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P09542 (MYL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin light chain 3
Alternative name(s):
Myosin light chain 1, slow-twitch muscle B/ventricular isoform
Short name=MLC1SB
Ventricular/slow twitch myosin alkali light chain
Gene names
Name:Myl3
Synonyms:Mlc1v, Mylc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulatory light chain of myosin. Does not bind calcium.

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Post-translational modification

N-terminus is methylated by METTL11A/NTM1. Ref.4

Sequence similarities

Contains 3 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 204203Myosin light chain 3
PRO_0000198697

Regions

Domain58 – 9538EF-hand 1
Domain137 – 17236EF-hand 2
Domain172 – 20433EF-hand 3

Amino acid modifications

Modified residue21N,N,N-trimethylalanine; by NTM1 Ref.4

Sequences

Sequence LengthMass (Da)Tools
P09542 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 3DF39389FF5BAB41

FASTA20422,422
        10         20         30         40         50         60 
MAPKKPEPKK DDAKAAAPKA APAPAAAPAA APAAAPEPER PKEAEFDASK IKIEFTPEQI 

        70         80         90        100        110        120 
EEFKEAFLLF DRTPKGEMKI TYGQCGDVLR ALGQNPTQAE VLRVLGKPKQ EELNSKMMDF 

       130        140        150        160        170        180 
ETFLPMLQHI SKNKDTGTYE DFVEGLRVFD KEGNGTVMGA ELRHVLATLG ERLTEDEVEK 

       190        200 
LMAGQEDSNG CINYEAFVKH IMAS

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Heart and Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.
[3]"Promoter analysis of myosin alkali light chain genes expressed in mouse striated muscle."
Cohen A., Barton P.J.R., Robert B., Garner I., Alonso S., Buckingham M.E.
Nucleic Acids Res. 16:10037-10052(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52.
Strain: C3H.
Tissue: Spleen.
[4]"NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein."
Tooley C.E., Petkowski J.J., Muratore-Schroeder T.L., Balsbaugh J.L., Shabanowitz J., Sabat M., Minor W., Hunt D.F., Macara I.G.
Nature 466:1125-1128(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE OF INITIATOR METHIONINE, METHYLATION AT ALA-2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK002312 mRNA. Translation: BAB22006.1.
AK011518 mRNA. Translation: BAB27672.1.
AK146943 mRNA. Translation: BAE27552.1.
BC061222 mRNA. Translation: AAH61222.1.
X12972 Genomic DNA. Translation: CAA31415.1.
IPIIPI00133392.
PIRS01945.
RefSeqNP_034989.1. NM_010859.2.
UniGeneMm.7353.

3D structure databases

ProteinModelPortalP09542.
SMRP09542. Positions 58-203.
ModBaseSearch...

PTM databases

PhosphoSiteP09542.

2D gel databases

UCD-2DPAGEP09542.

Proteomic databases

PaxDbP09542.
PRIDEP09542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741.
GeneID17897.
KEGGmmu:17897.
UCSCuc009rur.1. mouse.

Organism-specific databases

CTD4634.
MGIMGI:97268. Myl3.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00590000082921.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidP09542.
KOK12749.
OMAKMMDFDT.
OrthoDBEOG483D5S.

Gene expression databases

ArrayExpressP09542.
BgeeP09542.
CleanExMM_MYL3.
GenevestigatorP09542.
GermOnlineENSMUSG00000059741. Mus musculus.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-like_dom.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF_hand_4. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio292715.
SOURCESearch...

Entry information

Entry nameMYL3_MOUSE
AccessionPrimary (citable) accession number: P09542
Secondary accession number(s): Q3UIF4, Q9CQZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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