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Protein

Histone H2A

Gene

his-3

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • DNA repair Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:his-3
ORF Names:T10C6.12
AND
Name:his-7
ORF Names:F45F2.4
AND
Name:his-12
ORF Names:ZK131.6
AND
Name:his-16
ORF Names:ZK131.10
AND
Name:his-19
ORF Names:K06C4.11
AND
Name:his-21
ORF Names:K06C4.3
AND
Name:his-30
ORF Names:F35H10.1
AND
Name:his-33
ORF Names:F17E9.13
AND
Name:his-43
ORF Names:F08G2.2
AND
Name:his-47
ORF Names:B0035.7
AND
Name:his-51
ORF Names:F07B7.10
AND
Name:his-53
ORF Names:F07B7.3
AND
Name:his-57
ORF Names:F54E12.5
AND
Name:his-61
ORF Names:F55G1.10
AND
Name:his-65
ORF Names:H02I12.7
AND
Name:his-68
ORF Names:T23D8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome I, Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

WormBaseiB0035.7; CE04501; WBGene00001921; his-47.
F07B7.10; CE04501; WBGene00001925; his-51.
F07B7.3; CE04501; WBGene00001927; his-53.
F08G2.2; CE04501; WBGene00001917; his-43.
F17E9.13; CE04501; WBGene00001907; his-33.
F35H10.1; CE04501; WBGene00001904; his-30.
F45F2.4; CE04501; WBGene00001881; his-7.
F54E12.5; CE04501; WBGene00001931; his-57.
F55G1.10; CE04501; WBGene00001935; his-61.
H02I12.7; CE04501; WBGene00001939; his-65.
K06C4.11; CE04501; WBGene00001893; his-19.
K06C4.3; CE04501; WBGene00001895; his-21.
T10C6.12; CE04501; WBGene00001877; his-3.
T23D8.6; CE04501; WBGene00001942; his-68.
ZK131.10; CE04501; WBGene00001890; his-16.
ZK131.6; CE04501; WBGene00001886; his-12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000552102 – 127Histone H2AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine1 Publication1
Modified residuei6N6-acetyllysine; partial1 Publication1
Modified residuei9N6-acetyllysine; partial1 Publication1
Modified residuei11N6-acetyllysine; partial1 Publication1
Modified residuei106N5-methylglutamineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.Curated
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP09588.
PaxDbiP09588.
PRIDEiP09588.

PTM databases

iPTMnetiP09588.

Expressioni

Gene expression databases

BgeeiWBGene00001877.
ExpressionAtlasiP09588. differential.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi38282. 1 interactor.
42639. 1 interactor.
45064. 2 interactors.
51394. 1 interactor.
56170. 1 interactor.
56178. 1 interactor.
STRINGi6239.ZK131.6.

Structurei

3D structure databases

ProteinModelPortaliP09588.
SMRiP09588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
ENSGT00860000133717.
HOGENOMiHOG000234652.
InParanoidiP09588.
KOiK11251.
OrthoDBiEOG091G0XGD.
PhylomeDBiP09588.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA
110 120
GVTIAQGGVL PNIQAVLLPK KTGGDKE
Length:127
Mass (Da):13,405
Last modified:January 23, 2007 - v2
Checksum:iFBF085558F1BD340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33641.1.
FO081169 Genomic DNA. Translation: CCD69634.1.
FO081135 Genomic DNA. Translation: CCD69397.1.
FO081551 Genomic DNA. Translation: CCD72371.1.
FO081551 Genomic DNA. Translation: CCD72361.1.
FO081223 Genomic DNA. Translation: CCD70021.1.
Z73102 Genomic DNA. Translation: CAA97414.1.
Z81128 Genomic DNA. Translation: CAB03399.1.
Z81495 Genomic DNA. Translation: CAB04056.1.
Z82271 Genomic DNA. Translation: CAB05212.1.
Z83245 Genomic DNA. Translation: CAB05836.1.
Z83245 Genomic DNA. Translation: CAB05838.1.
Z92789 Genomic DNA. Translation: CAB07221.1.
Z93388 Genomic DNA. Translation: CAB07656.1.
FO081059 Genomic DNA. Translation: CCD68872.1.
FO081059 Genomic DNA. Translation: CCD68866.1.
FO081018 Genomic DNA. Translation: CCD68534.1.
PIRiS04238. HSKW2A.
RefSeqiNP_492642.1. NM_060241.4.
NP_496887.1. NM_064486.3.
NP_496891.1. NM_064490.1.
NP_496898.1. NM_064497.1.
NP_501201.1. NM_068800.3.
NP_501404.1. NM_069003.1.
NP_501408.1. NM_069007.1.
NP_502131.1. NM_069730.4.
NP_502141.1. NM_069740.1.
NP_502150.1. NM_069749.1.
NP_505198.1. NM_072797.1.
NP_505277.1. NM_072876.1.
NP_505280.1. NM_072879.1.
NP_505293.1. NM_072892.1.
NP_505296.1. NM_072895.1.
NP_507032.1. NM_074631.3.
UniGeneiCel.12763.
Cel.14855.
Cel.16705.
Cel.21396.
Cel.21446.
Cel.21869.
Cel.28727.
Cel.28728.
Cel.3208.
Cel.32608.
Cel.32622.
Cel.32841.
Cel.32966.

Genome annotation databases

EnsemblMetazoaiB0035.7; B0035.7; WBGene00001921.
F07B7.10; F07B7.10; WBGene00001925.
F07B7.3; F07B7.3; WBGene00001927.
F08G2.2; F08G2.2; WBGene00001917.
F17E9.13; F17E9.13; WBGene00001907.
F35H10.1; F35H10.1; WBGene00001904.
F45F2.4; F45F2.4; WBGene00001881.
F54E12.5a; F54E12.5a; WBGene00001931.
F55G1.10; F55G1.10; WBGene00001935.
H02I12.7; H02I12.7; WBGene00001939.
K06C4.11; K06C4.11; WBGene00001893.
K06C4.3; K06C4.3; WBGene00001895.
T10C6.12; T10C6.12; WBGene00001877.
T23D8.6; T23D8.6; WBGene00001942.
ZK131.10; ZK131.10; WBGene00001890.
ZK131.6; ZK131.6; WBGene00001886.
GeneIDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
KEGGicel:CELE_B0035.7.
cel:CELE_F07B7.10.
cel:CELE_F07B7.3.
cel:CELE_F08G2.2.
cel:CELE_F17E9.13.
cel:CELE_F35H10.1.
cel:CELE_F45F2.4.
cel:CELE_F55G1.10.
cel:CELE_H02I12.7.
cel:CELE_K06C4.11.
cel:CELE_K06C4.3.
cel:CELE_T10C6.12.
cel:CELE_T23D8.6.
cel:CELE_ZK131.10.
cel:CELE_ZK131.6.
UCSCiT23D8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33641.1.
FO081169 Genomic DNA. Translation: CCD69634.1.
FO081135 Genomic DNA. Translation: CCD69397.1.
FO081551 Genomic DNA. Translation: CCD72371.1.
FO081551 Genomic DNA. Translation: CCD72361.1.
FO081223 Genomic DNA. Translation: CCD70021.1.
Z73102 Genomic DNA. Translation: CAA97414.1.
Z81128 Genomic DNA. Translation: CAB03399.1.
Z81495 Genomic DNA. Translation: CAB04056.1.
Z82271 Genomic DNA. Translation: CAB05212.1.
Z83245 Genomic DNA. Translation: CAB05836.1.
Z83245 Genomic DNA. Translation: CAB05838.1.
Z92789 Genomic DNA. Translation: CAB07221.1.
Z93388 Genomic DNA. Translation: CAB07656.1.
FO081059 Genomic DNA. Translation: CCD68872.1.
FO081059 Genomic DNA. Translation: CCD68866.1.
FO081018 Genomic DNA. Translation: CCD68534.1.
PIRiS04238. HSKW2A.
RefSeqiNP_492642.1. NM_060241.4.
NP_496887.1. NM_064486.3.
NP_496891.1. NM_064490.1.
NP_496898.1. NM_064497.1.
NP_501201.1. NM_068800.3.
NP_501404.1. NM_069003.1.
NP_501408.1. NM_069007.1.
NP_502131.1. NM_069730.4.
NP_502141.1. NM_069740.1.
NP_502150.1. NM_069749.1.
NP_505198.1. NM_072797.1.
NP_505277.1. NM_072876.1.
NP_505280.1. NM_072879.1.
NP_505293.1. NM_072892.1.
NP_505296.1. NM_072895.1.
NP_507032.1. NM_074631.3.
UniGeneiCel.12763.
Cel.14855.
Cel.16705.
Cel.21396.
Cel.21446.
Cel.21869.
Cel.28727.
Cel.28728.
Cel.3208.
Cel.32608.
Cel.32622.
Cel.32841.
Cel.32966.

