Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09602

- HMGN2_MOUSE

UniProt

P09602 - HMGN2_MOUSE

Protein

Non-histone chromosomal protein HMG-17

Gene

Hmgn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-histone chromosomal protein HMG-17
    Alternative name(s):
    High mobility group nucleosome-binding domain-containing protein 2
    Gene namesi
    Name:Hmgn2
    Synonyms:Hmg-17, Hmg17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:96136. Hmgn2.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Cytoplasmic enrichment upon phosphorylation.By similarity

    GO - Cellular componenti

    1. chromatin Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251PhosphoserineBy similarity
    Modified residuei29 – 291PhosphoserineBy similarity
    Modified residuei82 – 821N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylation favors cytoplasmic localization.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP09602.
    PaxDbiP09602.
    PRIDEiP09602.

    PTM databases

    PhosphoSiteiP09602.

    Expressioni

    Gene expression databases

    BgeeiP09602.
    CleanExiMM_HMGN2.
    GenevestigatoriP09602.

    Interactioni

    Protein-protein interaction databases

    IntActiP09602. 1 interaction.
    MINTiMINT-4097504.

    Structurei

    3D structure databases

    ProteinModelPortaliP09602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGN family.Curated

    Phylogenomic databases

    eggNOGiNOG44189.
    HOGENOMiHOG000116395.
    HOVERGENiHBG073479.
    KOiK11300.
    OMAiSARLSAX.
    OrthoDBiEOG7FNCBN.
    PhylomeDBiP09602.

    Family and domain databases

    InterProiIPR000079. HMGN_fam.
    [Graphical view]
    PANTHERiPTHR23087. PTHR23087. 1 hit.
    PfamiPF01101. HMG14_17. 1 hit.
    [Graphical view]
    PRINTSiPR00925. NONHISHMG17.
    SMARTiSM00527. HMG17. 1 hit.
    [Graphical view]
    PROSITEiPS00355. HMG14_17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKRKAEGDA KGDKTKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE   50
    KVPKGKKGKA DAGKDANNPA ENGDAKTDQA QKAEGAGDAK 90
    Length:90
    Mass (Da):9,423
    Last modified:January 23, 2007 - v2
    Checksum:iB614F853310532D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12944 mRNA. Translation: CAA31404.1.
    AK002374 mRNA. Translation: BAB22051.1.
    AK078413 mRNA. Translation: BAC37262.1.
    BC084680 mRNA. Translation: AAH84680.1.
    CCDSiCCDS18759.1.
    PIRiS01946.
    RefSeqiNP_058653.1. NM_016957.3.
    UniGeneiMm.319660.

    Genome annotation databases

    EnsembliENSMUST00000075602; ENSMUSP00000075031; ENSMUSG00000070713.
    ENSMUST00000102552; ENSMUSP00000099612; ENSMUSG00000003038.
    ENSMUST00000102553; ENSMUSP00000099613; ENSMUSG00000003038.
    GeneIDi15331.
    KEGGimmu:15331.
    UCSCiuc008vdq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12944 mRNA. Translation: CAA31404.1 .
    AK002374 mRNA. Translation: BAB22051.1 .
    AK078413 mRNA. Translation: BAC37262.1 .
    BC084680 mRNA. Translation: AAH84680.1 .
    CCDSi CCDS18759.1.
    PIRi S01946.
    RefSeqi NP_058653.1. NM_016957.3.
    UniGenei Mm.319660.

    3D structure databases

    ProteinModelPortali P09602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P09602. 1 interaction.
    MINTi MINT-4097504.

    PTM databases

    PhosphoSitei P09602.

    Proteomic databases

    MaxQBi P09602.
    PaxDbi P09602.
    PRIDEi P09602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075602 ; ENSMUSP00000075031 ; ENSMUSG00000070713 .
    ENSMUST00000102552 ; ENSMUSP00000099612 ; ENSMUSG00000003038 .
    ENSMUST00000102553 ; ENSMUSP00000099613 ; ENSMUSG00000003038 .
    GeneIDi 15331.
    KEGGi mmu:15331.
    UCSCi uc008vdq.1. mouse.

    Organism-specific databases

    CTDi 3151.
    MGIi MGI:96136. Hmgn2.

    Phylogenomic databases

    eggNOGi NOG44189.
    HOGENOMi HOG000116395.
    HOVERGENi HBG073479.
    KOi K11300.
    OMAi SARLSAX.
    OrthoDBi EOG7FNCBN.
    PhylomeDBi P09602.

    Miscellaneous databases

    NextBioi 287955.
    PROi P09602.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09602.
    CleanExi MM_HMGN2.
    Genevestigatori P09602.

    Family and domain databases

    InterProi IPR000079. HMGN_fam.
    [Graphical view ]
    PANTHERi PTHR23087. PTHR23087. 1 hit.
    Pfami PF01101. HMG14_17. 1 hit.
    [Graphical view ]
    PRINTSi PR00925. NONHISHMG17.
    SMARTi SM00527. HMG17. 1 hit.
    [Graphical view ]
    PROSITEi PS00355. HMG14_17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse non-histone chromosomal protein HMG-17 cDNA sequence."
      Landsman D., Zavou S., Soares N., Goodwin G.H., Bustin M.
      Nucleic Acids Res. 16:10386-10386(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    4. "Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells."
      Vartiainen E., Palvimo J., Mahonen A., Linnala-Kankkunen A., Maeenpaeae P.H.
      FEBS Lett. 228:45-48(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiHMGN2_MOUSE
    AccessioniPrimary (citable) accession number: P09602
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3