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P09544 (WNT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-2
Alternative name(s):
Int-1-like protein 1
Int-1-related protein
Short name=IRP
Gene names
Name:WNT2
Synonyms:INT1L1, IRP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed in brain in the thalamus, in fetal and adult lung and in placenta. Ref.9

Post-translational modification

Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from direct assay PubMed 10557084. Source: UniProtKB

atrial cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from direct assay PubMed 10347172. Source: BHF-UCL

cardiac epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Inferred from direct assay PubMed 10557084. Source: BHF-UCL

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to transforming growth factor beta stimulus

Inferred from expression pattern PubMed 15040835. Source: UniProtKB

iris morphogenesis

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

labyrinthine layer blood vessel development

Inferred from electronic annotation. Source: Ensembl

lens development in camera-type eye

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

lung development

Inferred from electronic annotation. Source: Ensembl

lung induction

Inferred from electronic annotation. Source: Ensembl

mammary gland epithelium development

Inferred from expression pattern PubMed 8168088. Source: UniProtKB

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 17948129. Source: UniProtKB

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from direct assay PubMed 10347172. Source: BHF-UCL

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from mutant phenotype PubMed 19734317. Source: BHF-UCL

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 10557084. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 19038973PubMed 19239325. Source: UniProtKB

extracellular matrix

Inferred from direct assay PubMed 15507471. Source: UniProtKB

extracellular region

Non-traceable author statement Ref.1. Source: UniProtKB

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 10557084. Source: BHF-UCL

frizzled binding

Inferred from physical interaction PubMed 10557084PubMed 19038973. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 10347172. Source: BHF-UCL

receptor agonist activity

Inferred by curator PubMed 17948129. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 360335Protein Wnt-2
PRO_0000041410

Amino acid modifications

Lipidation761S-palmitoyl cysteine By similarity
Lipidation2121O-palmitoyl serine; by PORCN By similarity
Glycosylation2951N-linked (GlcNAc...) Potential

Natural variations

Natural variant51L → R. Ref.9
Corresponds to variant rs145839592 [ dbSNP | Ensembl ].
VAR_013865
Natural variant2941C → F.
Corresponds to variant rs1051751 [ dbSNP | Ensembl ].
VAR_052954
Natural variant2991R → W. Ref.9
Corresponds to variant rs148046128 [ dbSNP | Ensembl ].
VAR_013866

Sequences

Sequence LengthMass (Da)Tools
P09544 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: AA96325BF68C4788

FASTA36040,418
        10         20         30         40         50         60 
MNAPLGGIWL WLPLLLTWLT PEVNSSWWYM RATGGSSRVM CDNVPGLVSS QRQLCHRHPD 

        70         80         90        100        110        120 
VMRAISQGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV 

       130        140        150        160        170        180 
FAITRACSQG EVKSCSCDPK KMGSAKDSKG IFDWGGCSDN IDYGIKFARA FVDAKERKGK 

       190        200        210        220        230        240 
DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG 

       250        260        270        280        290        300 
AIQVVMNQDG TGFTVANERF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 

       310        320        330        340        350        360 
MDSCEVMCCG RGYDTSHVTR MTKCGCKFHW CCAVRCQDCL EALDVHTCKA PKNADWTTAT 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless."
Wainwright B.J., Scambler P.J., Stanier P., Watson E.K., Bell G., Wicking C., Estivill X., Courtney M., Boue A., Pedersen P.S., Williamson R., Farrall M.
EMBO J. 7:1743-1748(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]Farrall M.
Submitted (APR-1988) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lung and Testis.
[9]"Evidence supporting WNT2 as an autism susceptibility gene."
Wassink T.H., Piven J., Vieland V.J., Huang J., Swiderski R.E., Pietila J., Braun T., Beck G., Folstein S.E., Haines J.L., Sheffield V.C.
Am. J. Med. Genet. 105:406-413(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARG-5 AND TRP-299, TISSUE SPECIFICITY.
[10]"No association between the WNT2 gene and autistic disorder."
McCoy P.A., Shao Y., Wolpert C.M., Donnelly S.L., Ashley-Koch A., Abel H.L., Ravan S.A., Abramson R.K., Wright H.H., DeLong G.R., Cuccaro M.L., Gilbert J.R., Pericak-Vance M.A.
Am. J. Med. Genet. 114:106-109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SHOWS THAT WNT2 IS NOT LINKED TO AUTISM SUSCEPTIBILITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07876 mRNA. Translation: CAA30725.1.
AK056742 mRNA. Translation: BAG51800.1.
BT019608 mRNA. Translation: AAV38415.1.
AC002465 Genomic DNA. Translation: AAB67043.1.
AC006326 Genomic DNA. Translation: AAD28351.1.
CH236947 Genomic DNA. Translation: EAL24355.1.
CH471070 Genomic DNA. Translation: EAW83525.1.
BC029854 mRNA. Translation: AAH29854.1.
BC078170 mRNA. Translation: AAH78170.1.
CCDSCCDS5771.1.
PIRS00834.
RefSeqNP_003382.1. NM_003391.2.
UniGeneHs.567356.

3D structure databases

ProteinModelPortalP09544.
SMRP09544. Positions 64-348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113309. 7 interactions.
IntActP09544. 5 interactions.
STRING9606.ENSP00000265441.

Chemistry

BindingDBP09544.
ChEMBLCHEMBL1255132.

PTM databases

PhosphoSiteP09544.

Polymorphism databases

DMDM139750.

Proteomic databases

PaxDbP09544.
PRIDEP09544.

Protocols and materials databases

DNASU7472.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265441; ENSP00000265441; ENSG00000105989.
GeneID7472.
KEGGhsa:7472.
UCSCuc003viz.3. human.

Organism-specific databases

CTD7472.
GeneCardsGC07M116916.
HGNCHGNC:12780. WNT2.
HPACAB017098.
HPA020920.
MIM147870. gene.
neXtProtNX_P09544.
PharmGKBPA37381.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284879.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidP09544.
KOK00182.
OMAWKKYNGA.
OrthoDBEOG7C8GJ8.
PhylomeDBP09544.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP09544.

Gene expression databases

ArrayExpressP09544.
BgeeP09544.
CleanExHS_WNT2.
GenevestigatorP09544.

Family and domain databases

InterProIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWNT2.
GenomeRNAi7472.
NextBio29268.
PROP09544.
SOURCESearch...

Entry information

Entry nameWNT2_HUMAN
AccessionPrimary (citable) accession number: P09544
Secondary accession number(s): A4D0V1, Q75N05, Q9UDP9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM