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Protein

Arginine esterase

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This serine protease is found in dog seminal plasma, its exact physiological function is not known.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei119 – 1191Charge relay systemBy similarity
Active sitei212 – 2121Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.289.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine esterase (EC:3.4.21.35)
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Pathology & Biotechi

Protein family/group databases

Allergomei5762. Can f 5.
5763. Can f 5.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 247Activation peptide1 PublicationPRO_0000028019
Chaini25 – 260236Arginine esterasePRO_0000028020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 172PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...)Curated
Disulfide bondi151 ↔ 218PROSITE-ProRule annotation
Disulfide bondi183 ↔ 197PROSITE-ProRule annotation
Disulfide bondi208 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Inductioni

By androgens.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004309.

Structurei

3D structure databases

ProteinModelPortaliP09582.
SMRiP09582. Positions 25-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 257233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLALCLAM SLGWTGAEPH FQPRIIGGRE CLKNSQPWQV AVYHNGEFAC
60 70 80 90 100
GGVLVNPEWV LTAAHCANSN CEVWLGRHNL SESEDEGQLV QVRKSFIHPL
110 120 130 140 150
YKTKVPRAVI RPGEDRSHDL MLLHLEEPAK ITKAVRVMDL PKKEPPLGST
160 170 180 190 200
CYVSGWGSTD PETIFHPGSL QCVDLKLLSN NQCAKVYTQK VTKFMLCAGV
210 220 230 240 250
LEGKKDTCKG DSGGPLICDG ELVGITSWGA TPCGKPQMPS LYTRVMPHLM
260
WIKDTMKANT
Length:260
Mass (Da):28,746
Last modified:July 1, 1989 - v1
Checksum:i48768B6EF204775A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561N → H in AAA30831 (PubMed:1991049).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00751 mRNA. Translation: CAA68720.1.
M63669 Genomic DNA. Translation: AAA30831.1.
PIRiA30981.
A37938.
RefSeqiNP_001003284.1. NM_001003284.1.
UniGeneiCfa.3836.

Genome annotation databases

GeneIDi403967.
KEGGicfa:403967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00751 mRNA. Translation: CAA68720.1.
M63669 Genomic DNA. Translation: AAA30831.1.
PIRiA30981.
A37938.
RefSeqiNP_001003284.1. NM_001003284.1.
UniGeneiCfa.3836.

3D structure databases

ProteinModelPortaliP09582.
SMRiP09582. Positions 25-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004309.

Protein family/group databases

Allergomei5762. Can f 5.
5763. Can f 5.0101.
MEROPSiS01.289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403967.
KEGGicfa:403967.

Organism-specific databases

CTDi3817.

Phylogenomic databases

HOVERGENiHBG013304.
KOiK01325.

Miscellaneous databases

NextBioi20817457.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the androgen-dependent arginine esterase mRNA of canine prostate."
    Chapdelaine P., Ho-Kim M.-A., Tremblay R.R., Dube J.Y.
    FEBS Lett. 232:187-192(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.
  2. "Characterization and expression of the prostatic arginine esterase gene, a canine glandular kallikrein."
    Chapdelaine P., Gauthier E., Ho-Kim M.-A., Bissonnette L., Tremblay R.R., Dube J.Y.
    DNA Cell Biol. 10:49-59(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing."
    Lazure C., Leduc R., Seidah N.G., Chretien M., Dube J.Y., Chapdelaine P., Frenette G., Paquin R., Tremblay R.R.
    FEBS Lett. 175:1-7(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-50 AND 108-145.
    Tissue: Prostate.
  4. "Androgen regulation of canine prostatic arginine esterase mRNA using cloned cDNA."
    Chapdelaine P., Potvin C., Ho-Kim M.A., Larouche L., Bellemare G., Tremblay R.T., Dube J.Y.
    Mol. Cell. Endocrinol. 56:63-70(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 105-260.

Entry informationi

Entry nameiESTA_CANFA
AccessioniPrimary (citable) accession number: P09582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.