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Protein

Clathrin light chain B

Gene

CLTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175416-MONOMER.
ReactomeiR-HSA-190873. Gap junction degradation.
R-HSA-196025. Formation of annular gap junctions.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiP09497.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
Gene namesi
Name:CLTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2091. CLTB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1212.
OpenTargetsiENSG00000175416.
PharmGKBiPA26617.

Polymorphism and mutation databases

BioMutaiCLTB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057711 – 229Clathrin light chain BAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei187PhosphothreonineCombined sources1
Disulfide bondi199 ↔ 209By similarity
Modified residuei204N6-acetyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei223N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP09497.
MaxQBiP09497.
PaxDbiP09497.
PeptideAtlasiP09497.
PRIDEiP09497.

2D gel databases

OGPiP09497.

PTM databases

iPTMnetiP09497.
PhosphoSitePlusiP09497.

Miscellaneous databases

PMAP-CutDBP09497.

Expressioni

Gene expression databases

BgeeiENSG00000175416.
CleanExiHS_CLTB.
ExpressionAtlasiP09497. baseline and differential.
GenevisibleiP09497. HS.

Organism-specific databases

HPAiCAB003692.
HPA036458.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107622. 79 interactors.
IntActiP09497. 72 interactors.
MINTiMINT-1390805.
STRINGi9606.ENSP00000309415.

Structurei

3D structure databases

ProteinModelPortaliP09497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 155Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP09497.
KOiK04645.
OMAiQNPIQLQ.
OrthoDBiEOG091G0WEF.
PhylomeDBiP09497.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P09497-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS
60 70 80 90 100
HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP
110 120 130 140 150
ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN
160 170 180 190 200
KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD
210 220
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
Length:229
Mass (Da):25,190
Last modified:July 1, 1989 - v1
Checksum:i07DBA19D44648F6F
GO
Isoform Non-brain (identifier: P09497-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-173: Missing.

Show »
Length:211
Mass (Da):23,181
Checksum:i5B40F043E1809238
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5F → I in CAG38814 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001098156 – 173Missing in isoform Non-brain. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20469 mRNA. Translation: AAA51818.1.
M20470 mRNA. Translation: AAA59506.1.
BT007028 mRNA. Translation: AAP35675.1.
CR536577 mRNA. Translation: CAG38814.1.
CH471195 Genomic DNA. Translation: EAW85079.1.
BC006332 mRNA. Translation: AAH06332.1.
BC006457 mRNA. Translation: AAH06457.1.
CCDSiCCDS4402.1. [P09497-2]
CCDS4403.1. [P09497-1]
PIRiB31775.
RefSeqiNP_001825.1. NM_001834.3. [P09497-2]
NP_009028.1. NM_007097.3. [P09497-1]
UniGeneiHs.484241.

Genome annotation databases

EnsembliENST00000310418; ENSP00000309415; ENSG00000175416. [P09497-1]
ENST00000345807; ENSP00000310812; ENSG00000175416. [P09497-2]
GeneIDi1212.
KEGGihsa:1212.
UCSCiuc003meh.4. human. [P09497-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20469 mRNA. Translation: AAA51818.1.
M20470 mRNA. Translation: AAA59506.1.
BT007028 mRNA. Translation: AAP35675.1.
CR536577 mRNA. Translation: CAG38814.1.
CH471195 Genomic DNA. Translation: EAW85079.1.
BC006332 mRNA. Translation: AAH06332.1.
BC006457 mRNA. Translation: AAH06457.1.
CCDSiCCDS4402.1. [P09497-2]
CCDS4403.1. [P09497-1]
PIRiB31775.
RefSeqiNP_001825.1. NM_001834.3. [P09497-2]
NP_009028.1. NM_007097.3. [P09497-1]
UniGeneiHs.484241.

3D structure databases

ProteinModelPortaliP09497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107622. 79 interactors.
IntActiP09497. 72 interactors.
MINTiMINT-1390805.
STRINGi9606.ENSP00000309415.

PTM databases

iPTMnetiP09497.
PhosphoSitePlusiP09497.

Polymorphism and mutation databases

BioMutaiCLTB.

2D gel databases

OGPiP09497.

Proteomic databases

EPDiP09497.
MaxQBiP09497.
PaxDbiP09497.
PeptideAtlasiP09497.
PRIDEiP09497.

Protocols and materials databases

DNASUi1212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310418; ENSP00000309415; ENSG00000175416. [P09497-1]
ENST00000345807; ENSP00000310812; ENSG00000175416. [P09497-2]
GeneIDi1212.
KEGGihsa:1212.
UCSCiuc003meh.4. human. [P09497-1]

Organism-specific databases

CTDi1212.
DisGeNETi1212.
GeneCardsiCLTB.
HGNCiHGNC:2091. CLTB.
HPAiCAB003692.
HPA036458.
MIMi118970. gene.
neXtProtiNX_P09497.
OpenTargetsiENSG00000175416.
PharmGKBiPA26617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP09497.
KOiK04645.
OMAiQNPIQLQ.
OrthoDBiEOG091G0WEF.
PhylomeDBiP09497.
TreeFamiTF313162.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175416-MONOMER.
ReactomeiR-HSA-190873. Gap junction degradation.
R-HSA-196025. Formation of annular gap junctions.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiP09497.

Miscellaneous databases

ChiTaRSiCLTB. human.
GenomeRNAii1212.
PMAP-CutDBP09497.
PROiP09497.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175416.
CleanExiHS_CLTB.
ExpressionAtlasiP09497. baseline and differential.
GenevisibleiP09497. HS.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCB_HUMAN
AccessioniPrimary (citable) accession number: P09497
Secondary accession number(s): Q53Y37, Q6FHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.