T-cell antigen CD7 precursor - Homo sapiens (Human)

Contribute

Send feedback

Read comments (?) or add your own

P09564 (CD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 129. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
T-cell antigen CD7

Alternative name(s):
GP40
T-cell leukemia antigen
T-cell surface antigen Leu-9
TP41
CD_antigen=CD7

Gene names

Name:

CD7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not yet known.
Subunit structure	Interacts with SECTM1. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell activation Traceable author statement PubMed 11485208. Source: UniProtKB homeostasis of number of cells within a tissue Inferred from electronic annotation. Source: Compara immune response Traceable author statement PubMed 11485208. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway Non-traceable author statement PubMed 11485208. Source: UniProtKB
Cellular_component	integral to membrane Traceable author statement PubMed 11485208. Source: UniProtKB plasma membrane Traceable author statement PubMed 1695199 PubMed 3258561. Source: ProtInc
Molecular_function	receptor activity Traceable author statement PubMed 11485208. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

Chain

26 – 240

215

T-cell antigen CD7

PRO_0000014633

Regions

Topological domain

26 – 180

155

Extracellular Probable

Transmembrane

181 – 201

Helical; Probable

Topological domain

202 – 240

Cytoplasmic Probable

Domain

26 – 130

105

Ig-like

Repeat

Repeat

Repeat

Repeat

Region

4 X 9 AA tandem repeats, potential spacer function

Amino acid modifications

Lipidation

198

S-palmitoyl cysteine

Glycosylation

N-linked (GlcNAc...)

Glycosylation

N-linked (GlcNAc...) Ref.8 Ref.9

Disulfide bond

35 ↔ 142

Potential

Disulfide bond

48 ↔ 114

Potential

Natural variations

Natural variant

113

T → A.
Corresponds to variant rs34579511 [ dbSNP | Ensembl ].

VAR_049855

Sequences

Sequence

Length

Mass (Da)

Tools

P09564 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: EBBCE08279552108
Show »

FASTA

240

25,409

        10         20         30         40         50         60 
MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 

        70         80         90        100        110        120 
QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 

       130        140        150        160        170        180 
NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 

       190        200        210        220        230        240 
AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system." Aruffo A., Seed B. EMBO J. 6:3313-3316(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene." Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E. Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"Molecular cloning of the gene coding for the human T cell differentiation antigen CD7." Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T. Immunogenetics 33:352-360(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
[6]	"Characterization of the surface topography and putative tertiary structure of the human CD7 molecule." Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F. J. Immunol. 143:3632-3640(1989) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY.
[7]	"Identification of CD7 as a cognate of the human K12 (SECTM1) protein." Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C. J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SECTM1.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X06180 mRNA. Translation: CAA29546.1. M37271 Genomic DNA. Translation: AAA51953.1. BT006696 mRNA. Translation: AAP35342.1. BC009293 mRNA. Translation: AAH09293.1. BC013297 mRNA. Translation: AAH13297.1. D00749 Genomic DNA. Translation: BAA00646.1.
IPI	IPI00015199.
PIR	A39016.
RefSeq	NP_006128.1. NM_006137.6.
UniGene	Hs.36972.
3D structure databases
ProteinModelPortal	P09564.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09564. 3 interactions.
STRING	9606.ENSP00000312027.
PTM databases
PhosphoSite	P09564.
Polymorphism databases
DMDM	116031.
Proteomic databases
PaxDb	P09564.
PRIDE	P09564.
Protocols and materials databases
DNASU	924.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312648; ENSP00000312027; ENSG00000173762.
GeneID	924.
KEGG	hsa:924.
UCSC	uc002kel.1. human.
Organism-specific databases
CTD	924.
GeneCards	GC17M080272.
HGNC	HGNC:1695. CD7.
HPA	CAB002594.
MIM	186820. gene.
neXtProt	NX_P09564.
PharmGKB	PA26234.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43963.
HOGENOM	HOG000285979.
HOVERGEN	HBG005290.
InParanoid	P09564.
KO	K06457.
OMA	VYEDMSH.
OrthoDB	EOG42JNSK.
PhylomeDB	P09564.
Gene expression databases
ArrayExpress	P09564.
Bgee	P09564.
CleanEx	HS_CD7.
Genevestigator	P09564.
GermOnline	ENSG00000173762. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	924.
NextBio	3822.
SOURCE	Search...

Entry information

Entry name

CD7_HUMAN

Accession

Primary (citable) accession number: P09564

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 129 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents