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P09564

- CD7_HUMAN

UniProt

P09564 - CD7_HUMAN

Protein

T-cell antigen CD7

Gene

CD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Not yet known.

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. homeostasis of number of cells within a tissue Source: Ensembl
    2. immune response Source: UniProtKB
    3. T cell activation Source: UniProtKB
    4. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    SignaLinkiP09564.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell antigen CD7
    Alternative name(s):
    GP40
    T-cell leukemia antigen
    T-cell surface antigen Leu-9
    TP41
    CD_antigen: CD7
    Gene namesi
    Name:CD7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1695. CD7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB
    3. membrane Source: ProtInc
    4. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26234.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 240215T-cell antigen CD7PRO_0000014633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 142PROSITE-ProRule annotation
    Glycosylationi45 – 451N-linked (GlcNAc...)
    Disulfide bondi48 ↔ 114PROSITE-ProRule annotation
    Glycosylationi96 – 961N-linked (GlcNAc...)2 Publications
    Lipidationi198 – 1981S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP09564.
    PaxDbiP09564.
    PRIDEiP09564.

    PTM databases

    PhosphoSiteiP09564.

    Expressioni

    Gene expression databases

    ArrayExpressiP09564.
    BgeeiP09564.
    CleanExiHS_CD7.
    GenevestigatoriP09564.

    Organism-specific databases

    HPAiCAB002594.

    Interactioni

    Subunit structurei

    Interacts with SECTM1.1 Publication

    Protein-protein interaction databases

    BioGridi107362. 6 interactions.
    IntActiP09564. 5 interactions.
    MINTiMINT-4656262.
    STRINGi9606.ENSP00000312027.

    Structurei

    3D structure databases

    ProteinModelPortaliP09564.
    SMRiP09564. Positions 26-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 180155Extracellular1 PublicationAdd
    BLAST
    Topological domaini202 – 24039Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei181 – 20121HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 130105Ig-likeAdd
    BLAST
    Repeati145 – 15391
    Repeati154 – 16292
    Repeati163 – 17193
    Repeati172 – 18094

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 180364 X 9 AA tandem repeats, potential spacer functionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43963.
    HOGENOMiHOG000285979.
    HOVERGENiHBG005290.
    InParanoidiP09564.
    KOiK06457.
    OMAiYEDMSHS.
    PhylomeDBiP09564.
    TreeFamiTF338565.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09564-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST    50
    SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT 100
    MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS 150
    ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL 200
    ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ 240
    Length:240
    Mass (Da):25,409
    Last modified:July 1, 1989 - v1
    Checksum:iEBBCE08279552108
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131T → A.
    Corresponds to variant rs34579511 [ dbSNP | Ensembl ].
    VAR_049855

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06180 mRNA. Translation: CAA29546.1.
    M37271 Genomic DNA. Translation: AAA51953.1.
    BT006696 mRNA. Translation: AAP35342.1.
    BC009293 mRNA. Translation: AAH09293.1.
    BC013297 mRNA. Translation: AAH13297.1.
    D00749 Genomic DNA. Translation: BAA00646.1.
    CCDSiCCDS11807.1.
    PIRiA39016.
    RefSeqiNP_006128.1. NM_006137.6.
    UniGeneiHs.36972.

    Genome annotation databases

    EnsembliENST00000312648; ENSP00000312027; ENSG00000173762.
    GeneIDi924.
    KEGGihsa:924.
    UCSCiuc002kel.1. human.

    Polymorphism databases

    DMDMi116031.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06180 mRNA. Translation: CAA29546.1 .
    M37271 Genomic DNA. Translation: AAA51953.1 .
    BT006696 mRNA. Translation: AAP35342.1 .
    BC009293 mRNA. Translation: AAH09293.1 .
    BC013297 mRNA. Translation: AAH13297.1 .
    D00749 Genomic DNA. Translation: BAA00646.1 .
    CCDSi CCDS11807.1.
    PIRi A39016.
    RefSeqi NP_006128.1. NM_006137.6.
    UniGenei Hs.36972.

    3D structure databases

    ProteinModelPortali P09564.
    SMRi P09564. Positions 26-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107362. 6 interactions.
    IntActi P09564. 5 interactions.
    MINTi MINT-4656262.
    STRINGi 9606.ENSP00000312027.

    PTM databases

    PhosphoSitei P09564.

    Polymorphism databases

    DMDMi 116031.

    Proteomic databases

    MaxQBi P09564.
    PaxDbi P09564.
    PRIDEi P09564.

    Protocols and materials databases

    DNASUi 924.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312648 ; ENSP00000312027 ; ENSG00000173762 .
    GeneIDi 924.
    KEGGi hsa:924.
    UCSCi uc002kel.1. human.

    Organism-specific databases

    CTDi 924.
    GeneCardsi GC17M080272.
    HGNCi HGNC:1695. CD7.
    HPAi CAB002594.
    MIMi 186820. gene.
    neXtProti NX_P09564.
    PharmGKBi PA26234.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43963.
    HOGENOMi HOG000285979.
    HOVERGENi HBG005290.
    InParanoidi P09564.
    KOi K06457.
    OMAi YEDMSHS.
    PhylomeDBi P09564.
    TreeFami TF338565.

    Enzyme and pathway databases

    SignaLinki P09564.

    Miscellaneous databases

    GeneWikii CD7.
    GenomeRNAii 924.
    NextBioi 3822.
    PROi P09564.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09564.
    Bgeei P09564.
    CleanExi HS_CD7.
    Genevestigatori P09564.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system."
      Aruffo A., Seed B.
      EMBO J. 6:3313-3316(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PALMITOYLATION AT CYS-198.
    2. "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene."
      Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E.
      Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7."
      Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T.
      Immunogenetics 33:352-360(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
    6. "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule."
      Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F.
      J. Immunol. 143:3632-3640(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    7. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
      Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
      J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SECTM1.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
      Tissue: Liver.
    9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCD7_HUMAN
    AccessioniPrimary (citable) accession number: P09564
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 143 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3