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P09506 (P1_TYYVF) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein P1
Alternative name(s):
66.2 kDa protein
Genome-linked protein precursor
Protein ORF1

Cleaved into the following 2 chains:

  1. Serine protease
    EC=3.4.21.-
  2. VPg/P1-C25
Gene names
ORF Names:ORF1
OrganismTurnip yellows virus (isolate FL-1) (TuYV) (BWYV-FL1) [Complete proteome]
Taxonomic identifier12043 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Luteoviridae › Polerovirus ›
Virus hostBeta vulgaris (Sugar beet) [TaxID: 161934]
Brassica napus var. napobrassica [TaxID: 3709]
Brassica napus var. napus [TaxID: 138011]
Brassica nigra (Black mustard) (Sinapis nigra) [TaxID: 3710]
Brassica oleracea var. botrytis (Cauliflower) [TaxID: 3715]
Brassica oleracea var. capitata (Cabbage) [TaxID: 3716]
Brassica rapa (Turnip) [TaxID: 51350]
Capsicum annuum (Bell pepper) [TaxID: 4072]
Cicer arietinum (Chickpea) (Garbanzo) [TaxID: 3827]
Citrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654]
Crambe hispanica subsp. abyssinica (Abyssinian kale) (Crambe abyssinica) [TaxID: 3721]
Cucumis sativus (Cucumber) [TaxID: 3659]
Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663]
Glycine max (Soybean) (Glycine hispida) [TaxID: 3847]
Helianthus annuus (Common sunflower) [TaxID: 4232]
Lactuca sativa (Garden lettuce) [TaxID: 4236]
Phlox drummondii (Annual phlox) [TaxID: 103529]
Pisum sativum (Garden pea) [TaxID: 3888]
Raphanus sativus (Radish) [TaxID: 3726]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Spinacia oleracea (Spinach) [TaxID: 3562]
Trifolium subterraneum (Subterranean clover) [TaxID: 3900]
Vicia faba (Broad bean) (Faba vulgaris) [TaxID: 3906]

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication By similarity.

Subcellular location

Protein P1: Membrane; Multi-pass membrane protein Potential.

Domain

The C-terminus part of protein P1 and VPg/P1-C25 displays RNA-binding properties By similarity.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins. The protease probably cleaves itself and releases the VPg protein By similarity.

Sequence similarities

Belongs to the peptidase S39B family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityRibosomal frameshifting
   DomainSignal
Transmembrane
Transmembrane helix
   LigandRNA-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

viral reproductive process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform Protein P1 (identifier: P09506-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by conventional translation.
Isoform RNA-directed RNA polymerase (identifier: P09507-1)

The sequence of this isoform can be found in the external entry P09507.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting between codons 461 and 462.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 607585Protein P1
PRO_0000222395
Chain204 – 400197Serine protease Potential
PRO_0000390897
Chain401 – 607207VPg/P1-C25 Potential
PRO_0000390898

Regions

Transmembrane115 – 13521Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane167 – 18721Helical; Potential
Compositional bias525 – 5284Poly-Arg

Sites

Active site2541 By similarity
Active site2891 By similarity
Active site3571 By similarity
Site203 – 2042Cleavage; by viral serine protease Potential
Site400 – 4012Cleavage; by viral serine protease By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform Protein P1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 2A41F82911DEC84F

FASTA60766,211
        10         20         30         40         50         60 
MYSKLMFFFA LCSISFLFTS EAASTMLLES SYLPLNQSYA PGFLYKRDML PPPLQAVLTY 

        70         80         90        100        110        120 
TCPEPRPLAE ESYNDLLRAI SQKSSSDFQN AYSLALSFSS DFYQHGLKTL KDVSFLAVEK 

       130        140        150        160        170        180 
FLWGLTRLWS SLILASFSAL WWLVSNFTTP VFCLALLYTV TKYMVKTVSF LFGGLPIWII 

       190        200        210        220        230        240 
SIAFSLLKKS FSALRSTPKC LYEKAIDGFK SFTIPQSPPK SCVIPITHAS GNHAGYASCI 

       250        260        270        280        290        300 
KLYNGENALM TATHVLRDCP NAVAVSAKGL KTRIPLAEFK TIAKSDKGDV TLLRGPPNWE 

       310        320        330        340        350        360 
GLLGCKAANV ITAANLAKCK ASIYSFDRDG WVSSYAEIVG SEGTDVMVLS HTEGGHSGSP 

       370        380        390        400        410        420 
YFNGKTILGV HSGASATGNY NLMAPIPSLP GLTSPTYVFE TTAPQGRVFA QEDIAEIEGL 

       430        440        450        460        470        480 
YAQVMKRVQQ AEDFKPKTGK YWGDMEDDED IFFESKEDLS GNGVRGTVRG TNGEGSSTPK 

       490        500        510        520        530        540 
TSNVDGKEMM EKIISSLVGK INLENIERKV IEEISAKAMK TPKSRRRRAP KKQPESSKDT 

       550        560        570        580        590        600 
SPRSTTGKYQ PPHVRSPASV TAANCPNTTT PSKKKNLAGG RPSSGTIPRW VRKQAASAGP 


SSAPKQN

« Hide

Isoform RNA-directed RNA polymerase [UniParc].

See P09507.

––

References

[1]"Nucleotide sequence of beet western yellows virus RNA."
Veidt I., Lot H., Leiser M., Scheidecker D., Guilley H., Richards K.E., Jonard G.
Nucleic Acids Res. 16:9917-9932(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X13063 Genomic RNA. Translation: CAA31463.1.
PIRS01939.
RefSeqNP_620486.1. NC_003743.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSS39.002.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID940483.

Family and domain databases

InterProIPR018019. Luteovirus_Orf2.
IPR000382. Peptidase_S39B_luteovirus.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF02122. Peptidase_S39. 1 hit.
[Graphical view]
PRINTSPR00913. LVIRUSORF2.
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP1_TYYVF
AccessionPrimary (citable) accession number: P09506
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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