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P09572

- AT1A1_CHICK

UniProt

P09572 - AT1A1_CHICK

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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei374 – 37414-aspartylphosphate intermediateBy similarity
Binding sitei485 – 4851ATPBy similarity
Metal bindingi715 – 7151MagnesiumBy similarity
Metal bindingi719 – 7191MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:ATP1A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8580CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 12923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Topological domaini151 – 286136CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30620HelicalSequence AnalysisAdd
BLAST
Topological domaini307 – 31812ExtracellularSequence AnalysisAdd
BLAST
Transmembranei319 – 33618HelicalSequence AnalysisAdd
BLAST
Topological domaini337 – 770434CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei771 – 79020HelicalSequence AnalysisAdd
BLAST
Topological domaini791 – 80010ExtracellularSequence Analysis
Transmembranei801 – 82121HelicalSequence AnalysisAdd
BLAST
Topological domaini822 – 84120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei842 – 86423HelicalSequence AnalysisAdd
BLAST
Topological domaini865 – 91652ExtracellularSequence AnalysisAdd
BLAST
Transmembranei917 – 93620HelicalSequence AnalysisAdd
BLAST
Topological domaini937 – 94913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei950 – 96819HelicalSequence AnalysisAdd
BLAST
Topological domaini969 – 98315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei984 – 100421HelicalSequence AnalysisAdd
BLAST
Topological domaini1005 – 102117CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55PRO_0000002493
Chaini6 – 10211016Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphotyrosineBy similarity
Modified residuei16 – 161Phosphoserine; by PKCBy similarity
Modified residuei941 – 9411Phosphoserine; by PKABy similarity

Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09572.
PRIDEiP09572.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

BioGridi676774. 1 interaction.
DIPiDIP-27N.
IntActiP09572. 1 interaction.
STRINGi9031.ENSGALP00000036172.

Structurei

3D structure databases

ProteinModelPortaliP09572.
SMRiP09572. Positions 26-1021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 823Phosphoinositide-3 kinase bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP09572.
KOiK01539.
PhylomeDBiP09572.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09572-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKGAGRDKY EPTATSEHGT KKKKAKERDM DELKKEISMD DHKLSLDELH
60 70 80 90 100
RKYGTDLSRG LTTARAAEIL ARDGPNTLTP PPTTPEWVKF CRQLFGGFSL
110 120 130 140 150
LLWIGSLLCF LAYGITSVME GEPNSDNLYL GVVLAAVVII TGCFSYYQEA
160 170 180 190 200
KSSKIMESFK NMVPQQALVV RNGEKMSINA EGVVVGDLVE VKGGDRIPAD
210 220 230 240 250
LRIISAHGCK VDNSSLTGES EPQTRSPDFS NENPLETRNI AFFSTNCVEG
260 270 280 290 300
TAVGIVISTG DRTVMGRIAS LASGLEGGKT PIAMEIEHFI HLITGVAVFL
310 320 330 340 350
GVSFFILSLI LEYTWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVGTLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TENQSGASFD KSSATWLALS RIAGLCNRAV FQANQENVPI LKRAVAGDAS
460 470 480 490 500
ESALLKCIEL CCGSVKEMRE RYPKVVEIPF NSTNKYQLSI HKNANAGESR
510 520 530 540 550
HLLVMKGAPE RILDRCDSIL IHGKVQPLDE EIKDAFQNAY LELGGLGERV
560 570 580 590 600
LGFCHLALPD DQFPEGFQFD TDEVNFPVEK LCFVGLMSMI DPPRAAVPDA
610 620 630 640 650
VGKCRSAGIK VIMVTGDHPI TAKAIAKGVG IISDGNETVE DIAARLNIPV
660 670 680 690 700
SQVNPRDAKA CVVHGSDLKD MTSEQLDDIL LHHTEIVFAR TSPQQKLIIV
710 720 730 740 750
EGCQRQGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS KQAADMILLD
760 770 780 790 800
DNFASIVTGV EEGRLIFDNL KKSIAYTLTS NIPEITPFLI FIIANIPLPL
810 820 830 840 850
GTCTILCIDL GTDMVPAISL AYEQAESDIM KRQPRNPKTD KLVNERLISM
860 870 880 890 900
AYGQIGMIQA LGGFFTYFVI MAENGFLPSG LVGIRLQWDD RWINDVEDSY
910 920 930 940 950
GQQWTFEQRK IVEFTCHTAF FVSIVVVQWA DLIICKTRRN SVFQQGMKNK
960 970 980 990 1000
ILIFGLFEET ALAAFLSYCP GMDVALRMYP LKPTWWFCAF PYSLLIFLYD
1010 1020
EIRKLIIRRN PGGWVERETY Y
Length:1,021
Mass (Da):112,231
Last modified:July 1, 1989 - v1
Checksum:i921E86B6FD843EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03230 mRNA. Translation: AAA48607.1.
PIRiA28199.
RefSeqiNP_990852.1. NM_205521.1.
UniGeneiGga.2155.

Genome annotation databases

GeneIDi396530.
KEGGigga:396530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03230 mRNA. Translation: AAA48607.1 .
PIRi A28199.
RefSeqi NP_990852.1. NM_205521.1.
UniGenei Gga.2155.

3D structure databases

ProteinModelPortali P09572.
SMRi P09572. Positions 26-1021.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676774. 1 interaction.
DIPi DIP-27N.
IntActi P09572. 1 interaction.
STRINGi 9031.ENSGALP00000036172.

Proteomic databases

PaxDbi P09572.
PRIDEi P09572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396530.
KEGGi gga:396530.

Organism-specific databases

CTDi 476.

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000265622.
HOVERGENi HBG004298.
InParanoidi P09572.
KOi K01539.
PhylomeDBi P09572.

Miscellaneous databases

NextBioi 20816566.
PROi P09572.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ouabain-sensitive (Na+ + K+)-ATPase activity expressed in mouse L cells by transfection with DNA encoding the alpha-subunit of an avian sodium pump."
    Takeyasu K., Tamkun M.M., Renaud K.J., Fambrough D.M.
    J. Biol. Chem. 263:4347-4354(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiAT1A1_CHICK
AccessioniPrimary (citable) accession number: P09572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3