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P09505

- RDRP_BYDVP

UniProt

P09505 - RDRP_BYDVP

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Protein
Putative RNA-directed RNA polymerase
Gene
ORF1/ORF2
Organism
Barley yellow dwarf virus (isolate PAV) (BYDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probable polymerase.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-directed RNA polymerase (EC:2.7.7.48)
Gene namesi
ORF Names:ORF1/ORF2
OrganismiBarley yellow dwarf virus (isolate PAV) (BYDV)
Taxonomic identifieri12040 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageLuteoviridaeLuteovirus
Virus hostiAvena byzantina [TaxID: 146531]
Avena sativa (Oat) [TaxID: 4498]
Hordeum vulgare (Barley) [TaxID: 4513]
Lolium multiflorum (Italian ryegrass) (Lolium perenne subsp. multiflorum) [TaxID: 4521]
Lolium perenne (Perennial ryegrass) [TaxID: 4522]
Oryza sativa (Rice) [TaxID: 4530]
Secale cereale (Rye) [TaxID: 4550]
Triticum aestivum (Wheat) [TaxID: 4565]
Zea mays (Maize) [TaxID: 4577]
ProteomesiUP000006722: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Putative RNA-directed RNA polymerase
PRO_0000039186Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 676116RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR013674. Luteo_Rpol_P1-P2.
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF08467. Luteo_P1-P2. 1 hit.
PF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform Putative RNA-directed RNA polymerase (identifier: P09505-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFFEILIGAS AKAVKDFISH CYSRLKSIYY SFKRWLMEIS GQFKAHDAFV    50
NMCFGHMADI EDFEAELAEE FAEREDEVEE ARSLLKLLVA QKSKSGVTEA 100
WTDFFTKSRG GVYAPLSCEP TRQELEVKSE KLERLLEEQH QFEVRAAKKY 150
IKEKGRGFIN CWNDLRSRLR LVKDVKDEAK DNARAAAKIG AEMFAPVDVQ 200
DLYSFTEVKK VETGLMKEVV KEKNGEEEKH LEPIMEEVRS IKDTAEARDA 250
ASTWITETVK LKNATLNADE LSLATIARYV ENVGDKFKLD IASKTYLKQV 300
ASMSVPIPTN KDIKLKMVLQ SPEARARRER MDVLDSVGFL EGLCTASGFE 350
SPFPILGLPE IAVTDGARLR KVSSNIRYLS QTHLGLVYKA PNASLHNALV 400
AVERRVFTVG KGDKAIYPPR PEHDIFTDTM DYFQKSIIEE VGYCKTYPAQ 450
LLANSYSAGK RAMYHKAIAS LKTVPYHQKD ANVQAFLKKE KHWMTKDIAP 500
RLICPRSKRY NIILGTRLKF NEKKIMHAID SVFGSPTVLS GYDNFKQGRI 550
IAKKWQKFAC PVAIGVDASR FDQHVSEQAL KWEHGIYNGI FGDSEMALAL 600
EHQITNNIKM FVEDKMLRFK VRGHRMSGDI NTSMGNKLIM CGMMHAYLKK 650
LGVEAELCNN GDDCVIITDR ANEKLFDGMY DHFLQYGFNM VTEKPVYELE 700
QLEFCQSKPV SINGKYRMVR RPDSIGKDST TLLSMLNQSD VKSYMSAVAQ 750
CGLVLNAGVP ILESFYKCLY RSSGYKKVSE EFIKNVISYG TDERLQGRRT 800
YNETPITNHS RMSYWESFGV DPKIQQIVER YYDGLTVSAQ LQSVKVTTPH 850
LQSILLSIPE NHSQNEY 867

Note: Produced by -1 ribosomal frameshifting between codons 339 and 340.

Length:867
Mass (Da):98,662
Last modified:November 1, 1991 - v2
Checksum:i12E2C7AD52EE593B
GO
Isoform 39 kDa protein (identifier: P09505-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-867: Missing.

Note: Produced by conventional translation.

Show »
Length:339
Mass (Da):38,735
Checksum:iBAFA634C9E1F1732
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei340 – 867528Missing in isoform 39 kDa protein.
VSP_031895Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07653 Genomic RNA. Translation: CAA30498.1. Sequence problems.
PIRiA59303.
RefSeqiNP_840014.2. NC_004750.1. [P09505-1]
NP_840067.1. NC_004750.1. [P09505-2]

Genome annotation databases

GeneIDi1492001.
1492003.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07653 Genomic RNA. Translation: CAA30498.1 . Sequence problems.
PIRi A59303.
RefSeqi NP_840014.2. NC_004750.1. [P09505-1 ]
NP_840067.1. NC_004750.1. [P09505-2 ]

3D structure databases

ProteinModelPortali P09505.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1492001.
1492003.

Family and domain databases

InterProi IPR013674. Luteo_Rpol_P1-P2.
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF08467. Luteo_P1-P2. 1 hit.
PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and organization of barley yellow dwarf virus genomic RNA."
    Miller W.A., Waterhouse P.M., Gerlach W.L.
    Nucleic Acids Res. 16:6097-6111(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA."
    Barry J.K., Miller W.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:11133-11138(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: RIBOSOMAL FRAMESHIFT.

Entry informationi

Entry nameiRDRP_BYDVP
AccessioniPrimary (citable) accession number: P09505
Secondary accession number(s): P19648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: May 14, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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