Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone H2A

Gene

his-3

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • DNA repair Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-2299718. Condensation of Prophase Chromosomes.
R-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-3214858. RMTs methylate histone arginines.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:his-3
ORF Names:T10C6.12
AND
Name:his-7
ORF Names:F45F2.4
AND
Name:his-12
ORF Names:ZK131.6
AND
Name:his-16
ORF Names:ZK131.10
AND
Name:his-19
ORF Names:K06C4.11
AND
Name:his-21
ORF Names:K06C4.3
AND
Name:his-30
ORF Names:F35H10.1
AND
Name:his-33
ORF Names:F17E9.13
AND
Name:his-43
ORF Names:F08G2.2
AND
Name:his-47
ORF Names:B0035.7
AND
Name:his-51
ORF Names:F07B7.10
AND
Name:his-53
ORF Names:F07B7.3
AND
Name:his-57
ORF Names:F54E12.5
AND
Name:his-61
ORF Names:F55G1.10
AND
Name:his-65
ORF Names:H02I12.7
AND
Name:his-68
ORF Names:T23D8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

WormBaseiB0035.7; CE04501; WBGene00001921; his-47.
F07B7.10; CE04501; WBGene00001925; his-51.
F07B7.3; CE04501; WBGene00001927; his-53.
F08G2.2; CE04501; WBGene00001917; his-43.
F17E9.13; CE04501; WBGene00001907; his-33.
F35H10.1; CE04501; WBGene00001904; his-30.
F45F2.4; CE04501; WBGene00001881; his-7.
F54E12.5; CE04501; WBGene00001931; his-57.
F55G1.10; CE04501; WBGene00001935; his-61.
H02I12.7; CE04501; WBGene00001939; his-65.
K06C4.11; CE04501; WBGene00001893; his-19.
K06C4.3; CE04501; WBGene00001895; his-21.
T10C6.12; CE04501; WBGene00001877; his-3.
T23D8.6; CE04501; WBGene00001942; his-68.
ZK131.10; CE04501; WBGene00001890; his-16.
ZK131.6; CE04501; WBGene00001886; his-12.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000552102 – 127Histone H2AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine1 Publication1
Modified residuei6N6-acetyllysine; partial1 Publication1
Modified residuei9N6-acetyllysine; partial1 Publication1
Modified residuei11N6-acetyllysine; partial1 Publication1
Modified residuei106N5-methylglutamineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.Curated
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09588.
PaxDbiP09588.
PRIDEiP09588.

PTM databases

iPTMnetiP09588.

Expressioni

Gene expression databases

BgeeiWBGene00001877.
ExpressionAtlasiP09588. baseline.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38282. 1 interactor.
42639. 1 interactor.
45064. 2 interactors.
51394. 1 interactor.
56170. 1 interactor.
56178. 1 interactor.
STRINGi6239.ZK131.6.

Structurei

3D structure databases

ProteinModelPortaliP09588.
SMRiP09588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00860000133717.
HOGENOMiHOG000234652.
InParanoidiP09588.
KOiK11251.
OrthoDBiEOG091G0XGD.
PhylomeDBiP09588.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00046. HISTONE_H2A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA
110 120
GVTIAQGGVL PNIQAVLLPK KTGGDKE
Length:127
Mass (Da):13,405
Last modified:January 23, 2007 - v2
Checksum:iFBF085558F1BD340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33641.1.
FO081169 Genomic DNA. Translation: CCD69634.1.
FO081135 Genomic DNA. Translation: CCD69397.1.
FO081551 Genomic DNA. Translation: CCD72371.1.
FO081551 Genomic DNA. Translation: CCD72361.1.
FO081223 Genomic DNA. Translation: CCD70021.1.
Z73102 Genomic DNA. Translation: CAA97414.1.
Z81128 Genomic DNA. Translation: CAB03399.1.
Z81495 Genomic DNA. Translation: CAB04056.1.
Z82271 Genomic DNA. Translation: CAB05212.1.
Z83245 Genomic DNA. Translation: CAB05836.1.
Z83245 Genomic DNA. Translation: CAB05838.1.
Z92789 Genomic DNA. Translation: CAB07221.1.
Z93388 Genomic DNA. Translation: CAB07656.1.
FO081059 Genomic DNA. Translation: CCD68872.1.
FO081059 Genomic DNA. Translation: CCD68866.1.
FO081018 Genomic DNA. Translation: CCD68534.1.
PIRiS04238. HSKW2A.
RefSeqiNP_492642.1. NM_060241.4.
NP_496887.1. NM_064486.3.
NP_496891.1. NM_064490.1.
NP_496898.1. NM_064497.1.
NP_501201.1. NM_068800.3.
NP_501404.1. NM_069003.1.
NP_501408.1. NM_069007.1.
NP_502131.1. NM_069730.4.
NP_502141.1. NM_069740.1.
NP_502150.1. NM_069749.1.
NP_505198.1. NM_072797.1.
NP_505277.1. NM_072876.1.
NP_505280.1. NM_072879.1.
NP_505293.1. NM_072892.1.
NP_505296.1. NM_072895.1.
NP_507032.1. NM_074631.3.
UniGeneiCel.12763.
Cel.14855.
Cel.16705.
Cel.21396.
Cel.21446.
Cel.21869.
Cel.28727.
Cel.28728.
Cel.3208.
Cel.32608.
Cel.32622.
Cel.32841.
Cel.32966.

Genome annotation databases

EnsemblMetazoaiB0035.7; B0035.7; WBGene00001921.
F07B7.10; F07B7.10; WBGene00001925.
F07B7.3; F07B7.3; WBGene00001927.
F08G2.2; F08G2.2; WBGene00001917.
F17E9.13; F17E9.13; WBGene00001907.
F35H10.1; F35H10.1; WBGene00001904.
F45F2.4; F45F2.4; WBGene00001881.
F54E12.5a; F54E12.5a; WBGene00001931.
F55G1.10; F55G1.10; WBGene00001935.
H02I12.7; H02I12.7; WBGene00001939.
K06C4.11; K06C4.11; WBGene00001893.
K06C4.3; K06C4.3; WBGene00001895.
T10C6.12; T10C6.12; WBGene00001877.
T23D8.6; T23D8.6; WBGene00001942.
ZK131.10; ZK131.10; WBGene00001890.
ZK131.6; ZK131.6; WBGene00001886.
GeneIDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
KEGGicel:CELE_B0035.7.
cel:CELE_F07B7.10.
cel:CELE_F07B7.3.
cel:CELE_F08G2.2.
cel:CELE_F17E9.13.
cel:CELE_F35H10.1.
cel:CELE_F45F2.4.
cel:CELE_F55G1.10.
cel:CELE_H02I12.7.
cel:CELE_K06C4.11.
cel:CELE_K06C4.3.
cel:CELE_T10C6.12.
cel:CELE_T23D8.6.
cel:CELE_ZK131.10.
cel:CELE_ZK131.6.
UCSCiT23D8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33641.1.
FO081169 Genomic DNA. Translation: CCD69634.1.
FO081135 Genomic DNA. Translation: CCD69397.1.
FO081551 Genomic DNA. Translation: CCD72371.1.
FO081551 Genomic DNA. Translation: CCD72361.1.
FO081223 Genomic DNA. Translation: CCD70021.1.
Z73102 Genomic DNA. Translation: CAA97414.1.
Z81128 Genomic DNA. Translation: CAB03399.1.
Z81495 Genomic DNA. Translation: CAB04056.1.
Z82271 Genomic DNA. Translation: CAB05212.1.
Z83245 Genomic DNA. Translation: CAB05836.1.
Z83245 Genomic DNA. Translation: CAB05838.1.
Z92789 Genomic DNA. Translation: CAB07221.1.
Z93388 Genomic DNA. Translation: CAB07656.1.
FO081059 Genomic DNA. Translation: CCD68872.1.
FO081059 Genomic DNA. Translation: CCD68866.1.
FO081018 Genomic DNA. Translation: CCD68534.1.
PIRiS04238. HSKW2A.
RefSeqiNP_492642.1. NM_060241.4.
NP_496887.1. NM_064486.3.
NP_496891.1. NM_064490.1.
NP_496898.1. NM_064497.1.
NP_501201.1. NM_068800.3.
NP_501404.1. NM_069003.1.
NP_501408.1. NM_069007.1.
NP_502131.1. NM_069730.4.
NP_502141.1. NM_069740.1.
NP_502150.1. NM_069749.1.
NP_505198.1. NM_072797.1.
NP_505277.1. NM_072876.1.
NP_505280.1. NM_072879.1.
NP_505293.1. NM_072892.1.
NP_505296.1. NM_072895.1.
NP_507032.1. NM_074631.3.
UniGeneiCel.12763.
Cel.14855.
Cel.16705.
Cel.21396.
Cel.21446.
Cel.21869.
Cel.28727.
Cel.28728.
Cel.3208.
Cel.32608.
Cel.32622.
Cel.32841.
Cel.32966.

3D structure databases

ProteinModelPortaliP09588.
SMRiP09588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38282. 1 interactor.
42639. 1 interactor.
45064. 2 interactors.
51394. 1 interactor.
56170. 1 interactor.
56178. 1 interactor.
STRINGi6239.ZK131.6.

PTM databases

iPTMnetiP09588.

Proteomic databases

EPDiP09588.
PaxDbiP09588.
PRIDEiP09588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.7; B0035.7; WBGene00001921.
F07B7.10; F07B7.10; WBGene00001925.
F07B7.3; F07B7.3; WBGene00001927.
F08G2.2; F08G2.2; WBGene00001917.
F17E9.13; F17E9.13; WBGene00001907.
F35H10.1; F35H10.1; WBGene00001904.
F45F2.4; F45F2.4; WBGene00001881.
F54E12.5a; F54E12.5a; WBGene00001931.
F55G1.10; F55G1.10; WBGene00001935.
H02I12.7; H02I12.7; WBGene00001939.
K06C4.11; K06C4.11; WBGene00001893.
K06C4.3; K06C4.3; WBGene00001895.
T10C6.12; T10C6.12; WBGene00001877.
T23D8.6; T23D8.6; WBGene00001942.
ZK131.10; ZK131.10; WBGene00001890.
ZK131.6; ZK131.6; WBGene00001886.
GeneIDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
KEGGicel:CELE_B0035.7.
cel:CELE_F07B7.10.
cel:CELE_F07B7.3.
cel:CELE_F08G2.2.
cel:CELE_F17E9.13.
cel:CELE_F35H10.1.
cel:CELE_F45F2.4.
cel:CELE_F55G1.10.
cel:CELE_H02I12.7.
cel:CELE_K06C4.11.
cel:CELE_K06C4.3.
cel:CELE_T10C6.12.
cel:CELE_T23D8.6.
cel:CELE_ZK131.10.
cel:CELE_ZK131.6.
UCSCiT23D8.6. c. elegans.

Organism-specific databases

CTDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
WormBaseiB0035.7; CE04501; WBGene00001921; his-47.
F07B7.10; CE04501; WBGene00001925; his-51.
F07B7.3; CE04501; WBGene00001927; his-53.
F08G2.2; CE04501; WBGene00001917; his-43.
F17E9.13; CE04501; WBGene00001907; his-33.
F35H10.1; CE04501; WBGene00001904; his-30.
F45F2.4; CE04501; WBGene00001881; his-7.
F54E12.5; CE04501; WBGene00001931; his-57.
F55G1.10; CE04501; WBGene00001935; his-61.
H02I12.7; CE04501; WBGene00001939; his-65.
K06C4.11; CE04501; WBGene00001893; his-19.
K06C4.3; CE04501; WBGene00001895; his-21.
T10C6.12; CE04501; WBGene00001877; his-3.
T23D8.6; CE04501; WBGene00001942; his-68.
ZK131.10; CE04501; WBGene00001890; his-16.
ZK131.6; CE04501; WBGene00001886; his-12.

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00860000133717.
HOGENOMiHOG000234652.
InParanoidiP09588.
KOiK11251.
OrthoDBiEOG091G0XGD.
PhylomeDBiP09588.

Enzyme and pathway databases

ReactomeiR-CEL-2299718. Condensation of Prophase Chromosomes.
R-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-3214858. RMTs methylate histone arginines.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiPR:P09588.

Gene expression databases

BgeeiWBGene00001877.
ExpressionAtlasiP09588. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00046. HISTONE_H2A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2A_CAEEL
AccessioniPrimary (citable) accession number: P09588
Secondary accession number(s): Q7JKF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.