3D structure databases

ProteinModelPortaliP09588.
SMRiP09588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38282. 1 interactor.
42639. 1 interactor.
45064. 2 interactors.
51394. 1 interactor.
56170. 1 interactor.
56178. 1 interactor.
STRINGi6239.ZK131.6.

PTM databases

iPTMnetiP09588.

Proteomic databases

EPDiP09588.
PaxDbiP09588.
PRIDEiP09588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.7; B0035.7; WBGene00001921.
F07B7.10; F07B7.10; WBGene00001925.
F07B7.3; F07B7.3; WBGene00001927.
F08G2.2; F08G2.2; WBGene00001917.
F17E9.13; F17E9.13; WBGene00001907.
F35H10.1; F35H10.1; WBGene00001904.
F45F2.4; F45F2.4; WBGene00001881.
F54E12.5a; F54E12.5a; WBGene00001931.
F55G1.10; F55G1.10; WBGene00001935.
H02I12.7; H02I12.7; WBGene00001939.
K06C4.11; K06C4.11; WBGene00001893.
K06C4.3; K06C4.3; WBGene00001895.
T10C6.12; T10C6.12; WBGene00001877.
T23D8.6; T23D8.6; WBGene00001942.
ZK131.10; ZK131.10; WBGene00001890.
ZK131.6; ZK131.6; WBGene00001886.
GeneIDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
KEGGicel:CELE_B0035.7.
cel:CELE_F07B7.10.
cel:CELE_F07B7.3.
cel:CELE_F08G2.2.
cel:CELE_F17E9.13.
cel:CELE_F35H10.1.
cel:CELE_F45F2.4.
cel:CELE_F55G1.10.
cel:CELE_H02I12.7.
cel:CELE_K06C4.11.
cel:CELE_K06C4.3.
cel:CELE_T10C6.12.
cel:CELE_T23D8.6.
cel:CELE_ZK131.10.
cel:CELE_ZK131.6.
UCSCiT23D8.6. c. elegans.

Organism-specific databases

CTDi172860.
175025.
175028.
175034.
177521.
178048.
178056.
179261.
179265.
180073.
184112.
186671.
191669.
191676.
191678.
259800.
WormBaseiB0035.7; CE04501; WBGene00001921; his-47.
F07B7.10; CE04501; WBGene00001925; his-51.
F07B7.3; CE04501; WBGene00001927; his-53.
F08G2.2; CE04501; WBGene00001917; his-43.
F17E9.13; CE04501; WBGene00001907; his-33.
F35H10.1; CE04501; WBGene00001904; his-30.
F45F2.4; CE04501; WBGene00001881; his-7.
F54E12.5; CE04501; WBGene00001931; his-57.
F55G1.10; CE04501; WBGene00001935; his-61.
H02I12.7; CE04501; WBGene00001939; his-65.
K06C4.11; CE04501; WBGene00001893; his-19.
K06C4.3; CE04501; WBGene00001895; his-21.
T10C6.12; CE04501; WBGene00001877; his-3.
T23D8.6; CE04501; WBGene00001942; his-68.
ZK131.10; CE04501; WBGene00001890; his-16.
ZK131.6; CE04501; WBGene00001886; his-12.

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
ENSGT00860000133717.
HOGENOMiHOG000234652.
InParanoidiP09588.
KOiK11251.
OrthoDBiEOG091G0XGD.
PhylomeDBiP09588.

Miscellaneous databases

PROiP09588.

Gene expression databases

BgeeiWBGene00001877.
ExpressionAtlasiP09588. differential.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2A_CAEEL
AccessioniPrimary (citable) accession number: P09588
Secondary accession number(s): Q7JKF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.