Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin light chain 3

Gene

Myl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 3Curated
Alternative name(s):
Myosin alkali light chain 1, ventricular/slow skeletal muscle isoform1 Publication
Myosin light chain 1, slow-twitch muscle B/ventricular isoformBy similarity
Short name:
MLC1SBBy similarity
Gene namesi
Name:Myl3Imported
Synonyms:Mlc1vImported, MylcImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97268. Myl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986972 – 204Myosin light chain 3Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1
Modified residuei81PhosphothreonineBy similarity1
Modified residuei97PhosphothreonineBy similarity1
Modified residuei136PhosphothreonineCombined sources1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphotyrosineBy similarity1
Modified residuei188PhosphoserineCombined sources1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP09542.
MaxQBiP09542.
PaxDbiP09542.
PeptideAtlasiP09542.
PRIDEiP09542.

2D gel databases

UCD-2DPAGEP09542.

PTM databases

iPTMnetiP09542.
PhosphoSitePlusiP09542.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059741.
CleanExiMM_MYL3.
ExpressionAtlasiP09542. baseline and differential.
GenevisibleiP09542. MM.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201654. 1 interactor.
IntActiP09542. 2 interactors.
MINTiMINT-4102127.
STRINGi10090.ENSMUSP00000078715.

Structurei

3D structure databases

ProteinModelPortaliP09542.
SMRiP09542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini137 – 172EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini172 – 204EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP09542.
KOiK12749.
OMAiRPKEAEF.
OrthoDBiEOG091G0TQL.
PhylomeDBiP09542.
TreeFamiTF351553.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKPEPKK DDAKAAAPKA APAPAAAPAA APAAAPEPER PKEAEFDASK
60 70 80 90 100
IKIEFTPEQI EEFKEAFLLF DRTPKGEMKI TYGQCGDVLR ALGQNPTQAE
110 120 130 140 150
VLRVLGKPKQ EELNSKMMDF ETFLPMLQHI SKNKDTGTYE DFVEGLRVFD
160 170 180 190 200
KEGNGTVMGA ELRHVLATLG ERLTEDEVEK LMAGQEDSNG CINYEAFVKH

IMAS
Length:204
Mass (Da):22,422
Last modified:January 23, 2007 - v4
Checksum:i3DF39389FF5BAB41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002312 mRNA. Translation: BAB22006.1.
AK011518 mRNA. Translation: BAB27672.1.
AK146943 mRNA. Translation: BAE27552.1.
BC061222 mRNA. Translation: AAH61222.1.
X12972 Genomic DNA. Translation: CAA31415.1.
CCDSiCCDS23571.1.
PIRiS01945.
RefSeqiNP_034989.1. NM_010859.2.
UniGeneiMm.7353.

Genome annotation databases

EnsembliENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741.
GeneIDi17897.
KEGGimmu:17897.
UCSCiuc009rur.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002312 mRNA. Translation: BAB22006.1.
AK011518 mRNA. Translation: BAB27672.1.
AK146943 mRNA. Translation: BAE27552.1.
BC061222 mRNA. Translation: AAH61222.1.
X12972 Genomic DNA. Translation: CAA31415.1.
CCDSiCCDS23571.1.
PIRiS01945.
RefSeqiNP_034989.1. NM_010859.2.
UniGeneiMm.7353.

3D structure databases

ProteinModelPortaliP09542.
SMRiP09542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201654. 1 interactor.
IntActiP09542. 2 interactors.
MINTiMINT-4102127.
STRINGi10090.ENSMUSP00000078715.

PTM databases

iPTMnetiP09542.
PhosphoSitePlusiP09542.

2D gel databases

UCD-2DPAGEP09542.

Proteomic databases

EPDiP09542.
MaxQBiP09542.
PaxDbiP09542.
PeptideAtlasiP09542.
PRIDEiP09542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741.
GeneIDi17897.
KEGGimmu:17897.
UCSCiuc009rur.1. mouse.

Organism-specific databases

CTDi4634.
MGIiMGI:97268. Myl3.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP09542.
KOiK12749.
OMAiRPKEAEF.
OrthoDBiEOG091G0TQL.
PhylomeDBiP09542.
TreeFamiTF351553.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

PROiP09542.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059741.
CleanExiMM_MYL3.
ExpressionAtlasiP09542. baseline and differential.
GenevisibleiP09542. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYL3_MOUSE
AccessioniPrimary (citable) accession number: P09542
Secondary accession number(s): Q3UIF4, Q9CQZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.