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Protein

Protein Wnt-2

Gene

WNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • frizzled binding Source: UniProtKB
  • receptor agonist activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • atrial cardiac muscle tissue morphogenesis Source: Ensembl
  • canonical Wnt signaling pathway Source: BHF-UCL
  • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • cardiac epithelial to mesenchymal transition Source: Ensembl
  • cell-cell signaling Source: BHF-UCL
  • cell fate commitment Source: GO_Central
  • cell proliferation in midbrain Source: ParkinsonsUK-UCL
  • cellular response to retinoic acid Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • iris morphogenesis Source: BHF-UCL
  • labyrinthine layer blood vessel development Source: Ensembl
  • lens development in camera-type eye Source: BHF-UCL
  • lung development Source: Ensembl
  • lung induction Source: Ensembl
  • mammary gland epithelium development Source: UniProtKB
  • midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • neurogenesis Source: ParkinsonsUK-UCL
  • neuron differentiation Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of cardiac muscle cell proliferation Source: Ensembl
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: Ensembl
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  • positive regulation of fibroblast proliferation Source: BHF-UCL
  • positive regulation of mesenchymal cell proliferation Source: Ensembl
  • positive regulation of neurogenesis Source: Ensembl
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105989-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.
R-HSA-373080. Class B/2 (Secretin family receptors).
SignaLinkiP09544.
SIGNORiP09544.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Alternative name(s):
Int-1-like protein 1
Int-1-related protein
Short name:
IRP
Gene namesi
Name:WNT2
Synonyms:INT1L1, IRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12780. WNT2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular matrix Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • Wnt signalosome Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7472.
OpenTargetsiENSG00000105989.
PharmGKBiPA37381.

Chemistry databases

ChEMBLiCHEMBL1255132.

Polymorphism and mutation databases

BioMutaiWNT2.
DMDMi139750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004141026 – 360Protein Wnt-2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 87By similarity
Disulfide bondi127 ↔ 135By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212O-palmitoleyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP09544.
PeptideAtlasiP09544.
PRIDEiP09544.

PTM databases

iPTMnetiP09544.
PhosphoSitePlusiP09544.

Expressioni

Tissue specificityi

Expressed in brain in the thalamus, in fetal and adult lung and in placenta.1 Publication

Gene expression databases

BgeeiENSG00000105989.
CleanExiHS_WNT2.
ExpressionAtlasiP09544. baseline and differential.
GenevisibleiP09544. HS.

Organism-specific databases

HPAiHPA020920.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • frizzled binding Source: UniProtKB
  • receptor agonist activity Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi113309. 7 interactors.
IntActiP09544. 5 interactors.
STRINGi9606.ENSP00000265441.

Chemistry databases

BindingDBiP09544.

Structurei

3D structure databases

ProteinModelPortaliP09544.
SMRiP09544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP09544.
KOiK00182.
OMAiWKKYNGA.
OrthoDBiEOG091G0OFF.
PhylomeDBiP09544.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS
60 70 80 90 100
QRQLCHRHPD VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV
110 120 130 140 150
LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSAKDSKG
160 170 180 190 200
IFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR
210 220 230 240 250
FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG
260 270 280 290 300
TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG
310 320 330 340 350
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA
360
PKNADWTTAT
Length:360
Mass (Da):40,418
Last modified:July 1, 1989 - v1
Checksum:iAA96325BF68C4788
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0138655L → R.1 PublicationCorresponds to variant rs145839592dbSNPEnsembl.1
Natural variantiVAR_052954294C → F.Corresponds to variant rs1051751dbSNPEnsembl.1
Natural variantiVAR_013866299R → W.1 PublicationCorresponds to variant rs148046128dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07876 mRNA. Translation: CAA30725.1.
AK056742 mRNA. Translation: BAG51800.1.
BT019608 mRNA. Translation: AAV38415.1.
AC002465 Genomic DNA. Translation: AAB67043.1.
AC006326 Genomic DNA. Translation: AAD28351.1.
CH236947 Genomic DNA. Translation: EAL24355.1.
CH471070 Genomic DNA. Translation: EAW83525.1.
BC029854 mRNA. Translation: AAH29854.1.
BC078170 mRNA. Translation: AAH78170.1.
CCDSiCCDS5771.1.
PIRiS00834.
RefSeqiNP_003382.1. NM_003391.2.
UniGeneiHs.567356.

Genome annotation databases

EnsembliENST00000265441; ENSP00000265441; ENSG00000105989.
GeneIDi7472.
KEGGihsa:7472.
UCSCiuc003viz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07876 mRNA. Translation: CAA30725.1.
AK056742 mRNA. Translation: BAG51800.1.
BT019608 mRNA. Translation: AAV38415.1.
AC002465 Genomic DNA. Translation: AAB67043.1.
AC006326 Genomic DNA. Translation: AAD28351.1.
CH236947 Genomic DNA. Translation: EAL24355.1.
CH471070 Genomic DNA. Translation: EAW83525.1.
BC029854 mRNA. Translation: AAH29854.1.
BC078170 mRNA. Translation: AAH78170.1.
CCDSiCCDS5771.1.
PIRiS00834.
RefSeqiNP_003382.1. NM_003391.2.
UniGeneiHs.567356.

3D structure databases

ProteinModelPortaliP09544.
SMRiP09544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113309. 7 interactors.
IntActiP09544. 5 interactors.
STRINGi9606.ENSP00000265441.

Chemistry databases

BindingDBiP09544.
ChEMBLiCHEMBL1255132.

PTM databases

iPTMnetiP09544.
PhosphoSitePlusiP09544.

Polymorphism and mutation databases

BioMutaiWNT2.
DMDMi139750.

Proteomic databases

PaxDbiP09544.
PeptideAtlasiP09544.
PRIDEiP09544.

Protocols and materials databases

DNASUi7472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265441; ENSP00000265441; ENSG00000105989.
GeneIDi7472.
KEGGihsa:7472.
UCSCiuc003viz.4. human.

Organism-specific databases

CTDi7472.
DisGeNETi7472.
GeneCardsiWNT2.
HGNCiHGNC:12780. WNT2.
HPAiHPA020920.
MIMi147870. gene.
neXtProtiNX_P09544.
OpenTargetsiENSG00000105989.
PharmGKBiPA37381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP09544.
KOiK00182.
OMAiWKKYNGA.
OrthoDBiEOG091G0OFF.
PhylomeDBiP09544.
TreeFamiTF105310.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105989-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.
R-HSA-373080. Class B/2 (Secretin family receptors).
SignaLinkiP09544.
SIGNORiP09544.

Miscellaneous databases

GeneWikiiWNT2.
GenomeRNAii7472.
PROiP09544.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105989.
CleanExiHS_WNT2.
ExpressionAtlasiP09544. baseline and differential.
GenevisibleiP09544. HS.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT2_HUMAN
AccessioniPrimary (citable) accession number: P09544
Secondary accession number(s): A4D0V1, Q75N05, Q9UDP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.