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P09558

- EDN1_PIG

UniProt

P09558 - EDN1_PIG

Protein

Endothelin-1

Gene

EDN1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Biological processi

    1. regulation of vasoconstriction Source: InterPro
    2. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Short name:
    ET-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Cleaved into the following chain:
    Gene namesi
    Name:EDN1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 5025PRO_0000008065Add
    BLAST
    Peptidei53 – 8230Big endothelin-1PRO_0000008066Add
    BLAST
    Peptidei53 – 7321Endothelin-11 PublicationPRO_0000008067Add
    BLAST
    Propeptidei83 – 203121PRO_0000008068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67
    Disulfide bondi55 ↔ 63
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000001121.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12415Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    KOiK16366.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09558-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFPMIIAL LFVAFQGAPE TAVLGAELSP EAESQGETPS PHASWRPRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SRRSLKDLFP 100
    AKAADRRDRC QCASQKDKKC WSFCQAGKEI GRDQDTMEKR WDNQKKGTDC 150
    SKLGEKCIHR QLVMGRKIRR LEAISNSIKT SFHIAKLKAE LYRDKKVTHN 200
    RTH 203
    Length:203
    Mass (Da):23,259
    Last modified:July 1, 1989 - v1
    Checksum:iAE47E7A8634B157D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07383 mRNA. Translation: CAA30296.1.
    PIRiS03159. ANPG.
    RefSeqiNP_999047.1. NM_213882.1.
    UniGeneiSsc.9364.

    Genome annotation databases

    GeneIDi396915.
    KEGGissc:396915.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07383 mRNA. Translation: CAA30296.1 .
    PIRi S03159. ANPG.
    RefSeqi NP_999047.1. NM_213882.1.
    UniGenei Ssc.9364.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000001121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396915.
    KEGGi ssc:396915.

    Organism-specific databases

    CTDi 1906.

    Phylogenomic databases

    eggNOGi NOG46593.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    KOi K16366.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel potent vasoconstrictor peptide produced by vascular endothelial cells."
      Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yasaki Y., Goto K., Masaki T.
      Nature 332:411-415(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 53-73.
      Tissue: Endothelial cell.
    2. "Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1."
      Sawamura T., Kimura S., Shinmi O., Sugita Y., Yanagisawa M., Masaki T.
      Biochem. Biophys. Res. Commun. 162:1287-1294(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 53-82.
      Tissue: Endothelial cell.
    3. Cited for: PROTEIN SEQUENCE OF 53-82.
      Tissue: Endothelial cell.
    4. "Mode of cleavage of pig big endothelin-1 by chymotrypsin. Production and degradation of mature endothelin-1."
      Takaoka M., Miyata Y., Takenobu Y., Ikegawa R., Matsumura Y., Morimoto S.
      Biochem. J. 270:541-544(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEGRADATION BY CHYMOTRYPSIN.

    Entry informationi

    Entry nameiEDN1_PIG
    AccessioniPrimary (citable) accession number: P09558
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3