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P09505 (RDRP_BYDVP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length867 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable polymerase.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the luteoviruses RNA polymerase family.

Contains 1 RdRp catalytic domain.

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform Putative RNA-directed RNA polymerase (identifier: P09505-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by -1 ribosomal frameshifting between codons 339 and 340.
Isoform 39 kDa protein (identifier: P09505-2)

The sequence of this isoform differs from the canonical sequence as follows:
     340-867: Missing.
Note: Produced by conventional translation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 867867Putative RNA-directed RNA polymerase
PRO_0000039186

Regions

Domain561 – 676116RdRp catalytic

Natural variations

Alternative sequence340 – 867528Missing in isoform 39 kDa protein.
VSP_031895

Sequences

Sequence LengthMass (Da)Tools
Isoform Putative RNA-directed RNA polymerase [UniParc].

Last modified November 1, 1991. Version 2.
Checksum: 12E2C7AD52EE593B

FASTA86798,662
        10         20         30         40         50         60 
MFFEILIGAS AKAVKDFISH CYSRLKSIYY SFKRWLMEIS GQFKAHDAFV NMCFGHMADI 

        70         80         90        100        110        120 
EDFEAELAEE FAEREDEVEE ARSLLKLLVA QKSKSGVTEA WTDFFTKSRG GVYAPLSCEP 

       130        140        150        160        170        180 
TRQELEVKSE KLERLLEEQH QFEVRAAKKY IKEKGRGFIN CWNDLRSRLR LVKDVKDEAK 

       190        200        210        220        230        240 
DNARAAAKIG AEMFAPVDVQ DLYSFTEVKK VETGLMKEVV KEKNGEEEKH LEPIMEEVRS 

       250        260        270        280        290        300 
IKDTAEARDA ASTWITETVK LKNATLNADE LSLATIARYV ENVGDKFKLD IASKTYLKQV 

       310        320        330        340        350        360 
ASMSVPIPTN KDIKLKMVLQ SPEARARRER MDVLDSVGFL EGLCTASGFE SPFPILGLPE 

       370        380        390        400        410        420 
IAVTDGARLR KVSSNIRYLS QTHLGLVYKA PNASLHNALV AVERRVFTVG KGDKAIYPPR 

       430        440        450        460        470        480 
PEHDIFTDTM DYFQKSIIEE VGYCKTYPAQ LLANSYSAGK RAMYHKAIAS LKTVPYHQKD 

       490        500        510        520        530        540 
ANVQAFLKKE KHWMTKDIAP RLICPRSKRY NIILGTRLKF NEKKIMHAID SVFGSPTVLS 

       550        560        570        580        590        600 
GYDNFKQGRI IAKKWQKFAC PVAIGVDASR FDQHVSEQAL KWEHGIYNGI FGDSEMALAL 

       610        620        630        640        650        660 
EHQITNNIKM FVEDKMLRFK VRGHRMSGDI NTSMGNKLIM CGMMHAYLKK LGVEAELCNN 

       670        680        690        700        710        720 
GDDCVIITDR ANEKLFDGMY DHFLQYGFNM VTEKPVYELE QLEFCQSKPV SINGKYRMVR 

       730        740        750        760        770        780 
RPDSIGKDST TLLSMLNQSD VKSYMSAVAQ CGLVLNAGVP ILESFYKCLY RSSGYKKVSE 

       790        800        810        820        830        840 
EFIKNVISYG TDERLQGRRT YNETPITNHS RMSYWESFGV DPKIQQIVER YYDGLTVSAQ 

       850        860 
LQSVKVTTPH LQSILLSIPE NHSQNEY

« Hide

Isoform 39 kDa protein [UniParc].

Checksum: BAFA634C9E1F1732
Show »

FASTA33938,735

References

[1]"Sequence and organization of barley yellow dwarf virus genomic RNA."
Miller W.A., Waterhouse P.M., Gerlach W.L.
Nucleic Acids Res. 16:6097-6111(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA."
Barry J.K., Miller W.A.
Proc. Natl. Acad. Sci. U.S.A. 99:11133-11138(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: RIBOSOMAL FRAMESHIFT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X07653 Genomic RNA. Translation: CAA30498.1. Sequence problems.
PIRA59303.
RefSeqNP_840014.2. NC_004750.1.
NP_840067.1. NC_004750.1.

3D structure databases

ProteinModelPortalP09505.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1492001.
1492003.

Family and domain databases

InterProIPR013674. Luteo_Rpol_P1-P2.
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamPF08467. Luteo_P1-P2. 1 hit.
PF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_BYDVP
AccessionPrimary (citable) accession number: P09505
Secondary accession number(s): P19648
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: April 3, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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