Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09582

- ESTA_CANFA

UniProt

P09582 - ESTA_CANFA

Protein

Arginine esterase

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This serine protease is found in dog seminal plasma, its exact physiological function is not known.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei119 – 1191Charge relay systemBy similarity
    Active sitei212 – 2121Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.289.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine esterase (EC:3.4.21.35)
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Pathology & Biotechi

    Protein family/group databases

    Allergomei5762. Can f 5.
    5763. Can f 5.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 247Activation peptide1 PublicationPRO_0000028019
    Chaini25 – 260236Arginine esterasePRO_0000028020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 172PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi79 – 791N-linked (GlcNAc...)Curated
    Disulfide bondi151 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi183 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi208 ↔ 233PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Expressioni

    Inductioni

    By androgens.

    Structurei

    3D structure databases

    ProteinModelPortaliP09582.
    SMRiP09582. Positions 25-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 257233Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.
    KOiK01325.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09582-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFLALCLAM SLGWTGAEPH FQPRIIGGRE CLKNSQPWQV AVYHNGEFAC    50
    GGVLVNPEWV LTAAHCANSN CEVWLGRHNL SESEDEGQLV QVRKSFIHPL 100
    YKTKVPRAVI RPGEDRSHDL MLLHLEEPAK ITKAVRVMDL PKKEPPLGST 150
    CYVSGWGSTD PETIFHPGSL QCVDLKLLSN NQCAKVYTQK VTKFMLCAGV 200
    LEGKKDTCKG DSGGPLICDG ELVGITSWGA TPCGKPQMPS LYTRVMPHLM 250
    WIKDTMKANT 260
    Length:260
    Mass (Da):28,746
    Last modified:July 1, 1989 - v1
    Checksum:i48768B6EF204775A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561N → H in AAA30831. (PubMed:1991049)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00751 mRNA. Translation: CAA68720.1.
    M63669 Genomic DNA. Translation: AAA30831.1.
    PIRiA30981.
    A37938.
    RefSeqiNP_001003284.1. NM_001003284.1.
    UniGeneiCfa.3836.

    Genome annotation databases

    GeneIDi403967.
    KEGGicfa:403967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00751 mRNA. Translation: CAA68720.1 .
    M63669 Genomic DNA. Translation: AAA30831.1 .
    PIRi A30981.
    A37938.
    RefSeqi NP_001003284.1. NM_001003284.1.
    UniGenei Cfa.3836.

    3D structure databases

    ProteinModelPortali P09582.
    SMRi P09582. Positions 25-259.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 5762. Can f 5.
    5763. Can f 5.0101.
    MEROPSi S01.289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403967.
    KEGGi cfa:403967.

    Organism-specific databases

    CTDi 3817.

    Phylogenomic databases

    HOVERGENi HBG013304.
    KOi K01325.

    Miscellaneous databases

    NextBioi 20817457.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the androgen-dependent arginine esterase mRNA of canine prostate."
      Chapdelaine P., Ho-Kim M.-A., Tremblay R.R., Dube J.Y.
      FEBS Lett. 232:187-192(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostate.
    2. "Characterization and expression of the prostatic arginine esterase gene, a canine glandular kallikrein."
      Chapdelaine P., Gauthier E., Ho-Kim M.-A., Bissonnette L., Tremblay R.R., Dube J.Y.
      DNA Cell Biol. 10:49-59(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing."
      Lazure C., Leduc R., Seidah N.G., Chretien M., Dube J.Y., Chapdelaine P., Frenette G., Paquin R., Tremblay R.R.
      FEBS Lett. 175:1-7(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-50 AND 108-145.
      Tissue: Prostate.
    4. "Androgen regulation of canine prostatic arginine esterase mRNA using cloned cDNA."
      Chapdelaine P., Potvin C., Ho-Kim M.A., Larouche L., Bellemare G., Tremblay R.T., Dube J.Y.
      Mol. Cell. Endocrinol. 56:63-70(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 105-260.

    Entry informationi

    Entry nameiESTA_CANFA
    AccessioniPrimary (citable) accession number: P09582
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3