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Protein

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene

CNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.By similarity

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei251Proton acceptor1
Binding sitei253Substrate1
Active sitei330Proton donor1
Binding sitei332Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding

Enzyme and pathway databases

BRENDAi3.1.4.37 2681

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC:3.1.4.37)
Short name:
CNP
Short name:
CNPase
Gene namesi
Name:CNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173786.16
HGNCiHGNC:2158 CNP
MIMi123830 gene
neXtProtiNX_P09543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1267
OpenTargetsiENSG00000173786
PharmGKBiPA26680

Polymorphism and mutation databases

BioMutaiCNP
DMDMi1705945

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899611 – 4182',3'-cyclic-nucleotide 3'-phosphodiesteraseAdd BLAST418
PropeptideiPRO_0000422296419 – 421Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei110PhosphotyrosineBy similarity1
Modified residuei170PhosphoserineCombined sources1
Modified residuei359PhosphoserineBy similarity1
Modified residuei418Cysteine methyl esterBy similarity1
Lipidationi418S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP09543
MaxQBiP09543
PaxDbiP09543
PeptideAtlasiP09543
PRIDEiP09543

2D gel databases

UCD-2DPAGEiP09543

PTM databases

iPTMnetiP09543
PhosphoSitePlusiP09543
SwissPalmiP09543

Expressioni

Gene expression databases

BgeeiENSG00000173786
CleanExiHS_CNP
ExpressionAtlasiP09543 baseline and differential
GenevisibleiP09543 HS

Organism-specific databases

HPAiCAB002672
HPA023266
HPA023278
HPA023280
HPA023338

Interactioni

Subunit structurei

Exists as monomers and homodimers.By similarity

Protein-protein interaction databases

BioGridi107667, 22 interactors
IntActiP09543, 39 interactors
MINTiP09543
STRINGi9606.ENSP00000377470

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi188 – 194Combined sources7
Helixi196 – 215Combined sources20
Helixi217 – 221Combined sources5
Helixi223 – 226Combined sources4
Helixi238 – 241Combined sources4
Beta strandi251 – 256Combined sources6
Helixi258 – 260Combined sources3
Helixi265 – 270Combined sources6
Helixi272 – 277Combined sources6
Beta strandi281 – 291Combined sources11
Beta strandi293 – 301Combined sources9
Helixi306 – 309Combined sources4
Turni325 – 328Combined sources4
Beta strandi330 – 335Combined sources6
Helixi343 – 356Combined sources14
Beta strandi362 – 367Combined sources6
Beta strandi370 – 376Combined sources7
Beta strandi379 – 397Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOJX-ray1.80A186-399[»]
ProteinModelPortaliP09543
SMRiP09543
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09543

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IT06 Eukaryota
ENOG4111F3B LUCA
GeneTreeiENSGT00510000048410
HOGENOMiHOG000111838
HOVERGENiHBG001451
KOiK01121
OMAiLWPNDVD
OrthoDBiEOG091G0I8Z
PhylomeDBiP09543
TreeFamiTF332157

Family and domain databases

InterProiView protein in InterPro
IPR008431 CNPase
IPR009097 cNuc_Pdiesterase
IPR027417 P-loop_NTPase
PANTHERiPTHR10156 PTHR10156, 1 hit
PfamiView protein in Pfam
PF05881 CNPase, 1 hit
PIRSFiPIRSF000970 CNPase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55144 SSF55144, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CNPII (identifier: P09543-1) [UniParc]FASTAAdd to basket
Also known as: DNAII

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK
60 70 80 90 100
TLFILRGLPG SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY
110 120 130 140 150
KRLDEDLAAY CRRRDIRILV LDDTNHERER LEQLFEMADQ YQYQVVLVEP
160 170 180 190 200
KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG LEKDFLPLYF GWFLTKKSSE
210 220 230 240 250
TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT YFGKRPPGVL
260 270 280 290 300
HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV
310 320 330 340 350
ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE
360 370 380 390 400
ILRQEKGGSR GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK
410 420
GKPVPTQGSR KGGALQSCTI I
Length:421
Mass (Da):47,579
Last modified:October 1, 1996 - v2
Checksum:iCA6D0097DFD87255
GO
Isoform CNPI (identifier: P09543-2) [UniParc]FASTAAdd to basket
Also known as: DNAI

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:401
Mass (Da):45,099
Checksum:i81F0E080822D3B0D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033746207Q → R. Corresponds to variant dbSNP:rs34353668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0041711 – 20Missing in isoform CNPI. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46849
, S46843, S46845, S46846 Genomic DNA Translation: AAB23928.2
M19650 mRNA Translation: AAA35704.1
D13146 Genomic DNA Translation: BAA39694.1
D13146 Genomic DNA Translation: BAA02435.1
S50017
, S50013, S50014, S50016 Genomic DNA Translation: AAB24298.2
AC125257 Genomic DNA No translation available.
BC001362 mRNA Translation: AAH01362.1
BC006392 mRNA Translation: AAH06392.1
BC011046 mRNA Translation: AAH11046.1
BC028040 mRNA Translation: AAH28040.1
CCDSiCCDS11414.2 [P09543-1]
CCDS82123.1 [P09543-2]
PIRiJC1517
RefSeqiNP_001317145.1, NM_001330216.1 [P09543-2]
NP_149124.3, NM_033133.4 [P09543-1]
XP_011522642.1, XM_011524340.2 [P09543-2]
UniGeneiHs.273621

Genome annotation databases

EnsembliENST00000393888; ENSP00000377466; ENSG00000173786 [P09543-2]
ENST00000393892; ENSP00000377470; ENSG00000173786 [P09543-1]
GeneIDi1267
KEGGihsa:1267
UCSCiuc002hyl.2 human [P09543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCN37_HUMAN
AccessioniPrimary (citable) accession number: P09543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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