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P09505

- RDRP_BYDVP

UniProt

P09505 - RDRP_BYDVP

Protein

Putative RNA-directed RNA polymerase

Gene

ORF1/ORF2

Organism
Barley yellow dwarf virus (isolate PAV) (BYDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Probable polymerase.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA-directed RNA polymerase (EC:2.7.7.48)
    Gene namesi
    ORF Names:ORF1/ORF2
    OrganismiBarley yellow dwarf virus (isolate PAV) (BYDV)
    Taxonomic identifieri12040 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageLuteoviridaeLuteovirus
    Virus hostiAvena byzantina [TaxID: 146531]
    Avena sativa (Oat) [TaxID: 4498]
    Hordeum vulgare (Barley) [TaxID: 4513]
    Lolium multiflorum (Italian ryegrass) (Lolium perenne subsp. multiflorum) [TaxID: 4521]
    Lolium perenne (Perennial ryegrass) [TaxID: 4522]
    Oryza sativa (Rice) [TaxID: 4530]
    Secale cereale (Rye) [TaxID: 4550]
    Triticum aestivum (Wheat) [TaxID: 4565]
    Zea mays (Maize) [TaxID: 4577]
    ProteomesiUP000006722: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Putative RNA-directed RNA polymerasePRO_0000039186Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP09505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini561 – 676116RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the luteoviruses RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR013674. Luteo_Rpol_P1-P2.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF08467. Luteo_P1-P2. 1 hit.
    PF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform Putative RNA-directed RNA polymerase (identifier: P09505-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFFEILIGAS AKAVKDFISH CYSRLKSIYY SFKRWLMEIS GQFKAHDAFV    50
    NMCFGHMADI EDFEAELAEE FAEREDEVEE ARSLLKLLVA QKSKSGVTEA 100
    WTDFFTKSRG GVYAPLSCEP TRQELEVKSE KLERLLEEQH QFEVRAAKKY 150
    IKEKGRGFIN CWNDLRSRLR LVKDVKDEAK DNARAAAKIG AEMFAPVDVQ 200
    DLYSFTEVKK VETGLMKEVV KEKNGEEEKH LEPIMEEVRS IKDTAEARDA 250
    ASTWITETVK LKNATLNADE LSLATIARYV ENVGDKFKLD IASKTYLKQV 300
    ASMSVPIPTN KDIKLKMVLQ SPEARARRER MDVLDSVGFL EGLCTASGFE 350
    SPFPILGLPE IAVTDGARLR KVSSNIRYLS QTHLGLVYKA PNASLHNALV 400
    AVERRVFTVG KGDKAIYPPR PEHDIFTDTM DYFQKSIIEE VGYCKTYPAQ 450
    LLANSYSAGK RAMYHKAIAS LKTVPYHQKD ANVQAFLKKE KHWMTKDIAP 500
    RLICPRSKRY NIILGTRLKF NEKKIMHAID SVFGSPTVLS GYDNFKQGRI 550
    IAKKWQKFAC PVAIGVDASR FDQHVSEQAL KWEHGIYNGI FGDSEMALAL 600
    EHQITNNIKM FVEDKMLRFK VRGHRMSGDI NTSMGNKLIM CGMMHAYLKK 650
    LGVEAELCNN GDDCVIITDR ANEKLFDGMY DHFLQYGFNM VTEKPVYELE 700
    QLEFCQSKPV SINGKYRMVR RPDSIGKDST TLLSMLNQSD VKSYMSAVAQ 750
    CGLVLNAGVP ILESFYKCLY RSSGYKKVSE EFIKNVISYG TDERLQGRRT 800
    YNETPITNHS RMSYWESFGV DPKIQQIVER YYDGLTVSAQ LQSVKVTTPH 850
    LQSILLSIPE NHSQNEY 867

    Note: Produced by -1 ribosomal frameshifting between codons 339 and 340.

    Length:867
    Mass (Da):98,662
    Last modified:November 1, 1991 - v2
    Checksum:i12E2C7AD52EE593B
    GO
    Isoform 39 kDa protein (identifier: P09505-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-867: Missing.

    Note: Produced by conventional translation.

    Show »
    Length:339
    Mass (Da):38,735
    Checksum:iBAFA634C9E1F1732
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei340 – 867528Missing in isoform 39 kDa protein. CuratedVSP_031895Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07653 Genomic RNA. Translation: CAA30498.1. Sequence problems.
    PIRiA59303.
    RefSeqiNP_840014.2. NC_004750.1. [P09505-1]
    NP_840067.1. NC_004750.1. [P09505-2]

    Genome annotation databases

    GeneIDi1492001.
    1492003.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07653 Genomic RNA. Translation: CAA30498.1 . Sequence problems.
    PIRi A59303.
    RefSeqi NP_840014.2. NC_004750.1. [P09505-1 ]
    NP_840067.1. NC_004750.1. [P09505-2 ]

    3D structure databases

    ProteinModelPortali P09505.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1492001.
    1492003.

    Family and domain databases

    InterProi IPR013674. Luteo_Rpol_P1-P2.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF08467. Luteo_P1-P2. 1 hit.
    PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and organization of barley yellow dwarf virus genomic RNA."
      Miller W.A., Waterhouse P.M., Gerlach W.L.
      Nucleic Acids Res. 16:6097-6111(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA."
      Barry J.K., Miller W.A.
      Proc. Natl. Acad. Sci. U.S.A. 99:11133-11138(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: RIBOSOMAL FRAMESHIFT.

    Entry informationi

    Entry nameiRDRP_BYDVP
    AccessioniPrimary (citable) accession number: P09505
    Secondary accession number(s): P19648
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3