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Protein

Myosin light chain 3

Gene

Myl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 3Curated
Alternative name(s):
Myosin alkali light chain 1, ventricular/slow skeletal muscle isoform1 Publication
Myosin light chain 1, slow-twitch muscle B/ventricular isoformBy similarity
Short name:
MLC1SBBy similarity
Gene namesi
Name:Myl3Imported
Synonyms:Mlc1vImported, MylcImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97268. Myl3.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986972 – 204Myosin light chain 3Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1
Modified residuei97PhosphothreonineBy similarity1
Modified residuei136PhosphothreonineCombined sources1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphotyrosineBy similarity1
Modified residuei188PhosphoserineCombined sources1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP09542.
MaxQBiP09542.
PaxDbiP09542.
PeptideAtlasiP09542.
PRIDEiP09542.

2D gel databases

UCD-2DPAGEiP09542.

PTM databases

iPTMnetiP09542.
PhosphoSitePlusiP09542.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059741.
CleanExiMM_MYL3.
ExpressionAtlasiP09542. baseline and differential.
GenevisibleiP09542. MM.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201654. 1 interactor.
IntActiP09542. 2 interactors.
MINTiMINT-4102127.
STRINGi10090.ENSMUSP00000078715.

Structurei

3D structure databases

ProteinModelPortaliP09542.
SMRiP09542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini137 – 172EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini172 – 204EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP09542.
KOiK12749.
OMAiELNSKMM.
OrthoDBiEOG091G0TQL.
PhylomeDBiP09542.
TreeFamiTF351553.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKPEPKK DDAKAAAPKA APAPAAAPAA APAAAPEPER PKEAEFDASK
60 70 80 90 100
IKIEFTPEQI EEFKEAFLLF DRTPKGEMKI TYGQCGDVLR ALGQNPTQAE
110 120 130 140 150
VLRVLGKPKQ EELNSKMMDF ETFLPMLQHI SKNKDTGTYE DFVEGLRVFD
160 170 180 190 200
KEGNGTVMGA ELRHVLATLG ERLTEDEVEK LMAGQEDSNG CINYEAFVKH

IMAS
Length:204
Mass (Da):22,422
Last modified:January 23, 2007 - v4
Checksum:i3DF39389FF5BAB41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002312 mRNA. Translation: BAB22006.1.
AK011518 mRNA. Translation: BAB27672.1.
AK146943 mRNA. Translation: BAE27552.1.
BC061222 mRNA. Translation: AAH61222.1.
X12972 Genomic DNA. Translation: CAA31415.1.
CCDSiCCDS23571.1.
PIRiS01945.
RefSeqiNP_034989.1. NM_010859.2.
UniGeneiMm.7353.

Genome annotation databases

EnsembliENSMUST00000079784; ENSMUSP00000078715; ENSMUSG00000059741.
GeneIDi17897.
KEGGimmu:17897.
UCSCiuc009rur.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMYL3_MOUSE
AccessioniPrimary (citable) accession number: P09542
Secondary accession number(s): Q3UIF4, Q9CQZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 139 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot