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Protein

Protein DVR-1

Gene

dvr1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DVR-1
Alternative name(s):
Vegetal hemisphere VG1 protein
Short name:
VG-1
Gene namesi
Name:dvr1
Synonyms:vg1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000003381417 – 246Add BLAST230
ChainiPRO_0000033815247 – 360Protein DVR-1Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi181N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi259 ↔ 325By similarity
Disulfide bondi288 ↔ 357By similarity
Disulfide bondi292 ↔ 359By similarity
Glycosylationi301N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi324InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP09534.

Expressioni

Tissue specificityi

Vegetal region of the egg.

Developmental stagei

Abundant in oocytes and present throughout cleavage and gastrula stage. Not readily detected at a stage when somitogenesis is nearly complete in 24 hours embryos. Steady state level decreases in a continuous fashion with developmental age.

Interactioni

Subunit structurei

Homodimer.Curated

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP09534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004860.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWLRLWAFL HILAIVTLDP ELKRREELFL RSLGFSSKPN PVSPPPVPSI
60 70 80 90 100
LWRIFNQRMG SSIQKKKPDL CFVEEFNVPG SVIRVFPDQG RFIIPYSDDI
110 120 130 140 150
HPTQCLEKRL FFNISAIEKE ERVTMGSGIE VQPEHLLRKG IDLRLYRTLQ
160 170 180 190 200
ITLKGMGRSK TSRKLLVAQT FRLLHKSLFF NLTEICQSWQ DPLKNLGLVL
210 220 230 240 250
EIFPKKESSW MSTANDECKD IQTFLYTSLL TVTLNPLRCK RPRRKRSYSK
260 270 280 290 300
LPFTASNICK KRHLYVEFKD VGWQNWVIAP QGYMANYCYG ECPYPLTEIL
310 320 330 340 350
NGSNHAILQT LVHSIEPEDI PLPCCVPTKM SPISMLFYDN NDNVVLRHYE
360
NMAVDECGCR
Length:360
Mass (Da):41,773
Last modified:July 1, 1989 - v1
Checksum:iE444A18AA2750984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18055 Genomic DNA. Translation: AAA49727.1.
PIRiA29619.
UniGeneiXl.25780.

Similar proteinsi

Entry informationi

Entry nameiDVR1_XENLA
AccessioniPrimary (citable) accession number: P09534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families