96136. Hmgn2.

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP09602.
KOiK11300.
OMAiSARLSAX.
PhylomeDBiP09602.

Miscellaneous databases

PROiPR:P09602.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003038.
CleanExiMM_HMGN2.
ExpressionAtlasiP09602. baseline and differential.
GenevisibleiP09602. MM.

Family and domain databases

InterProiView protein in InterPro
IPR000079. HMGN_fam.
PfamiView protein in Pfam
PF01101. HMG14_17. 1 hit.
PRINTSiPR00925. NONHISHMG17.
SMARTiView protein in SMART
SM00527. HMG17. 1 hit.
PROSITEiView protein in PROSITE
PS00355. HMG14_17. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN2_MOUSE
AccessioniPrimary (citable) accession number: P09602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.