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P09556 (UMPS_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine 5'-monophosphate synthase

Short name=UMP synthase

Including the following 2 domains:

  1. Orotate phosphoribosyltransferase
    Short name=OPRTase
    EC=2.4.2.10
  2. Orotidine 5'-phosphate decarboxylase
    EC=4.1.1.23
    Alternative name(s):
    OMPdecase
Gene names
Name:pyr56
Synonyms:pyr5-6
ORF Names:DDB_G0280041
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

In the C-terminal section; belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Uridine 5'-monophosphate synthase HAMAP-Rule MF_01208
PRO_0000139651

Regions

Region1 – 210210OPRTase HAMAP-Rule MF_01208
Region117 – 1259Phosphoribosyl pyrophosphate binding site Potential
Region211 – 22919Domain linker Potential
Region230 – 478249OMPdecase HAMAP-Rule MF_01208

Sites

Active site3131 By similarity

Experimental info

Sequence conflict11 – 144NEID → MKLM in CAA30443. Ref.1
Sequence conflict1551Q → E in CAA30443. Ref.1
Sequence conflict3371D → V in CAA30443. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P09556 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 0A5F45A4B0738636

FASTA47852,519
        10         20         30         40         50         60 
MNIKELVLKL NEIDAIKLGE FKLKSGIISP IYIDLRVTVS SPPLLAAIAE MMYQKVYKSG 

        70         80         90        100        110        120 
NAQETPALVC GVPYTALPIA TGMSIANNIP MVVRRKEAKA YGTKQLIEGR FKEGDNVLVV 

       130        140        150        160        170        180 
EDLVTSGASV LETVRDLNSV GLKVTDVVVL LDRQQGARQA LEKQGYRLHS VFTMEELINT 

       190        200        210        220        230        240 
LIEAGKLTGR TLELVQSFLD ANRNVVVPLP PTLAPPAPAP IVINKPFEER AKLASNPMAS 

       250        260        270        280        290        300 
KLFTLMSSKK TNLAVAADLT DKQQLLDLAE SIGSEICVLK THVDIIDNYD EEFIKSLKCI 

       310        320        330        340        350        360 
AAKHNFLIFE DRKFADIGNT VKYQFENGVY KISKWADMVT VHGVAGSSIV DGFKSGLKEY 

       370        380        390        400        410        420 
GSGLLLLAQM SSKGSLCVGD YTTQMIEMAN NNKEEVMGLI CQERLPSMTD GLVLMTPGVQ 

       430        440        450        460        470 
FNSTGDAMGQ QYNTPEYIIK EKNTDVIIVG RGIYQSNDPK SVANKYRTAA WETYQSKF 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the DdPYR5-6 gene coding for UMP synthase in Dictyostelium discoideum and comparison with orotate phosphoribosyl transferases and OMP decarboxylases."
Jacquet M., Guilbaud R., Garreau H.
Mol. Gen. Genet. 211:441-445(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07560 Genomic DNA. Translation: CAA30443.1.
AAFI02000035 Genomic DNA. Translation: EAL67247.1.
PIRS03826.
RefSeqXP_641269.1. XM_636177.1.

3D structure databases

ProteinModelPortalP09556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0214958.

Proteomic databases

PRIDEP09556.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0214958; DDB0214958; DDB_G0280041.
GeneID8622401.
KEGGddi:DDB_G0280041.

Organism-specific databases

dictyBaseDDB_G0280041. pyr56.

Phylogenomic databases

eggNOGCOG0284.
OMASMKPEFL.
PhylomeDBP09556.

Enzyme and pathway databases

UniPathwayUPA00070; UER00119.
UPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPMF_01208. PyrE.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP09556.

Entry information

Entry nameUMPS_DICDI
AccessionPrimary (citable) accession number: P09556
Secondary accession number(s): Q54VT6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase