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P09564 (CD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell antigen CD7
Alternative name(s):
GP40
T-cell leukemia antigen
T-cell surface antigen Leu-9
TP41
CD_antigen=CD7
Gene names
Name:CD7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not yet known.

Subunit structure

Interacts with SECTM1. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Chain26 – 240215T-cell antigen CD7
PRO_0000014633

Regions

Topological domain26 – 180155Extracellular Probable
Transmembrane181 – 20121Helical; Probable
Topological domain202 – 24039Cytoplasmic Probable
Domain26 – 130105Ig-like
Repeat145 – 15391
Repeat154 – 16292
Repeat163 – 17193
Repeat172 – 18094
Region145 – 180364 X 9 AA tandem repeats, potential spacer function

Amino acid modifications

Lipidation1981S-palmitoyl cysteine Probable
Glycosylation451N-linked (GlcNAc...)
Glycosylation961N-linked (GlcNAc...) Ref.8 Ref.9
Disulfide bond35 ↔ 142 Potential
Disulfide bond48 ↔ 114 Potential

Natural variations

Natural variant1131T → A.
Corresponds to variant rs34579511 [ dbSNP | Ensembl ].
VAR_049855

Sequences

Sequence LengthMass (Da)Tools
P09564 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: EBBCE08279552108

FASTA24025,409
        10         20         30         40         50         60 
MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 

        70         80         90        100        110        120 
QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 

       130        140        150        160        170        180 
NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 

       190        200        210        220        230        240 
AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system."
Aruffo A., Seed B.
EMBO J. 6:3313-3316(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PALMITOYLATION AT CYS-198.
[2]"Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene."
Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E.
Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"Molecular cloning of the gene coding for the human T cell differentiation antigen CD7."
Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T.
Immunogenetics 33:352-360(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
[6]"Characterization of the surface topography and putative tertiary structure of the human CD7 molecule."
Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F.
J. Immunol. 143:3632-3640(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY.
[7]"Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SECTM1.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
Tissue: Liver.
[9]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
Tissue: Leukemic T-cell.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06180 mRNA. Translation: CAA29546.1.
M37271 Genomic DNA. Translation: AAA51953.1.
BT006696 mRNA. Translation: AAP35342.1.
BC009293 mRNA. Translation: AAH09293.1.
BC013297 mRNA. Translation: AAH13297.1.
D00749 Genomic DNA. Translation: BAA00646.1.
CCDSCCDS11807.1.
PIRA39016.
RefSeqNP_006128.1. NM_006137.6.
UniGeneHs.36972.

3D structure databases

ProteinModelPortalP09564.
SMRP09564. Positions 26-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107362. 6 interactions.
IntActP09564. 5 interactions.
MINTMINT-4656262.
STRING9606.ENSP00000312027.

PTM databases

PhosphoSiteP09564.

Polymorphism databases

DMDM116031.

Proteomic databases

MaxQBP09564.
PaxDbP09564.
PRIDEP09564.

Protocols and materials databases

DNASU924.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312648; ENSP00000312027; ENSG00000173762.
GeneID924.
KEGGhsa:924.
UCSCuc002kel.1. human.

Organism-specific databases

CTD924.
GeneCardsGC17M080272.
HGNCHGNC:1695. CD7.
HPACAB002594.
MIM186820. gene.
neXtProtNX_P09564.
PharmGKBPA26234.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43963.
HOGENOMHOG000285979.
HOVERGENHBG005290.
InParanoidP09564.
KOK06457.
OMAYEDMSHS.
PhylomeDBP09564.
TreeFamTF338565.

Enzyme and pathway databases

SignaLinkP09564.

Gene expression databases

ArrayExpressP09564.
BgeeP09564.
CleanExHS_CD7.
GenevestigatorP09564.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD7.
GenomeRNAi924.
NextBio3822.
PROP09564.
SOURCESearch...

Entry information

Entry nameCD7_HUMAN
AccessionPrimary (citable) accession number: P09564
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries