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P09544

- WNT2_HUMAN

UniProt

P09544 - WNT2_HUMAN

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Protein

Protein Wnt-2

Gene

WNT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. frizzled binding Source: UniProtKB
  3. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
  2. canonical Wnt signaling pathway Source: BHF-UCL
  3. cardiac epithelial to mesenchymal transition Source: Ensembl
  4. cell-cell signaling Source: BHF-UCL
  5. cell fate commitment Source: RefGenome
  6. cellular response to retinoic acid Source: UniProtKB
  7. cellular response to transforming growth factor beta stimulus Source: UniProtKB
  8. iris morphogenesis Source: BHF-UCL
  9. labyrinthine layer blood vessel development Source: Ensembl
  10. lens development in camera-type eye Source: BHF-UCL
  11. lung development Source: Ensembl
  12. lung induction Source: Ensembl
  13. mammary gland epithelium development Source: UniProtKB
  14. neuron differentiation Source: UniProtKB
  15. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  16. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  17. positive regulation of cell proliferation Source: BHF-UCL
  18. positive regulation of endothelial cell proliferation Source: Ensembl
  19. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  20. positive regulation of fibroblast proliferation Source: BHF-UCL
  21. positive regulation of mesenchymal cell proliferation Source: Ensembl
  22. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinkiP09544.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Alternative name(s):
Int-1-like protein 1
Int-1-related protein
Short name:
IRP
Gene namesi
Name:WNT2
Synonyms:INT1L1, IRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:12780. WNT2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular matrix Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: RefGenome
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 360335Protein Wnt-2PRO_0000041410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 87By similarity
Disulfide bondi127 ↔ 135By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP09544.
PRIDEiP09544.

PTM databases

PhosphoSiteiP09544.

Expressioni

Tissue specificityi

Expressed in brain in the thalamus, in fetal and adult lung and in placenta.1 Publication

Gene expression databases

BgeeiP09544.
CleanExiHS_WNT2.
ExpressionAtlasiP09544. baseline and differential.
GenevestigatoriP09544.

Organism-specific databases

HPAiCAB017098.
HPA020920.

Interactioni

Protein-protein interaction databases

BioGridi113309. 8 interactions.
IntActiP09544. 5 interactions.
STRINGi9606.ENSP00000265441.

Structurei

3D structure databases

ProteinModelPortaliP09544.
SMRiP09544. Positions 64-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP09544.
KOiK00182.
OMAiWKKYNGA.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP09544.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09544-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS
60 70 80 90 100
QRQLCHRHPD VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV
110 120 130 140 150
LLRSSRESAF VYAISSAGVV FAITRACSQG EVKSCSCDPK KMGSAKDSKG
160 170 180 190 200
IFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR
210 220 230 240 250
FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG
260 270 280 290 300
TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG
310 320 330 340 350
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA
360
PKNADWTTAT
Length:360
Mass (Da):40,418
Last modified:July 1, 1989 - v1
Checksum:iAA96325BF68C4788
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51L → R.1 Publication
Corresponds to variant rs145839592 [ dbSNP | Ensembl ].
VAR_013865
Natural varianti294 – 2941C → F.
Corresponds to variant rs1051751 [ dbSNP | Ensembl ].
VAR_052954
Natural varianti299 – 2991R → W.1 Publication
Corresponds to variant rs148046128 [ dbSNP | Ensembl ].
VAR_013866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07876 mRNA. Translation: CAA30725.1.
AK056742 mRNA. Translation: BAG51800.1.
BT019608 mRNA. Translation: AAV38415.1.
AC002465 Genomic DNA. Translation: AAB67043.1.
AC006326 Genomic DNA. Translation: AAD28351.1.
CH236947 Genomic DNA. Translation: EAL24355.1.
CH471070 Genomic DNA. Translation: EAW83525.1.
BC029854 mRNA. Translation: AAH29854.1.
BC078170 mRNA. Translation: AAH78170.1.
CCDSiCCDS5771.1.
PIRiS00834.
RefSeqiNP_003382.1. NM_003391.2.
UniGeneiHs.567356.

Genome annotation databases

EnsembliENST00000265441; ENSP00000265441; ENSG00000105989.
GeneIDi7472.
KEGGihsa:7472.
UCSCiuc003viz.3. human.

Polymorphism databases

DMDMi139750.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07876 mRNA. Translation: CAA30725.1 .
AK056742 mRNA. Translation: BAG51800.1 .
BT019608 mRNA. Translation: AAV38415.1 .
AC002465 Genomic DNA. Translation: AAB67043.1 .
AC006326 Genomic DNA. Translation: AAD28351.1 .
CH236947 Genomic DNA. Translation: EAL24355.1 .
CH471070 Genomic DNA. Translation: EAW83525.1 .
BC029854 mRNA. Translation: AAH29854.1 .
BC078170 mRNA. Translation: AAH78170.1 .
CCDSi CCDS5771.1.
PIRi S00834.
RefSeqi NP_003382.1. NM_003391.2.
UniGenei Hs.567356.

3D structure databases

ProteinModelPortali P09544.
SMRi P09544. Positions 64-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113309. 8 interactions.
IntActi P09544. 5 interactions.
STRINGi 9606.ENSP00000265441.

Chemistry

BindingDBi P09544.
ChEMBLi CHEMBL1255132.

PTM databases

PhosphoSitei P09544.

Polymorphism databases

DMDMi 139750.

Proteomic databases

PaxDbi P09544.
PRIDEi P09544.

Protocols and materials databases

DNASUi 7472.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265441 ; ENSP00000265441 ; ENSG00000105989 .
GeneIDi 7472.
KEGGi hsa:7472.
UCSCi uc003viz.3. human.

Organism-specific databases

CTDi 7472.
GeneCardsi GC07M116916.
HGNCi HGNC:12780. WNT2.
HPAi CAB017098.
HPA020920.
MIMi 147870. gene.
neXtProti NX_P09544.
PharmGKBi PA37381.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00760000118943.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi P09544.
KOi K00182.
OMAi WKKYNGA.
OrthoDBi EOG7C8GJ8.
PhylomeDBi P09544.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinki P09544.

Miscellaneous databases

GeneWikii WNT2.
GenomeRNAii 7472.
NextBioi 29268.
PROi P09544.
SOURCEi Search...

Gene expression databases

Bgeei P09544.
CleanExi HS_WNT2.
ExpressionAtlasi P09544. baseline and differential.
Genevestigatori P09544.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless."
    Wainwright B.J., Scambler P.J., Stanier P., Watson E.K., Bell G., Wicking C., Estivill X., Courtney M., Boue A., Pedersen P.S., Williamson R., Farrall M.
    EMBO J. 7:1743-1748(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. Farrall M.
    Submitted (APR-1988) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.
  9. Cited for: VARIANTS ARG-5 AND TRP-299, TISSUE SPECIFICITY.
  10. Cited for: SHOWS THAT WNT2 IS NOT LINKED TO AUTISM SUSCEPTIBILITY.

Entry informationi

Entry nameiWNT2_HUMAN
AccessioniPrimary (citable) accession number: P09544
Secondary accession number(s): A4D0V1, Q75N05, Q9UDP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3