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Protein

T-cell antigen CD7

Gene

CD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • homeostasis of number of cells within a tissue Source: Ensembl
  • immune response Source: UniProtKB
  • T cell activation Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

SignaLinkiP09564.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell antigen CD7
Alternative name(s):
GP40
T-cell leukemia antigen
T-cell surface antigen Leu-9
TP41
CD_antigen: CD7
Gene namesi
Name:CD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1695. CD7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 180155Extracellular1 PublicationAdd
BLAST
Transmembranei181 – 20121HelicalCuratedAdd
BLAST
Topological domaini202 – 24039Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26234.

Polymorphism and mutation databases

BioMutaiCD7.
DMDMi116031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 240215T-cell antigen CD7PRO_0000014633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 142PROSITE-ProRule annotation
Glycosylationi45 – 451N-linked (GlcNAc...)
Disulfide bondi48 ↔ 114PROSITE-ProRule annotation
Glycosylationi96 – 961N-linked (GlcNAc...)2 Publications
Lipidationi198 – 1981S-palmitoyl cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP09564.
PaxDbiP09564.
PRIDEiP09564.

PTM databases

PhosphoSiteiP09564.

Expressioni

Gene expression databases

BgeeiP09564.
CleanExiHS_CD7.
ExpressionAtlasiP09564. baseline and differential.
GenevisibleiP09564. HS.

Organism-specific databases

HPAiCAB002594.
HPA039079.

Interactioni

Subunit structurei

Interacts with SECTM1.1 Publication

Protein-protein interaction databases

BioGridi107362. 6 interactions.
IntActiP09564. 5 interactions.
MINTiMINT-4656262.
STRINGi9606.ENSP00000312027.

Structurei

3D structure databases

ProteinModelPortaliP09564.
SMRiP09564. Positions 28-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 130105Ig-likeAdd
BLAST
Repeati145 – 15391
Repeati154 – 16292
Repeati163 – 17193
Repeati172 – 18094

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 180364 X 9 AA tandem repeats, potential spacer functionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43963.
GeneTreeiENSGT00390000013965.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP09564.
KOiK06457.
OMAiYEDMSHS.
PhylomeDBiP09564.
TreeFamiTF338565.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST
60 70 80 90 100
SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT
110 120 130 140 150
MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS
160 170 180 190 200
ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL
210 220 230 240
ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ
Length:240
Mass (Da):25,409
Last modified:July 1, 1989 - v1
Checksum:iEBBCE08279552108
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131T → A.
Corresponds to variant rs34579511 [ dbSNP | Ensembl ].
VAR_049855

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06180 mRNA. Translation: CAA29546.1.
M37271 Genomic DNA. Translation: AAA51953.1.
BT006696 mRNA. Translation: AAP35342.1.
BC009293 mRNA. Translation: AAH09293.1.
BC013297 mRNA. Translation: AAH13297.1.
D00749 Genomic DNA. Translation: BAA00646.1.
CCDSiCCDS11807.1.
PIRiA39016.
RefSeqiNP_006128.1. NM_006137.6.
UniGeneiHs.36972.

Genome annotation databases

EnsembliENST00000312648; ENSP00000312027; ENSG00000173762.
GeneIDi924.
KEGGihsa:924.
UCSCiuc002kel.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06180 mRNA. Translation: CAA29546.1.
M37271 Genomic DNA. Translation: AAA51953.1.
BT006696 mRNA. Translation: AAP35342.1.
BC009293 mRNA. Translation: AAH09293.1.
BC013297 mRNA. Translation: AAH13297.1.
D00749 Genomic DNA. Translation: BAA00646.1.
CCDSiCCDS11807.1.
PIRiA39016.
RefSeqiNP_006128.1. NM_006137.6.
UniGeneiHs.36972.

3D structure databases

ProteinModelPortaliP09564.
SMRiP09564. Positions 28-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107362. 6 interactions.
IntActiP09564. 5 interactions.
MINTiMINT-4656262.
STRINGi9606.ENSP00000312027.

PTM databases

PhosphoSiteiP09564.

Polymorphism and mutation databases

BioMutaiCD7.
DMDMi116031.

Proteomic databases

MaxQBiP09564.
PaxDbiP09564.
PRIDEiP09564.

Protocols and materials databases

DNASUi924.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312648; ENSP00000312027; ENSG00000173762.
GeneIDi924.
KEGGihsa:924.
UCSCiuc002kel.1. human.

Organism-specific databases

CTDi924.
GeneCardsiGC17M080272.
HGNCiHGNC:1695. CD7.
HPAiCAB002594.
HPA039079.
MIMi186820. gene.
neXtProtiNX_P09564.
PharmGKBiPA26234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43963.
GeneTreeiENSGT00390000013965.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP09564.
KOiK06457.
OMAiYEDMSHS.
PhylomeDBiP09564.
TreeFamiTF338565.

Enzyme and pathway databases

SignaLinkiP09564.

Miscellaneous databases

GeneWikiiCD7.
GenomeRNAii924.
NextBioi3822.
PROiP09564.
SOURCEiSearch...

Gene expression databases

BgeeiP09564.
CleanExiHS_CD7.
ExpressionAtlasiP09564. baseline and differential.
GenevisibleiP09564. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system."
    Aruffo A., Seed B.
    EMBO J. 6:3313-3316(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PALMITOYLATION AT CYS-198.
  2. "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene."
    Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E.
    Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7."
    Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T.
    Immunogenetics 33:352-360(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
  6. "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule."
    Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F.
    J. Immunol. 143:3632-3640(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  7. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
    Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
    J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SECTM1.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
    Tissue: Liver.
  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCD7_HUMAN
AccessioniPrimary (citable) accession number: P09564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 22, 2015
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.