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P09582 (ESTA_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This serine protease is found in dog seminal plasma, its exact physiological function is not known.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Induction

By androgens.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 247Activation peptide
PRO_0000028019
Chain25 – 260236Arginine esterase
PRO_0000028020

Regions

Domain25 – 257233Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1191Charge relay system By similarity
Active site2121Charge relay system By similarity

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Probable
Disulfide bond31 ↔ 172 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond151 ↔ 218 By similarity
Disulfide bond183 ↔ 197 By similarity
Disulfide bond208 ↔ 233 By similarity

Experimental info

Sequence conflict561N → H in AAA30831. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P09582 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 48768B6EF204775A

FASTA26028,746
        10         20         30         40         50         60 
MWFLALCLAM SLGWTGAEPH FQPRIIGGRE CLKNSQPWQV AVYHNGEFAC GGVLVNPEWV 

        70         80         90        100        110        120 
LTAAHCANSN CEVWLGRHNL SESEDEGQLV QVRKSFIHPL YKTKVPRAVI RPGEDRSHDL 

       130        140        150        160        170        180 
MLLHLEEPAK ITKAVRVMDL PKKEPPLGST CYVSGWGSTD PETIFHPGSL QCVDLKLLSN 

       190        200        210        220        230        240 
NQCAKVYTQK VTKFMLCAGV LEGKKDTCKG DSGGPLICDG ELVGITSWGA TPCGKPQMPS 

       250        260 
LYTRVMPHLM WIKDTMKANT 

« Hide

References

[1]"Nucleotide sequence of the androgen-dependent arginine esterase mRNA of canine prostate."
Chapdelaine P., Ho-Kim M.-A., Tremblay R.R., Dube J.Y.
FEBS Lett. 232:187-192(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Prostate.
[2]"Characterization and expression of the prostatic arginine esterase gene, a canine glandular kallikrein."
Chapdelaine P., Gauthier E., Ho-Kim M.-A., Bissonnette L., Tremblay R.R., Dube J.Y.
DNA Cell Biol. 10:49-59(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing."
Lazure C., Leduc R., Seidah N.G., Chretien M., Dube J.Y., Chapdelaine P., Frenette G., Paquin R., Tremblay R.R.
FEBS Lett. 175:1-7(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-50 AND 108-145.
Tissue: Prostate.
[4]"Androgen regulation of canine prostatic arginine esterase mRNA using cloned cDNA."
Chapdelaine P., Potvin C., Ho-Kim M.A., Larouche L., Bellemare G., Tremblay R.T., Dube J.Y.
Mol. Cell. Endocrinol. 56:63-70(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 105-260.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00751 mRNA. Translation: CAA68720.1.
M63669 Genomic DNA. Translation: AAA30831.1.
PIRA30981.
A37938.
RefSeqNP_001003284.1. NM_001003284.1.
UniGeneCfa.3836.

3D structure databases

ProteinModelPortalP09582.
SMRP09582. Positions 25-259.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome5762. Can f 5.
5763. Can f 5.0101.
MEROPSS01.289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403967.
KEGGcfa:403967.

Organism-specific databases

CTD3817.

Phylogenomic databases

HOVERGENHBG013304.
KOK01325.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817457.

Entry information

Entry nameESTA_CANFA
AccessionPrimary (citable) accession number: P09582
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries