ID   ESTA_CANFA              Reviewed;         260 AA.
AC   P09582;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   26-MAY-2009, entry version 77.
DE   RecName: Full=Arginine esterase;
DE            EC=3.4.21.35;
DE   Flags: Precursor;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Prostate;
RX   MEDLINE=88211858; PubMed=2835268; DOI=10.1016/0014-5793(88)80414-9;
RA   Chapdelaine P., Ho-Kim M.-A., Tremblay R.R., Dube J.Y.;
RT   "Nucleotide sequence of the androgen-dependent arginine esterase mRNA
RT   of canine prostate.";
RL   FEBS Lett. 232:187-192(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91119675; PubMed=1991049; DOI=10.1089/dna.1991.10.49;
RA   Chapdelaine P., Gauthier E., Ho-Kim M.-A., Bissonnette L.,
RA   Tremblay R.R., Dube J.Y.;
RT   "Characterization and expression of the prostatic arginine esterase
RT   gene, a canine glandular kallikrein.";
RL   DNA Cell Biol. 10:49-59(1991).
RN   [3]
RP   PROTEIN SEQUENCE OF 25-50 AND 108-145.
RC   TISSUE=Prostate;
RX   MEDLINE=85004070; PubMed=6566614; DOI=10.1016/0014-5793(84)80557-8;
RA   Lazure C., Leduc R., Seidah N.G., Chretien M., Dube J.Y.,
RA   Chapdelaine P., Frenette G., Paquin R., Tremblay R.R.;
RT   "The major androgen-dependent protease in dog prostate belongs to the
RT   kallikrein family: confirmation by partial amino acid sequencing.";
RL   FEBS Lett. 175:1-7(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 105-260.
RX   MEDLINE=88225749; PubMed=3371547; DOI=10.1016/0303-7207(88)90009-3;
RA   Chapdelaine P., Potvin C., Ho-Kim M.A., Larouche L., Bellemare G.,
RA   Tremblay R.T., Dube J.Y.;
RT   "Androgen regulation of canine prostatic arginine esterase mRNA using
RT   cloned cDNA.";
RL   Mol. Cell. Endocrinol. 56:63-70(1988).
CC   -!- FUNCTION: This serine protease is found in dog seminal plasma, its
CC       exact physiological function is not known.
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in
CC       small molecule substrates. Highly selective action to release
CC       kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of
CC       Met-|-Xaa or Leu-|-Xaa.
CC   -!- INDUCTION: By androgens.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Kallikrein
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   EMBL; Y00751; CAA68720.1; -; mRNA.
DR   EMBL; M63669; AAA30831.1; -; Genomic_DNA.
DR   PIR; A30981; A30981.
DR   PIR; A37938; A37938.
DR   RefSeq; NP_001003284.1; -.
DR   UniGene; Cfa.3836; -.
DR   HSSP; P00752; 2PKA.
DR   MEROPS; S01.289; -.
DR   GeneID; 403967; -.
DR   KEGG; cfa:403967; -.
DR   HOVERGEN; P09582; -.
DR   BRENDA; 3.4.21.35; 463.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase;
KW   Protease; Serine protease; Signal; Zymogen.
FT   SIGNAL        1     17       Potential.
FT   PROPEP       18     24       Activation peptide.
FT                                /FTId=PRO_0000028019.
FT   CHAIN        25    260       Arginine esterase.
FT                                /FTId=PRO_0000028020.
FT   DOMAIN       25    257       Peptidase S1.
FT   ACT_SITE     65     65       Charge relay system (By similarity).
FT   ACT_SITE    119    119       Charge relay system (By similarity).
FT   ACT_SITE    212    212       Charge relay system (By similarity).
FT   CARBOHYD     79     79       N-linked (GlcNAc...) (Probable).
FT   DISULFID     31    172       By similarity.
FT   DISULFID     50     66       By similarity.
FT   DISULFID    151    218       By similarity.
FT   DISULFID    183    197       By similarity.
FT   DISULFID    208    233       By similarity.
FT   CONFLICT     56     56       N -> H (in Ref. 2; AAA30831).
SQ   SEQUENCE   260 AA;  28746 MW;  48768B6EF204775A CRC64;
     MWFLALCLAM SLGWTGAEPH FQPRIIGGRE CLKNSQPWQV AVYHNGEFAC GGVLVNPEWV
     LTAAHCANSN CEVWLGRHNL SESEDEGQLV QVRKSFIHPL YKTKVPRAVI RPGEDRSHDL
     MLLHLEEPAK ITKAVRVMDL PKKEPPLGST CYVSGWGSTD PETIFHPGSL QCVDLKLLSN
     NQCAKVYTQK VTKFMLCAGV LEGKKDTCKG DSGGPLICDG ELVGITSWGA TPCGKPQMPS
     LYTRVMPHLM WIKDTMKANT
//