Reviewed, UniProtKB/Swiss-Prot P09564 (CD7_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell antigen CD7
Alternative name(s):
    GP40
    T-cell leukemia antigen
    TP41
    Leu-9
    CD_antigen=CD7

Gene names

Name:

CD7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Not yet known.
Subunit structure	Interacts with SECTM1. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	T cell activation Traceable author statement. Source: UniProtKB immune response Traceable author statement. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Traceable author statement. Source: UniProtKB membrane fraction Ref.1 Traceable author statement. Source: ProtInc plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25
	Chain	26 – 240	215	T-cell antigen CD7		PRO_0000014633
Regions
	Topological domain	26 – 180	155	Extracellular Probable
	Transmembrane	181 – 201	21	Probable
	Topological domain	202 – 240	39	Cytoplasmic Probable
	Domain	26 – 130	105	Ig-like
	Repeat	145 – 153	9	1
	Repeat	154 – 162	9	2
	Repeat	163 – 171	9	3
	Repeat	172 – 180	9	4
	Region	145 – 180	36	4 X 9 AA tandem repeats, potential spacer function
Amino acid modifications
	Lipidation	198	1	S-palmitoyl cysteine
	Glycosylation	45	1	N-linked (GlcNAc...)
	Glycosylation	96	1	N-linked (GlcNAc...) Ref.8 Ref.9
	Disulfide bond	35 ↔ 142		Potential
	Disulfide bond	48 ↔ 114		Potential
Natural variations
	Natural variant	113	1	T → A: dbSNP rs34579511.		VAR_049855

Sequences

	Sequence		Length	Mass (Da)
	P09564-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: EBBCE08279552108	FASTA	240	25,409
	10 20 30 40 50 60 MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 70 80 90 100 110 120 QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 130 140 150 160 170 180 NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 190 200 210 220 230 240 AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system." Aruffo A., Seed B. EMBO J. 6:3313-3316(1987) [PubMed: 3501369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene." Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E. Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed: 1703303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"Molecular cloning of the gene coding for the human T cell differentiation antigen CD7." Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T. Immunogenetics 33:352-360(1991) [PubMed: 1711009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
[6]	"Characterization of the surface topography and putative tertiary structure of the human CD7 molecule." Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F. J. Immunol. 143:3632-3640(1989) [PubMed: 2479685] [Abstract] Cited for: TOPOLOGY.
[7]	"Identification of CD7 as a cognate of the human K12 (SECTM1) protein." Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C. J. Biol. Chem. 275:3431-3437(2000) [PubMed: 10652336] [Abstract] Cited for: INTERACTION WITH SECTM1.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X06180 mRNA. Translation: CAA29546.1. M37271 Genomic DNA. Translation: AAA51953.1. BT006696 mRNA. Translation: AAP35342.1. BC009293 mRNA. Translation: AAH09293.1. BC013297 mRNA. Translation: AAH13297.1. D00749 Genomic DNA. Translation: BAA00646.1.
IPI	IPI00015199.
PIR	A39016.
RefSeq	NP_006128.1.
UniGene	Hs.36972
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P09564.
PTM databases
PhosphoSite	P09564.
Proteomic databases
PRIDE	P09564.
Genome annotation databases
Ensembl	ENST00000312648; ENSP00000312027; ENSG00000173762; Homo sapiens. [Genome view]
GeneID	924.
KEGG	hsa:924.
UCSC	uc002kel.1. human.
Organism-specific databases
CTD	924.
GeneCards	GC17M077866.
H-InvDB	HIX0014252.
HGNC	HGNC:1695. CD7.
HPA	CAB002594.
MIM	186820. gene.
PharmGKB	PA26234.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P09564.
HOVERGEN	P09564.
OMA	VYEDMSH
OrthoDB	EOG9GB9ST
Gene expression databases
ArrayExpress	P09564.
Bgee	P09564.
CleanEx	HS_CD7.
Genevestigator	P09564.
GermOnline	ENSG00000173762. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3822.
SOURCE	Search...

Entry information

Entry name

CD7_HUMAN

Accession

Primary (citable) accession number: P09564

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 24, 2009
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.