Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone H2A

Gene

his-3

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • DNA repair Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-3214847 HATs acetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5689880 Ub-specific processing proteases
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:his-3
ORF Names:T10C6.12
AND
Name:his-7
ORF Names:F45F2.4
AND
Name:his-12
ORF Names:ZK131.6
AND
Name:his-16
ORF Names:ZK131.10
AND
Name:his-19
ORF Names:K06C4.11
AND
Name:his-21
ORF Names:K06C4.3
AND
Name:his-30
ORF Names:F35H10.1
AND
Name:his-33
ORF Names:F17E9.13
AND
Name:his-43
ORF Names:F08G2.2
AND
Name:his-47
ORF Names:B0035.7
AND
Name:his-51
ORF Names:F07B7.10
AND
Name:his-53
ORF Names:F07B7.3
AND
Name:his-57
ORF Names:F54E12.5
AND
Name:his-61
ORF Names:F55G1.10
AND
Name:his-65
ORF Names:H02I12.7
AND
Name:his-68
ORF Names:T23D8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

WormBaseiB0035.7 ; CE04501 ; WBGene00001921 ; his-47
F07B7.10 ; CE04501 ; WBGene00001925 ; his-51
F07B7.3 ; CE04501 ; WBGene00001927 ; his-53
F08G2.2 ; CE04501 ; WBGene00001917 ; his-43
F17E9.13 ; CE04501 ; WBGene00001907 ; his-33
F35H10.1 ; CE04501 ; WBGene00001904 ; his-30
F45F2.4 ; CE04501 ; WBGene00001881 ; his-7
F54E12.5 ; CE04501 ; WBGene00001931 ; his-57
F55G1.10 ; CE04501 ; WBGene00001935 ; his-61
H02I12.7 ; CE04501 ; WBGene00001939 ; his-65
K06C4.11 ; CE04501 ; WBGene00001893 ; his-19
K06C4.3 ; CE04501 ; WBGene00001895 ; his-21
T10C6.12 ; CE04501 ; WBGene00001877 ; his-3
T23D8.6 ; CE04501 ; WBGene00001942 ; his-68
ZK131.10 ; CE04501 ; WBGene00001890 ; his-16
ZK131.6 ; CE04501 ; WBGene00001886 ; his-12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000552102 – 127Histone H2AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine1 Publication1
Modified residuei6N6-acetyllysine; partial1 Publication1
Modified residuei9N6-acetyllysine; partial1 Publication1
Modified residuei11N6-acetyllysine; partial1 Publication1
Modified residuei106N5-methylglutamineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.Curated
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09588
PaxDbiP09588
PRIDEiP09588

PTM databases

iPTMnetiP09588

Expressioni

Gene expression databases

BgeeiWBGene00001877
ExpressionAtlasiP09588 baseline

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38282, 1 interactor
42639, 1 interactor
45064, 2 interactors
51394, 1 interactor
56170, 1 interactor
56178, 1 interactor
STRINGi6239.ZK131.6

Structurei

3D structure databases

ProteinModelPortaliP09588
SMRiP09588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234652
InParanoidiP09588
KOiK11251
OMAiLEYLAXA
OrthoDBiEOG091G0XGD
PhylomeDBiP09588

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA
110 120
GVTIAQGGVL PNIQAVLLPK KTGGDKE
Length:127
Mass (Da):13,405
Last modified:January 23, 2007 - v2
Checksum:iFBF085558F1BD340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA Translation: CAA33641.1
FO081169 Genomic DNA Translation: CCD69634.1
FO081135 Genomic DNA Translation: CCD69397.1
FO081551 Genomic DNA Translation: CCD72371.1
FO081551 Genomic DNA Translation: CCD72361.1
FO081223 Genomic DNA Translation: CCD70021.1
Z73102 Genomic DNA Translation: CAA97414.1
Z81128 Genomic DNA Translation: CAB03399.1
Z81495 Genomic DNA Translation: CAB04056.1
Z82271 Genomic DNA Translation: CAB05212.1
Z83245 Genomic DNA Translation: CAB05836.1
Z83245 Genomic DNA Translation: CAB05838.1
Z92789 Genomic DNA Translation: CAB07221.1
Z93388 Genomic DNA Translation: CAB07656.1
FO081059 Genomic DNA Translation: CCD68872.1
FO081059 Genomic DNA Translation: CCD68866.1
FO081018 Genomic DNA Translation: CCD68534.1
PIRiS04238 HSKW2A
RefSeqiNP_492642.1, NM_060241.4
NP_496887.1, NM_064486.3
NP_496891.1, NM_064490.1
NP_496898.1, NM_064497.1
NP_501201.1, NM_068800.3
NP_501404.1, NM_069003.1
NP_501408.1, NM_069007.1
NP_502131.1, NM_069730.4
NP_502141.1, NM_069740.1
NP_502150.1, NM_069749.1
NP_505198.1, NM_072797.1
NP_505277.1, NM_072876.1
NP_505280.1, NM_072879.1
NP_505293.1, NM_072892.1
NP_505296.1, NM_072895.1
NP_507032.1, NM_074631.3
UniGeneiCel.12763
Cel.14855
Cel.16705
Cel.21396
Cel.21446
Cel.21869
Cel.28727
Cel.28728
Cel.3208
Cel.32608
Cel.32622
Cel.32841
Cel.32966

Genome annotation databases

EnsemblMetazoaiB0035.7; B0035.7; WBGene00001921
F07B7.10; F07B7.10; WBGene00001925
F07B7.3; F07B7.3; WBGene00001927
F08G2.2; F08G2.2; WBGene00001917
F17E9.13; F17E9.13; WBGene00001907
F35H10.1; F35H10.1; WBGene00001904
F45F2.4; F45F2.4; WBGene00001881
F54E12.5a; F54E12.5a; WBGene00001931
F55G1.10; F55G1.10; WBGene00001935
H02I12.7; H02I12.7; WBGene00001939
K06C4.11; K06C4.11; WBGene00001893
K06C4.3; K06C4.3; WBGene00001895
T10C6.12; T10C6.12; WBGene00001877
T23D8.6; T23D8.6; WBGene00001942
ZK131.10; ZK131.10; WBGene00001890
ZK131.6; ZK131.6; WBGene00001886
GeneIDi172860
175025
175028
175034
177521
178048
178056
179261
179265
180073
184112
186671
191669
191676
191678
259800
KEGGicel:CELE_B0035.7
cel:CELE_F07B7.10
cel:CELE_F07B7.3
cel:CELE_F08G2.2
cel:CELE_F17E9.13
cel:CELE_F35H10.1
cel:CELE_F45F2.4
cel:CELE_F55G1.10
cel:CELE_H02I12.7
cel:CELE_K06C4.11
cel:CELE_K06C4.3
cel:CELE_T10C6.12
cel:CELE_T23D8.6
cel:CELE_ZK131.10
cel:CELE_ZK131.6
UCSCiT23D8.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiH2A_CAEEL
AccessioniPrimary (citable) accession number: P09588
Secondary accession number(s): Q7JKF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health