Reviewed,
UniProtKB/Swiss-Prot P09564 (CD7_HUMAN)
Last modified
November 24, 2009.
Version 99.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: T-cell antigen CD7 Alternative name(s): GP40 T-cell leukemia antigen TP41 Leu-9 CD_antigen=CD7 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 240 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Not yet known. |
| Subunit structure | Interacts with SECTM1. Ref.7 |
| Subcellular location | |
| Sequence similarities | Contains 1 Ig-like (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Immune response |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Immunoglobulin domain Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | T cell activation Traceable author statement. Source: UniProtKB immune responseTraceable author statement. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathwayNon-traceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Traceable author statement. Source: UniProtKB membrane fraction Ref.1Traceable author statement. Source: ProtInc plasma membraneTraceable author statement. Source: ProtInc |
| Molecular function | receptor activity Traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | |||||||||
| Chain | 26 – 240 | 215 | T-cell antigen CD7 | PRO_0000014633 | |||||||
Regions | |||||||||||
| Topological domain | 26 – 180 | 155 | Extracellular Probable | ||||||||
| Transmembrane | 181 – 201 | 21 | Probable | ||||||||
| Topological domain | 202 – 240 | 39 | Cytoplasmic Probable | ||||||||
| Domain | 26 – 130 | 105 | Ig-like | ||||||||
| Repeat | 145 – 153 | 9 | 1 | ||||||||
| Repeat | 154 – 162 | 9 | 2 | ||||||||
| Repeat | 163 – 171 | 9 | 3 | ||||||||
| Repeat | 172 – 180 | 9 | 4 | ||||||||
| Region | 145 – 180 | 36 | 4 X 9 AA tandem repeats, potential spacer function | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 198 | 1 | S-palmitoyl cysteine | ||||||||
| Glycosylation | 45 | 1 | N-linked (GlcNAc...) | ||||||||
| Glycosylation | 96 | 1 | N-linked (GlcNAc...) Ref.8 Ref.9 | ||||||||
| Disulfide bond | 35 ↔ 142 | Potential | |||||||||
| Disulfide bond | 48 ↔ 114 | Potential | |||||||||
Natural variations | |||||||||||
| Natural variant | 113 | 1 | T → A: dbSNP rs34579511. | VAR_049855 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system." Aruffo A., Seed B. EMBO J. 6:3313-3316(1987) [PubMed: 3501369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene." Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E. Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed: 1703303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle. |
| [5] | "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7." Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T. Immunogenetics 33:352-360(1991) [PubMed: 1711009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240. |
| [6] | "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule." Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F. J. Immunol. 143:3632-3640(1989) [PubMed: 2479685] [Abstract] Cited for: TOPOLOGY. |
| [7] | "Identification of CD7 as a cognate of the human K12 (SECTM1) protein." Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C. J. Biol. Chem. 275:3431-3437(2000) [PubMed: 10652336] [Abstract] Cited for: INTERACTION WITH SECTM1. |
| [8] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY. Tissue: Liver. |
| [9] | "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X06180 mRNA. Translation: CAA29546.1. M37271 Genomic DNA. Translation: AAA51953.1. BT006696 mRNA. Translation: AAP35342.1. BC009293 mRNA. Translation: AAH09293.1. BC013297 mRNA. Translation: AAH13297.1. D00749 Genomic DNA. Translation: BAA00646.1. | |
| IPI | IPI00015199. |
| PIR | A39016. |
| RefSeq | NP_006128.1. |
| UniGene | Hs.36972 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P09564. |
PTM databases | |
| PhosphoSite | P09564. |
Proteomic databases | |
| PRIDE | P09564. |
Genome annotation databases | |
| Ensembl | ENST00000312648; ENSP00000312027; ENSG00000173762; Homo sapiens. [Genome view] |
| GeneID | 924. |
| KEGG | hsa:924. |
| UCSC | uc002kel.1. human. |
Organism-specific databases | |
| CTD | 924. |
| GeneCards | GC17M077866. |
| H-InvDB | HIX0014252. |
| HGNC | HGNC:1695. CD7. |
| HPA | CAB002594. |
| MIM | 186820. gene. |
| PharmGKB | PA26234. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P09564. |
| HOVERGEN | P09564. |
| OMA | VYEDMSH |
| OrthoDB | EOG9GB9ST |
Gene expression databases | |
| ArrayExpress | P09564. |
| Bgee | P09564. |
| CleanEx | HS_CD7. |
| Genevestigator | P09564. |
| GermOnline | ENSG00000173762. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 1 hit. |
| Pfam | PF07686. V-set. 1 hit. [Graphical view] |
| SMART | SM00409. IG. 1 hit. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 3822. |
| SOURCE | Search... |
Entry information
| Entry name | CD7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P09564 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


