Reviewed, UniProtKB/Swiss-Prot P09580 (GAL7_KLULA)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	GAL7
Ordered Locus Names:	KLLA0F08437g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Galactose-1-phosphate uridylyltransferase		PRO_0000169889
Sites
	Active site	179	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	51	1	Zinc By similarity
	Metal binding	54	1	Zinc By similarity
	Metal binding	121	1	Zinc By similarity
	Metal binding	177	1	Zinc By similarity
	Metal binding	195	1	Iron By similarity
	Metal binding	311	1	Iron By similarity
	Metal binding	313	1	Iron By similarity
Experimental info
	Sequence conflict	292 – 294	3	GLH → VFN in CAA30091. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P09580-1 [UniParc]. Last modified September 27, 2004. Version 2. Checksum: 8EFDC8CBFD12E547	FASTA	370	42,734
	10 20 30 40 50 60 MSFDLTDHSH ARYNPLTDSW ILVSPHRAKR PWLGQQEKPG RNDAPDHDDK CYLCPGTTRA 70 80 90 100 110 120 TGEQNPDYES TYVFTNGYPA VKLEQPDPEL TVSNCDALKE RLFKLKGVKG NCYVICFSPK 130 140 150 160 170 180 HNLSFPQMAQ SEIMNVVKTW TNLFQTLEKE ALEENKPYKY LQIFENKGTA MGCSNLHPHG 190 200 210 220 230 240 QAWCLDSIPS EPAKEFDHFE KYEHQHGAHL LEDYVNLELR EKERIVCEND SFLVVVPYWA 250 260 270 280 290 300 VWPFETMVLS KRRIPSLNQF TDKEREDLAS IIRNLTIRYD NLFETSFPYS MGLHQASLNA 310 320 330 340 350 360 TEGELKAAWF HMHFYPPLLR SATVRKFLVG FELLGQPQRD LTAEQAADRL KALSGEVHYL 370 AKLEQEESKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the galactose gene cluster of Kluyveromyces lactis." Webster T.D., Dickson R.C. Nucleic Acids Res. 16:8192-8194(1988) [PubMed: 3419917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X07039 Genomic DNA. Translation: CAA30091.1. CR382126 Genomic DNA. Translation: CAG98171.1.
PIR	XNVKUD. S01408.
RefSeq	XP_455463.1.
3D structure databases
HSSP	HSSP built from PDB template 1HXP based on UniProtKB P09148.
ModBase	Search...
Protein-protein interaction databases
STRING	P09580.
Genome annotation databases
GeneID	2894952.
GenomeReviews	Gene locus KLLA0F08437g in contig CR382126_GR.
KEGG	kla:KLLA0F08437g.
Phylogenomic databases
HOGENOM	P09580.
OMA	DHWQLHA.
Enzyme and pathway databases
BRENDA	2.7.7.12. 74088.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
ProDom	PD005051. GalP_Utransf. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_KLULA

Accession

Primary (citable) accession number: P09580
Secondary accession number(s): Q6CKS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	September 27, 2004
Last modified:	November 3, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)