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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3744-aspartylphosphate intermediateBy similarity1
Binding sitei485ATPBy similarity1
Metal bindingi715MagnesiumBy similarity1
Metal bindingi719MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:ATP1A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 85CytoplasmicSequence analysisAdd BLAST80
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 129ExtracellularSequence analysisAdd BLAST23
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 286CytoplasmicSequence analysisAdd BLAST136
Transmembranei287 – 306HelicalSequence analysisAdd BLAST20
Topological domaini307 – 318ExtracellularSequence analysisAdd BLAST12
Transmembranei319 – 336HelicalSequence analysisAdd BLAST18
Topological domaini337 – 770CytoplasmicSequence analysisAdd BLAST434
Transmembranei771 – 790HelicalSequence analysisAdd BLAST20
Topological domaini791 – 800ExtracellularSequence analysis10
Transmembranei801 – 821HelicalSequence analysisAdd BLAST21
Topological domaini822 – 841CytoplasmicSequence analysisAdd BLAST20
Transmembranei842 – 864HelicalSequence analysisAdd BLAST23
Topological domaini865 – 916ExtracellularSequence analysisAdd BLAST52
Transmembranei917 – 936HelicalSequence analysisAdd BLAST20
Topological domaini937 – 949CytoplasmicSequence analysisAdd BLAST13
Transmembranei950 – 968HelicalSequence analysisAdd BLAST19
Topological domaini969 – 983ExtracellularSequence analysisAdd BLAST15
Transmembranei984 – 1004HelicalSequence analysisAdd BLAST21
Topological domaini1005 – 1021CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000024931 – 55
ChainiPRO_00000024946 – 1021Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST1016

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei16Phosphoserine; by PKCBy similarity1
Modified residuei941Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09572.
PRIDEiP09572.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

BioGridi676774. 1 interactor.
DIPiDIP-27N.
IntActiP09572. 1 interactor.
STRINGi9031.ENSGALP00000036172.

Structurei

3D structure databases

ProteinModelPortaliP09572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 82Phosphoinositide-3 kinase bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP09572.
KOiK01539.
PhylomeDBiP09572.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGAGRDKY EPTATSEHGT KKKKAKERDM DELKKEISMD DHKLSLDELH
60 70 80 90 100
RKYGTDLSRG LTTARAAEIL ARDGPNTLTP PPTTPEWVKF CRQLFGGFSL
110 120 130 140 150
LLWIGSLLCF LAYGITSVME GEPNSDNLYL GVVLAAVVII TGCFSYYQEA
160 170 180 190 200
KSSKIMESFK NMVPQQALVV RNGEKMSINA EGVVVGDLVE VKGGDRIPAD
210 220 230 240 250
LRIISAHGCK VDNSSLTGES EPQTRSPDFS NENPLETRNI AFFSTNCVEG
260 270 280 290 300
TAVGIVISTG DRTVMGRIAS LASGLEGGKT PIAMEIEHFI HLITGVAVFL
310 320 330 340 350
GVSFFILSLI LEYTWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVGTLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TENQSGASFD KSSATWLALS RIAGLCNRAV FQANQENVPI LKRAVAGDAS
460 470 480 490 500
ESALLKCIEL CCGSVKEMRE RYPKVVEIPF NSTNKYQLSI HKNANAGESR
510 520 530 540 550
HLLVMKGAPE RILDRCDSIL IHGKVQPLDE EIKDAFQNAY LELGGLGERV
560 570 580 590 600
LGFCHLALPD DQFPEGFQFD TDEVNFPVEK LCFVGLMSMI DPPRAAVPDA
610 620 630 640 650
VGKCRSAGIK VIMVTGDHPI TAKAIAKGVG IISDGNETVE DIAARLNIPV
660 670 680 690 700
SQVNPRDAKA CVVHGSDLKD MTSEQLDDIL LHHTEIVFAR TSPQQKLIIV
710 720 730 740 750
EGCQRQGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS KQAADMILLD
760 770 780 790 800
DNFASIVTGV EEGRLIFDNL KKSIAYTLTS NIPEITPFLI FIIANIPLPL
810 820 830 840 850
GTCTILCIDL GTDMVPAISL AYEQAESDIM KRQPRNPKTD KLVNERLISM
860 870 880 890 900
AYGQIGMIQA LGGFFTYFVI MAENGFLPSG LVGIRLQWDD RWINDVEDSY
910 920 930 940 950
GQQWTFEQRK IVEFTCHTAF FVSIVVVQWA DLIICKTRRN SVFQQGMKNK
960 970 980 990 1000
ILIFGLFEET ALAAFLSYCP GMDVALRMYP LKPTWWFCAF PYSLLIFLYD
1010 1020
EIRKLIIRRN PGGWVERETY Y
Length:1,021
Mass (Da):112,231
Last modified:July 1, 1989 - v1
Checksum:i921E86B6FD843EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03230 mRNA. Translation: AAA48607.1.
PIRiA28199.
RefSeqiNP_990852.1. NM_205521.1.
UniGeneiGga.2155.

Genome annotation databases

GeneIDi396530.
KEGGigga:396530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03230 mRNA. Translation: AAA48607.1.
PIRiA28199.
RefSeqiNP_990852.1. NM_205521.1.
UniGeneiGga.2155.

3D structure databases

ProteinModelPortaliP09572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676774. 1 interactor.
DIPiDIP-27N.
IntActiP09572. 1 interactor.
STRINGi9031.ENSGALP00000036172.

Proteomic databases

PaxDbiP09572.
PRIDEiP09572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396530.
KEGGigga:396530.

Organism-specific databases

CTDi476.

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP09572.
KOiK01539.
PhylomeDBiP09572.

Miscellaneous databases

PROiP09572.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A1_CHICK
AccessioniPrimary (citable) accession number: P09572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.