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Protein

Endothelin-1

Gene

EDN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000806526 – 50By similarityAdd BLAST25
PeptideiPRO_000000806653 – 82Big endothelin-12 PublicationsAdd BLAST30
PeptideiPRO_000000806753 – 73Endothelin-11 PublicationAdd BLAST21
PropeptideiPRO_000000806883 – 203Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 671 Publication
Disulfide bondi55 ↔ 631 Publication
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP09558.
PRIDEiP09558.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001121.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 124Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP09558.
KOiK16366.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIIAL LFVAFQGAPE TAVLGAELSP EAESQGETPS PHASWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SRRSLKDLFP
110 120 130 140 150
AKAADRRDRC QCASQKDKKC WSFCQAGKEI GRDQDTMEKR WDNQKKGTDC
160 170 180 190 200
SKLGEKCIHR QLVMGRKIRR LEAISNSIKT SFHIAKLKAE LYRDKKVTHN

RTH
Length:203
Mass (Da):23,259
Last modified:July 1, 1989 - v1
Checksum:iAE47E7A8634B157D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07383 mRNA. Translation: CAA30296.1.
PIRiS03159. ANPG.
RefSeqiNP_999047.1. NM_213882.1.
UniGeneiSsc.9364.

Genome annotation databases

GeneIDi396915.
KEGGissc:396915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07383 mRNA. Translation: CAA30296.1.
PIRiS03159. ANPG.
RefSeqiNP_999047.1. NM_213882.1.
UniGeneiSsc.9364.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001121.

Proteomic databases

PaxDbiP09558.
PRIDEiP09558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396915.
KEGGissc:396915.

Organism-specific databases

CTDi1906.

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP09558.
KOiK16366.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDN1_PIG
AccessioniPrimary (citable) accession number: P09558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.