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P09558

- EDN1_PIG

UniProt

P09558 - EDN1_PIG

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Protein
Endothelin-1
Gene
EDN1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL By similarity

GO - Biological processi

  1. regulation of vasoconstriction Source: InterPro
  2. vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 5025
PRO_0000008065Add
BLAST
Peptidei53 – 8230Big endothelin-12 Publications
PRO_0000008066Add
BLAST
Peptidei53 – 7321Endothelin-11 Publication
PRO_0000008067Add
BLAST
Propeptidei83 – 203121
PRO_0000008068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67
Disulfide bondi55 ↔ 63
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001121.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
KOiK16366.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09558-1 [UniParc]FASTAAdd to Basket

« Hide

MDYFPMIIAL LFVAFQGAPE TAVLGAELSP EAESQGETPS PHASWRPRRS    50
KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SRRSLKDLFP 100
AKAADRRDRC QCASQKDKKC WSFCQAGKEI GRDQDTMEKR WDNQKKGTDC 150
SKLGEKCIHR QLVMGRKIRR LEAISNSIKT SFHIAKLKAE LYRDKKVTHN 200
RTH 203
Length:203
Mass (Da):23,259
Last modified:July 1, 1989 - v1
Checksum:iAE47E7A8634B157D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07383 mRNA. Translation: CAA30296.1.
PIRiS03159. ANPG.
RefSeqiNP_999047.1. NM_213882.1.
UniGeneiSsc.9364.

Genome annotation databases

GeneIDi396915.
KEGGissc:396915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07383 mRNA. Translation: CAA30296.1 .
PIRi S03159. ANPG.
RefSeqi NP_999047.1. NM_213882.1.
UniGenei Ssc.9364.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000001121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396915.
KEGGi ssc:396915.

Organism-specific databases

CTDi 1906.

Phylogenomic databases

eggNOGi NOG46593.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
KOi K16366.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel potent vasoconstrictor peptide produced by vascular endothelial cells."
    Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yasaki Y., Goto K., Masaki T.
    Nature 332:411-415(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 53-73.
    Tissue: Endothelial cell.
  2. "Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1."
    Sawamura T., Kimura S., Shinmi O., Sugita Y., Yanagisawa M., Masaki T.
    Biochem. Biophys. Res. Commun. 162:1287-1294(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 53-82.
    Tissue: Endothelial cell.
  3. Cited for: PROTEIN SEQUENCE OF 53-82.
    Tissue: Endothelial cell.
  4. "Mode of cleavage of pig big endothelin-1 by chymotrypsin. Production and degradation of mature endothelin-1."
    Takaoka M., Miyata Y., Takenobu Y., Ikegawa R., Matsumura Y., Morimoto S.
    Biochem. J. 270:541-544(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEGRADATION BY CHYMOTRYPSIN.

Entry informationi

Entry nameiEDN1_PIG
AccessioniPrimary (citable) accession number: P09558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 13, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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