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Protein

T-cell antigen CD7

Gene

CD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • immune response Source: UniProtKB
  • T cell activation Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

SignaLinkiP09564

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell antigen CD7
Alternative name(s):
GP40
T-cell leukemia antigen
T-cell surface antigen Leu-9
TP41
CD_antigen: CD7
Gene namesi
Name:CD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173762.7
HGNCiHGNC:1695 CD7
MIMi186820 gene
neXtProtiNX_P09564

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 180Extracellular1 PublicationAdd BLAST155
Transmembranei181 – 201HelicalCuratedAdd BLAST21
Topological domaini202 – 240Cytoplasmic1 PublicationAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi924
OpenTargetsiENSG00000173762
PharmGKBiPA26234

Polymorphism and mutation databases

BioMutaiCD7
DMDMi116031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001463326 – 240T-cell antigen CD7Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 142PROSITE-ProRule annotation
Glycosylationi45N-linked (GlcNAc...) asparagine1
Disulfide bondi48 ↔ 114PROSITE-ProRule annotation
Glycosylationi96N-linked (GlcNAc...) asparagine2 Publications1
Lipidationi198S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP09564
PeptideAtlasiP09564
PRIDEiP09564

PTM databases

iPTMnetiP09564
PhosphoSitePlusiP09564
SwissPalmiP09564

Expressioni

Gene expression databases

BgeeiENSG00000173762
CleanExiHS_CD7
ExpressionAtlasiP09564 baseline and differential
GenevisibleiP09564 HS

Organism-specific databases

HPAiCAB002594
HPA039079

Interactioni

Subunit structurei

Interacts with SECTM1.1 Publication

Protein-protein interaction databases

BioGridi1073628 interactors.
IntActiP09564 5 interactors.
MINTiP09564
STRINGi9606.ENSP00000312027

Structurei

3D structure databases

ProteinModelPortaliP09564
SMRiP09564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 130Ig-likeAdd BLAST105
Repeati145 – 15319
Repeati154 – 16229
Repeati163 – 17139
Repeati172 – 18049

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 1804 X 9 AA tandem repeats, potential spacer functionAdd BLAST36

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYNZ Eukaryota
ENOG41117EQ LUCA
GeneTreeiENSGT00390000013965
HOGENOMiHOG000285979
HOVERGENiHBG005290
InParanoidiP09564
KOiK06457
OMAiYEDMSHS
OrthoDBiEOG091G0Q1Y
PhylomeDBiP09564
TreeFamiTF338565

Family and domain databases

Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST
60 70 80 90 100
SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT
110 120 130 140 150
MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS
160 170 180 190 200
ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL
210 220 230 240
ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ
Length:240
Mass (Da):25,409
Last modified:July 1, 1989 - v1
Checksum:iEBBCE08279552108
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049855113T → A. Corresponds to variant dbSNP:rs34579511Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06180 mRNA Translation: CAA29546.1
M37271 Genomic DNA Translation: AAA51953.1
BT006696 mRNA Translation: AAP35342.1
BC009293 mRNA Translation: AAH09293.1
BC013297 mRNA Translation: AAH13297.1
D00749 Genomic DNA Translation: BAA00646.1
CCDSiCCDS11807.1
PIRiA39016
RefSeqiNP_006128.1, NM_006137.6
UniGeneiHs.36972

Genome annotation databases

EnsembliENST00000312648; ENSP00000312027; ENSG00000173762
GeneIDi924
KEGGihsa:924

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD7_HUMAN
AccessioniPrimary (citable) accession number: P09564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome