P09569 (ADEN_ADE12) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 62.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenain EC=3.4.22.39 Alternative name(s): Endoprotease Late L3 23 kDa protein |
| Organism | Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) |
| Taxonomic identifier | 28282 [NCBI] |
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A |
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 206 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Thiol protease cleaving specific Gly-Ala peptides in a number of viral precursor proteins (terminal, IIIa, VI, VII, VIII, IIa and mu) which are required for virion maturation. Also cleaves host cells cytoskeletal keratins K7 and K18. |
| Catalytic activity | Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid). |
| Sequence similarities | Belongs to the peptidase C5 family. |
Ontologies
| Keywords | |
|---|---|
| Developmental stage | Late protein |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Autocatalytic cleavage |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 206 | 206 | Adenain | PRO_0000218028 | |||||
Sites | |||||||||
| Active site | 54 | 1 | By similarity | ||||||
| Active site | 71 | 1 | By similarity | ||||||
| Active site | 122 | 1 | By similarity | ||||||
| Site | 46 – 47 | 2 | Cleavage; by autolysis Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 180 | 1 | N → S in CAA30501. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The primary structure of human adenovirus type 12 protease." Weber J.M., Houde A. Nucleic Acids Res. 16:7195-7195(1988) [PubMed: 3043380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Pereira 1131. |
| [2] | "Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X07655 Genomic DNA. Translation: CAA30501.1. X73487 Genomic DNA. Translation: CAA51892.1. |
| PIR | W2AD12. S01731. |
| RefSeq | NP_040925.1. NC_001460.1. |
3D structure databases | |
| ProteinModelPortal | P09569. |
| SMR | P09569. Positions 1-203. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | C05.001. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1460858. |
Phylogenomic databases | |
| ProtClustDB | CLSP2513881. |
Family and domain databases | |
| InterPro | IPR000855. Peptidase_C5. [Graphical view] |
| Gene3D | G3DSA:3.40.395.10. Peptidase_C5. 1 hit. |
| Pfam | PF00770. Peptidase_C5. 1 hit. [Graphical view] |
| PIRSF | PIRSF001218. Protease_ADV. 1 hit. |
| PRINTS | PR00703. ADVENDOPTASE. |
| ProDom | PD003705. Peptidase_C5. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | ADEN_ADE12 | ||||||||
| Accession | Primary (citable) accession number: P09569 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with