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Protein

Lysine/arginine/ornithine-binding periplasmic protein

Gene

argT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ARGT-MONOMER.
ECOL316407:JW2307-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.
3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine/arginine/ornithine-binding periplasmic protein
Short name:
LAO-binding protein
Gene namesi
Name:argT
Ordered Locus Names:b2310, JW2307
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10072. argT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003174923 – 260Lysine/arginine/ornithine-binding periplasmic proteinAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 67By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP09551.
PaxDbiP09551.
PRIDEiP09551.

2D gel databases

SWISS-2DPAGEP09551.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (ArgT).By similarity

Protein-protein interaction databases

BioGridi4260525. 11 interactors.
DIPiDIP-9148N.
STRINGi511145.b2310.

Structurei

3D structure databases

ProteinModelPortaliP09551.
SMRiP09551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E89. Bacteria.
COG0834. LUCA.
HOGENOMiHOG000031896.
InParanoidiP09551.
KOiK10013.
OMAiNWRSKGV.
PhylomeDBiP09551.

Family and domain databases

InterProiIPR005768. Lys_Arg_Orn-bd.
IPR018313. SBP_3_CS.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF00497. SBP_bac_3. 1 hit.
[Graphical view]
SMARTiSM00062. PBPb. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01096. 3A0103s03R. 1 hit.
PROSITEiPS01039. SBP_BACTERIAL_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSILALSL LVGLSTAASS YAALPETVRI GTDTTYAPFS SKDAKGDFVG
60 70 80 90 100
FDIDLGNEMC KRMQVKCTWV ASDFDALIPS LKAKKIDAII SSLSITDKRQ
110 120 130 140 150
QEIAFSDKLY AADSRLIAAK GSPIQPTLDS LKGKHVGVLQ GSTQEAYANE
160 170 180 190 200
TWRSKGVDVV AYANQDLVYS DLAAGRLDAA LQDEVAASEG FLKQPAGKDF
210 220 230 240 250
AFAGSSVKDK KYFGDGTGVG LRKDDAELTA AFNKALGELR QDGTYDKMAK
260
KYFDFNVYGD
Length:260
Mass (Da):27,992
Last modified:July 15, 1998 - v3
Checksum:iE9BF1ECF0BB8A6FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → P in AAA23971 (PubMed:3040734).Curated1
Sequence conflicti86 – 87ID → ST (PubMed:3040734).Curated2
Sequence conflicti95I → V (PubMed:3040734).Curated1
Sequence conflicti200 – 201FA → SP in AAA85768 (Ref. 5) Curated2
Sequence conflicti213F → L in AAA85768 (Ref. 5) Curated1
Sequence conflicti237 – 239GEL → ACV in AAA85768 (Ref. 5) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75370.1.
AP009048 Genomic DNA. Translation: BAA16156.1.
M68935 Genomic DNA. Translation: AAA23971.1.
U47027 Genomic DNA. Translation: AAA85768.1.
PIRiD65003. JKECT.
RefSeqiNP_416813.1. NC_000913.3.
WP_000748271.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75370; AAC75370; b2310.
BAA16156; BAA16156; BAA16156.
GeneIDi949030.
KEGGiecj:JW2307.
eco:b2310.
PATRICi32119991. VBIEscCol129921_2405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75370.1.
AP009048 Genomic DNA. Translation: BAA16156.1.
M68935 Genomic DNA. Translation: AAA23971.1.
U47027 Genomic DNA. Translation: AAA85768.1.
PIRiD65003. JKECT.
RefSeqiNP_416813.1. NC_000913.3.
WP_000748271.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP09551.
SMRiP09551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260525. 11 interactors.
DIPiDIP-9148N.
STRINGi511145.b2310.

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.
3.A.1.3.29. the atp-binding cassette (abc) superfamily.

2D gel databases

SWISS-2DPAGEP09551.

Proteomic databases

EPDiP09551.
PaxDbiP09551.
PRIDEiP09551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75370; AAC75370; b2310.
BAA16156; BAA16156; BAA16156.
GeneIDi949030.
KEGGiecj:JW2307.
eco:b2310.
PATRICi32119991. VBIEscCol129921_2405.

Organism-specific databases

EchoBASEiEB0070.
EcoGeneiEG10072. argT.

Phylogenomic databases

eggNOGiENOG4105E89. Bacteria.
COG0834. LUCA.
HOGENOMiHOG000031896.
InParanoidiP09551.
KOiK10013.
OMAiNWRSKGV.
PhylomeDBiP09551.

Enzyme and pathway databases

BioCyciEcoCyc:ARGT-MONOMER.
ECOL316407:JW2307-MONOMER.

Miscellaneous databases

PROiP09551.

Family and domain databases

InterProiIPR005768. Lys_Arg_Orn-bd.
IPR018313. SBP_3_CS.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF00497. SBP_bac_3. 1 hit.
[Graphical view]
SMARTiSM00062. PBPb. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01096. 3A0103s03R. 1 hit.
PROSITEiPS01039. SBP_BACTERIAL_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGT_ECOLI
AccessioniPrimary (citable) accession number: P09551
Secondary accession number(s): P77476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.