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P09544

- WNT2_HUMAN

UniProt

P09544 - WNT2_HUMAN

Protein

Protein Wnt-2

Gene

WNT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. frizzled binding Source: UniProtKB
    3. protein binding Source: BHF-UCL
    4. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    2. canonical Wnt signaling pathway Source: BHF-UCL
    3. cardiac epithelial to mesenchymal transition Source: Ensembl
    4. cell-cell signaling Source: BHF-UCL
    5. cell fate commitment Source: RefGenome
    6. cellular response to retinoic acid Source: UniProtKB
    7. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    8. iris morphogenesis Source: BHF-UCL
    9. labyrinthine layer blood vessel development Source: Ensembl
    10. lens development in camera-type eye Source: BHF-UCL
    11. lung development Source: Ensembl
    12. lung induction Source: Ensembl
    13. mammary gland epithelium development Source: UniProtKB
    14. neuron differentiation Source: UniProtKB
    15. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    16. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    17. positive regulation of cell proliferation Source: BHF-UCL
    18. positive regulation of endothelial cell proliferation Source: Ensembl
    19. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    20. positive regulation of fibroblast proliferation Source: BHF-UCL
    21. positive regulation of mesenchymal cell proliferation Source: Ensembl
    22. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    SignaLinkiP09544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2
    Alternative name(s):
    Int-1-like protein 1
    Int-1-related protein
    Short name:
    IRP
    Gene namesi
    Name:WNT2
    Synonyms:INT1L1, IRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:12780. WNT2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular matrix Source: UniProtKB
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: RefGenome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37381.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 360335Protein Wnt-2PRO_0000041410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 87By similarity
    Disulfide bondi127 ↔ 135By similarity
    Disulfide bondi137 ↔ 157By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP09544.
    PRIDEiP09544.

    PTM databases

    PhosphoSiteiP09544.

    Expressioni

    Tissue specificityi

    Expressed in brain in the thalamus, in fetal and adult lung and in placenta.1 Publication

    Gene expression databases

    ArrayExpressiP09544.
    BgeeiP09544.
    CleanExiHS_WNT2.
    GenevestigatoriP09544.

    Organism-specific databases

    HPAiCAB017098.
    HPA020920.

    Interactioni

    Protein-protein interaction databases

    BioGridi113309. 7 interactions.
    IntActiP09544. 5 interactions.
    STRINGi9606.ENSP00000265441.

    Structurei

    3D structure databases

    ProteinModelPortaliP09544.
    SMRiP09544. Positions 64-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiP09544.
    KOiK00182.
    OMAiWKKYNGA.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP09544.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS    50
    QRQLCHRHPD VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV 100
    LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSAKDSKG 150
    IFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR 200
    FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG 250
    TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 300
    MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA 350
    PKNADWTTAT 360
    Length:360
    Mass (Da):40,418
    Last modified:July 1, 1989 - v1
    Checksum:iAA96325BF68C4788
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51L → R.1 Publication
    Corresponds to variant rs145839592 [ dbSNP | Ensembl ].
    VAR_013865
    Natural varianti294 – 2941C → F.
    Corresponds to variant rs1051751 [ dbSNP | Ensembl ].
    VAR_052954
    Natural varianti299 – 2991R → W.1 Publication
    Corresponds to variant rs148046128 [ dbSNP | Ensembl ].
    VAR_013866

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07876 mRNA. Translation: CAA30725.1.
    AK056742 mRNA. Translation: BAG51800.1.
    BT019608 mRNA. Translation: AAV38415.1.
    AC002465 Genomic DNA. Translation: AAB67043.1.
    AC006326 Genomic DNA. Translation: AAD28351.1.
    CH236947 Genomic DNA. Translation: EAL24355.1.
    CH471070 Genomic DNA. Translation: EAW83525.1.
    BC029854 mRNA. Translation: AAH29854.1.
    BC078170 mRNA. Translation: AAH78170.1.
    CCDSiCCDS5771.1.
    PIRiS00834.
    RefSeqiNP_003382.1. NM_003391.2.
    UniGeneiHs.567356.

    Genome annotation databases

    EnsembliENST00000265441; ENSP00000265441; ENSG00000105989.
    GeneIDi7472.
    KEGGihsa:7472.
    UCSCiuc003viz.3. human.

    Polymorphism databases

    DMDMi139750.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07876 mRNA. Translation: CAA30725.1 .
    AK056742 mRNA. Translation: BAG51800.1 .
    BT019608 mRNA. Translation: AAV38415.1 .
    AC002465 Genomic DNA. Translation: AAB67043.1 .
    AC006326 Genomic DNA. Translation: AAD28351.1 .
    CH236947 Genomic DNA. Translation: EAL24355.1 .
    CH471070 Genomic DNA. Translation: EAW83525.1 .
    BC029854 mRNA. Translation: AAH29854.1 .
    BC078170 mRNA. Translation: AAH78170.1 .
    CCDSi CCDS5771.1.
    PIRi S00834.
    RefSeqi NP_003382.1. NM_003391.2.
    UniGenei Hs.567356.

    3D structure databases

    ProteinModelPortali P09544.
    SMRi P09544. Positions 64-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113309. 7 interactions.
    IntActi P09544. 5 interactions.
    STRINGi 9606.ENSP00000265441.

    Chemistry

    BindingDBi P09544.
    ChEMBLi CHEMBL1255132.

    PTM databases

    PhosphoSitei P09544.

    Polymorphism databases

    DMDMi 139750.

    Proteomic databases

    PaxDbi P09544.
    PRIDEi P09544.

    Protocols and materials databases

    DNASUi 7472.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265441 ; ENSP00000265441 ; ENSG00000105989 .
    GeneIDi 7472.
    KEGGi hsa:7472.
    UCSCi uc003viz.3. human.

    Organism-specific databases

    CTDi 7472.
    GeneCardsi GC07M116916.
    HGNCi HGNC:12780. WNT2.
    HPAi CAB017098.
    HPA020920.
    MIMi 147870. gene.
    neXtProti NX_P09544.
    PharmGKBi PA37381.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi P09544.
    KOi K00182.
    OMAi WKKYNGA.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P09544.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    SignaLinki P09544.

    Miscellaneous databases

    GeneWikii WNT2.
    GenomeRNAii 7472.
    NextBioi 29268.
    PROi P09544.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09544.
    Bgeei P09544.
    CleanExi HS_WNT2.
    Genevestigatori P09544.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless."
      Wainwright B.J., Scambler P.J., Stanier P., Watson E.K., Bell G., Wicking C., Estivill X., Courtney M., Boue A., Pedersen P.S., Williamson R., Farrall M.
      EMBO J. 7:1743-1748(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. Farrall M.
      Submitted (APR-1988) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Testis.
    9. Cited for: VARIANTS ARG-5 AND TRP-299, TISSUE SPECIFICITY.
    10. Cited for: SHOWS THAT WNT2 IS NOT LINKED TO AUTISM SUSCEPTIBILITY.

    Entry informationi

    Entry nameiWNT2_HUMAN
    AccessioniPrimary (citable) accession number: P09544
    Secondary accession number(s): A4D0V1, Q75N05, Q9UDP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3